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This study investigated the effectiveness of ONS intake in the late afternoon and for longer duration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Subjects\/Methods<\/jats:title>\n                <jats:p>Twenty-one healthy females (mean\u2009\u00b1\u2009SD, age 25\u2009\u00b1\u20095 years; BMI 18.7\u2009\u00b1\u20091.2\u2009kg\/m<jats:sup>2<\/jats:sup>) participated in a randomised, crossover study with two experimental trials. In the afternoon of days 1\u20135, participants consumed either ONS (2.510\u2009MJ) or low-energy PLACEBO drink (0.377\u2009MJ) and recorded food eaten at home. On day six, energy intake was measured during buffet meals, and energy expenditure, appetite measurements and blood samples were collected throughout the day.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Result<\/jats:title>\n                <jats:p>Over the 5-day period, in the ONS trial energy intake from evening meals was lower (ONS, 2.7\u2009\u00b1\u20090.25 MJ; Placebo, 3.6\u2009\u00b1\u20090.25 MJ, <jats:italic>P<\/jats:italic>\u2009=\u20090.01) but averaged total daily energy intake was higher (ONS, 9.2\u2009\u00b1\u20090.3\u2009MJ; PLACEBO, 8.2\u2009\u00b1\u20090.4\u2009MJ, <jats:italic>P<\/jats:italic>\u2009=\u20090.03). On day six, energy intake, appetite scores, plasma GLP-1 and PYY, and energy expenditure were not significantly different between the two trials but fasting insulin concentration and HOMA<jats:sub>IR<\/jats:sub>, were higher (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and insulin sensitivity score based on fasting insulin and TAG lower (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in ONS trial.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Late afternoon consumption of ONS for five consecutive days by females with a lower BMI has only a partial and short-lived energy intake suppression and thus increases daily energy intake but reduces insulin sensitivity.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41430-021-01042-w","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T12:02:27Z","timestamp":1636718547000},"page":"811-818","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of high energy oral nutritional supplements consumed in the late afternoon on appetite, energy intake and cardio-metabolic risk factors in females with lower BMI"],"prefix":"10.1038","volume":"76","author":[{"given":"Sadia","family":"Fatima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Gerasimidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-6315","authenticated-orcid":false,"given":"Charlotte","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-0528","authenticated-orcid":false,"given":"Dalia","family":"Malkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"1042_CR1","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.2147\/CIA.S140859","volume":"12","author":"Aziz NASA","year":"2017","unstructured":"NASA Aziz, NIMF Teng, Hamid MRA, Ismail NH. 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