{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:51:03Z","timestamp":1769061063835,"version":"3.49.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Australian Lung Foundation\/Edith Cowan University PhD Scholarship and Australian Government Research Training Program Scholarship."},{"name":"Cancer Council Western Australia Postdoctoral Fellowship"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Skeletal muscle loss is common in advanced cancer and is associated with negative outcomes. In malignant pleural mesothelioma (MPM), no study has reported body composition changes or factors associated with these changes. This study aimed to describe changes in body composition over time and its relationship with activity levels, dietary intake and survival.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The study was a secondary analysis of data collected from a longitudinal observational study of patients with MPM. Participants completed 3-month assessments for up to 18 months. Participants with two dual-energy x-ray absorptiometry (DXA) scans were included. Changes in appendicular skeletal muscle mass (ASM) and total fat mass were used to categorise participants into phenotypes. Activity levels were measured with an ActiGraph GT3X+ accelerometer and energy and protein intake was measured with a 3-day food record and 24-h recall.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eighteen participants were included (89% men, mean age 68.9\u2009\u00b1\u20097.1 years). Median time between DXA was 91 [IQR 84\u2013118] days. Compared to participants with ASM maintenance (<jats:italic>n<\/jats:italic>\u2009=\u20099), fewer participants with ASM loss (<jats:italic>n<\/jats:italic>\u2009=\u20099) survived \u226512 months from follow-up (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). Participants with ASM loss increased sedentary time (<jats:italic>p<\/jats:italic>\u2009=\u20090.028) and decreased light activity (<jats:italic>p<\/jats:italic>\u2009=\u20090.028) and step count (<jats:italic>p<\/jats:italic>\u2009=\u20090.008). Activity levels did not change in participants with ASM maintenance (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Energy and protein intake did not change in either group (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Muscle loss was associated with poorer survival and decreased activity levels. Interventions that improve physical activity or muscle mass could benefit patients with MPM.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41430-021-01062-6","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T10:03:53Z","timestamp":1642413833000},"page":"979-986","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Changes in body composition in patients with malignant pleural mesothelioma and the relationship with activity levels and dietary intake"],"prefix":"10.1038","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9463-3196","authenticated-orcid":false,"given":"Emily","family":"Jeffery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. C. Gary","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-6129","authenticated-orcid":false,"given":"Robert U.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippa","family":"Lyons-Wall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"McVeigh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre B.","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-4128","authenticated-orcid":false,"given":"Leon","family":"Straker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn J.","family":"Peddle-McIntyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"1062_CR1","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0140-6736(05)67025-0","volume":"366","author":"BWS Robinson","year":"2005","unstructured":"Robinson BWS, Musk AW, Lake RA. Malignant mesothelioma. Lancet. 2005;366:397\u2013408.","journal-title":"Lancet."},{"key":"1062_CR2","doi-asserted-by":"publisher","unstructured":"Finn RS, Brims FJ, Gandhi A, Olsen N, Musk AW, Maskell NA, et al. Postmortem findings of malignant pleural mesothelioma: a two-center study of 318 patients. Chest. 2012;142:1267\u201373. https:\/\/doi.org\/10.1378\/chest.11-3204.","DOI":"10.1378\/chest.11-3204"},{"key":"1062_CR3","doi-asserted-by":"publisher","unstructured":"Fearon K, Arends J, Baracos V. Understanding the mechanisms and treatment options in cancer cachexia. Nat Rev Clin Oncol. 2013;10:90\u201399. https:\/\/doi.org\/10.1038\/nrclinonc.2012.209.","DOI":"10.1038\/nrclinonc.2012.209"},{"key":"1062_CR4","doi-asserted-by":"publisher","unstructured":"Fearon K, Arends J, Baracos V. Understanding the mechanisms and treatment options in cancer cachexia. Nat RevBye A, Sjoblom B, Wentzel-Larsen T, Gronberg BH, Baracos VE, Hjermstad MJ, et al. Muscle mass and association to quality of life in non-small cell lung cancer patients. J Cachexia Sarcopenia Muscle. 2017;8:759\u201367. 10.1002\/jcsm.12206Clin Oncol. 2013;10:90\u201399. https:\/\/doi.org\/10.1038\/nrclinonc.2012.209.","DOI":"10.1038\/nrclinonc.2012.209"},{"key":"1062_CR5","doi-asserted-by":"crossref","unstructured":"Jeffery E, Lee YCG, Newton RU, Lyons-Wall P, McVeigh J, Nowak AK, et al. Body composition and nutritional status in malignant pleural mesothelioma: implications for activity levels and quality of life. Eur J Clin Nutr. 2019;73:1412\u201321.","DOI":"10.1038\/s41430-019-0418-9"},{"key":"1062_CR6","doi-asserted-by":"publisher","unstructured":"Shachar SS, Williams GR, Muss HB, Nishijima TF. Prognostic value of sarcopenia in adults with solid tumours: a meta-analysis and systematic review. Eur J Cancer. 2016;57:58\u201367. https:\/\/doi.org\/10.1016\/j.ejca.2015.12.030.","DOI":"10.1016\/j.ejca.2015.12.030"},{"key":"1062_CR7","doi-asserted-by":"publisher","unstructured":"Baracos VE, Arribas L. Sarcopenic obesity: hidden muscle wasting and its impact for survival and complications of cancer therapy. Ann Oncol.2018;29(Suppl_2):ii1\u2013ii9. https:\/\/doi.org\/10.1093\/annonc\/mdx810.","DOI":"10.1093\/annonc\/mdx810"},{"key":"1062_CR8","doi-asserted-by":"publisher","unstructured":"Brook MS, Wilkinson DJ, Smith K, Atherton PJ. The metabolic and temporal basis of muscle hypertrophy in response to resistance exercise. Eur J Sport Sci. 2016;16:633\u201344. https:\/\/doi.org\/10.1080\/17461391.2015.1073362.","DOI":"10.1080\/17461391.2015.1073362"},{"key":"1062_CR9","doi-asserted-by":"publisher","unstructured":"Steffl M, Bohannon RW, Sontakova L, Tufano JJ, Shiells K, Holmerova I. Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis. Clin Inter Aging. 2017;12:835\u201345. https:\/\/doi.org\/10.2147\/cia.S132940.","DOI":"10.2147\/cia.S132940"},{"key":"1062_CR10","doi-asserted-by":"publisher","unstructured":"Houston DK, Nicklas BJ, Ding J, Harris TB, Tylavsky FA, Newman AB, et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2008;87:150\u20135. https:\/\/doi.org\/10.1093\/ajcn\/87.1.150.","DOI":"10.1093\/ajcn\/87.1.150"},{"key":"1062_CR11","doi-asserted-by":"publisher","unstructured":"Jequier E, Tappy L. Regulation of body weight in humans. Physiol Rev. 1999;79:451\u201380. https:\/\/doi.org\/10.1152\/physrev.1999.79.2.451.","DOI":"10.1152\/physrev.1999.79.2.451"},{"key":"1062_CR12","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","volume":"5","author":"MM Oken","year":"1982","unstructured":"Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5:649\u201355.","journal-title":"Am J Clin Oncol"},{"key":"1062_CR13","unstructured":"World Health Organisation. Waist circumference and waist-hip ratio: reports of a WHO expert consultation, 8\u201311 December 2008. Geneva: World Health Organisation. 2011."},{"key":"1062_CR14","doi-asserted-by":"publisher","unstructured":"Nowitz M, Monahan P. Short term in vivo precision of whole body composition measurements on the Horizon A densitometer. J Med Imaging Radiat Oncol. 2018;62:179\u201382. https:\/\/doi.org\/10.1111\/1754-9485.12646.","DOI":"10.1111\/1754-9485.12646"},{"key":"1062_CR15","unstructured":"Centres for Disease Control and Prevention. National Health and Nutrition Examination Survey (NHANES) body composition procedures manual. 2013."},{"key":"1062_CR16","first-page":"620","volume":"14","author":"NH Hart","year":"2015","unstructured":"Hart NH, Nimphius S, Spiteri T, Cochrane JL, Newton RU. Segmental musculoskeletal examinations using dual-energy X-ray absorptiometry (DXA): positioning and analysis considerations. J Sports Sci Med. 2015;14:620\u20136.","journal-title":"J Sports Sci Med"},{"key":"1062_CR17","doi-asserted-by":"publisher","unstructured":"Mourtzakis M, Prado CM, Lieffers JR, Reiman T, McCargar LJ, Baracos VE. A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab. 2008;33:997\u20131006. https:\/\/doi.org\/10.1139\/h08-075.","DOI":"10.1139\/h08-075"},{"key":"1062_CR18","doi-asserted-by":"publisher","unstructured":"Kirk B, Bani Hassan E, Brennan-Olsen S, Vogrin S, Bird S, Zanker J, et al. Body composition reference ranges in community-dwelling adults using dual-energy X-ray absorptiometry: the Australian Body Composition (ABC) Study. J Cachexia Sarcopenia Muscle. 2021;12:880\u201390. https:\/\/doi.org\/10.1002\/jcsm.12712.","DOI":"10.1002\/jcsm.12712"},{"key":"1062_CR19","doi-asserted-by":"publisher","unstructured":"Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48:16\u201331. https:\/\/doi.org\/10.1093\/ageing\/afy169.","DOI":"10.1093\/ageing\/afy169"},{"key":"1062_CR20","doi-asserted-by":"publisher","unstructured":"Prado CM, Heymsfield SB. Lean tissue imaging: a new era for nutritional assessment and intervention. JPEN J Parenter Enter Nutr. 2014;38:940\u201353. https:\/\/doi.org\/10.1177\/0148607114550189.","DOI":"10.1177\/0148607114550189"},{"key":"1062_CR21","doi-asserted-by":"publisher","unstructured":"Santos-Lozano A, Mar\u00edn PJ, Torres-Luque G, Ruiz JR, Luc\u00eda A, Garatachea N. Technical variability of the GT3X accelerometer. Med Eng Phys. 2012;34:787\u201390. https:\/\/doi.org\/10.1016\/j.medengphy.2012.02.005.","DOI":"10.1016\/j.medengphy.2012.02.005"},{"key":"1062_CR22","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1097\/00005768-199805000-00021","volume":"30","author":"PS Freedson","year":"1998","unstructured":"Freedson PS, Melanson E, Sirard J. Calibration of the Computer Science and Applications, Inc. accelerometer. Med Sci Sports Exerc. 1998;30:777\u201381.","journal-title":"Med Sci Sports Exerc"},{"key":"1062_CR23","doi-asserted-by":"publisher","unstructured":"Matthews CE, Chen KY, Freedson PS, Buchowski MS, Beech BM, Pate RR, et al. Amount of time spent in sedentary behaviors in the United States, 2003-2004. Am J Epidemiol. 2008;167:875\u201381. https:\/\/doi.org\/10.1093\/aje\/kwm390.","DOI":"10.1093\/aje\/kwm390"},{"key":"1062_CR24","doi-asserted-by":"publisher","unstructured":"Gariballa SE, Forster SJ. Dietary intake of older patients in hospital and at home: the validity of patient kept food diaries. J Nutr Health Aging. 2008;12:102\u20136. https:\/\/doi.org\/10.1007\/bf02982561.","DOI":"10.1007\/bf02982561"},{"key":"1062_CR25","doi-asserted-by":"publisher","unstructured":"Conway JM, Ingwersen LA, Moshfegh AJ. Accuracy of dietary recall using the USDA five-step multiple-pass method in men: an observational validation study. J Am Diet Assoc. 2004;104:595\u2013603. https:\/\/doi.org\/10.1016\/j.jada.2004.01.007.","DOI":"10.1016\/j.jada.2004.01.007"},{"key":"1062_CR26","doi-asserted-by":"publisher","unstructured":"Prado CM, Sawyer MB, Ghosh S, Lieffers JR, Esfandiari N, Antoun S, et al. Central tenet of cancer cachexia therapy: do patients with advanced cancer have exploitable anabolic potential? Am J Clin Nutr. 2013;98:1012\u20139. https:\/\/doi.org\/10.3945\/ajcn.113.060228.","DOI":"10.3945\/ajcn.113.060228"},{"key":"1062_CR27","doi-asserted-by":"publisher","unstructured":"Argiles JM, Busquets S, Stemmler B, Lopez-Soriano FJ. Cancer cachexia: understanding the molecular basis. Nat Rev Cancer. 2014;14:754\u201362. https:\/\/doi.org\/10.1038\/nrc3829.","DOI":"10.1038\/nrc3829"},{"key":"1062_CR28","doi-asserted-by":"publisher","unstructured":"Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003;21:2636\u201344. https:\/\/doi.org\/10.1200\/jco.2003.11.136.","DOI":"10.1200\/jco.2003.11.136"},{"key":"1062_CR29","unstructured":"Peddle-McIntyre C, Jeffery E, Lee YCG, Nowak A, McVeigh J, Nguyen B, et al. Resistance exercise training improves physical functioning and sarcopenia status in patients with malignant pleural disease. In preparation."},{"key":"1062_CR30","doi-asserted-by":"publisher","unstructured":"Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr. 2017;36:11\u201348. https:\/\/doi.org\/10.1016\/j.clnu.2016.07.015.","DOI":"10.1016\/j.clnu.2016.07.015"},{"key":"1062_CR31","doi-asserted-by":"publisher","unstructured":"Tobberup R, Rasmussen HH, Holst M, Jensen NA, Falkmer UG, Bogsted M, et al. Exploring the dietary protein intake and skeletal muscle during first-line anti-neoplastic treatment in patients with non-small cell lung cancer. Clin Nutr Espen. 2019;34:94\u2013100. https:\/\/doi.org\/10.1016\/j.clnesp.2019.08.006.","DOI":"10.1016\/j.clnesp.2019.08.006"},{"key":"1062_CR32","doi-asserted-by":"publisher","unstructured":"Ulmann G, Jouinot A, Tlemsani C, Curis E, Kousignian I, Neveux N, et al. Lean body mass and endocrine status but not age are determinants of resting energy expenditure in patients with non-small cell lung cancer. Ann Nutr Metab. 2019;75:223\u201330. https:\/\/doi.org\/10.1159\/000504874.","DOI":"10.1159\/000504874"},{"key":"1062_CR33","doi-asserted-by":"publisher","unstructured":"Cao DX, Wu GH, Zhang B, Quan YJ, Wei J, Jin H, et al. Resting energy expenditure and body composition in patients with newly detected cancer. Clin Nutr. 2010;29:72\u20137. https:\/\/doi.org\/10.1016\/j.clnu.2009.07.001.","DOI":"10.1016\/j.clnu.2009.07.001"},{"key":"1062_CR34","doi-asserted-by":"publisher","unstructured":"Engelen MP, van der Meij BS, Deutz NE. Protein anabolic resistance in cancer: does it really exist? Curr Opin Clin Nutr Metab Care. 2016;19:39\u201347. https:\/\/doi.org\/10.1097\/mco.0000000000000236.","DOI":"10.1097\/mco.0000000000000236"},{"key":"1062_CR35","doi-asserted-by":"publisher","unstructured":"Kilgour RD, Cardiff K, Rosenthall L, Lucar E, Trutschnigg B, Vigano A. Use of prediction equations to determine the accuracy of whole-body fat and fat-free mass and appendicular skeletal muscle mass measurements from a single abdominal image using computed tomography in advanced cancer patients. Appl Physiol Nutr Metab. 2016;41:70\u20135. https:\/\/doi.org\/10.1139\/apnm-2015-0068.","DOI":"10.1139\/apnm-2015-0068"},{"key":"1062_CR36","doi-asserted-by":"publisher","unstructured":"Cleland C, Ferguson S, Ellis G, Hunter RF. Validity of the International Physical Activity Questionnaire (IPAQ) for assessing moderate-to-vigorous physical activity and sedentary behaviour of older adults in the United Kingdom. BMC Med Res Methodol. 2018;18:176. https:\/\/doi.org\/10.1186\/s12874-018-0642-3.","DOI":"10.1186\/s12874-018-0642-3"}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41430-021-01062-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41430-021-01062-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41430-021-01062-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T07:15:21Z","timestamp":1657264521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41430-021-01062-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["1062"],"URL":"https:\/\/doi.org\/10.1038\/s41430-021-01062-6","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]},"assertion":[{"value":"4 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}