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There is limited information about the dietary regimen in patients with GSD, which might affect the intestinal luminal pH and microbiota composition. The aim of this study to investigate the intestinal microbiota composition in patients with GSD receiving diet treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Twelve patients who were followed up with GSD I after the diagnosis receiving diet therapy and 11 healthy children have been enrolled. Intestinal microbiota composition was evaluated by 16\u2009s rRNA gene sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant difference was found for beta-diversity between the GSD group and controls. A significantly lower abundance of Firmicutes and higher abundance of Actinobacteria was found in GSD group compared to the controls.\n                      <jats:italic>Akkermansia, Pseudoalteromonas, Uruburella, and Castellaniella<\/jats:italic>\n                      were dominant in the GSD patients at the genus level, while\n                      <jats:italic>Faecalibacterium, Bacterioides, Gemmiger, Parabacteroides<\/jats:italic>\n                      in the control group. At species level,\n                      <jats:italic>Faecalibacterium prausnitzii<\/jats:italic>\n                      decreased, and\n                      <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                      were dominant in children with GSD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      There is a substantial change in the composition of the gut microbiota, reduction of\n                      <jats:italic>F. prausnitzii<\/jats:italic>\n                      and an increase of\n                      <jats:italic>A. muciniphila<\/jats:italic>\n                      in children with GSD receiving consumption of uncooked cornstarch. Alterations of the intestinal microbiota might be related with the disease itself or dietary restrictions in patients with GSD, however, in certain condition, dysbiosis can negatively affect the course and make it difficult to control the disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41430-024-01412-0","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T13:02:14Z","timestamp":1708779734000},"page":"407-412","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intestinal microbiota composition of children with glycogen storage Type I patients"],"prefix":"10.1038","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5383-5632","authenticated-orcid":false,"given":"Sabire","family":"Gokalp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ener Cagri","family":"Dinleyici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansu","family":"Muluk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Inci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Aktas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyas","family":"Okur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Ezgu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Tumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"1412_CR1","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1007\/s00431-002-0999-4","volume":"161","author":"JP Rake","year":"2002","unstructured":"Rake JP, Visser G, Labrune P, Leonard JV, Ullrich K, Smit GP. 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The following sentence was added to the Funding section: \"The study was supported by the Gazi University Scientific Research Projects Department (Gazi University - TGA-2021-7036).\" Additionally, the following Acknowledgements section was included: \"The authors appreciate the Gazi University Scientific Research Projects Department for their financial support.\"","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2024","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41430-024-01533-6","URL":"https:\/\/doi.org\/10.1038\/s41430-024-01533-6","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}