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All outcomes and BMI were recorded at the time of enrolment. Participants were categorised into normal (&lt;25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and high (\u226525\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) BMI. Age at disease diagnosis was categorised into pre-puberty\/early puberty (&lt;11 years), puberty (11\u201314 years) and post-puberty (15\u201317 years). Spearman rank correlation was used to test the associations between continuous variables and chi-square test to compare categorical variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      848 participants with CD were included (51.8% males) and median age at diagnosis was 14 years. Participants with high BMI experienced a greater frequency of EIMs (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.05) than those with low BMI (1 type of EIM: 18.5% vs. 13.2%, respectively; \u22652 types of EIMs: 7.8% vs. 5.6%, respectively). Age at diagnosis and BMI showed weak correlations with corticosteroid use (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.08,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03 and\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u2009\u22120.09,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01; respectively). An early diagnosis (&lt;11 years) was associated with higher occurrence of stenosing and penetrating disease behaviour (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01) and hospitalisations (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A higher BMI and an earlier age of disease onset are associated with worse CD clinical presentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41430-024-01425-9","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T17:22:06Z","timestamp":1710264126000},"page":"534-540","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between body mass index and age of disease onset with clinical outcomes in paediatric-onset Crohn\u2019s Disease (CD): a UK nation-wide analyses using the NIHR-IBD BioResource"],"prefix":"10.1038","volume":"78","author":[{"given":"Bayan","family":"Aljilani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kostas","family":"Tsintzas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-0944","authenticated-orcid":false,"given":"Mario","family":"Siervo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-8020","authenticated-orcid":false,"given":"Gordon W.","family":"Moran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"1425_CR1","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1056\/NEJMra2002697","volume":"383","author":"JT Chang","year":"2020","unstructured":"Chang JT. 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