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Their care is complicated by under-recognised and under-treated wasting disorders: malnutrition, sarcopenia, and cachexia. We aimed to investigate the prevalence, overlap, and patients\u2019 views and experiences of malnutrition, sarcopenia, and cachexia, in older adults with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mixed-methods study with cross-sectional study and qualitative interviews. Interviews were thematically analysed through a phenomenological lens, with feedback loop analysis investigating relationships between themes and findings synthesised using modified critical interpretative synthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930 were screened for malnutrition, sarcopenia, and cachexia,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098 completed semi-structured interviews. Eighteen (60.0%) were malnourished, 16 (53.3%) sarcopenic, and 17 (56.7%) cachexic. One or more condition was seen in 80%, and all three in 30%. In univariate analysis, Rockwood clinical frailty score (OR 2.94 [95% CI: 1.26\u20136.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013]) was associated with sarcopenia, reported percentage meal consumption (OR 2.28 [95% CI: 1.24\u20134.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008]), and visible wasting (OR 8.43 [95% CI: 1.9\u201337.3]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) with malnutrition, and percentage monthly weight loss (OR 8.71 [95% CI: 1.87\u201340.60]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) with cachexia. Screening tools identified established conditions rather than \u2018risk\u2019. Nutritional and functional problems were often overlooked, overshadowed, and misunderstood by both patients and (in patients\u2019 perceptions) by clinicians; misattributed to ageing, cancer, or comorbidities. Patients viewed these conditions as both personal impossibilities, yet accepted inevitabilities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Perceptions, identification, and management of these conditions needs to improve, and their importance recognised by clinicians and patients so those truly \u2018at risk\u2019 are identified whilst conditions are more remediable to interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41430-024-01433-9","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T07:02:03Z","timestamp":1712300523000},"page":"486-493","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Malnutrition, sarcopenia and cachexia: exploring prevalence, overlap, and perceptions in older adults with cancer"],"prefix":"10.1038","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4065-3925","authenticated-orcid":false,"given":"Alex F.","family":"Bullock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-1558","authenticated-orcid":false,"given":"Michael J.","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis W.","family":"Paton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Currow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam J.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"1433_CR1","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1016\/j.clnu.2016.12.003","volume":"36","author":"P Caillet","year":"2017","unstructured":"Caillet P, Liuu E, Raynaud Simon A, Bonnefoy M, Guerin O, Berrut G, et al. 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