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M\u00f8ller Fonden Til L\u00e6gevidenskabens Fremme"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Children with stunting are at risk of infections. We assessed the effect of lipid-based nutrient supplement (LNS) on morbidity in children with stunting.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This was a secondary analysis of a randomized, 2\u00d72 factorial trial among 12\u201359 months-old, stunted children in Uganda. Children were randomized to LNS containing milk or soy protein and whey permeate or maltodextrin, or no supplementation, for 12 weeks. The outcomes were caregiver-reported morbidity after 2, 4, 8 and 12 weeks, serum C-reactive protein (S-CRP), \u03b1<jats:sub>1<\/jats:sub>-acid glycoprotein (S-AGP), and phase-angle (PhA) by bioimpedance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Of 750 children, mean (SD) age was 32.0 (11.7) months, 55% (<jats:italic>n<\/jats:italic>\u2009=\u2009412) were male. LNS increased diarrhoea prevalence (18.1% vs 7.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001) during the first two weeks, but not thereafter. There was no effect of LNS on cough or fever. LNS resulted in greater decline in S-AGP (\u22120.10\u2009g\/L, 95% CI: \u22120.17, \u22120.03, <jats:italic>P<\/jats:italic>\u2009=\u20090.003) but not S-CRP (25%, 95% CI: \u221211, 74, <jats:italic>P<\/jats:italic>\u2009=\u20090.193), and greater increase in PhA (0.10 degrees, 95% CI: 0.01, 0.18, <jats:italic>P<\/jats:italic>\u2009=\u20090.030), explained by greater fat-free mass. Milk compared to soy protein in LNS resulted in higher PhA (0.10 degrees, 95% CI: 0.02, 0.17, <jats:italic>P<\/jats:italic>\u2009=\u20090.013), not explained by fat-free mass.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>LNS supplementation in children with stunting had no effect on morbidity but resulted in a small reduction in sub-acute systemic inflammation. The possible effect of LNS supplementation on inflammation in stunted children requires further evaluation. (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.isrctn.com\" ext-link-type=\"uri\">www.isrctn.com<\/jats:ext-link>: ISRCTN13093195).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1038\/s41430-025-01611-3","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T16:49:13Z","timestamp":1743439753000},"page":"756-761","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of lipid-based nutrient supplements on morbidity among children with stunting: secondary analysis of a randomized trial in Uganda"],"prefix":"10.1038","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1311-9946","authenticated-orcid":false,"given":"Rolland","family":"Mutumba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Mbabazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Pesu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9483-912X","authenticated-orcid":false,"given":"Jack I.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"M\u00f8lgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-0624","authenticated-orcid":false,"given":"Christian","family":"Ritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5742-6403","authenticated-orcid":false,"given":"Mette F.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Briend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette","family":"Nabukeera-Barungi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-8025","authenticated-orcid":false,"given":"Jonathan C.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Friis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikte","family":"Grenov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-9009","authenticated-orcid":false,"given":"Ezekiel","family":"Mupere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"1611_CR1","unstructured":"United Nations Children\u2019s Fund, World Health Organization, World Bank. 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Lancet Glob Health. 2019;7:e1139\u2013e46.","journal-title":"Lancet Glob Health"}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41430-025-01611-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41430-025-01611-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41430-025-01611-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T08:30:12Z","timestamp":1757147412000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41430-025-01611-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1611"],"URL":"https:\/\/doi.org\/10.1038\/s41430-025-01611-3","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]},"assertion":[{"value":"26 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"HF, BG and CM have received research grants from the Arla Food for Health and\/or Danish Dairy Research Foundation. CM has received funds from Arla Foods Amba. HF, CM, BG and AB have had research collaboration with Nutriset, a producer of lipid-based nutrient supplements. Other authors declare no financial relationships with any organizations that might have an interest in the submitted work in the previous five years and declare no other relationships or activities that could appear to have influenced the submitted work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}