{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:10:43Z","timestamp":1781921443419,"version":"3.54.5"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kidney replacement therapy (KRT) is frequently implemented in the intensive care unit. While measuring energy expenditure is recommended in the critically ill, the influence of KRT on indirect calorimetry (IC) is not fully clear. This prospective study aimed to investigate the influence of continuous veno-venous hemodialysis (CVVHD) and slow extended daily dialysis (SLEDD) on IC variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We included critically ill mechanically ventilated adult medical patients on KRT for acute kidney injury. CVVHD was run with regional citrate anticoagulation, while SLEDD with systemic heparin anticoagulation. We conducted IC twice on every patient, either immediately before the planned termination of KRT and then an hour after the end of KRT or immediately before commencement of KRT and then again after an hour on KRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 100 patients (75 males) with a median age of 64.0 years, a mean APACHE-II score of 30.9 and a mean SOFA score of 11.3 on the day of IC. There was no significant difference in median resting energy expenditure with versus without CVVHD (8029 [6993\u20139644] versus 7814 [6962\u20139304] kJ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.75) as well as with versus without SLEDD (9258 [8017\u201310,364] versus 9269 [8070\u201311,065] kJ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.63). The difference in resting energy expenditure between the two measurements was also not significant regardless of the sequence of IC measurements (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.69).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This prospective study on critically ill adult patients did not show any significant difference for indirect calorimetry variables between measurements conducted during CVVHD and SLEDD compared to those without KRT. ClinicalTrials.gov ID: NCT04599569<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41430-025-01643-9","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:55:13Z","timestamp":1753883713000},"page":"1144-1148","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of kidney replacement therapy on indirect calorimetry in critically ill patients"],"prefix":"10.1038","volume":"79","author":[{"given":"Annalena","family":"Knoll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-756X","authenticated-orcid":false,"given":"Sirak","family":"Petros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-3828","authenticated-orcid":false,"given":"Bastian","family":"Pasieka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Weidhase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"1643_CR1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.clnu.2018.08.037","volume":"38","author":"P Singer","year":"2019","unstructured":"Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, et al. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019;38:48\u201379.","journal-title":"Clin Nutr"},{"key":"1643_CR2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1177\/0148607115621863","volume":"40","author":"SA McClave","year":"2016","unstructured":"McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: society of critical care medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enter Nutr. 2016;40:159\u2013211.","journal-title":"JPEN J Parenter Enter Nutr"},{"key":"1643_CR3","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/CCM.0000000000003701","volume":"47","author":"JS Rachoin","year":"2019","unstructured":"Rachoin JS, Weisberg LS. Renal replacement therapy in the ICU. Crit Care Med. 2019;47:715\u201321.","journal-title":"Crit Care Med"},{"key":"1643_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/cc13767","volume":"18","author":"R Bellomo","year":"2014","unstructured":"Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lee J, et al. Calorie intake and patient outcomes in severe acute kidney injury: findings from The Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy (RENAL) study trial. Crit Care. 2014;18:R45.","journal-title":"Crit Care"},{"key":"1643_CR5","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1007\/s00134-015-3934-7","volume":"41","author":"EA Hoste","year":"2015","unstructured":"Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015;41:1411\u201323.","journal-title":"Intensive Care Med"},{"key":"1643_CR6","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.clnu.2019.02.034","volume":"39","author":"J Jonckheer","year":"2020","unstructured":"Jonckheer J, Spapen H, Malbrain M, Oschima T, De Waele E. Energy expenditure and caloric targets during continuous renal replacement therapy under regional citrate anticoagulation. A viewpoint. Clin Nutr. 2020;39:353\u20137.","journal-title":"Clin Nutr"},{"key":"1643_CR7","unstructured":"Hall JE. Transport of oxygen and carbon dioxide in blood and tissue fluids. In: GUYTON and HALL textbook of medical physiology. Philadelphia, USA: Elsevier; 2016. pp 527\u201337."},{"key":"1643_CR8","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/ki.1984.97","volume":"25","author":"JP Bosch","year":"1984","unstructured":"Bosch JP, Glabman S, Moutoussis G, Belledonne M, von Albertini B, Kahn T. Carbon dioxide removal in acetate hemodialysis: effects on acid base balance. Kidney Int. 1984;25:830\u20137.","journal-title":"Kidney Int"},{"key":"1643_CR9","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/ki.1992.162","volume":"41","author":"T Symreng","year":"1992","unstructured":"Symreng T, Flanigan MJ, Lim VS. Ventilatory and metabolic changes during high efficiency hemodialysis. Kidney Int. 1992;41:1064\u20139.","journal-title":"Kidney Int"},{"key":"1643_CR10","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1111\/j.1525-1594.2005.00126.x","volume":"29","author":"KI Sombolos","year":"2005","unstructured":"Sombolos KI, Bamichas GI, Christidou FN, Gionanlis LD, Karagianni AC, Anagnostopoulos TC, et al. pO2 and pCO2 increment in post-dialyzer blood: the role of dialysate. Artif Organs. 2005;29:892\u20138.","journal-title":"Artif Organs"},{"key":"1643_CR11","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s12882-019-1378-y","volume":"20","author":"J Jonckheer","year":"2019","unstructured":"Jonckheer J, Spapen H, Debain A, Demol J, Diltoer M, Costa O, et al. CO2 and O2 removal during continuous veno-venous hemofiltration: a pilot study. BMC Nephrol. 2019;20:222.","journal-title":"BMC Nephrol"},{"key":"1643_CR12","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.clnu.2016.08.008","volume":"36","author":"CR de G\u00f3es","year":"2017","unstructured":"de G\u00f3es CR, Vogt BP, Sanches ACS, Balbi AL, Ponce D. Influence of different dialysis modalities in the measurement of resting energy expenditure in patients with acute kidney injury in ICU. Clin Nutr. 2017;36:1170\u20134.","journal-title":"Clin Nutr"},{"key":"1643_CR13","unstructured":"Hamwi GJ. Therapy: changing dietary concepts. In: Danowski TS, editor. Diabetes mellitus: diagnosis and treatment, vol. 1. New York: American Diabetes Association; 1964, p. 73\u201378."},{"key":"1643_CR14","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1016\/j.clnu.2020.04.017","volume":"39","author":"J Jonckheer","year":"2020","unstructured":"Jonckheer J, Demol J, Lanckmans K, Malbrain M, Spapen H, De Waele E. MECCIAS trial: metabolic consequences of continuous veno-venous hemofiltration on indirect calorimetry. Clin Nutr. 2020;39:3797\u2013803.","journal-title":"Clin Nutr"},{"key":"1643_CR15","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1007\/s001340051204","volume":"26","author":"J Levraut","year":"2000","unstructured":"Levraut J, Garcia P, Giunti C, Ichai C, Bouregba M, Ciebiera JP, et al. The increase in CO2 production induced by NaHCO3 depends on blood albumin and hemoglobin concentrations. Intensive Care Med. 2000;26:558\u201364.","journal-title":"Intensive Care Med"},{"key":"1643_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-74977-2","volume":"14","author":"M Bell","year":"2024","unstructured":"Bell M, Hertzberg D, Hansson F, Carlsson A, Berkius J, Vimlati L, et al. Modern CRRT systems are associated with lower risk of hypothermia. Sci Rep. 2024;14:23162.","journal-title":"Sci Rep"},{"key":"1643_CR17","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.3945\/ajcn.116.139014","volume":"105","author":"AM New","year":"2017","unstructured":"New AM, Nystrom EM, Frazee E, Dillon JJ, Kashani KB, Miles JM. Continuous renal replacement therapy: a potential source of calories in the critically ill. Am J Clin Nutr. 2017;105:1559\u201363.","journal-title":"Am J Clin Nutr"},{"key":"1643_CR18","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1177\/1751143720937451","volume":"22","author":"AR Rogers","year":"2021","unstructured":"Rogers AR, Jenkins B. Calorie provision from citrate anticoagulation in continuous renal replacement therapy in critical care. J Intensive Care Soc. 2021;22:183\u20136.","journal-title":"J Intensive Care Soc"},{"key":"1643_CR19","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s40620-014-0160-2","volume":"28","author":"E Fiaccadori","year":"2015","unstructured":"Fiaccadori E, Pistolesi V, Mariano F, Mancini E, Canepari G, Inguaggiato P, et al. Regional citrate anticoagulation for renal replacement therapies in patients with acute kidney injury: a position statement of the Work Group \u201cRenal Replacement Therapies in Critically Ill Patients\u201d of the Italian Society of Nephrology. J Nephrol. 2015;28:151\u201364.","journal-title":"J Nephrol"},{"key":"1643_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/cc11645","volume":"16","author":"HM Oudemans-van Straaten","year":"2012","unstructured":"Oudemans-van Straaten HM, Ostermann M. Bench-to-bedside review: citrate for continuous renal replacement therapy, from science to practice. Crit Care. 2012;16:249.","journal-title":"Crit Care"},{"key":"1643_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3390\/nu15010063","volume":"15","author":"S Wechselberger","year":"2022","unstructured":"Wechselberger S, Compton F, Schilling J. Impact of continuous veno-venous HemoDiALYsis with regional citrate anticoagulation on non-NUTRItional calorie balance in patients on the ICU-the NUTRI-DAY study. Nutrients. 2022;15:63.","journal-title":"Nutrients"},{"key":"1643_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1880-1","volume":"21","author":"AG Schneider","year":"2017","unstructured":"Schneider AG, Journois D, Rimmele T. Complications of regional citrate anticoagulation: accumulation or overload?. Crit Care. 2017;21:281.","journal-title":"Crit Care"},{"key":"1643_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05069-w","volume":"28","author":"D Hu","year":"2024","unstructured":"Hu D, Sheeja Prabhakaran H, Zhang YY, Luo G, He W, Liou YC. Mitochondrial dysfunction in sepsis: mechanisms and therapeutic perspectives. Crit Care. 2024;28:292.","journal-title":"Crit Care"},{"key":"1643_CR24","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1016\/j.clnu.2023.07.011","volume":"42","author":"P Singer","year":"2023","unstructured":"Singer P, Blaser AR, Berger MM, Calder PC, Casaer M, Hiesmayr M, et al. ESPEN practical and partially revised guideline: clinical nutrition in the intensive care unit. Clin Nutr. 2023;42:1671\u201389.","journal-title":"Clin Nutr"},{"key":"1643_CR25","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jcrc.2017.05.002","volume":"41","author":"DM Nash","year":"2017","unstructured":"Nash DM, Przech S, Wald R, O\u2019Reilly D. Systematic review and meta-analysis of renal replacement therapy modalities for acute kidney injury in the intensive care unit. J Crit Care. 2017;41:138\u201344.","journal-title":"J Crit Care"}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41430-025-01643-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41430-025-01643-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41430-025-01643-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T23:02:00Z","timestamp":1762124520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41430-025-01643-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["1643"],"URL":"https:\/\/doi.org\/10.1038\/s41430-025-01643-9","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,30]]},"assertion":[{"value":"19 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the institutional review board of the University of Leipzig (338\/20-ek). All methods were performed in accordance with the relevant guidelines and regulations. Informed consent for study participation was obtained from every study participant or legal guardian.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}]}}