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Children were classified as: 1.\u201cnormal-weight lean\u201d (NWL) when they had normal-weight by BMI and adequate fat percentage assessed by DXA; 2. \u201cnormal-weight obesity\u201d (NWO) for those with normal-weight and excess fat; and 3. \u201cexcess weight\u201d for those with overweight\/obesity and excess fat. The score for the MetS and its components was estimated, and the inflammatory and oxidative stress markers were measured. Multiple linear regression was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of thirteen cardiometabolic risk factors investigated, five were positively associated with the NWO, compared to NWL. Moreover, eleven cardiometabolic risk factors were associated with excess weight, compared to NWL. When the two phenotypes of excess body fat were contrasted, we found eight cardiometabolic risk factors associated with excess weight, compared to NWO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An intermediate cardiometabolic risk was observed in children with the NWO phenotype when comparing the status of NWL to excess weight. This study reinforces the importance of investigating cardiometabolic risk in early ages, independent of BMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41430-026-01700-x","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:52:50Z","timestamp":1770270770000},"page":"270-277","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Progressive increase of cardiometabolic risk in Brazilian children according to obesity phenotypes"],"prefix":"10.1038","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3733-5125","authenticated-orcid":false,"given":"Bruna Clemente","family":"Cota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-6126","authenticated-orcid":false,"given":"Mariana de Santis","family":"Filgueiras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5179-2908","authenticated-orcid":false,"given":"Nalva de Paula","family":"Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8012-6006","authenticated-orcid":false,"given":"Leidjaira Lopes","family":"Juvanhol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-2944","authenticated-orcid":false,"given":"Patr\u00edcia Feliciano","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-5096","authenticated-orcid":false,"given":"Juliana Farias de","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"1700_CR1","unstructured":"World Health Organization (WHO). 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