{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:38:53Z","timestamp":1774345133164,"version":"3.50.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"JY was funded by the Australian Government Research Training Program."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Limited studies have explored the longitudinal alterations of fat-free mass (FFM), fat mass (FM), and phase angle (PhA) in the motor neuron disease (MND) population. This pilot longitudinal study investigated body composition changes via bioimpedance analysis (BIA) at time of diagnosis and gastrostomy. Nineteen patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200911, 57.9% females) were included. Statistically significant reductions in FFM [median (IQR) 43.0 (17.8) kg to 42.1 (16.7) kg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001] and PhA [4.6 (2.0)\u00b0 to 4.5 (2.1)\u00b0,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012] were found. FFM (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007, 95% CI 0.505, 1.32) and FM (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024, 95% CI 0.160, 1.249) were significant predictors of weight change, with FFM accounting for 72% of the change. Larger longitudinal studies are needed to explore the clinical benefit associated with reducing pre-gastrostomy FFM loss in the MND population. In the interim, clinicians should consider monitoring body composition and implementing interventions aimed at preserving body weight and composition, particularly FFM, prior to gastrostomy placement.\n                  <\/jats:p>","DOI":"10.1038\/s41430-026-01702-9","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:36:59Z","timestamp":1770439019000},"page":"329-331","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in body composition and phase angle from diagnosis to gastrostomy, in motor neuron disease patients: a longitudinal study"],"prefix":"10.1038","volume":"80","author":[{"given":"Jie","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6071-0272","authenticated-orcid":false,"given":"Mario","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merrilee","family":"Needham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-8932","authenticated-orcid":false,"given":"Andrea","family":"Begley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-233X","authenticated-orcid":false,"given":"Emily","family":"Calton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"1702_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/B978-0-12-802973-2.00013-6","volume":"138","author":"EO Talbott","year":"2016","unstructured":"Talbott EO, Malek AM, Lacomis D. The epidemiology of amyotrophic lateral sclerosis. Handb Clin Neurol. 2016;138:225\u201338.","journal-title":"Handb Clin Neurol"},{"key":"1702_CR2","unstructured":"National Clinical Guideline Centre. National Institute for Health and Care Excellence: Clinical Guidelines. Motor Neurone Disease: Assessment and Management. London: National Institute for Health and Care Excellence (UK) National Clinical Guideline Centre; 2016."},{"key":"1702_CR3","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1002\/mus.28245","volume":"70","author":"J Yang","year":"2024","unstructured":"Yang J, Zhao Y, Soares M, Needham M, Begley A, Calton E. Predictors of mortality post-gastrostomy in motor neuron disease patients. Muscle Nerve. 2024;70:1010\u20137.","journal-title":"Muscle Nerve"},{"key":"1702_CR4","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/mus.24419","volume":"51","author":"V Roubeau","year":"2015","unstructured":"Roubeau V, Blasco H, Maillot F, Corcia P, Praline J. 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Am J Clin Nutr. 2003;77:1179\u201385.","journal-title":"Am J Clin Nutr"},{"key":"1702_CR9","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/mus.26749","volume":"61","author":"T Mezoian","year":"2020","unstructured":"Mezoian T, Belt E, Garry J, Hubbard J, Breen CT, Miller L, et al. Loss of appetite in amyotrophic lateral sclerosis is associated with weight loss and decreased calorie consumption independent of dysphagia. Muscle Nerve. 2020;61:230\u20134.","journal-title":"Muscle Nerve"},{"key":"1702_CR10","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1136\/jnnp-2017-317887","volume":"89","author":"F Steyn","year":"2018","unstructured":"Steyn F, Ioannides Z, Heggie S, Thorpe K, Ceslis A, Henders A, et al. Hypermetabolism in ALS is associated with greater functional decline and shorter survival. 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At the time of manuscript submission for peer review, the Editor in Chief of European Journal of Clinical Nutrition was a coauthor of this publication. This was declared prior to peer review so that the review process was independent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Ethics approval was granted through South Metropolitan Health Service Human Research Ethics Committee ((RGS4710) and reciprocal approval through Curtin University\u2019s Human Research Ethics (HRE2021-0594). An exemption from requiring written informed consent was granted.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}