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Genetic testing\u00a0and screening programs for SCD and the sickle cell trait (SCT) are valuable for early diagnosis and\u00a0management of children living with SCD, and in the identification of carriers of SCT. People with SCT are for the most part asymptomatic and mainly identified as through genetic testing or when they have a child with SCD.\u00a0This qualitative study explored perceptions towards genetic testing for SCD and SCT in Cameroon, Ghana, and Tanzania. The results show a general preference for newborn screening for SCD over\u00a0prenatal and\u00a0premarital\/preconception testing, primarily due to its simpler decision-making process and lower risk for stigmatization. Premarital testing\u00a0for SCT was perceived to be of low public health value, as couples are unlikely to alter their marriage plans despite being aware of their risk of having a child with SCD. Adolescents were identified as a more suitable population for SCT testing. In the case of\u00a0prenatal testing, major concerns were centred on cultural, religious, and personal values on pregnancy termination. The study revealed a gender dimension to SCD\/SCT testing. Participants mentionned\u00a0that women bear a heightened burden of decision making in SCD\/SCT testing,\u00a0face a higher risk of rejection by potential in-laws\/partners\u00a0if the carriers of SCT, as well as the possibility of\u00a0 divorce if they have a child with SCD. The study highlights the complex cultural, ethical, religious and social dynamics surrounding genetic testing for SCD\u00a0and emphasises the need for public education\u00a0on SCD and\u00a0the necessity of incorporating genetic and psychosocial counselling into SCD\/SCT testing\u00a0programs.<\/jats:p>","DOI":"10.1038\/s41431-024-01553-7","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T08:02:05Z","timestamp":1708329725000},"page":"1307-1313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Perceptions and preferences for genetic testing for sickle cell disease or trait: a qualitative study in Cameroon, Ghana and Tanzania"],"prefix":"10.1038","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1498-3602","authenticated-orcid":false,"given":"Nchangwi Syntia","family":"Munung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Kengne","family":"Kamga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha J","family":"Treadwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemima","family":"Dennis-Antwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0513-3331","authenticated-orcid":false,"given":"Kofi A","family":"Anie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daima","family":"Bukini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Makani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1420-9051","authenticated-orcid":false,"given":"Ambroise","family":"Wonkam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"1553_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/ijns5020020","volume":"5","author":"BPD Inusa","year":"2019","unstructured":"Inusa BPD, Hsu LL, Kohli N, Patel A, Ominu-Evbota K, Anie KA, et al. 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