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BabyScreen+ piloted gNBS for 1000 newborns in Victoria, Australia. Prospective parents consented online with genetic counselling available on request. We aimed to explore how BabyScreen+ participants (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091139) made decisions about gNBS using a convergent parallel mixed methods design. Demographic (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091080), survey (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091010), and interview (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924) data were analysed using descriptive statistics, logistic regression, and deductive content analysis mapped to the Health Belief Model\n                    <jats:italic>(domains indicated in italics)<\/jats:italic>\n                    . Most participants perceived low\n                    <jats:italic>susceptibility<\/jats:italic>\n                    of having a child with a genetic condition and found it difficult to conceptualise\n                    <jats:italic>severity<\/jats:italic>\n                    . Participants were motivated to consider gNBS due to\n                    <jats:italic>benefits<\/jats:italic>\n                    such as information about their child\u2019s health, reassurance, and research contributions. Some perceived\n                    <jats:italic>barriers<\/jats:italic>\n                    included inequitable access to gNBS information, difficulty navigating high chance results, and potential data misuse. Most participants\u00a0(987\/1139, 87%) proceeded with gNBS because they believed\n                    <jats:italic>barriers<\/jats:italic>\n                    were outweighed by\n                    <jats:italic>benefits<\/jats:italic>\n                    or were\u00a0manageable due to high\n                    <jats:italic>self-efficacy<\/jats:italic>\n                    . Remaining participants (152\/1139, 13%) did not proceed with gNBS because\n                    <jats:italic>benefits<\/jats:italic>\n                    were unclear, or due to low\n                    <jats:italic>self-efficacy<\/jats:italic>\n                    . Experiences were modified by\n                    <jats:italic>sociodemographic factors<\/jats:italic>\n                    and the BabyScreen+ model of care. This research provides timely evidence about parental gNBS decision-making. It supports acceptability and feasibility of the BabyScreen+ model of care. Moving forward, education and consent processes must be equitable, tailored to individual context, and designed to foster self-efficacy. Such considerations will support decision-making and reduce psychological impacts for parents considering gNBS in the future.\n                  <\/jats:p>","DOI":"10.1038\/s41431-026-02159-x","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:17:34Z","timestamp":1782490654000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How parents decide whether to have genomic newborn screening: experiences from BabyScreen+"],"prefix":"10.1038","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4656-9246","authenticated-orcid":false,"given":"Anaita","family":"Kanga-Parabia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Tutty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3575-4347","authenticated-orcid":false,"given":"Nathasha","family":"Kugenthiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0335-6224","authenticated-orcid":false,"given":"Jade","family":"Caruana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3914-5592","authenticated-orcid":false,"given":"Lilian","family":"Downie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Gaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitzan","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7168-0723","authenticated-orcid":false,"given":"Sebastian","family":"Lunke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5195-9727","authenticated-orcid":false,"given":"Katrina","family":"Scarff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zornitza","family":"Stark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1107-8976","authenticated-orcid":false,"given":"Stephanie","family":"Best","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison D.","family":"Archibald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"2159_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/ijns10020038","volume":"10","author":"BL Therrell","year":"2024","unstructured":"Therrell BL, Padilla CD, Borrajo GJC, Khneisser I, Schielen PCJI, Knight-Madden J, et al. 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