{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:15:29Z","timestamp":1775146529517,"version":"3.50.1"},"reference-count":4,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Evid Based Dent"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Design<\/jats:title>\n                <jats:p>A retrospective cohort design was used to assess the long-term clinical effectiveness of systemic amoxicillin and metronidazole, used adjunctively with non-surgical peri-implantitis treatment (NST) and whether it prevents the need for further surgical interventions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Cohort selection<\/jats:title>\n                <jats:p>Of the 57 peri-implantitis patients examined, 45 patients were included in this study. The participants were divided into two subgroups in accordance to who had received NST with or without systemic antibiotics. Selection was based on prior participation in a three-month randomised control trial, ensuring comparability of data regarding peri-implantitis severity and treatment history.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Data analysis<\/jats:title>\n                <jats:p>Data were extracted pre-treatment, 3-months post-treatment and at a long-term follow-up interval of 36 months. The primary outcome was the need for additional surgical intervention and was analysed via Kaplan\u2013Meier analysis and Cox regression. A multitude of secondary clinical outcomes were evaluated using parametric and non-parametric tests, including peri- implant probing depth, bleeding scores and treatment success.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Overall, 62.2% of the 45 NST patients did not need surgical peri-implantitis treatment: 73.9% of the subgroup with antibiotics and 50% of the subgroup without antibiotics respectively. However, the difference between the two groups was not statistically significant (log-rank test, <jats:italic>p<\/jats:italic>\u2009=\u20090.110). The Cox regression analysis also displayed no significance over the first three years post-treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.115). Additionally, the study found that deeper peri- implant pockets at baseline significantly predicted the need for future surgical treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.031), highlighting the importance of initial disease severity in treatment outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The study concludes that the adjunctive use of systemic amoxicillin and metronidazole with NST may delay but not statistically reduce or prevent a future surgical need. Although a short-term reduction in clinical inflammatory parameters was evident, the long-term effectiveness in altering the progression of peri-implantitis remains limited.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41432-024-01071-x","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T16:02:04Z","timestamp":1728489724000},"page":"182-183","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Can systemic antibiotics reduce the need for surgical intervention in treating peri-implantitis?"],"prefix":"10.1038","volume":"25","author":[{"given":"Nidhi","family":"Parmar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"1071_CR1","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/prd.12149","volume":"76","author":"S Renvert","year":"2018","unstructured":"Renvert S, Polyzois I. Treatment of pathologic peri\u2010implant pockets. Periodontology. 2018;76:180\u201390.","journal-title":"Periodontology"},{"key":"1071_CR2","doi-asserted-by":"publisher","first-page":"660","DOI":"10.11607\/jomi.9659","volume":"37","author":"BG dos Santos Martins","year":"2022","unstructured":"dos Santos Martins BG, Hasse Fernandes JC, Gomes Martins A, de Moraes Castilho R, de Oliveira Fernandes GV. Surgical and Nonsurgical Treatment Protocols for Peri-implantitis: An Overview of Systematic Reviews. Int J Oral Maxillofac Implants. 2022;37:660\u201376.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"1071_CR3","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/jcpe.14024","volume":"51","author":"J Hakkers","year":"2024","unstructured":"Hakkers J, Vangsted TE, van Winkelhoff AJ, de Waal YCM. Do systemic amoxicillin and metronidazole during the non-surgical peri-implantitis treatment phase prevent the need for future surgical treatment? A retrospective long-term cohort study. J Clin Periodontol. 2024;51:997\u20131004.","journal-title":"J Clin Periodontol"},{"key":"1071_CR4","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/cid.13239","volume":"25","author":"M Feres","year":"2023","unstructured":"Feres M, Martins R, Souza JG, Bertolini M, Bar\u00e3o VA, Shibli JA. Unraveling the effectiveness of antibiotics for peri\u2010implantitis treatment: A scoping review. Clin Implant Dent Relat Res. 2023;25:767\u201381.","journal-title":"Clin Implant Dent Relat Res"}],"container-title":["Evidence-Based Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41432-024-01071-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41432-024-01071-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41432-024-01071-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T10:07:18Z","timestamp":1734689238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41432-024-01071-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1071"],"URL":"https:\/\/doi.org\/10.1038\/s41432-024-01071-x","relation":{},"ISSN":["1462-0049","1476-5446"],"issn-type":[{"value":"1462-0049","type":"print"},{"value":"1476-5446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"assertion":[{"value":"27 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author declares no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}