{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:17:38Z","timestamp":1780546658464,"version":"3.54.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Evid Based Dent"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Design<\/jats:title>\n            <jats:p>This multi-center, randomized clinical trial compared the long-term outcomes of guided bone regeneration (GBR) with open flap debridement (OFD) in treating peri-implantitis-related bony defects with \u22653 osseous walls over 36 months. The study aimed to evaluate the healing potential of GBR using a deproteinized bovine bone mineral (DBBM) graft and native bilayer collagen membrane (NBCM) compared to OFD without the use of graft materials.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case selection<\/jats:title>\n            <jats:p>Sixty-six individuals diagnosed with peri-implantitis were randomly assigned to either GBR (34 patients) or OFD (32 patients). The OFD group served as the control, where inflamed tissue was removed and the implant surface decontaminated using 3% hydrogen peroxide, but no bone graft was placed. The GBR group received DBBM and NBCM for defect reconstruction. Radiographic defect fill (RDF), probing pocket depth (PPD), bleeding on probing (BOP), suppuration (SUP), mucosal recession (MREC), and patient-reported outcomes (PROs) were assessed over the study duration. Post-surgical care included azithromycin, ibuprofen, and chlorhexidine rinses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Study timeline<\/jats:title>\n            <jats:p>The study involved baseline assessments, surgical interventions, and follow-ups at 6, 12, and 36 months. Supportive peri-implant therapy was provided every 3 months during the additional 24-month follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Data analysis<\/jats:title>\n            <jats:p>Primary outcome was RDF at 36 months. Secondary outcomes included PPD, BOP, SUP, MREC, and PROs. Descriptive statistics and ANCOVA models were used for analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>At 36 months, GBR resulted in a mean RDF of 2.13\u2009\u2009\u00b1\u2009\u20091.26\u2009mm, compared to 1.64\u2009\u2009\u00b1\u2009\u20091.54\u2009mm with OFD (p\u2009\u2009=\u2009\u2009.18). No significant differences were found in PPD, BOP, SUP, REC, or PROs between the groups. Treatment success (defined as no additional bone loss, PPD\u2009\u2264\u20095\u2009mm, no BOP, and no SUP) was achieved in 46.2% of GBR cases and 20% of OFD cases (p = 0.053).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>GBR provided improved short-term defect fill and higher treatment success compared to OFD, although the differences were not statistically significant. Both procedures maintained clinical parameters over 36 months, with similar patient satisfaction (PROs) observed for GBR and OFD. The adjunct use of DBBM and NBCM may offer clinical benefits for peri-implantitis cases with specific bony defect morphology.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1038\/s41432-024-01073-9","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T02:02:04Z","timestamp":1728871324000},"page":"29-31","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Guided bone regeneration improves defect fill and reconstructive outcomes in 3-wall peri-implantitis defects"],"prefix":"10.1038","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6053-8967","authenticated-orcid":false,"given":"Kelvin I.","family":"Afrashtehfar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayam A.","family":"Alfallaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souheil","family":"Hussaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"1073_CR1","doi-asserted-by":"publisher","unstructured":"Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 2018;45. Suppl 20. https:\/\/doi.org\/10.1111\/jcpe.12957.","DOI":"10.1111\/jcpe.12957"},{"key":"1073_CR2","doi-asserted-by":"publisher","unstructured":"Renvert S, Giovannoli JL, Rinke S. The efficacy of reconstructive therapy in the surgical management of peri-implantitis: a 3-year follow-up of a randomized clinical trial. J Clin Periodontol. 2024. https:\/\/doi.org\/10.1111\/jcpe.14049.","DOI":"10.1111\/jcpe.14049"},{"issue":"Suppl 26","key":"1073_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/jcpe.13823.","volume":"50","author":"H Herrera","year":"2023","unstructured":"Herrera H, Berglundh T, Schwarz F, Chapple I, Jepsen S, Sculean A. et al. Prevention and treatment of peri-implant diseases\u2014The EFP S3 level clinical practice guideline. J Clin Periodontol. 2023;50. Suppl 26:4\u201376. https:\/\/doi.org\/10.1111\/jcpe.13823.","journal-title":"J Clin Periodontol"},{"key":"1073_CR4","doi-asserted-by":"publisher","first-page":"5247","DOI":"10.1007\/s00784-022-04493-y.","volume":"26","author":"SC Isler","year":"2022","unstructured":"Isler SC, Soysal F, Ceyhanl\u0131 T, Bak\u0131rarar B, Unsal B. Efficacy of concentrated growth factor versus collagen membrane in reconstructive surgical therapy of peri-implantitis: 3-year results of a randomized clinical trial. Clin Oral Investig. 2022;26:5247\u201360. https:\/\/doi.org\/10.1007\/s00784-022-04493-y.","journal-title":"Clin Oral Investig"},{"key":"1073_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-020-00219-5.","volume":"6","author":"A Aghazadeh","year":"2020","unstructured":"Aghazadeh A, Persson RG, Renvert S. Impact of bone defect morphology on the outcome of reconstructive treatment of peri-implantitis. Int J Implant Dent. 2020;6:33. https:\/\/doi.org\/10.1186\/s40729-020-00219-5.","journal-title":"Int J Implant Dent"},{"key":"1073_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-015-0023-1.","volume":"1","author":"F Schwarz","year":"2015","unstructured":"Schwarz F, Schmucker A, Becker J. Efficacy of alternative or adjunctive measures to conventional treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis. Int J Implant Dent. 2015;1:22. https:\/\/doi.org\/10.1186\/s40729-015-0023-1.","journal-title":"Int J Implant Dent"},{"key":"1073_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41432-024-00999-4.","volume":"25","author":"KI Afrashtehfar","year":"2024","unstructured":"Afrashtehfar KI, Jurado CA, Abu Fanas SH, Del Fabbro M. Short-term data suggests cognitive benefits in the elderly with single-implant overdentures. Evid Based Dent. 2024;25:71\u201372. https:\/\/doi.org\/10.1038\/s41432-024-00999-4.","journal-title":"Evid Based Dent"},{"key":"1073_CR8","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/clr.13972","volume":"33","author":"J Derks","year":"2022","unstructured":"Derks J, Ortiz-Vig\u00f3n A, Guerrero A, Donati M, Bressan E, Ghensi P, et al. Reconstructive surgical therapy of peri-implantitis: a multicenter randomized controlled clinical trial. Clin Oral Implants Res. 2022;33:921\u201344. https:\/\/doi.org\/10.1111\/clr.13972. Erratum in: Clin Oral Implants Res. 2023;34:78-79.","journal-title":"Clin Oral Implants Res."},{"key":"1073_CR9","doi-asserted-by":"publisher","first-page":"MR000033","DOI":"10.1002\/14651858.MR000033.pub3.","volume":"2","author":"A Lundh","year":"2017","unstructured":"Lundh A, Lexchin J, Mintzes B, Schroll JB, Bero L. Industry sponsorship and research outcome. Cochrane Database Syst Rev. 2017;2:MR000033. https:\/\/doi.org\/10.1002\/14651858.MR000033.pub3.","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Evidence-Based Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41432-024-01073-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41432-024-01073-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41432-024-01073-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T02:10:51Z","timestamp":1743214251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41432-024-01073-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["1073"],"URL":"https:\/\/doi.org\/10.1038\/s41432-024-01073-9","relation":{},"ISSN":["1462-0049","1476-5446"],"issn-type":[{"value":"1462-0049","type":"print"},{"value":"1476-5446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,14]]},"assertion":[{"value":"23 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}