{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:41:59Z","timestamp":1792269719366,"version":"4.4.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T00:00:00Z","timestamp":1529280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1038\/s41433-018-0144-x","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T09:48:06Z","timestamp":1529315286000},"page":"1555-1562","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A British Ophthalmological Surveillance Unit (BOSU) study into dysthyroid optic neuropathy in the United Kingdom"],"prefix":"10.1038","volume":"32","author":[{"given":"Yun","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Perros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Dayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha","family":"Veeramani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barny","family":"Foot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,18]]},"reference":[{"key":"144_CR1","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1210\/jc.2012-3873","volume":"98","author":"ML Tanda","year":"2013","unstructured":"Tanda ML, Piantanida E, Liparulo L, Veronesi G, Lai A, Sassi L, et al. Prevalence and natural history of Graves\u2019 orbitopathy in a large series of patients with newly diagnosed graves\u2019 hyperthyroidism seen at a single center. J Clin Endocrinol Metab. 2013;98:1443\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"144_CR2","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1136\/bjophthalmol-2015-306733.","volume":"99","author":"Perros","year":"2015","unstructured":"Perros, et al. PREGO (presentation of Graves\u2019 orbitopathy) study: changes in referral patterns to European Group On Graves\u2019 Orbitopathy (EUGOGO) centres over the period from 2000 to 2012. Br J Ophthalmol. 2015;99:1531\u20135. \n                    https:\/\/doi.org\/10.1136\/bjophthalmol-2015-306733\n                    \n                  .","journal-title":"Br J Ophthalmol"},{"key":"144_CR3","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1210\/jc.2012-1275","volume":"97","author":"Laurberg","year":"2012","unstructured":"Laurberg, et al. Incidence and clinical presentation of moderate to severe graves\u2019 orbitopathy in a Danish population before and after iodine fortification of salt. J Clin Endocrinol Metab. 2012;97:2325\u201332. \n                    https:\/\/doi.org\/10.1210\/jc.2012-1275\n                    \n                  .","journal-title":"J Clin Endocrinol Metab"},{"key":"144_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1089\/thy.2007.0315","volume":"18","author":"L Bartalena","year":"2008","unstructured":"Bartalena L, Baldeschi L, Dickinson A, Eckstein A, Kendall-Taylor P, Marcocci C, Mourits M, Perros P, Boboridis K, Boschi A, Curr\u00f2 N, Daumerie C, Kahaly GJ, Krassas GE, Lane CM, Lazarus JH, Marin\u00f2 M, Nardi M, Neoh C, Orgiazzi J, Pearce S, Pinchera A, Pitz S, Salvi M, Sivelli P, Stahl M, Wiersinga WM. European Group on Graves\u2019 Orbitopathy (EUGOGO). Consensus statement of the European Group on Graves\u2019 orbitopathy (EUGOGO) on management of GO. Thyroid. 2008;18:281\u20132.","journal-title":"Thyroid"},{"key":"144_CR5","first-page":"155207","volume":"1","author":"Perros","year":"2006","unstructured":"Perros, et al. A questionnaire survey on the management of Graves\u2019 orbitopathy in Europe. Eur J Endocrinol August. 2006;1:155207\u201311.","journal-title":"Eur J Endocrinol August"},{"key":"144_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0625-1","volume":"12","author":"P Perros","year":"2017","unstructured":"Perros P, Heged\u00fcs L, Bartalena L, Marcocci C, Kahaly GJ, Baldeschi L, Salvi M, Lazarus JH, Eckstein A, Pitz S, Boboridis K, Anagnostis P, Ayvaz G, Boschi A, Brix TH, Curr\u00f2 N, Konuk O, Marin\u00f2 M, Mitchell AL, Stankovic B, T\u00f6r\u00fcner FB, von Arx G, Zarkovi\u0107 M, Wiersinga WM. Graves\u2019 orbitopathy as a rare disease in Europe: a European Group on Graves\u2019 Orbitopathy (EUGOGO) position statement. Orphanet J Rare Dis. 2017;12:72.","journal-title":"Orphanet J Rare Dis"},{"key":"144_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3109\/01676830.2013.851707","volume":"33","author":"A Dharmasena","year":"2014","unstructured":"Dharmasena A, Keenan TD, Goldacre MJ. Orbital decompression for thyroid-associated orbitopathy in England: trends over time and geographical variation. Orbit. 2014;33:109\u201314.","journal-title":"Orbit"},{"key":"144_CR8","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/eye.2011.323","volume":"26","author":"P Perros","year":"2012","unstructured":"Perros P, Chandler T, Dayan CM, Dickinson AJ, Foley P, Hickey J, MacEwen CJ, Lazarus JH, McLaren J, Rose GE, Uddin JM, Vaidya B. Orbital decompression for Graves\u2019 orbitopathy in England. Eye. 2012;26:434\u20137.","journal-title":"Eye"},{"key":"144_CR9","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3341\/kjo.2012.26.2.73","volume":"26","author":"Chan Jeon","year":"2012","unstructured":"Jeon Chan, Shin JaeHo, Woo KyungIn, Kim Yoon-Duck. Clinical profile and visual outcomes after treatment in patients with dysthyroid optic neuropathy. Korean J Ophthalmol. 2012;26:73\u20139.","journal-title":"Korean J Ophthalmol"},{"key":"144_CR10","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1136\/bjo.2006.094607","volume":"91","author":"D McKeag","year":"2007","unstructured":"McKeag D, Lane C, Lazarus JH, Baldeschi L, Boboridis K, Dickinson AJ, Hullo AI, Kahaly G, Krassas G, Marcocci C, Marin\u00f2 M, Mourits MP, Nardi M, Neoh C, Orgiazzi J, Perros P, Pinchera A, Pitz S, Prummel MF, Sartini MS, Wiersinga WM. European Group on Graves\u2019 Orbitopathy (EUGOGO), Clinical features of dysthyroid optic neuropathy: a European Group on Graves\u2019 Orbitopathy (EUGOGO) survey. Br J Ophthalmol. 2007;91:455\u20138.","journal-title":"Br J Ophthalmol"},{"key":"144_CR11","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1136\/bjo.80.12.1034","volume":"80","author":"J Rootman","year":"1996","unstructured":"Rootman J. Retrobulbar pressures in dysthyroid optic neuropathy. Br J Ophthalmol. 1996;80:1034.","journal-title":"Br J Ophthalmol"},{"key":"144_CR12","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/eye.1994.159","volume":"8","author":"MD Tsaloumas","year":"1994","unstructured":"Tsaloumas MD, Good PA, Burdon MA, Misson GP. Flash and pattern visual evoked potentials in the diagnosis and monitoring of dysthyroid optic neuropathy. Eye. 1994;8:638\u201345.","journal-title":"Eye"},{"key":"144_CR13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1023\/A:1022561530782","volume":"106","author":"G Ambrosio","year":"2003","unstructured":"Ambrosio G, Ferrara G, Vitale R, De Marco R. Visual evoked potentials in patients with Graves\u2019 ophthalmopathy complicated by ocular hypertension and suspect glaucoma or dysthyroid optic neuropathy. Doc Ophthalmol. 2003;106:99\u2013104.","journal-title":"Doc Ophthalmol"},{"issue":"1","key":"144_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000443828","volume":"5","author":"Luigi Bartalena","year":"2016","unstructured":"Bartalena L, Baldeschi L, Boboridis K, Eckstein, Kahaly GJ, Marcocci C, Perros P, Salvi M, Wiersinga WM, on behalf of the European Group on Graves\u201d Orbitopathy (EUGOGO). The 2016 European Thyroid Association\/European Group on Graves\u2019 Orbitopathy Guidelines for the Management of Graves\u2019 Orbitopathy. Eur Thyroid J. 2016;5:9\u201326.","journal-title":"European Thyroid Journal"},{"key":"144_CR15","first-page":"505","volume":"16","author":"DE Sholter","year":"2000","unstructured":"Sholter DE, Armstrong PW. Adverse effects of corticosteroids on the cardiovascular system. Can J Cardiol. 2000;16:505\u201311.","journal-title":"Can J Cardiol"},{"key":"144_CR16","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/S0161-6420(89)32784-9","volume":"96","author":"JR Guy","year":"1989","unstructured":"Guy JR, Fagien S, Donovan JP, Rubin ML. Methyl prednisolone pulse therapy in severe dysthyroid optic neuropathy. Ophthalmology. 1989;96:1048\u201352.","journal-title":"Ophthalmology"},{"key":"144_CR17","doi-asserted-by":"publisher","first-page":"5234","DOI":"10.1210\/jc.2005-0148","volume":"90","author":"J Kahaly","year":"2005","unstructured":"Kahaly J, et al. Randomized, single blind trial of intravenous versus oral steroid monotherapy in Graves\u2019 orbitopathy. J Clin Endocrinol Metab. 2005;90:5234\u201340.","journal-title":"J Clin Endocrinol Metab"},{"key":"144_CR18","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1056\/NEJMoa1614949","volume":"376","author":"JS Terry","year":"2017","unstructured":"Terry JS, et al. Teprotumumab for thyroid-associated ophthalmopathy. N Engl J Med. 2017;376:1748\u201361.","journal-title":"N Engl J Med"},{"key":"144_CR19","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1056\/NEJMoa1012985","volume":"364","author":"C Marcocc","year":"2011","unstructured":"Marcocc C, et al. Claudio Marcocc, selenium and the course of mild Graves\u2019 orbitopathy. N Engl J Med. 2011;364:1920\u201331.","journal-title":"N Engl J Med"},{"key":"144_CR20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1089\/105072502753600223","volume":"12","author":"L Bartalena","year":"2002","unstructured":"Bartalena L, Marcocci C, Tanda ML, Rocchi R, Mazzi B, Barbesino G, Pinchera A. Orbital radiotherapy for Graves\u2019 ophthalmopathy. Thyroid. 2002;12:245\u201350.","journal-title":"Thyroid"},{"key":"144_CR21","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3109\/01676831003660663","volume":"29","author":"K Tambe","year":"2010","unstructured":"Tambe K, Bhargava J, Tripathi A, Gregory M, Burns J, Sampath R. The role of intravenous methyl prednisolone immunosuppression in the management of active thyroid eye disease. Orbit. 2010;29:227\u201331.","journal-title":"Orbit"},{"issue":"4","key":"144_CR22","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S2213-8587(18)30021-4","volume":"6","author":"Rathie Rajendram","year":"2018","unstructured":"Rajendram R, Taylor PN, Wilson VJ, Harris N, Morris OC, Tomlinson M, Yarrow S, Garrott H, Herbert HM, Dick AD, Cook A, Gattamaneni R,Jain R, Olver J, Hurel SJ, Bremner F, Drummond SR, Kemp E, Ritchie DM, Rumsey N, Morris D, Lane C, Palaniappan N, Li C, Pell J, Hills R, Ezra DG, Potts MJ, Jackson S, Rose GE, Plowman N, Bunce C, Uddin JM, Lee RWJ, Dayan CM. Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 \u00d7 2 factorial, double-blind, randomised controlled trial. Lancet Diabetes Endocrinol. 2018;6:299\u2013309.","journal-title":"The Lancet Diabetes & Endocrinology"},{"key":"144_CR23","first-page":"179","volume":"128","author":"J Ciri\u0107","year":"2000","unstructured":"Ciri\u0107 J, Zarkovi\u0107 M, Stojanovi\u0107 M, Pepenezi\u0107 Z, Randjelovi\u0107 G, Gligorovi\u0107 M, Trbojevi\u0107 B, Drezgi\u0107 M, Nesovi\u0107 M. Treatment of Grave\u2019s ophthalmopathy with high doses of corticosteroids. Srp Arh Celok Lek. 2000;128:179\u201383.","journal-title":"Srp Arh Celok Lek"},{"key":"144_CR24","first-page":"642","volume":"140","author":"L Baldeschi","year":"2005","unstructured":"Baldeschi L, MacAndie K, Hintschich C, Wakelkamp IM, Prummel MF, Wiersinga WM. The removal of the deep lateral wall in orbital decompression: its contribution to exophthalmos reduction and influence on consecutive diplopia. Am J Ophthlmol. 2005;140:642\u20137.","journal-title":"Am J Ophthlmol"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41433-018-0144-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41433-018-0144-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41433-018-0144-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:04:38Z","timestamp":1684616678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41433-018-0144-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,18]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["144"],"URL":"https:\/\/doi.org\/10.1038\/s41433-018-0144-x","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,18]]},"assertion":[{"value":"8 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}