{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:47:51Z","timestamp":1788353271517,"version":"build-2803163510"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1038\/s41433-019-0424-0","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T11:29:55Z","timestamp":1554118195000},"page":"1305-1313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Myopic traction maculopathy biomarkers on optical coherence tomography angiography\u2014An overlooked mechanism of visual acuity correction in myopic eyes"],"prefix":"10.1038","volume":"33","author":[{"given":"Shih-Wen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Chi","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ying","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muh-Shy","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzyy-Chang","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"424_CR1","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/S0002-9394(99)00186-5","volume":"128","author":"M Takano","year":"1999","unstructured":"Takano M, Kishi S. Foveal retinoschisis and retinal detachment in severely myopic eyes with posterior staphyloma. Am J Ophthalmol. 1999;128:472\u20136.","journal-title":"Am J Ophthalmol"},{"key":"424_CR2","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1001\/archopht.122.10.1455","volume":"122","author":"G Panozzo","year":"2004","unstructured":"Panozzo G, Mercanti A. Optical coherence tomography findings in myopic traction maculopathy. Arch Ophthalmol. 2004;122:1455\u201360.","journal-title":"Arch Ophthalmol"},{"key":"424_CR3","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/eye.2013.280","volume":"28","author":"PJ Foster","year":"2014","unstructured":"Foster PJ, Jiang Y. Epidemiology of myopia. Eye. 2014;28:202\u20138.","journal-title":"Eye"},{"key":"424_CR4","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1097\/APO.0000000000000234","volume":"5","author":"YL Wong","year":"2016","unstructured":"Wong YL, Saw SM. Epidemiology of pathologic myopia in Asia and worldwide. Asia Pac J Ophthalmol. 2016;5:394\u2013402.","journal-title":"Asia Pac J Ophthalmol"},{"key":"424_CR5","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s10384-008-0544-8","volume":"52","author":"Y Ikuno","year":"2008","unstructured":"Ikuno Y, Sayanagi K, Soga K, Oshima Y, Ohji M, Tano Y. Foveal anatomical status and surgical results in vitrectomy for myopic foveoschisis. Jpn J Ophthalmol. 2008;52:269\u201376.","journal-title":"Jpn J Ophthalmol"},{"key":"424_CR6","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1097\/IAE.0b013e3182a4892b","volume":"33","author":"S Taniuchi","year":"2013","unstructured":"Taniuchi S, Hirakata A, Itoh Y, Hirota K, Inoue M. Vitrectomy with or without internal limiting membrane peeling for each stage of myopic traction maculopathy. Retina. 2013;33:2018\u201325.","journal-title":"Retina"},{"key":"424_CR7","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/S0002-9394(02)01394-6","volume":"133","author":"N Benhamou","year":"2002","unstructured":"Benhamou N, Massin P, Haouchine B, Erginay A, Gaudric A. Macular retinoschisis in highly myopic eyes. Am J Ophthalmol. 2002;133:794\u2013800.","journal-title":"Am J Ophthalmol"},{"key":"424_CR8","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.ajo.2006.10.053","volume":"143","author":"D Gaucher","year":"2007","unstructured":"Gaucher D, Haouchine B, Tadayoni R, Massin P, Erginay A, Benhamou N, et al. Long-term follow-up of high myopic foveoschisis: natural course and surgical outcome. Am J Ophthalmol. 2007;143:455\u201362.","journal-title":"Am J Ophthalmol"},{"key":"424_CR9","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.ajo.2013.06.031","volume":"156","author":"N Shimada","year":"2013","unstructured":"Shimada N, Tanaka Y, Tokoro T, Ohno-Matsui K. Natural course of myopic traction maculopathy and factors associated with progression or resolusion. Am J Ophthalmol. 2013;156:948\u201357.","journal-title":"Am J Ophthalmol"},{"key":"424_CR10","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.ajo.2008.01.012","volume":"145","author":"D Gaucher","year":"2008","unstructured":"Gaucher D, Erginay A, Lecleire-Collet A, Haouchine B, Puech M, Cohen SY, et al. Dome-shaped macula in eyes with myopic posterior staphyloma. Am J Ophthalmol. 2008;145:909\u201314.","journal-title":"Am J Ophthalmol"},{"key":"424_CR11","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.ajo.2012.08.007","volume":"155","author":"AA Ellabban","year":"2013","unstructured":"Ellabban AA, Tsujikawa A, Matsumoto A, Yamashiro K, Oishi A, Ooto S, et al. Three-dimensional tomographic features of dome-shaped macula by swept-source optical coherence tomography. Am J Ophthalmol. 2013;155:320\u20138.","journal-title":"Am J Ophthalmol"},{"key":"424_CR12","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1007\/s00417-015-3148-2","volume":"254","author":"FJ Freiberg","year":"2016","unstructured":"Freiberg FJ, Pfau M, Wons J, Wirth MA, Becker MD, Michels S. Optical coherence tomography angiography of the foveal avascular zone in diabetic retinopathy. Graefes Arch Clin And Exp Ophthalmol. 2016;254:1051\u20138.","journal-title":"Graefes Arch Clin And Exp Ophthalmol"},{"key":"424_CR13","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1007\/s00417-015-3228-3","volume":"254","author":"JY Kim","year":"2016","unstructured":"Kim JY, Kwon OW, Oh HS, Kim SH, You YS. Optical coherence tomography angiography in patients with polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol. 2016;254:1505\u201310.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"424_CR14","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s00417-016-3552-2","volume":"255","author":"T Yoshida-Uemur","year":"2017","unstructured":"Yoshida-Uemur T, Katagiri S, Yokoi T, Nishina S, Azuma N. Different foveal schisis patterns in each retinal layer in eyes with hereditary juvenile retinoschisis evaluated by en-face optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2017;255:719\u201323.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"424_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1167\/iovs.15-19043","volume":"57","author":"SS Gao","year":"2016","unstructured":"Gao SS, Jia Y, Zhang M, Su JP, Liu G, Hwang TS, et al. Optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016;57:27\u201336.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"424_CR16","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.ajo.2008.05.032","volume":"146","author":"RF Spaide","year":"2008","unstructured":"Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol. 2008;146:496\u2013500.","journal-title":"Am J Ophthalmol"},{"key":"424_CR17","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.oret.2016.08.008","volume":"1","author":"MA Klufas","year":"2017","unstructured":"Klufas MA, Phasukkijwatana N, Iafe NA. Optical coherence tomography angiography reveals choriocapillaris flow reduction in placoid chorioretinitis. Ophthalmoly Retina. 2017;1:77\u201391.","journal-title":"Ophthalmoly Retina"},{"key":"424_CR18","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.ajo.2015.06.030","volume":"160","author":"L Kuehlewein","year":"2015","unstructured":"Kuehlewein L, Bansal M, Lenis TL, Iafe NA, Sadda SR, Bonini Filho MA, et al. Optical coherence tomography angiography of type 1 neovascularization in age-related macular degeneration. Am J Ophthalmol. 2015;160:739\u2013.e2.","journal-title":"Am J Ophthalmol"},{"key":"424_CR19","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1002\/glia.22477","volume":"61","author":"A Reichenbach","year":"2015","unstructured":"Reichenbach A, Bringmann A. New functions of M\u00fcller cells. Glia. 2015;61:651\u201378.","journal-title":"Glia"},{"key":"424_CR20","doi-asserted-by":"publisher","first-page":"8287","DOI":"10.1073\/pnas.0611180104","volume":"104","author":"K Franze","year":"2007","unstructured":"Franze K, Grosche J, Skatchkov SN, Schinkinger S, Foja C, Schild D, et al. M\u00fcller cells are living optical fibers in the vertebrate retina. Proc Natl Acad Sci USA. 2007;104:8287\u201392.","journal-title":"Proc Natl Acad Sci USA"},{"key":"424_CR21","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1001\/archopht.117.6.821","volume":"117","author":"JD Gass","year":"1999","unstructured":"Gass JD. M\u00fcller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacular retinoschisis. Arch Ophthalmol. 1999;117:821\u20133.","journal-title":"Arch Ophthalmol"},{"key":"424_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/175613","volume":"2010","author":"Johnny Tang","year":"2010","unstructured":"Tang J, Rivers MB, Moshfeghi AA, Flynn HW Jr, Chan C Pathology of macular foveoschisis associated with degenerative myopia. J Ophthalmol 2010; 175613. \nhttps:\/\/doi.org\/10.1155\/2010\/175613","journal-title":"Journal of Ophthalmology"},{"key":"424_CR23","doi-asserted-by":"publisher","first-page":"702","DOI":"10.7150\/ijbs.6473","volume":"9","author":"S Park","year":"2013","unstructured":"Park S, Lee YJ. Nano-mechanical compliance of M\u00fcller cells investigated by atomic force microscopy. Int J Biol Sci. 2013;9:702\u20136.","journal-title":"Int J Biol Sci"},{"key":"424_CR24","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ajo.2009.04.029","volume":"148","author":"T Fujiwara","year":"2009","unstructured":"Fujiwara T, Imamura Y, Margolis R, Slakter JS, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol. 2009;148:445\u201350.","journal-title":"Am J Ophthalmol"},{"key":"424_CR25","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ajo.2012.07.015","volume":"155","author":"I F lores-Moreno","year":"2013","unstructured":"F lores-Moreno I, Lugo F, Duker JS, Ruiz-Moreno JM. The relationship between axial length and choroidal thickness in eyes with high myopia. Am J Ophthalmol. 2013;155:314\u20139.","journal-title":"Am J Ophthalmol"},{"key":"424_CR26","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1097\/IAE.0b013e318242b990","volume":"32","author":"Y Nishida","year":"2012","unstructured":"Nishida Y, Fujiwara T, Imamura Y, Lima LH, Kurosaka D, Spaide RF. Choroidal thickness and visual acuity in highly myopic eyes. Retina. 2012;32:1229\u201336.","journal-title":"Retina"},{"key":"424_CR27","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1177\/112067219700700313","volume":"7","author":"N Gozum","year":"1997","unstructured":"Gozum N, Cakir M, Gucukoglu A, Sezen F. Relationship between retinal lesions and axial length, age and sex in high myopia. Eur J Ophthalmol. 1997;7:277\u201382.","journal-title":"Eur J Ophthalmol"},{"key":"424_CR28","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.ajo.2006.04.046","volume":"142","author":"T Baba","year":"2006","unstructured":"Baba T, Tanaka S, Maesawa A, Teramatsu T, Noda Y, Yamamoto S. Scleral buckling with macular plombe for eyes with myopic macular retinoschisis and retinal detachment without macular hole. Am J Ophthalmol. 2006;142:483\u20137.","journal-title":"Am J Ophthalmol"},{"key":"424_CR29","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1097\/IAE.0b013e31822e5c32","volume":"32","author":"C Mateo","year":"2012","unstructured":"Mateo C, Bures-Jelstrup A, Navarro R, Corcostegui B. Macular buckling for eyes with myopic foveoschisis secondary to posterior staphyloma. Retina. 2012;32:1121\u20138.","journal-title":"Retina"},{"key":"424_CR30","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1167\/iovs.16-21289","volume":"58","author":"M Al-Sheikh","year":"2017","unstructured":"Al-Sheikh M, Phasukkijwatana N, Dolz-Marco R, Rahimi M, Iafe NA, Freund KB, et al. Quantitative OCT angiography of the retinal microvasculature and the choriocapillaris in myopic eyes. Invest Ophthalmol Vis Sci. 2017;58:2063\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"424_CR31","doi-asserted-by":"publisher","first-page":"5780","DOI":"10.1167\/iovs.16-20045","volume":"57","author":"NA Iafe","year":"2016","unstructured":"Iafe NA, Phasukkijwatana N, Chen X, Sarraf D. Retinal capillary density and foveal avascular zone area are age-dependent: quantitative analysis using optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016;57:5780\u20137.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"424_CR32","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1097\/IAE.0000000000000847","volume":"35","author":"WA Samara","year":"2015","unstructured":"Samara WA, Say EA, Khoo CT, Higgins TP, Magrath G, Ferenczy S, et al. Correlation of foveal avascular zone size with foveal morphology in normal eyes using optical coherence tomography angiography. Retina. 2015;35:2188\u201395.","journal-title":"Retina"},{"key":"424_CR33","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1097\/IAE.0000000000000849","volume":"35","author":"N Takase","year":"2015","unstructured":"Takase N, Nozaki M, Kato A, Ozeki H, Yoshida M, Ogura Y. Enlargement of foveal avascular zone in diabetic eyes evaluated by en face optical coherence tomography angiography. Retina. 2015;35:2377\u201383.","journal-title":"Retina"},{"key":"424_CR34","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1167\/iovs.15-18630","volume":"57","author":"J Yu","year":"2016","unstructured":"Yu J, Gu R, Zong Y, Xu H, Wang X, Sun X, et al. Relationship between retinal perfusion and retinal thickness in healthy subjects: an optical coherence tomography angiography study. Invest OphthalmolVisl Sci. 2016;57:204\u201310.","journal-title":"Invest OphthalmolVisl Sci"},{"key":"424_CR35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1159\/000189819","volume":"223","author":"G Landa","year":"2009","unstructured":"Landa G, Garcia PM, Rosen RB. Correlation between retina blood flow velocity assessed by retinal function imager and retina thickness estimated by scanning laser ophthalmoscopy\/optical coherence tomography. Ophthalmologica. 2009;223:155\u201361.","journal-title":"Ophthalmologica"},{"key":"424_CR36","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1097\/IAE.0000000000000149","volume":"34","author":"TC Ho","year":"2014","unstructured":"Ho TC, Yang CM, Huang JS, Yang CH, Yeh PT, Chen TC, et al. Long-term outcome of foveolar internal limiting membrane nonpeeling for myopic traction maculopathy. Retina. 2014;34:1833\u201340.","journal-title":"Retina"},{"key":"424_CR37","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.compbiomed.2017.08.008","volume":"89","author":"N Eladawi","year":"2017","unstructured":"Eladawi N, Elmogy M, Helmy O, Aboelfetouh A, Riad A, Sandhu H, et al. Automatic blood vessels segmentation based on different retinal maps from OCTA scans. Comput Biol Med. 2017;89:150\u201361.","journal-title":"Comput Biol Med"},{"key":"424_CR38","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1097\/IAE.0000000000000765","volume":"35","author":"RF Spaide","year":"2015","unstructured":"Spaide RF, Fujimoto JG, Waheed NK. Image artifacts in optical coherence tomography angiography. Retina. 2015;35:2163\u201380.","journal-title":"Retina"},{"key":"424_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-017-0068-9","volume":"3","author":"M Al-Sheikh","year":"2017","unstructured":"Al-Sheikh M, Falavarjani KG, Akil H, Sadda SR. Impact of image quality on OCT angiography based quantitative measurements. Int J Retina Vitreous. 2017;3:13.","journal-title":"Int J Retina Vitreous"},{"key":"424_CR40","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1016\/j.ophtha.2017.04.028","volume":"124","author":"CMG Cheung","year":"2017","unstructured":"Cheung CMG, Arnold JJ, Holz FG, Park KH, Lai TYY, Larsen M, et al. Myopic choroidal neovascularization: review, guidance, and consensus statement on management. Ophthalmology. 2017;124:1690\u2013711.","journal-title":"Ophthalmology"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41433-019-0424-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41433-019-0424-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41433-019-0424-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:06:59Z","timestamp":1684616819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41433-019-0424-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,1]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["424"],"URL":"https:\/\/doi.org\/10.1038\/s41433-019-0424-0","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,1]]},"assertion":[{"value":"4 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}