{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:40:37Z","timestamp":1787002837232,"version":"build-2736575974"},"reference-count":102,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000053","name":"U.S. Department of Health & Human Services | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["R01 EY022305"],"award-info":[{"award-number":["R01 EY022305"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"U.S. Department of Health & Human Services | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["P30 EY014104"],"award-info":[{"award-number":["P30 EY014104"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Department of Health & Human Services | NIH | National Eye Institute"},{"name":"Moorfields Eye Charity Career Development Fellowship"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1038\/s41433-019-0632-7","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T10:33:09Z","timestamp":1571826789000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Clinical implications of recent advances in primary open-angle glaucoma genetics"],"prefix":"10.1038","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-8667","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Choquet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janey L.","family":"Wiggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-8585","authenticated-orcid":false,"given":"Anthony P.","family":"Khawaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"632_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ajhg.2017.06.005","volume":"101","author":"PM Visscher","year":"2017","unstructured":"Visscher PM, Wray NR, Zhang Q, Sklar P, McCarthy MI, Brown MA, et al. 10 years of GWAS discovery: biology, function, and translation. Am J Hum Genet. 2017;101:5\u201322.","journal-title":"Am J Hum Genet."},{"issue":"D1","key":"632_CR2","doi-asserted-by":"publisher","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","volume":"45","author":"J MacArthur","year":"2017","unstructured":"MacArthur J, Bowler E, Cerezo M, Gil L, Hall P, Hastings E, et al. The new NHGRI-EBI catalog of published genome-wide association studies (GWAS Catalog). Nucleic Acids Res. 2017;45(D1):D896\u2013D901.","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"632_CR3","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41576-019-0127-1","volume":"20","author":"Vivian Tam","year":"2019","unstructured":"Tam V, Patel N, Turcotte M, Bosse Y, Pare G, Meyre D. Benefits and limitations of genome-wide association studies. Nat Rev Genet. 2019;20:467\u201384.","journal-title":"Nature Reviews Genetics"},{"issue":"R1","key":"632_CR4","doi-asserted-by":"publisher","first-page":"R21","DOI":"10.1093\/hmg\/ddx184","volume":"26","author":"JL Wiggs","year":"2017","unstructured":"Wiggs JL, Pasquale LR. Genetics of glaucoma. Hum Mol Genet. 2017;26(R1):R21\u2013R7.","journal-title":"Hum Mol Genet."},{"key":"632_CR5","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/ng.824","volume":"43","author":"KP Burdon","year":"2011","unstructured":"Burdon KP, Macgregor S, Hewitt AW, Sharma S, Chidlow G, Mills RA, et al. Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. Nat Genet. 2011;43:574\u20138.","journal-title":"Nat Genet"},{"key":"632_CR6","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/ng.661","volume":"42","author":"G Thorleifsson","year":"2010","unstructured":"Thorleifsson G, Walters GB, Hewitt AW, Masson G, Helgason A, DeWan A, et al. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nat Genet. 2010;42:906\u20139.","journal-title":"Nat Genet"},{"key":"632_CR7","doi-asserted-by":"publisher","first-page":"e1002654","DOI":"10.1371\/journal.pgen.1002654","volume":"8","author":"JL Wiggs","year":"2012","unstructured":"Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Allingham RR, Olson LM, et al. Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet. 2012;8:e1002654.","journal-title":"PLoS Genet"},{"key":"632_CR8","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1093\/hmg\/dds103","volume":"21","author":"W Osman","year":"2012","unstructured":"Osman W, Low SK, Takahashi A, Kubo M, Nakamura Y. A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. Hum Mol Genet. 2012;21:2836\u201342.","journal-title":"Hum Mol Genet."},{"key":"632_CR9","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1038\/ng.3079","volume":"46","author":"P Gharahkhani","year":"2014","unstructured":"Gharahkhani P, Burdon KP, Fogarty R, Sharma S, Hewitt AW, Martin S, et al. Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma. Nat Genet. 2014;46:1120\u20135.","journal-title":"Nat Genet"},{"key":"632_CR10","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1038\/ng.3078","volume":"46","author":"Y Chen","year":"2014","unstructured":"Chen Y, Lin Y, Vithana EN, Jia L, Zuo X, Wong TY, et al. Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma. Nat Genet. 2014;46:1115\u20139.","journal-title":"Nat Genet."},{"key":"632_CR11","doi-asserted-by":"publisher","first-page":"3880","DOI":"10.1093\/hmg\/ddv128","volume":"24","author":"Z Li","year":"2015","unstructured":"Li Z, Allingham RR, Nakano M, Jia L, Chen Y, Ikeda Y, et al. A common variant near TGFBR3 is associated with primary open angle glaucoma. Hum Mol Genet. 2015;24:3880\u201392.","journal-title":"Hum Mol Genet"},{"key":"632_CR12","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1093\/hmg\/ddv027","volume":"24","author":"H Springelkamp","year":"2015","unstructured":"Springelkamp H, Iglesias AI, Cuellar-Partida G, Amin N, Burdon KP, van Leeuwen EM, et al. ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure. Hum Mol Genet. 2015;24:2689\u201399.","journal-title":"Hum Mol Genet"},{"key":"632_CR13","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/ng.3482","volume":"48","author":"JN Bailey","year":"2016","unstructured":"Bailey JN, Loomis SJ, Kang JH, Allingham RR, Gharahkhani P, Khor CC, et al. Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nat Genet. 2016;48:189\u201394.","journal-title":"Nat Genet"},{"key":"632_CR14","doi-asserted-by":"crossref","unstructured":"Thorleifsson G, et al. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nat Genet. 2010;42:906\u20139.","DOI":"10.1038\/ng.661"},{"key":"632_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04555-4","volume":"9","author":"H Choquet","year":"2018","unstructured":"Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, et al. A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. Nat Commun. 2018;9:2278.","journal-title":"Nat Commun."},{"key":"632_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20435-9","volume":"8","author":"P Gharahkhani","year":"2018","unstructured":"Gharahkhani P, Burdon KP, Cooke Bailey JN, Hewitt AW, Law MH, Pasquale LR, et al. Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. Sci Rep. 2018;8:3124.","journal-title":"Sci Rep."},{"key":"632_CR17","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1093\/hmg\/ddy053","volume":"27","author":"Y Shiga","year":"2018","unstructured":"Shiga Y, Akiyama M, Nishiguchi KM, Sato K, Shimozawa N, Takahashi A, et al. Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma. Hum Mol Genet. 2018;27:1486\u201396.","journal-title":"Hum Mol Genet"},{"key":"632_CR18","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/s41588-018-0176-y","volume":"50","author":"S MacGregor","year":"2018","unstructured":"MacGregor S, Ong JS, An J, Han X, Zhou T, Siggs OM, et al. Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma. Nat Genet. 2018;50:1067\u201371.","journal-title":"Nat Genet."},{"key":"632_CR19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","volume":"562","author":"C Bycroft","year":"2018","unstructured":"Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, et al. The UK Biobank resource with deep phenotyping and genomic data. Nature. 2018;562:203\u20139.","journal-title":"Nature."},{"key":"632_CR20","doi-asserted-by":"publisher","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","volume":"12","author":"C Sudlow","year":"2015","unstructured":"Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12:e1001779.","journal-title":"PLoS Med."},{"key":"632_CR21","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1534\/genetics.115.178616","volume":"200","author":"Y Banda","year":"2015","unstructured":"Banda Y, Kvale MN, Hoffmann TJ, Hesselson SE, Ranatunga D, Tang H, et al. Characterizing race\/ethnicity and genetic ancestry for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015;200:1285\u201395.","journal-title":"Genetics."},{"key":"632_CR22","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1534\/genetics.115.178905","volume":"200","author":"MN Kvale","year":"2015","unstructured":"Kvale MN, Hesselson S, Hoffmann TJ, Cao Y, Chan D, Connell S, et al. Genotyping informatics and quality control for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015;200:1051\u201360.","journal-title":"Genetics."},{"key":"632_CR23","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1017\/thg.2014.79","volume":"18","author":"A Mishra","year":"2015","unstructured":"Mishra A, Macgregor S. VEGAS2: software for more flexible gene-based testing. Twin Res Hum Genet. 2015;18:86\u201391.","journal-title":"Twin Res Hum Genet"},{"key":"632_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01261-5","volume":"8","author":"K Watanabe","year":"2017","unstructured":"Watanabe K, Taskesen E, van Bochoven A, Posthuma D. Functional mapping and annotation of genetic associations with FUMA. Nat Commun. 2017;8:1826.","journal-title":"Nat Commun."},{"key":"632_CR25","doi-asserted-by":"publisher","first-page":"e33389","DOI":"10.1371\/journal.pone.0033389","volume":"7","author":"M Nakano","year":"2012","unstructured":"Nakano M, Ikeda Y, Tokuda Y, Fuwa M, Omi N, Ueno M, et al. Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese. PLoS One. 2012;7:e33389.","journal-title":"PLoS One."},{"key":"632_CR26","doi-asserted-by":"publisher","first-page":"6634","DOI":"10.1093\/hmg\/ddu364","volume":"23","author":"TJ Hoffmann","year":"2014","unstructured":"Hoffmann TJ, Tang H, Thornton TA, Caan B, Haan M, Millen AE, et al. Genome-wide association and admixture analysis of glaucoma in the women\u2019s health initiative. Hum Mol Genet. 2014;23:6634\u201343.","journal-title":"Hum Mol Genet."},{"key":"632_CR27","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.ophtha.2018.10.031","volume":"126","author":"KD Taylor","year":"2019","unstructured":"Taylor KD, Guo X, Zangwill LM, Liebmann JM, Girkin CA, Feldman RM, et al. Genetic architecture of primary open-angle glaucoma in individuals of african descent: the African Descent and Glaucoma Evaluation Study III. Ophthalmology. 2019;126:38\u201348.","journal-title":"Ophthalmology."},{"key":"632_CR28","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s00439-018-1943-7","volume":"137","author":"PWM Bonnemaijer","year":"2018","unstructured":"Bonnemaijer PWM, Iglesias AI, Nadkarni GN, Sanyiwa AJ, Hassan HG, Cook C, et al. Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations. Hum Genet. 2018;137:847\u201362.","journal-title":"Hum Genet"},{"key":"632_CR29","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.ajo.2015.01.011","volume":"159","author":"N Khachatryan","year":"2015","unstructured":"Khachatryan N, Medeiros FA, Sharpsten L, Bowd C, Sample PA, Liebmann JM, et al. The African Descent and Glaucoma Evaluation Study (ADAGES): predictors of visual field damage in glaucoma suspects. Am J Ophthalmol. 2015;159:777\u201387.","journal-title":"Am J Ophthalmol."},{"key":"632_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.4103\/0974-9233.110605","volume":"20","author":"F Kyari","year":"2013","unstructured":"Kyari F, Abdull MM, Bastawrous A, Gilbert CE, Faal H. Epidemiology of glaucoma in sub-saharan Africa: prevalence, incidence and risk factors. Middle East Afr J Ophthalmol. 2013;20:111\u201325.","journal-title":"Middle East Afr J Ophthalmol."},{"key":"632_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/srep08378","volume":"5","author":"SE Williams","year":"2015","unstructured":"Williams SE, Carmichael TR, Allingham RR, Hauser M, Ramsay M. The genetics of POAG in black South Africans: a candidate gene association study. Sci Rep. 2015;5:8378.","journal-title":"Sci Rep."},{"key":"632_CR32","doi-asserted-by":"publisher","first-page":"e39278","DOI":"10.1371\/journal.pone.0039278","volume":"7","author":"D Cao","year":"2012","unstructured":"Cao D, Jiao X, Liu X, Hennis A, Leske MC, Nemesure B, et al. CDKN2B polymorphism is associated with primary open-angle glaucoma (POAG) in the Afro-Caribbean population of Barbados, West Indies. PLoS One. 2012;7:e39278.","journal-title":"PLoS One."},{"key":"632_CR33","doi-asserted-by":"publisher","first-page":"6248","DOI":"10.1167\/iovs.13-12779","volume":"54","author":"Y Liu","year":"2013","unstructured":"Liu Y, Hauser MA, Akafo SK, Qin X, Miura S, Gibson JR, et al. Investigation of known genetic risk factors for primary open angle glaucoma in two populations of African ancestry. Invest Ophthalmol Vis Sci. 2013;54:6248\u201354.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"Suppl 3","key":"632_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-018-0392-4","volume":"11","author":"NA Restrepo","year":"2018","unstructured":"Restrepo NA, Laper SM, Farber-Eger E, Crawford DC. Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records. BMC Med Genomics. 2018;11 Suppl 3 :70.","journal-title":"BMC Med Genomics."},{"key":"632_CR35","doi-asserted-by":"publisher","first-page":"e1004372","DOI":"10.1371\/journal.pgen.1004372","volume":"10","author":"MU Carnes","year":"2014","unstructured":"Carnes MU, Liu YP, Allingham RR, Whigham BT, Havens S, Garrett ME, et al. Discovery and functional annotation of SIX6 variants in primary open-angle glaucoma. PLoS Genet. 2014;10:e1004372.","journal-title":"PLoS Genet."},{"key":"632_CR36","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.ajpath.2015.11.026","volume":"186","author":"S Gao","year":"2016","unstructured":"Gao S, Jakobs TC. Mice homozygous for a deletion in the glaucoma susceptibility locus ink4 show increased vulnerability of retinal ganglion cells to elevated intraocular pressure. Am J Pathol. 2016;186:985\u20131005.","journal-title":"Am J Pathol."},{"key":"632_CR37","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.molcel.2015.07.027","volume":"59","author":"D Skowronska-Krawczyk","year":"2015","unstructured":"Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, et al. P16INK4a upregulation mediated by six6 defines retinal ganglion cell pathogenesis in glaucoma. Mol Cell. 2015;59:931\u201340.","journal-title":"Mol Cell."},{"key":"632_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/srep37127","volume":"6","author":"MH Elliott","year":"2016","unstructured":"Elliott MH, Ashpole NE, Gu X, Herrnberger L, McClellan ME, Griffith GL, et al. Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma. Sci Rep. 2016;6:37127.","journal-title":"Sci Rep."},{"key":"632_CR39","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/1521-1878(200007)22:7<616::AID-BIES4>3.0.CO;2-R","volume":"22","author":"K Kawakami","year":"2000","unstructured":"Kawakami K, Sato S, Ozaki H, Ikeda K. Six family genes-structure and function as transcription factors and their roles in development. Bioessays. 2000;22:616\u201326.","journal-title":"Bioessays."},{"key":"632_CR40","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00018-008-8335-4","volume":"66","author":"JP Kumar","year":"2009","unstructured":"Kumar JP. The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease. Cell Mol Life Sci. 2009;66:565\u201383.","journal-title":"Cell Mol Life Sci."},{"key":"632_CR41","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1093\/hmg\/ddt522","volume":"23","author":"AI Iglesias","year":"2014","unstructured":"Iglesias AI, Springelkamp H, van der Linde H, Severijnen LA, Amin N, Oostra B, et al. Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age. Hum Mol Genet. 2014;23:1320\u201332.","journal-title":"Hum Mol Genet."},{"key":"632_CR42","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1002\/cne.22516","volume":"519","author":"A Bosco","year":"2011","unstructured":"Bosco A, Steele MR, Vetter ML. Early microglia activation in a mouse model of chronic glaucoma. J Comp Neurol. 2011;519:599\u2013620.","journal-title":"J Comp Neurol."},{"key":"632_CR43","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1242\/dmm.018788","volume":"8","author":"A Bosco","year":"2015","unstructured":"Bosco A, Romero CO, Breen KT, Chagovetz AA, Steele MR, Ambati BK, et al. Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma. Dis Model Mech. 2015;8:443\u201355.","journal-title":"Dis Model Mech."},{"key":"632_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01913-6","volume":"8","author":"H Choquet","year":"2017","unstructured":"Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, et al. A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. Nat Commun. 2017;8:2108.","journal-title":"Nat Commun."},{"key":"632_CR45","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1136\/bjo.2006.092619","volume":"90","author":"Z Mimiwati","year":"2006","unstructured":"Mimiwati Z, Mackey DA, Craig JE, Mackinnon JR, Rait JL, Liebelt JE, et al. Nail-patella syndrome and its association with glaucoma: a review of eight families. Br J Ophthalmol. 2006;90:1505\u20139.","journal-title":"Br J Ophthalmol."},{"key":"632_CR46","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1136\/jmg.40.3.153","volume":"40","author":"E Sweeney","year":"2003","unstructured":"Sweeney E, Fryer A, Mountford R, Green A, McIntosh I. Nail patella syndrome: a review of the phenotype aided by developmental biology. J Med Genet. 2003;40:153\u201362.","journal-title":"J Med Genet."},{"key":"632_CR47","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/S0002-9394(14)70866-9","volume":"124","author":"PR Lichter","year":"1997","unstructured":"Lichter PR, Richards JE, Downs CA, Stringham HM, Boehnke M, Farley FA. Cosegregation of open-angle glaucoma and the nail-patella syndrome. Am J Ophthalmol. 1997;124:506\u201315.","journal-title":"Am J Ophthalmol."},{"key":"632_CR48","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/ng.3367","volume":"47","author":"ER Gamazon","year":"2015","unstructured":"Gamazon ER, Wheeler HE, Shah KP, Mozaffari SV, Aquino-Michaels K, Carroll RJ, et al. A gene-based association method for mapping traits using reference transcriptome data. Nat Genet. 2015;47:1091\u20138.","journal-title":"Nat Genet"},{"key":"632_CR49","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/ng.3506","volume":"48","author":"A Gusev","year":"2016","unstructured":"Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat Genet. 2016;48:245\u201352.","journal-title":"Nat Genet"},{"key":"632_CR50","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet. 2016;48:481\u20137.","journal-title":"Nat Genet."},{"key":"632_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6890","volume":"6","author":"TH Pers","year":"2015","unstructured":"Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun. 2015;6:5890.","journal-title":"Nat Commun."},{"key":"632_CR52","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature11247","volume":"489","author":"EP Consortium","year":"2012","unstructured":"Consortium EP. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012;489:57\u201374.","journal-title":"Nature."},{"key":"632_CR53","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nature14248","volume":"518","author":"C Roadmap Epigenomics","year":"2015","unstructured":"Roadmap Epigenomics C, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, et al. Integrative analysis of 111 reference human epigenomes. Nature. 2015;518:317\u201330.","journal-title":"Nature."},{"key":"632_CR54","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ng.2653","volume":"45","author":"GT Consortium","year":"2013","unstructured":"Consortium GT. The Genotype-Tissue Expression (GTEx) project. Nat Genet. 2013;45:580\u20135.","journal-title":"Nat Genet."},{"key":"632_CR55","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/ng.3087","volume":"46","author":"PG Hysi","year":"2014","unstructured":"Hysi PG, Cheng CY, Springelkamp H, Macgregor S, Bailey JNC, Wojciechowski R, et al. Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. Nat Genet. 2014;46:1126\u201330.","journal-title":"Nat Genet."},{"key":"632_CR56","doi-asserted-by":"publisher","first-page":"e1000978","DOI":"10.1371\/journal.pgen.1000978","volume":"6","author":"WD Ramdas","year":"2010","unstructured":"Ramdas WD, van Koolwijk LM, Ikram MK, Jansonius NM, de Jong PT, Bergen AA, et al. A genome-wide association study of optic disc parameters. PLoS Genet. 2010;6:e1000978.","journal-title":"PLoS Genet"},{"key":"632_CR57","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1126\/science.1146554","volume":"317","author":"G Thorleifsson","year":"2007","unstructured":"Thorleifsson G, Magnusson KP, Sulem P, Walters GB, Gudbjartsson DF, Stefansson H, et al. Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma. Science. 2007;317:1397\u2013400.","journal-title":"Science."},{"key":"632_CR58","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/ng.3875","volume":"49","author":"T Aung","year":"2017","unstructured":"Aung T, Ozaki M, Lee MC, Schlotzer-Schrehardt U, Thorleifsson G, Mizoguchi T, et al. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat Genet. 2017;49:993\u20131004.","journal-title":"Nat Genet"},{"key":"632_CR59","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15466","volume":"8","author":"F Pasutto","year":"2017","unstructured":"Pasutto F, Zenkel M, Hoja U, Berner D, Uebe S, Ferrazzi F, et al. Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1. Nat Commun. 2017;8:15466.","journal-title":"Nat Commun"},{"key":"632_CR60","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/ng.2554","volume":"45","author":"VJ Verhoeven","year":"2013","unstructured":"Verhoeven VJ, Hysi PG, Wojciechowski R, Fan Q, Guggenheim JA, Hohn R, et al. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet. 2013;45:314\u20138.","journal-title":"Nat Genet."},{"key":"632_CR61","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1126\/science.1109557","volume":"308","author":"RJ Klein","year":"2005","unstructured":"Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, et al. Complement factor H polymorphism in age-related macular degeneration. Science. 2005;308:385\u20139.","journal-title":"Science."},{"key":"632_CR62","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/ng.2741","volume":"45","author":"JM Seddon","year":"2013","unstructured":"Seddon JM, Yu Y, Miller EC, Reynolds R, Tan PL, Gowrisankar S, et al. Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nat Genet. 2013;45:1366\u201370.","journal-title":"Nat Genet"},{"key":"632_CR63","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/ng.3448","volume":"48","author":"LG Fritsche","year":"2016","unstructured":"Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, Bragg-Gresham JL, et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet. 2016;48:134\u201343.","journal-title":"Nat Genet"},{"key":"632_CR64","doi-asserted-by":"publisher","DOI":"10.1038\/srep26885","volume":"6","author":"G Cuellar-Partida","year":"2016","unstructured":"Cuellar-Partida G, Craig JE, Burdon KP, Wang JJ, Vote BJ, Souzeau E, et al. Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration. Sci Rep. 2016;6:26885.","journal-title":"Sci Rep"},{"key":"632_CR65","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ng.3406","volume":"47","author":"B Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan B, Finucane HK, Anttila V, Gusev A, Day FR, Loh PR, et al. An atlas of genetic correlations across human diseases and traits. Nat Genet. 2015;47:1236\u201341.","journal-title":"Nat Genet"},{"key":"632_CR66","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/ng.3570","volume":"48","author":"JK Pickrell","year":"2016","unstructured":"Pickrell JK, Berisa T, Liu JZ, Segurel L, Tung JY, Hinds DA. Detection and interpretation of shared genetic influences on 42 human traits. Nat Genet. 2016;48:709\u201317.","journal-title":"Nat Genet"},{"key":"632_CR67","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.ajhg.2011.10.004","volume":"89","author":"S Sivakumaran","year":"2011","unstructured":"Sivakumaran S, Agakov F, Theodoratou E, Prendergast JG, Zgaga L, Manolio T, et al. Abundant pleiotropy in human complex diseases and traits. Am J Hum Genet. 2011;89:607\u201318.","journal-title":"Am J Hum Genet."},{"key":"632_CR68","doi-asserted-by":"publisher","first-page":"e1006711","DOI":"10.1371\/journal.pgen.1006711","volume":"13","author":"T Ge","year":"2017","unstructured":"Ge T, Chen CY, Neale BM, Sabuncu MR, Smoller JW. Phenome-wide heritability analysis of the UK Biobank. PLoS Genet .2017;13:e1006711.","journal-title":"PLoS Genet"},{"key":"632_CR69","doi-asserted-by":"publisher","DOI":"10.1038\/srep32894","volume":"6","author":"A Bakshi","year":"2016","unstructured":"Bakshi A, Zhu Z, Vinkhuyzen AA, Hill WD, McRae AF, Visscher PM, et al. Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits. Sci Rep. 2016;6:32894.","journal-title":"Sci Rep."},{"key":"632_CR70","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nrg.2017.101","volume":"19","author":"NJ Timpson","year":"2018","unstructured":"Timpson NJ, Greenwood CMT, Soranzo N, Lawson DJ, Richards JB. Genetic architecture: the shape of the genetic contribution to human traits and disease. Nat Rev Genet. 2018;19:110\u201324.","journal-title":"Nat Rev Genet"},{"key":"632_CR71","doi-asserted-by":"publisher","first-page":"e0172427","DOI":"10.1371\/journal.pone.0172427","volume":"12","author":"T Zhou","year":"2017","unstructured":"Zhou T, Souzeau E, Sharma S, Landers J, Mills R, Goldberg I, et al. Whole exome sequencing implicates eye development, the unfolded protein response and plasma membrane homeostasis in primary open-angle glaucoma. PLoS One. 2017;12:e0172427.","journal-title":"PLoS One."},{"key":"632_CR72","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1016\/j.ophtha.2005.04.018","volume":"112","author":"S de Voogd","year":"2005","unstructured":"de Voogd S, Ikram MK, Wolfs RC, Jansonius NM, Hofman A, de Jong PT. Incidence of open-angle glaucoma in a general elderly population: the Rotterdam Study. Ophthalmology. 2005;112:1487\u201393.","journal-title":"Ophthalmology."},{"key":"632_CR73","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/S0140-6736(14)62111-5","volume":"385","author":"DF Garway-Heath","year":"2015","unstructured":"Garway-Heath DF, Crabb DP, Bunce C, Lascaratos G, Amalfitano F, Anand N, et al. Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial. Lancet. 2015;385:1295\u2013304.","journal-title":"Lancet."},{"key":"632_CR74","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.survophthal.2010.07.003","volume":"55","author":"PG Sanfilippo","year":"2010","unstructured":"Sanfilippo PG, Hewitt AW, Hammond CJ, Mackey DA. The heritability of ocular traits. Surv Ophthalmol. 2010;55:561\u201383.","journal-title":"Surv Ophthalmol."},{"key":"632_CR75","first-page":"438","volume":"26","author":"H Springelkamp","year":"2017","unstructured":"Springelkamp H, Iglesias AI, Mishra A, Hohn R, Wojciechowski R, Khawaja AP, et al. New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Hum Mol Genet. 2017;26:438\u201353.","journal-title":"Hum Mol Genet"},{"key":"632_CR76","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/s41588-018-0126-8","volume":"50","author":"AP Khawaja","year":"2018","unstructured":"Khawaja AP, Cooke Bailey JN, Wareham NJ, Scott RA, Simcoe M, Igo RP Jr., et al. Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nat Genet. 2018;50:778\u201382.","journal-title":"Nat Genet."},{"key":"632_CR77","doi-asserted-by":"publisher","first-page":"e002684","DOI":"10.1136\/bmjopen-2013-002684","volume":"3","author":"AP Khawaja","year":"2013","unstructured":"Khawaja AP, Chan MP, Hayat S, Broadway DC, Luben R, Garway-Heath DF, et al. The EPIC-Norfolk Eye Study: rationale, methods and a cross-sectional analysis of visual impairment in a population-based cohort. BMJ Open. 2013;3:e002684. pii.","journal-title":"BMJ Open."},{"key":"632_CR78","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1517\/14728222.2014.888416","volume":"18","author":"R Agarwal","year":"2014","unstructured":"Agarwal R, Agarwal P. Newer targets for modulation of intraocular pressure: focus on adenosine receptor signaling pathways. Expert Opin Ther Targets. 2014;18:527\u201339.","journal-title":"Expert Opin Ther Targets."},{"key":"632_CR79","doi-asserted-by":"publisher","first-page":"3975","DOI":"10.1172\/JCI75395","volume":"124","author":"A Aspelund","year":"2014","unstructured":"Aspelund A, Tammela T, Antila S, Nurmi H, Leppanen VM, Zarkada G, et al. The Schlemm\u2019s canal is a VEGF-C\/VEGFR-3-responsive lymphatic-like vessel. J Clin Invest. 2014;124:3975\u201386.","journal-title":"J Clin Invest."},{"key":"632_CR80","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1172\/JCI85830","volume":"126","author":"T Souma","year":"2016","unstructured":"Souma T, Tompson SW, Thomson BR, Siggs OM, Kizhatil K, Yamaguchi S, et al. Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. J Clin Invest. 2016;126:2575\u201387.","journal-title":"J Clin Invest"},{"key":"632_CR81","doi-asserted-by":"publisher","first-page":"e1001912","DOI":"10.1371\/journal.pbio.1001912","volume":"12","author":"K Kizhatil","year":"2014","unstructured":"Kizhatil K, Ryan M, Marchant JK, Henrich S, John SW. Schlemm\u2019s canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process. PLoS Biol. 2014;12:e1001912.","journal-title":"PLoS Biol"},{"key":"632_CR82","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1172\/JCI77162","volume":"124","author":"BR Thomson","year":"2014","unstructured":"Thomson BR, Heinen S, Jeansson M, Ghosh AK, Fatima A, Sung HK, et al. A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest. 2014;124:4320\u20134.","journal-title":"J Clin Invest."},{"key":"632_CR83","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1016\/j.ophtha.2012.05.030","volume":"119","author":"X Jiang","year":"2012","unstructured":"Jiang X, Varma R, Wu S, Torres M, Azen SP, Francis BA, et al. Baseline risk factors that predict the development of open-angle glaucoma in a population: the Los Angeles Latino Eye Study. Ophthalmology. 2012;119:2245\u201353.","journal-title":"Ophthalmology."},{"key":"632_CR84","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.ophtha.2007.03.016","volume":"114","author":"MC Leske","year":"2007","unstructured":"Leske MC, Heijl A, Hyman L, Bengtsson B, Dong L, Yang Z, et al. Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology. 2007;114:1965\u201372.","journal-title":"Ophthalmology."},{"key":"632_CR85","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1001\/archopht.120.6.714","volume":"120","author":"MO Gordon","year":"2002","unstructured":"Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, et al. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120:714\u201320. discussion829-30.","journal-title":"Arch Ophthalmol"},{"key":"632_CR86","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/ng.2506","volume":"45","author":"Y Lu","year":"2013","unstructured":"Lu Y, Vitart V, Burdon KP, Khor CC, Bykhovskaya Y, Mirshahi A, et al. Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nat Genet 2013;45:155\u201363.","journal-title":"Nat Genet"},{"key":"632_CR87","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03646-6","volume":"9","author":"AI Iglesias","year":"2018","unstructured":"Iglesias AI, Mishra A, Vitart V, Bykhovskaya Y, Hohn R, Springelkamp H, et al. Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nat Commun 2018;9:1864.","journal-title":"Nat Commun"},{"key":"632_CR88","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09304-9","volume":"10","author":"EV Ivarsdottir","year":"2019","unstructured":"Ivarsdottir EV, Benonisdottir S, Thorleifsson G, Sulem P, Oddsson A, Styrkarsdottir U, et al. Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density. Nat Commun 2019;10:1284.","journal-title":"Nat Commun"},{"key":"632_CR89","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1097\/IJG.0000000000001026","volume":"27","author":"AP Khawaja","year":"2018","unstructured":"Khawaja AP, Chan MPY, Yip JLY, Broadway DC, Garway-Heath DF, Viswanathan AC, et al. A common glaucoma-risk variant of six6 alters retinal nerve fiber layer and optic disc measures in a european population: the EPIC-Norfolk Eye Study. J Glaucoma 2018;27:743\u20139.","journal-title":"J Glaucoma"},{"key":"632_CR90","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta11410","volume":"11","author":"JM Burr","year":"2007","unstructured":"Burr JM, Mowatt G, Hernandez R, Siddiqui MA, Cook J, Lourenco T, et al. The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation. Health Technol Assess 2007;11:1\u2013190. iii-iv, ix-x.","journal-title":"Health Technol Assess"},{"key":"632_CR91","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.ophtha.2016.11.011","volume":"124","author":"E Souzeau","year":"2017","unstructured":"Souzeau E, Tram KH, Witney M, Ruddle JB, Graham SL, Healey PR, et al. Myocilin predictive genetic testing for primary open-angle glaucoma leads to early identification of at-risk individuals. Ophthalmology 2017;124:303\u20139.","journal-title":"Ophthalmology"},{"key":"632_CR92","doi-asserted-by":"publisher","first-page":"a017277","DOI":"10.1101\/cshperspect.a017277","volume":"5","author":"KF Allen","year":"2015","unstructured":"Allen KF, Gaier ED, Wiggs JL. Genetics of primary inherited disorders of the optic nerve: clinical applications. Cold Spring Harb Perspect Med 2015;5:a017277.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"632_CR93","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1001\/jamaophthalmol.2013.4509","volume":"131","author":"JL Wiggs","year":"2013","unstructured":"Wiggs JL, Pierce EA. Genetic testing for inherited eye disease: who benefits? JAMA Ophthalmol 2013;131:1265\u20136.","journal-title":"JAMA Ophthalmol"},{"issue":"10","key":"632_CR94","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1001\/jamaophthalmol.2019.3109","volume":"137","author":"Bao Jian Fan","year":"2019","unstructured":"Fan BJ, Bailey JC, Igo RP, Jr., Kang JH, Boumenna T, Brilliant MH, et al. Association of a primary open-angle glaucoma genetic risk score with earlier age at diagnosis. JAMA Ophthalmol. 2019;137:1190\u20134.","journal-title":"JAMA Ophthalmology"},{"key":"632_CR95","first-page":"80","volume":"6","author":"T Borras","year":"2017","unstructured":"Borras T. The pathway from genes to gene therapy in glaucoma: a review of possibilities for using genes as glaucoma drugs. Asia Pac J Ophthalmol (Philos) 2017;6:80\u201393.","journal-title":"Asia Pac J Ophthalmol (Philos)"},{"key":"632_CR96","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1093\/hmg\/ddx028","volume":"26","author":"J O\u2019Callaghan","year":"2017","unstructured":"O\u2019Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Flugel-Koch C, Lutjen-Drecoll E, et al. Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma. Hum Mol Genet. 2017;26:1230\u201346.","journal-title":"Hum Mol Genet"},{"key":"632_CR97","doi-asserted-by":"publisher","first-page":"11199","DOI":"10.1073\/pnas.1706193114","volume":"114","author":"A Jain","year":"2017","unstructured":"Jain A, Zode G, Kasetti RB, Ran FA, Yan W, Sharma TP, et al. CRISPR-Cas9-based treatment of myocilin-associated glaucoma. Proc Natl Acad Sci USA 2017;114:11199\u2013204.","journal-title":"Proc Natl Acad Sci USA"},{"key":"632_CR98","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1056\/NEJMra0804630","volume":"360","author":"YH Kwon","year":"2009","unstructured":"Kwon YH, Fingert JH, Kuehn MH, Alward WL. Primary open-angle glaucoma. N Engl J Med 2009;360:1113\u201324.","journal-title":"N Engl J Med"},{"key":"632_CR99","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.1172\/JCI95545","volume":"127","author":"BR Thomson","year":"2017","unstructured":"Thomson BR, Souma T, Tompson SW, Onay T, Kizhatil K, Siggs OM, et al. Angiopoietin-1 is required for Schlemm\u2019s canal development in mice and humans. J Clin Invest 2017;127:4421\u201336.","journal-title":"J Clin Invest"},{"key":"632_CR100","first-page":"94","volume":"112","author":"JL Wiggs","year":"2014","unstructured":"Wiggs JL, Langgurth AM, Allen KF. Carrier frequency of CYP1B1 mutations in the United States (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc 2014;112:94\u2013102.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"632_CR101","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.omtn.2018.08.018","volume":"13","author":"K Yongblah","year":"2018","unstructured":"Yongblah K, Alford SC, Ryan BC, Chow RL, Howard PL. Protecting Pax6 3\u2019 UTR from microrna-7 partially restores pax6 in islets from an aniridia mouse model. Mol Ther Nucleic Acids 2018;13:144\u201353.","journal-title":"Mol Ther Nucleic Acids"},{"key":"632_CR102","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1001\/jamaophthalmol.2019.0900","volume":"137","author":"JH Kang","year":"2019","unstructured":"Kang JH, Boumenna T, Stein JD, Khawaja A, Rosner BA, Wiggs JL, et al. Association of statin use and high serum cholesterol levels with risk of primary open-angle glaucoma. JAMA Ophthalmol 2019;137:756\u201365.","journal-title":"JAMA Ophthalmol"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41433-019-0632-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-019-0632-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-019-0632-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T15:06:26Z","timestamp":1650467186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41433-019-0632-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,23]]},"references-count":102,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["632"],"URL":"https:\/\/doi.org\/10.1038\/s41433-019-0632-7","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,23]]},"assertion":[{"value":"18 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}