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Tolerance to defocus was evaluated using computer simulations of the uncorrected distance sVA under defocus. To evaluate the dysphotopsia profile, halo pictures obtained using an IOL-telescope, as well as simulated images in a realistic eye model under defocus were assessed. The results of the refractive EDF, TECNIS PureSee\u2122 IOL, were compared to those of a diffractive EDF, TECNIS Symfony\u2122 IOL, of the same platform.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The refractive EDF IOL provides similar range of vision to the diffractive EDF IOL with the same distance, and similar intermediate and near sVA. The refractive EDF IOL provides the same tolerance to hyperopia as the diffractive EDF but more tolerance to myopia. Halo pictures and simulations showed that the refractive EDF provides comparable dysphotopsia profile to the monofocal IOL and better than the diffractive EDF.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The results of this preclinical study in clinically relevant conditions show that the new refractive EDF IOL is expected to provide similar range of vision to the diffractive IOL of the same platform and higher tolerance to refractive errors. The refractive EDF provides a dysphotopsia profile that is better than the diffractive EDF and comparable to that of the monofocal IOL, also in the presence of residual refractive errors.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41433-024-03041-0","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T12:02:12Z","timestamp":1712318532000},"page":"4-8","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Optical and clinical simulated performance of a new refractive extended depth of focus intraocular lens"],"prefix":"10.1038","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-0141","authenticated-orcid":false,"given":"Aixa","family":"Alarcon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5179-837X","authenticated-orcid":false,"given":"Antonio","family":"del Aguila Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Gounou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"Weeber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"C\u00e1novas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Piers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"3041_CR1","unstructured":"Faverio M. 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The \u2018OBJECTIVES\u2019 section of the abstract was corrected from \u201cThe purpose of this study is to evaluate the optical and expected clinical performance of a new refractive Extended Depth of Focus (EDF) intraocular lens (IOL) designed to maintain a monofocal-like dysphotopsia profile\u201d to \u201cThe purpose of this study is to evaluate the optical and expected clinical performance of a new refractive Extended Depth of Focus (EDF) intraocular lens (IOL), TECNIS PureSee\u2122 IOL, designed to maintain a monofocal-like dysphotopsia profile\u201d. Additionally, in the \u2018METHODS\u2019 section of the abstract, the last sentence was corrected from \u201cThe results of the refractive EDF were compared to those of a diffractive EDF of the same platform\u201d to \u201cThe results of the refractive EDF, TECNIS PureSee\u2122 IOL, were compared to those of a diffractive EDF, TECNIS Symfony\u2122 IOL, of the same platform\u201d.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2024","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41433-024-03423-4","URL":"https:\/\/doi.org\/10.1038\/s41433-024-03423-4","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All authors of this study are employees of Johnson and Johnson Vision.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}