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To identify the ocular and systemic risk factors associated with choroidal thinning in high myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Based on the Beijing Eye Study, a detailed ophthalmic examination was performed including EDI SD-OCT for the measurement of SFCT. OCT images were obtained from 103 highly myopic eyes (\u2265\u2009\u22126.00 dioptres) and 227 normal eyes randomly selected from the baseline population, matched for age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean SFCT was 110.6\u2009\u00b1\u200985.2\u2009\u03bcm in highly myopic eyes (range, 3\u2013395\u2009\u03bcm). Mean regional choroidal thickness was lowest on the nasal and inferior sides of the macula, and slightly higher on the temporal and superior sides than at the fovea. On multivariate analysis, SFCT was associated with age (\n                      <jats:italic>b<\/jats:italic>\n                      \u2009=\u2009\u22120.48;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), axial length (\n                      <jats:italic>b<\/jats:italic>\n                      \u2009=\u2009\u22120.44;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), gender (\n                      <jats:italic>b<\/jats:italic>\n                      \u2009=\u2009\u22120.31;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) and staphyloma (\n                      <jats:italic>b<\/jats:italic>\n                      \u2009=\u2009\u22120.26;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.05). In highly myopic eyes, SFCT decreased by 5.1\u2009\u03bcm\/year of age, by 9.2\u2009\u00b5m\/D of myopia, and by 22.6\u2009\u00b5m\/mm of axial length.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The SFCT decreases with age and increased axial length in highly myopic eyes. The formation of a posterior staphyloma has been identified as a major contributor to choroidal thinning and is therefore a reliable indicator for risk management. The involvement of choroidal abnormalities may be a significant factor in the development of myopic degeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41433-024-03383-9","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T12:03:03Z","timestamp":1729771383000},"page":"102-108","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Distribution and associated factors of choroidal thickness in highly myopic eyes\u2014a real-world study based on a Chinese population"],"prefix":"10.1038","volume":"39","author":[{"given":"Lei","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HanQing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RuiHeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenDa","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-0989","authenticated-orcid":false,"given":"Wen Bin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"3383_CR1","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.preteyeres.2017.09.004","volume":"62","author":"IG Morgan","year":"2018","unstructured":"Morgan IG, French AN, Ashby RS, Guo X, Ding X, He M, et al. 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