{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:42:39Z","timestamp":1772134959356,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1038\/s41433-025-03598-4","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T15:04:52Z","timestamp":1736780692000},"page":"544-547","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anatomical and functional results of patients with late-stage age-related macular degeneration 6 months after smaller-incision new-generation implantable miniature telescope (SING IMT\u2122) implantation"],"prefix":"10.1038","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9417-1200","authenticated-orcid":false,"given":"Ginevra Giovanna","family":"Adamo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Nasini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-4531","authenticated-orcid":false,"given":"Pietro Maria","family":"Talli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Sarti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piera","family":"Perri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Parmeggiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Mura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"3598_CR1","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","volume":"2","author":"WL Wong","year":"2014","unstructured":"Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2:e106\u201316.","journal-title":"Lancet Glob Health"},{"key":"3598_CR2","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1016\/j.clinthera.2021.08.011","volume":"43","author":"NM Schultz","year":"2021","unstructured":"Schultz NM, Bhardwaj S, Barclay C, Gaspar L, Schwartz J. Global burden of dry age-related macular degeneration: a targeted literature review. Clin Ther. 2021;43:1792\u2013818.","journal-title":"Clin Ther"},{"key":"3598_CR3","doi-asserted-by":"publisher","first-page":"11769","DOI":"10.3390\/ijms231911769","volume":"23","author":"RM Galindo-Camacho","year":"2022","unstructured":"Galindo-Camacho RM, Blanco-Llamero C, da Ana R, Fuertes MA, Se\u00f1or\u00e1ns FJ, Silva AM, et al. Therapeutic approaches for age-related macular degeneration. Int J Mol Sci. 2022;23:11769.","journal-title":"Int J Mol Sci"},{"key":"3598_CR4","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1080\/07853890600946724","volume":"38","author":"KM Gehrs","year":"2006","unstructured":"Gehrs KM, Anderson DH, Johnson LV, Hageman GS. Age-related macular degeneration-emerging pathogenetic and therapeutic concepts. Ann Med. 2006;38:450\u201371.","journal-title":"Ann Med"},{"key":"3598_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.18240\/ijo.2022.01.23","volume":"15","author":"R Rubner","year":"2022","unstructured":"Rubner R, Canto-Soler MV, Li KV. Progress of clinical therapies for dry age-related macular degeneration. Int J Ophthalmol. 2022;15:157\u201366.","journal-title":"Int J Ophthalmol"},{"key":"3598_CR6","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1007\/s00417-017-3740-8","volume":"255","author":"A Grzybowski","year":"2017","unstructured":"Grzybowski A, Wasinska-Borowiec W, Alio JL, Amat-Peral P, Tabernero J. Intraocular lenses in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2017;255:1687\u201396.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"3598_CR7","first-page":"33","volume":"6","author":"MA Singer","year":"2012","unstructured":"Singer MA, Amir N, Herro A, Porbandarwalla SS, Pollard J. Improving quality of life in patients with end-stage age-related macular degeneration: focus on miniature ocular implants. Clin Ophthalmol. 2012;6:33\u20139.","journal-title":"Clin Ophthalmol"},{"key":"3598_CR8","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.survophthal.2016.12.003","volume":"62","author":"BL Teh","year":"2017","unstructured":"Teh BL, Megaw R, Borooah S, Dhillon B. Optimizing cataract surgery in patients with age-related macular degeneration. Surv Ophthalmol. 2017;62:346\u201356.","journal-title":"Surv Ophthalmol"},{"key":"3598_CR9","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1364\/BOE.6.001010","volume":"6","author":"J Tabernero","year":"2015","unstructured":"Tabernero J, Qureshi MA, Robbie SJ, Artal P. An aspheric intraocular telescope for agerelated macular degeneration patients. Biomed Opt Express. 2015;6:1010\u201320.","journal-title":"Biomed Opt Express"},{"key":"3598_CR10","doi-asserted-by":"publisher","first-page":"682","DOI":"10.3390\/ijms23020682","volume":"23","author":"R Raimondi","year":"2022","unstructured":"Raimondi R, Zollet P, De Rosa FP, Tsoutsanis P, Stravalaci M, Paulis M. Where are we with RPE replacement therapy? A translational review from the ophthalmologist perspective. Int J Mol Sci. 2022;23:682.","journal-title":"Int J Mol Sci."},{"key":"3598_CR11","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41433-022-02179-z","volume":"37","author":"AF Borkenstein","year":"2023","unstructured":"Borkenstein AF, Borkenstein EM, Augustin AJ. Implantable vision-enhancing devices and postoperative rehabilitation in advanced age-related macular degeneration. Eye. 2023;37:597\u2013606.","journal-title":"Eye."},{"key":"3598_CR12","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.21037\/atm-20-5851","volume":"8","author":"A Grzybowski","year":"2020","unstructured":"Grzybowski A, Wang J, Mao F, Wang D, Wang N. Intraocular vision-improving devices in age-related macular degeneration. Ann Transl Med. 2020;8:1549.","journal-title":"Ann Transl Med"},{"key":"3598_CR13","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1001\/archopht.125.8.1118","volume":"125","author":"KA Colby","year":"2007","unstructured":"Colby KA, Chang DF, Stulting RD, Lane SS. Surgical placement of an optical prosthetic device for end-stage macular degeneration: the implantable miniature telescope. Arch Ophthalmol. 2007;125:1118\u201321.","journal-title":"Arch Ophthalmol."},{"key":"3598_CR14","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.oret.2022.05.017","volume":"6","author":"A Savastano","year":"2022","unstructured":"Savastano A, Caporossi T, Sasso P, De Vico U, Rizzo S. A new intraocular telescopic device for age-related macular degeneration. Ophthalmol Retin. 2022;6:971\u20132.","journal-title":"Ophthalmol Retin"},{"key":"3598_CR15","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.ajo.2004.01.030","volume":"137","author":"SS Lane","year":"2004","unstructured":"Lane SS, Kuppermann BD, Fine IH, Hamill MB, Gordon JF, Chuck RS, et al. A prospective multicenter clinical trial to evaluate the safety and effectiveness of the implantable miniature telescope. Am J Ophthalmol. 2004;137:993\u20131001.","journal-title":"Am J Ophthalmol"},{"key":"3598_CR16","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.ajo.2008.07.003","volume":"146","author":"HL Hudson","year":"2008","unstructured":"Hudson HL, Stulting RD, Heier JS, Lane SS, Chang DF, Singerman LJ, et al. Implantable telescope for end-stage age-related macular degeneration: long-term visual acuity and safety outcomes. Am J Ophthalmol. 2008;146:664\u201373.","journal-title":"Am J Ophthalmol"},{"key":"3598_CR17","volume":"4","author":"G Virgili","year":"2018","unstructured":"Virgili G, Acosta R, Bentley SA, Giacomelli G, Allcock C, Evans JR. Reading aids for adults with low vision. Cochrane Database Syst Rev. 2018;4:CD003303.","journal-title":"Cochrane Database Syst Rev"},{"key":"3598_CR18","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s40123-018-0129-7","volume":"7","author":"HMP Dunbar","year":"2018","unstructured":"Dunbar HMP, Dhawahir-Scala FE. A discussion of commercially available intraocular telescopic implants for patients with age-related macular degeneration. Ophthalmol Ther. 2018;7:33\u201348.","journal-title":"Ophthalmol Ther"},{"key":"3598_CR19","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.2147\/OPTH.S86208","volume":"9","author":"D Boyer","year":"2015","unstructured":"Boyer D, Freund KB, Regillo C, Levy MH, Garg S. Long-term (60-month) results for the implantable miniature telescope: efficacy and safety outcomes stratified by age in patients with end-stage age-related macular degeneration. Clin Ophthalmol. 2015;9:1099\u2013107.","journal-title":"Clin Ophthalmol"},{"key":"3598_CR20","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1016\/j.ophtha.2006.07.010","volume":"113","author":"HL Hudson","year":"2006","unstructured":"Hudson HL, Lane SS, Heier JS, Stulting RD, Singerman L, Lichter PR, et al. IMT-002 Study Group. Implantable miniature telescope for the treatment of visual acuity loss resulting from end-stage age-related macular degeneration: 1-year results. Ophthalmology. 2006;113:1987\u20132001.","journal-title":"Ophthalmology"},{"key":"3598_CR21","doi-asserted-by":"publisher","first-page":"518","DOI":"10.3390\/jcm12020518","volume":"12","author":"MD Toro","year":"2023","unstructured":"Toro MD, Vidal-Aroca F, Montemagni M, Xompero C, Fioretto G, Costagliola C. Three-month safety and efficacy outcomes for the smaller-incision new-generation implantable miniature telescope (SING IMT\u2122). J Clin Med. 2023;12:518.","journal-title":"J Clin Med"},{"key":"3598_CR22","unstructured":"Avisol Capital Partners. Samsara vision: developing implantable miniature telescopes for late-stage AMD patients. Seeking Alpha 2021. Updated Nov 9, 2021. https:\/\/seekingalpha.com\/article\/4467579-samsara-vision-smsa-implantabletelescopes-for-late-stage-amd-patients."},{"key":"3598_CR23","doi-asserted-by":"publisher","unstructured":"Savastano A, D\u2019Onofrio NC, Francione G, Sasso P, Hu L, Rizzo S. SING IMT removal for unsatisfied patients: step-by-step surgery for a safe explant. Retina. 2024. https:\/\/doi.org\/10.1097\/IAE.0000000000004209.","DOI":"10.1097\/IAE.0000000000004209"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-03598-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-03598-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-03598-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T05:14:13Z","timestamp":1738646053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-03598-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["3598"],"URL":"https:\/\/doi.org\/10.1038\/s41433-025-03598-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4227094\/v1","asserted-by":"object"}]},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]},"assertion":[{"value":"6 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}