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Radiographic images of the orbits were analysed for the presence of optic nerve kinking.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In the axial plane at least one optic nerve kink was found in 49 of 57 (86%) optic nerves in patients with NTG and in 10 of 57 (18%) optic nerves in controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) while in the sagittal plane in 28 of 57 (49%) optic nerves in patients with NTG and in 1 of 57 (2%) optic nerves in controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) (Fisher\u2019s two-tailed exact test).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This study demonstrates a high statistically significant incidence of optic nerve kinking in patients with NTG compared to controls without known optic nerve diseases. Its possible role involved in the pathophysiology of NTG needs to be evaluated.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1038\/s41433-025-03608-5","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T17:42:36Z","timestamp":1737222156000},"page":"1270-1275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Incidence of optic nerve kinking in a cohort of patients with Normal tension glaucoma"],"prefix":"10.1038","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3784-1666","authenticated-orcid":false,"given":"Achmed","family":"Pircher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-8308","authenticated-orcid":false,"given":"Jatta","family":"Berberat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Remonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-4163","authenticated-orcid":false,"given":"Cynthia J.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9254-5558","authenticated-orcid":false,"given":"Albert","family":"Neutzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2265-7233","authenticated-orcid":false,"given":"Hanspeter E.","family":"Killer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"3608_CR1","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/s41433-018-0042-2","volume":"32","author":"HE Killer","year":"2018","unstructured":"Killer HE, Pircher A. 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