{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:18:58Z","timestamp":1793488738041,"version":"4.5.0"},"reference-count":108,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The cornea serves to protect the eye from external insults and refracts light to the retina. Maintaining ocular homeostasis requires constant epithelial renewal and an efficient healing process following injury. Corneal wound healing is a dynamic process involving several key cell populations and molecular pathways. Immediately after a large corneal epithelial injury involving limbal stem cells, conjunctival epithelial cells migrate toward the center of the wound guided by the newly formed electrical field (EF). Proliferation and transdifferentiation play a critical role in corneal epithelial regeneration. Corneal nerve endings migrate through the EF, connect with the migrating epithelial cells, and provide them with multiple growth factors. Finally, the migrated epithelial cells undergo differentiation, which is also regulated by corneal nerve endings. All these processes require energy and effective cellular cross-talk between different cell lines and extracellular matrix molecules. We provide an overview of the roles and interactions between corneal wound regeneration components that may help develop fascinating new targeted therapeutic strategies to enhance corneal wound healing with less injury-related corneal opacity and neovascularization.<\/jats:p>","DOI":"10.1038\/s41433-025-03619-2","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T09:54:28Z","timestamp":1739354068000},"page":"1047-1055","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Navigating the path to corneal healing success and challenges: a comprehensive overview"],"prefix":"10.1038","volume":"39","author":[{"given":"Athar","family":"Shadmani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1360-8248","authenticated-orcid":false,"given":"Albert Y.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"3619_CR1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/BF00143661","volume":"5\u20136","author":"JS Friedenwald","year":"1951","unstructured":"Friedenwald JS. Growth pressure and metaplasia of conjunctival and corneal epithelium. Doc Ophthalmol. 1951;5\u20136:184\u201392.","journal-title":"Doc Ophthalmol"},{"key":"3619_CR2","first-page":"135","volume":"21","author":"MS Shapiro","year":"1981","unstructured":"Shapiro MS, Friend J, Thoft RA. Corneal re-epithelialization from the conjunctiva. Invest Ophthalmol Vis Sci. 1981;21:135\u201342.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR3","unstructured":"Kuwabara T, Perkins DG, Cogan DG. Sliding of the epithelium in experimental corneal wounds. Invest Ophthalmol. 1976;15."},{"key":"3619_CR4","doi-asserted-by":"publisher","first-page":"107998","DOI":"10.1016\/j.exer.2020.107998","volume":"194","author":"P Parlanti","year":"2020","unstructured":"Parlanti P, Pal-Ghosh S, Williams A, Tadvalkar G, Popratiloff A, Stepp MA. Axonal debris accumulates in corneal epithelial cells after intraepithelial corneal nerves are damaged: A focused Ion Beam Scanning Electron Microscopy (FIB-SEM) study. Exp Eye Res. 2020;194:107998.","journal-title":"Exp Eye Res"},{"key":"3619_CR5","first-page":"464","volume":"27","author":"CE Crosson","year":"1986","unstructured":"Crosson CE, Klyce SD, Beuerman RW. Epithelial wound closure in the rabbit cornea. A biphasic process. Invest Ophthalmol Vis Sci. 1986;27:464\u201373.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR6","first-page":"161","volume":"16","author":"RA Anderson","year":"1977","unstructured":"Anderson RA. Actin filaments in normal and migrating corneal epithelial cells. Invest Ophthalmol Vis Sci. 1977;16:161\u20136.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1126\/science.276.5309.75","volume":"276","author":"P Martin","year":"1997","unstructured":"Martin P. Wound healing-aiming for perfect skin regeneration. Science. 1997;276:75\u201381.","journal-title":"Science"},{"key":"3619_CR8","doi-asserted-by":"crossref","unstructured":"Park M, Zhang R, Pandzic E, Sun M, Coulson-Thomas VJ, Di Girolamo N Plasticity of ocular surface epithelia: Using a murine model of limbal stem cell deficiency to delineate metaplasia and transdifferentiation. Stem Cell Rep [Internet]. 2022 Nov 8 [cited 2023 Feb 1];17:2451\u201366. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S221367112200460X","DOI":"10.1016\/j.stemcr.2022.09.011"},{"key":"3619_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108089","volume":"197","author":"SE Wilson","year":"2020","unstructured":"Wilson SE. Corneal wound healing. Exp Eye Res. 2020;197:108089.","journal-title":"Exp Eye Res"},{"key":"3619_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3389\/fbioe.2019.00135","volume":"7","author":"M Mobaraki","year":"2019","unstructured":"Mobaraki M, Abbasi R, Omidian Vandchali S, Ghaffari M, Moztarzadeh F, Mozafari M. Corneal repair and regeneration: current concepts and future directions. Front Bioeng Biotechnol. 2019;7:135.","journal-title":"Front Bioeng Biotechnol"},{"key":"3619_CR11","first-page":"897","volume":"26","author":"M Matsuda","year":"1985","unstructured":"Matsuda M, Ubels JL, Edelhauser HF. A larger corneal epithelial wound closes at a faster rate. Invest Ophthalmol Vis Sci. 1985;26:897\u2013900.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR12","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jtos.2020.10.006","volume":"19","author":"S Kamil","year":"2021","unstructured":"Kamil S, Mohan RR. Corneal stromal wound healing: major regulators and therapeutic targets. Ocul Surf. 2021;19:290\u2013306.","journal-title":"Ocul Surf"},{"key":"3619_CR13","doi-asserted-by":"crossref","unstructured":"Shadmani A, Dhowre HS, Ercal O, Meng XQ, Wu AY. Corneal and limbal alkali injury induction using a Punch-Trephine technique in a mouse model. J Vis Exp Jove. 2023;.","DOI":"10.3791\/65609"},{"key":"3619_CR14","first-page":"256","volume":"29","author":"A Shadmani","year":"2023","unstructured":"Shadmani A, Jarin T, Meng XQ, Rajaendran Y, Uzun S, Wu AY. Evaluation of the Algerbrush II rotating burr as a tool for inducing ocular surface failure in a mouse model. Mol Vis. 2023;29:256.","journal-title":"Mol Vis"},{"key":"3619_CR15","first-page":"1814","volume":"34","author":"ZG Wei","year":"1993","unstructured":"Wei ZG, Wu RL, Lavker RM, Sun TT. In vitro growth and differentiation of rabbit bulbar, fornix, and palpebral conjunctival epithelia: Implications on conjunctival epithelial transdifferentiation and stem cells. Invest Ophthalmol Vis Sci. 1993;34:1814\u201328.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR16","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/tvst.12.12.12","volume":"12","author":"A Shadmani","year":"2023","unstructured":"Shadmani A, Ercal O, Uzun S, Swarup A, Wu AY. Regenerated corneal epithelium expresses more \u03b2III-Tubulin after chemical injuries compared to mechanical injuries. Transl Vis Sci Technol. 2023;12:12.","journal-title":"Transl Vis Sci Technol"},{"key":"3619_CR17","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1167\/iovs.16-20737","volume":"58","author":"JK Kubilus","year":"2017","unstructured":"Kubilus JK, Zapater I, Morales C, Linsenmayer TF. The corneal epithelial barrier and its developmental role in isolating corneal epithelial and conjunctival cells from one another. Invest Ophthalmol Vis Sci. 2017;58:1665\u201372. https:\/\/doi.org\/10.1167\/iovs.16-20737","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR18","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1136\/bjo.78.5.401","volume":"78","author":"HS Dua","year":"1994","unstructured":"Dua HS, Gomes JA, Singh A. Corneal epithelial wound healing. Br J Ophthalmol. 1994;78:401\u20138.","journal-title":"Br J Ophthalmol"},{"key":"3619_CR19","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1242\/jcs.111.19.2867","volume":"111","author":"MS Lehrer","year":"1998","unstructured":"Lehrer MS, Sun TT, Lavker RM. Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation. J Cell Sci. 1998;111:2867\u201375.","journal-title":"J Cell Sci"},{"key":"3619_CR20","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1083\/jcb.145.4.769","volume":"145","author":"G Pellegrini","year":"1999","unstructured":"Pellegrini G, Golisano O, Paterna P, Lambiase A, Bonini S, Rama P, et al. Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface. J Cell Biol. 1999;145:769\u201382.","journal-title":"J Cell Biol"},{"key":"3619_CR21","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0092-8674(89)90958-6","volume":"57","author":"G Cotsarelis","year":"1989","unstructured":"Cotsarelis G, Cheng SZ, Dong G, Sun TT, Lavker RM. Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell. 1989;57:201\u20139.","journal-title":"Cell"},{"key":"3619_CR22","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1089\/scd.2012.0180","volume":"21","author":"P Trosan","year":"2012","unstructured":"Trosan P, Svobodova E, Chudickova M, Krulova M, Zajicova A, Holan V. The key role of insulin-like growth factor I in limbal stem cell differentiation and the corneal wound-healing process. Stem Cells Dev. 2012;21:3341\u201350.","journal-title":"Stem Cells Dev"},{"key":"3619_CR23","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.preteyeres.2015.07.002","volume":"49","author":"AV Ljubimov","year":"2015","unstructured":"Ljubimov AV, Saghizadeh M. Progress in corneal wound healing. Prog Retin Eye Res. 2015;49:17\u201345.","journal-title":"Prog Retin Eye Res"},{"key":"3619_CR24","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.stemcr.2018.11.014","volume":"12","author":"M Park","year":"2019","unstructured":"Park M, Richardson A, Pandzic E, Lobo EP, Whan R, Watson SL, et al. Visualizing the contribution of keratin-14+ limbal epithelial precursors in corneal wound healing. Stem Cell Rep. 2019;12:14\u201328.","journal-title":"Stem Cell Rep."},{"key":"3619_CR25","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/stem.1840","volume":"33","author":"A Amitai-Lange","year":"2015","unstructured":"Amitai-Lange A, Altshuler A, Bubley J, Dbayat N, Tiosano B, Shalom-Feuerstein R. Lineage tracing of stem and progenitor cells of the murine corneal epithelium. Stem Cells. 2015;33:230\u20139.","journal-title":"Stem Cells"},{"key":"3619_CR26","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/ICO.0000000000001820","volume":"38","author":"SX Deng","year":"2019","unstructured":"Deng SX, Borderie V, Chan CC, Dana R, Figueiredo FC, Gomes JA, et al. Global consensus on the definition, classification, diagnosis and staging of limbal stem cell deficiency. Cornea. 2019;38:364.","journal-title":"Cornea"},{"key":"3619_CR27","first-page":"1445","volume":"28","author":"S Danjo","year":"1987","unstructured":"Danjo S, Friend J, Thoft RA. Conjunctival epithelium in healing of corneal epithelial wounds. Invest Ophthalmol Vis Sci. 1987;28:1445\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR28","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/j.1755-3768.1989.tb00749.x","volume":"67","author":"E H\u00e5skjold","year":"1989","unstructured":"H\u00e5skjold E, Bjerknes R, Refsum SB. Cell kinetics during healing of corneal epithelial wounds. Acta Ophthalmol (Copenh). 1989;67:174\u201380.","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"3619_CR29","first-page":"1008","volume":"24","author":"S Kinoshita","year":"1983","unstructured":"Kinoshita S, Friend J, Thoft RA. Biphasic cell proliferation in transdifferentiation of conjunctival to corneal epithelium in rabbits. Invest Ophthalmol Vis Sci. 1983;24:1008\u201314.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.stemcr.2018.12.009","volume":"12","author":"J Wijnholds","year":"2019","unstructured":"Wijnholds J. Basal cell migration\u201d in regeneration of the corneal wound-bed. Stem Cell Rep. 2019;12:3\u20135.","journal-title":"Stem Cell Rep."},{"key":"3619_CR31","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1056\/NEJMoa0905955","volume":"363","author":"P Rama","year":"2010","unstructured":"Rama P, Matuska S, Paganoni G, Spinelli A, De Luca M, Pellegrini G. Limbal stem-cell therapy and long-term corneal regeneration. N Engl J Med. 2010;363:147\u201355.","journal-title":"N Engl J Med"},{"key":"3619_CR32","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/35058521","volume":"2","author":"BS Khakh","year":"2001","unstructured":"Khakh BS. Molecular physiology of p2x receptors and atp signalling at synapses. Nat Rev Neurosci. 2001;2:165\u201374.","journal-title":"Nat Rev Neurosci"},{"key":"3619_CR33","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1002\/jcb.20258","volume":"93","author":"VE Klepeis","year":"2004","unstructured":"Klepeis VE, Weinger I, Kaczmarek E, Trinkaus-Randall V. P2Y receptors play a critical role in epithelial cell communication and migration. J Cell Biochem. 2004;93:1115\u201333.","journal-title":"J Cell Biochem"},{"key":"3619_CR34","doi-asserted-by":"publisher","first-page":"C972","DOI":"10.1152\/ajpcell.00110.2013","volume":"306","author":"A Lee","year":"2014","unstructured":"Lee A, Derricks K, Minns M, Ji S, Chi C, Nugent MA, et al. Hypoxia-induced changes in Ca2+ mobilization and protein phosphorylation implicated in impaired wound healing. Am J Physiol-Cell Physiol. 2014;306:C972\u201385.","journal-title":"Am J Physiol-Cell Physiol"},{"key":"3619_CR35","doi-asserted-by":"publisher","first-page":"198","DOI":"10.33594\/000000014","volume":"52","author":"KI Nakajima","year":"2019","unstructured":"Nakajima KI, Tatsumi M, Zhao M. An essential and synergistic role of purinergic signaling in guided migration of corneal epithelial cells in physiological electric fields. Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol. 2019;52:198.","journal-title":"Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol"},{"key":"3619_CR36","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/nature05249","volume":"443","author":"BK Ambati","year":"2006","unstructured":"Ambati BK, Nozaki M, Singh N, Takeda A, Jani PD, Suthar T, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006;443:993\u20137.","journal-title":"Nature"},{"key":"3619_CR37","doi-asserted-by":"publisher","first-page":"11405","DOI":"10.1073\/pnas.0506112103","volume":"103","author":"C Cursiefen","year":"2006","unstructured":"Cursiefen C, Chen L, Saint-Geniez M, Hamrah P, Jin Y, Rashid S, et al. Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci. 2006;103:11405\u201310.","journal-title":"Proc Natl Acad Sci"},{"key":"3619_CR38","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.exer.2008.02.001","volume":"86","author":"WM Stapleton","year":"2008","unstructured":"Stapleton WM, Chaurasia SS, Medeiros FW, Mohan RR, Sinha S, Wilson SE. Topical interleukin-1 receptor antagonist inhibits inflammatory cell infiltration into the cornea. Exp Eye Res. 2008;86:753\u20137.","journal-title":"Exp Eye Res"},{"key":"3619_CR39","doi-asserted-by":"publisher","first-page":"838","DOI":"10.2353\/ajpath.2007.070008","volume":"171","author":"Z Li","year":"2007","unstructured":"Li Z, Burns AR, Rumbaut RE, Smith CW. \u03b3\u03b4 T cells are necessary for platelet and neutrophil accumulation in limbal vessels and efficient epithelial repair after corneal abrasion. Am J Pathol. 2007;171:838\u201345.","journal-title":"Am J Pathol"},{"key":"3619_CR40","doi-asserted-by":"publisher","first-page":"4794","DOI":"10.1167\/iovs.06-0381","volume":"47","author":"Z Li","year":"2006","unstructured":"Li Z, Rumbaut RE, Burns AR, Smith CW. Platelet response to corneal abrasion is necessary for acute inflammation and efficient re-epithelialization. Invest Ophthalmol Vis Sci. 2006;47:4794\u2013802.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR41","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00441-009-0908-5","volume":"339","author":"Y Gong","year":"2010","unstructured":"Gong Y, Koh DR. Neutrophils promote inflammatory angiogenesis via release of preformed VEGF in an in vivo corneal model. Cell Tissue Res. 2010;339:437\u201348.","journal-title":"Cell Tissue Res"},{"key":"3619_CR42","doi-asserted-by":"publisher","first-page":"3870","DOI":"10.1167\/iovs.07-1418","volume":"49","author":"QY Charles","year":"2008","unstructured":"Charles QY, Zhang M, Matis KI, Kim C, Rosenblatt MI. Vascular endothelial growth factor mediates corneal nerve repair. Invest Ophthalmol Vis Sci. 2008;49:3870\u20138.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR43","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.ajpath.2010.12.001","volume":"178","author":"Z Li","year":"2011","unstructured":"Li Z, Burns AR, Han L, Rumbaut RE, Smith CW. IL-17 and VEGF are necessary for efficient corneal nerve regeneration. Am J Pathol. 2011;178:1106\u201316.","journal-title":"Am J Pathol"},{"key":"3619_CR44","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ophtha.2013.06.049","volume":"121","author":"SN Arafat","year":"2014","unstructured":"Arafat SN, Suelves AM, Spurr-Michaud S, Chodosh J, Foster CS, Dohlman CH, et al. Neutrophil Collagenase, Gelatinase, and Myeloperoxidase in tears of patients with Stevens-Johnson Syndrome and ocular Cicatricial Pemphigoid. Ophthalmology. 2014;121:79\u201387.","journal-title":"Ophthalmology"},{"key":"3619_CR45","doi-asserted-by":"publisher","unstructured":"Singh A, Cho WJ, Pulimamidi VK, Mittal SK, Chauhan SK Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing. Invest Ophthalmol Vis Sci. Available from: https:\/\/doi.org\/10.1167\/iovs.64.14.1","DOI":"10.1167\/iovs.64.14.1"},{"key":"3619_CR46","doi-asserted-by":"crossref","unstructured":"Stepp MA, Pal-Ghosh S, Downie LE, Zhang AC, Chinnery HR, Machet J, et al. Corneal Epithelial \u201cNeuromas\u201d: A Case of Mistaken Identity? Cornea [Internet]. 2020;39. Available from: https:\/\/journals.lww.com\/corneajrnl\/fulltext\/2020\/07000\/corneal_epithelial__neuromas___a_case_of_mistaken.24.aspx","DOI":"10.1097\/ICO.0000000000002294"},{"key":"3619_CR47","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.2337\/db19-0870","volume":"69","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Gao N, Wu L, Lee PS, Me R, Dai C, et al. Role of VIP and sonic hedgehog signaling pathways in mediating epithelial wound healing, sensory nerve regeneration, and their defects in diabetic corneas. Diabetes. 2020;69:1549\u201361.","journal-title":"Diabetes"},{"key":"3619_CR48","first-page":"461","volume":"30","author":"CF Marfurt","year":"1989","unstructured":"Marfurt CF, Kingsley RE, Echtenkamp SE. Sensory and sympathetic innervation of the mammalian cornea. A retrograde tracing study. Invest Ophthalmol Vis Sci. 1989;30:461\u201372.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR49","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1167\/iovs.11-8438","volume":"53","author":"H Ueno","year":"2012","unstructured":"Ueno H, Ferrari G, Hattori T, Saban DR, Katikireddy KR, Chauhan SK, et al. Dependence of corneal stem\/progenitor cells on ocular surface innervation. Invest Ophthalmol Vis Sci. 2012;53:867\u201372.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR50","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1038\/s41385-018-0031-6","volume":"11","author":"Y Xue","year":"2018","unstructured":"Xue Y, He J, Xiao C, Guo Y, Fu T, Liu J, et al. The mouse autonomic nervous system modulates inflammation and epithelial renewal after corneal abrasion through the activation of distinct local macrophages. Mucosal Immunol. 2018;11:1496\u2013511.","journal-title":"Mucosal Immunol"},{"key":"3619_CR51","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","volume":"76","author":"LJ M\u00fcller","year":"2003","unstructured":"M\u00fcller LJ, Marfurt CF, Kruse F, Tervo TMT. Corneal nerves: structure, contents and function. Exp Eye Res. 2003;76:521\u201342.","journal-title":"Exp Eye Res"},{"key":"3619_CR52","doi-asserted-by":"crossref","unstructured":"Kowtharapu BS, Stahnke T, Wree A, Guthoff RF, Stachs O Corneal epithelial and neuronal interactions: Role in wound healing. Exp Eye Res;125:53\u201361.","DOI":"10.1016\/j.exer.2014.05.006"},{"key":"3619_CR53","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/0014-4886(80)90154-5","volume":"69","author":"RW Beuerman","year":"1980","unstructured":"Beuerman RW, Schimmelpfennig B. Sensory denervation of the rabbit cornea affects epithelial properties. Exp Neurol. 1980;69:196\u2013201.","journal-title":"Exp Neurol"},{"key":"3619_CR54","doi-asserted-by":"publisher","first-page":"4695","DOI":"10.1167\/iovs.16-21372","volume":"58","author":"G Di","year":"2017","unstructured":"Di G, Qi X, Zhao X, Zhang S, Danielson P, Zhou Q. Corneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration. Invest Ophthalmol Vis Sci. 2017;58:4695\u2013702. https:\/\/doi.org\/10.1167\/iovs.16-21372","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR55","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.jtos.2018.06.004","volume":"16","author":"D Roshandel","year":"2018","unstructured":"Roshandel D, Eslani M, Baradaran-Rafii A, Cheung AY, Kurji K, Jabbehdari S, et al. Current and Upcoming Therapies for Corneal Neovascularization. Ocul Surf. 2018;16:398\u2013414.","journal-title":"Ocul Surf"},{"key":"3619_CR56","first-page":"692","volume":"41","author":"L You","year":"2000","unstructured":"You L, Kruse FE, V\u00f6lcker HE. Neurotrophic Factors in the Human Cornea. Invest Ophthalmol Vis Sci. 2000;41:692\u2013702.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR57","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/0304-3940(87)90118-2","volume":"82","author":"I Emoto","year":"1987","unstructured":"Emoto I, Beuerman RW. Stimulation of neurite growth by epithelial implants into corneal stroma. Neurosci Lett. 1987;82:140\u20134.","journal-title":"Neurosci Lett"},{"key":"3619_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100974","volume":"86","author":"RM Lasagni Vitar","year":"2022","unstructured":"Lasagni Vitar RM, Rama P, Ferrari G. The two-faced effects of nerves and neuropeptides in corneal diseases. Prog Retin Eye Res. 2022;86:100974.","journal-title":"Prog Retin Eye Res"},{"key":"3619_CR59","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1167\/iovs.11-8379","volume":"54","author":"G Ferrari","year":"2013","unstructured":"Ferrari G, Hajrasouliha AR, Sadrai Z, Ueno H, Chauhan SK, Dana R. Nerves and Neovessels Inhibit Each Other in the Cornea. Invest Ophthalmol Vis Sci. 2013;54:813\u201320.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR60","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1248\/bpb.b16-00583","volume":"40","author":"A Matsuyama","year":"2017","unstructured":"Matsuyama A, Takatori S, Sone Y, Ochi E, Goda M, Zamami Y, et al. Effect of Nerve Growth Factor on Innervation of Perivascular Nerves in Neovasculatures of Mouse Cornea. Biol Pharm Bull. 2017;40:396\u2013401.","journal-title":"Biol Pharm Bull"},{"key":"3619_CR61","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1080\/10623320600669053","volume":"13","author":"P Lazarovici","year":"2006","unstructured":"Lazarovici P, Gazit A, Staniszewska I, Marcinkiewicz C, Lelkes PI. Nerve growth factor (NGF) promotes angiogenesis in the quail chorioallantoic membrane. Endothelium. 2006;13:51\u20139.","journal-title":"Endothelium"},{"key":"3619_CR62","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1006\/exer.1994.1152","volume":"59","author":"SE Wilson","year":"1994","unstructured":"Wilson SE, He YG, Weng J, Zieske JD, Jester JV, Schultz GS. Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells. Exp Eye Res. 1994;59:665\u201378.","journal-title":"Exp Eye Res"},{"key":"3619_CR63","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1126\/science.1840698","volume":"251","author":"S Higashiyama","year":"1991","unstructured":"Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science. 1991;251:936\u20139.","journal-title":"Science"},{"key":"3619_CR64","first-page":"165","volume":"1198","author":"NE Hynes","year":"1994","unstructured":"Hynes NE, Stern DF. The biology of erbB-2\/nue\/HER-2 and its role in cancer. Biochim Biophys Acta BBA-Rev Cancer. 1994;1198:165\u201384.","journal-title":"Biochim Biophys Acta BBA-Rev Cancer"},{"key":"3619_CR65","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/jcb.240450407","volume":"45","author":"G Schultz","year":"1991","unstructured":"Schultz G, Clark W, Rotatori DS. EGF and TGF-\u03b1 in wound healing and repair. J Cell Biochem. 1991;45:346\u201352.","journal-title":"J Cell Biochem"},{"key":"3619_CR66","first-page":"F179","volume":"1333","author":"G Raab","year":"1997","unstructured":"Raab G, Klagsbrun M. Heparin-binding EGF-like growth factor. Biochim Biophys Acta BBA-Rev Cancer. 1997;1333:F179\u201399.","journal-title":"Biochim Biophys Acta BBA-Rev Cancer"},{"key":"3619_CR67","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1073\/pnas.86.3.802","volume":"86","author":"JS Rubin","year":"1989","unstructured":"Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA. Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci. 1989;86:802\u20136.","journal-title":"Proc Natl Acad Sci"},{"key":"3619_CR68","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1083\/jcb.127.6.1783","volume":"127","author":"EM Rosen","year":"1994","unstructured":"Rosen EM, Nigam SK, Goldberg ID. Scatter factor and the c-met receptor: a paradigm for mesenchymal\/epithelial interaction. J Cell Biol. 1994;127:1783\u20137.","journal-title":"J Cell Biol"},{"key":"3619_CR69","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/jcp.1041630108","volume":"163","author":"DQ Li","year":"1995","unstructured":"Li DQ, Tseng SC. Three patterns of cytokine expression potentially involved in epithelial-fibroblast interactions of human ocular surface. J Cell Physiol. 1995;163:61\u201379.","journal-title":"J Cell Physiol"},{"key":"3619_CR70","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1076\/ceyr.16.6.605.5081","volume":"16","author":"JL Andresen","year":"1997","unstructured":"Andresen JL, Ledet T, Ehlers N. Keratocyte migration and peptide growth factors: the effect of PDGF, bFGF, EGF, IGF-I, aFGF and TGF-beta on human keratocyte migration in a collagen gel. Curr Eye Res. 1997;16:605\u201313.","journal-title":"Curr Eye Res"},{"key":"3619_CR71","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04963-x","volume":"13","author":"K Chen","year":"2022","unstructured":"Chen K, Li Y, Zhang X, Ullah R, Tong J, Shen Y. The role of the PI3K\/AKT signalling pathway in the corneal epithelium: recent updates. Cell Death Dis. 2022;13:513","journal-title":"Cell Death Dis"},{"key":"3619_CR72","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.3390\/cells10092409","volume":"10","author":"JL Peterson","year":"2021","unstructured":"Peterson JL, Ceresa BP. Epidermal growth factor receptor expression in the corneal epithelium. Cells. 2021;10:2409.","journal-title":"Cells"},{"key":"3619_CR73","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.1167\/iovs.10-5670","volume":"52","author":"K Xu","year":"2011","unstructured":"Xu K. Fu-Shin XY. Impaired epithelial wound healing and EGFR signaling pathways in the corneas of diabetic rats. Invest Ophthalmol Vis Sci. 2011;52:3301\u20138.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR74","doi-asserted-by":"publisher","first-page":"3319","DOI":"10.1016\/j.yexcr.2007.06.006","volume":"313","author":"JK Spix","year":"2007","unstructured":"Spix JK, Chay EY, Block ER, Klarlund JK. Hepatocyte growth factor induces epithelial cell motility through transactivation of the epidermal growth factor receptor. Exp Cell Res. 2007;313:3319\u201325.","journal-title":"Exp Cell Res"},{"key":"3619_CR75","doi-asserted-by":"publisher","first-page":"9373","DOI":"10.1074\/jbc.M109.094425","volume":"285","author":"L Lu","year":"2010","unstructured":"Lu L, Wang L, Li T, Wang J. NF-\u03baB subtypes regulate CCCTC binding factor affecting corneal epithelial cell fate. J Biol Chem. 2010;285:9373\u201382.","journal-title":"J Biol Chem"},{"key":"3619_CR76","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.brainresbull.2009.08.024","volume":"81","author":"XY Fu-Shin","year":"2010","unstructured":"Fu-Shin XY, Yin J, Xu K, Huang J. Growth factors and corneal epithelial wound healing. Brain Res Bull. 2010;81:229\u201335.","journal-title":"Brain Res Bull"},{"key":"3619_CR77","doi-asserted-by":"publisher","first-page":"4267","DOI":"10.1242\/jcs.023564","volume":"122","author":"CD McCaig","year":"2009","unstructured":"McCaig CD, Song B, Rajnicek AM. Electrical dimensions in cell science. J Cell Sci. 2009;122:4267\u201376.","journal-title":"J Cell Sci"},{"key":"3619_CR78","first-page":"379","volume":"19","author":"B Reid","year":"2005","unstructured":"Reid B, Song B, McCaig CD, Zhao M. Wound healing in rat cornea: the role of electric currents. FASEB J Publ Fed Am Soc Exp Biol. 2005;19:379.","journal-title":"FASEB J Publ Fed Am Soc Exp Biol"},{"key":"3619_CR79","doi-asserted-by":"publisher","first-page":"a041236","DOI":"10.1101\/cshperspect.a041236","volume":"14","author":"M Zhao","year":"2022","unstructured":"Zhao M, Rolandi M, Isseroff RR. Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing. Cold Spring Harb Perspect Biol. 2022;14:a041236.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3619_CR80","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/0304-3940(84)90228-3","volume":"44","author":"RW Beuerman","year":"1984","unstructured":"Beuerman RW, R\u00f3zsa AJ. Collateral sprouts are replaced by regenerating neurites in the wounded corneal epithelium. Neurosci Lett. 1984;44:99\u2013104.","journal-title":"Neurosci Lett"},{"key":"3619_CR81","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1242\/jcs.01341","volume":"117","author":"B Song","year":"2004","unstructured":"Song B, Zhao M, Forrester JV, McCaig CD. Nerves are guided and nerve sprouting is stimulated by a naturally occurring electrical field in vivo. J Cell Sci. 2004;117:4681\u201390.","journal-title":"J Cell Sci"},{"key":"3619_CR82","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/S0161-6420(90)32575-7","volume":"97","author":"RJF Tsai","year":"1990","unstructured":"Tsai RJF, Sun TT, Tseng SCG. Comparison of Limbal and Conjunctival Autograft Transplantation in Corneal Surface Reconstruction in Rabbits. Ophthalmology. 1990;97:446\u201355.","journal-title":"Ophthalmology"},{"key":"3619_CR83","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.matbio.2017.06.003","volume":"64","author":"SE Wilson","year":"2017","unstructured":"Wilson SE, Marino GK, Torricelli AA, Medeiros CS. Injury and defective regeneration of the epithelial basement membrane in corneal fibrosis: a paradigm for fibrosis in other organs? Matrix Biol. 2017;64:17\u201326.","journal-title":"Matrix Biol"},{"key":"3619_CR84","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1167\/iovs.61.2.28","volume":"61","author":"RC de Oliveira","year":"2020","unstructured":"de Oliveira RC, Wilson SE. Fibrocytes, wound healing, and corneal fibrosis. Invest Ophthalmol Vis Sci. 2020;61:28.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR85","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3928\/1081597X-20170126-02","volume":"33","author":"GK Marino","year":"2017","unstructured":"Marino GK, Santhiago MR, Santhanam A, Torricelli AAM, Wilson SE. Regeneration of Defective Epithelial Basement Membrane and Restoration of Corneal Transparency After Photorefractive Keratectomy. J Refract Surg. 2017;33:337\u201346.","journal-title":"J Refract Surg"},{"key":"3619_CR86","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.exer.2014.09.013","volume":"129","author":"AAM Torricelli","year":"2014","unstructured":"Torricelli AAM, Wilson SE. Cellular and extracellular matrix modulation of corneal stromal opacity. Exp Eye Res. 2014;129:151\u201360.","journal-title":"Exp Eye Res"},{"key":"3619_CR87","first-page":"2514","volume":"41","author":"W Philipp","year":"2000","unstructured":"Philipp W, Speicher L, Humpel C. Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas. Invest Ophthalmol Vis Sci. 2000;41:2514\u201322.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR88","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1097\/01.ico.0000178736.35297.9d","volume":"24","author":"KH Sonoda","year":"2005","unstructured":"Sonoda KH, Nakao S, Nakamura T, Oshima T, Qiao H, Hisatomi T, et al. Cellular events in the normal and inflamed cornea. Cornea. 2005;24:S50\u20134.","journal-title":"Cornea"},{"key":"3619_CR89","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/jcp.25623","volume":"232","author":"L Mastropasqua","year":"2017","unstructured":"Mastropasqua L, Massaro-Giordano G, Nubile M, Sacchetti M. Understanding the Pathogenesis of Neurotrophic Keratitis: The Role of Corneal Nerves. J Cell Physiol. 2017;232:717\u201324.","journal-title":"J Cell Physiol"},{"key":"3619_CR90","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1167\/iovs.10-5902","volume":"52","author":"CC McKenna","year":"2011","unstructured":"McKenna CC, Lwigale PY. Innervation of the Mouse Cornea during Development. Invest Ophthalmol Vis Sci. 2011;52:30\u20135.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR91","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/00004397-198402440-00011","volume":"24","author":"J Friend","year":"1984","unstructured":"Friend J, Thoft RA. The diabetic cornea. Int Ophthalmol Clin. 1984;24:111\u201323.","journal-title":"Int Ophthalmol Clin"},{"key":"3619_CR92","first-page":"1168","volume":"25","author":"SC Tseng","year":"1984","unstructured":"Tseng SC, Hirst LW, Farazdaghi M, Green WR. Goblet cell density and vascularization during conjunctival transdifferentiation. Invest Ophthalmol Vis Sci. 1984;25:1168\u201376.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR93","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30964-y","volume":"8","author":"KI Jeon","year":"2018","unstructured":"Jeon KI, Hindman HB, Bubel T, McDaniel T, DeMagistris M, Callan C, et al. Corneal myofibroblasts inhibit regenerating nerves during wound healing. Sci Rep. 2018;8:12945","journal-title":"Sci Rep"},{"key":"3619_CR94","doi-asserted-by":"crossref","unstructured":"Aggarwal S, Colon C, Kheirkhah A, Hamrah P Efficacy of autologous serum tears for treatment of neuropathic corneal pain. Ocul Surf [Internet]. 2019 Jul 1 [cited 2024 Sep 8];17:532\u20139. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1542012418302386","DOI":"10.1016\/j.jtos.2019.01.009"},{"key":"3619_CR95","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.2147\/OPTH.S284622","volume":"15","author":"MD Yu","year":"2021","unstructured":"Yu MD, Park JK, Kossler AL. Stimulating Tear Production: Spotlight on Neurostimulation. Clin Ophthalmol. 2021;15:4219\u201326.","journal-title":"Clin Ophthalmol"},{"key":"3619_CR96","doi-asserted-by":"crossref","unstructured":"Pflugfelder SC Antiinflammatory therapy for dry eye. Am J Ophthalmol [Internet]. 2004 Feb 1 [cited 2024 Aug 23];137:337\u201342. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002939403013230","DOI":"10.1016\/j.ajo.2003.10.036"},{"key":"3619_CR97","doi-asserted-by":"crossref","unstructured":"Dursun D, Kim MC, Solomon A, Pflugfelder SC Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. Am J Ophthalmol [Internet]. 2001 [cited 2024 Aug 25];132:8\u201313. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002939401009138","DOI":"10.1016\/S0002-9394(01)00913-8"},{"key":"3619_CR98","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.ophtha.2018.02.022","volume":"125","author":"S Bonini","year":"2018","unstructured":"Bonini S, Lambiase A, Rama P, Sinigaglia F, Allegretti M, Chao W, et al. Phase II randomized, double-masked, vehicle-controlled trial of recombinant human nerve growth factor for neurotrophic keratitis. Ophthalmology. 2018;125:1332\u201343.","journal-title":"Ophthalmology"},{"key":"3619_CR99","doi-asserted-by":"publisher","first-page":"266ra172","DOI":"10.1126\/scitranslmed.3009644","volume":"6","author":"S Basu","year":"2014","unstructured":"Basu S, Hertsenberg AJ, Funderburgh ML, Burrow MK, Mann MM, Du Y, et al. Human limbal biopsy\u2013derived stromal stem cells prevent corneal scarring. Sci Transl Med. 2014;6:266ra172.","journal-title":"Sci Transl Med"},{"key":"3619_CR100","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.3727\/096368914X685744","volume":"24","author":"CC Hsu","year":"2015","unstructured":"Hsu CC, Peng CH, Hung KH, Lee YY, Lin TC, Jang SF, et al. Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal Disorders. Cell Transplant. 2015;24:1915\u201330.","journal-title":"Cell Transplant"},{"key":"3619_CR101","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4103\/JOCO.JOCO_246_20","volume":"33","author":"A Shadmani","year":"2021","unstructured":"Shadmani A, Razmkhah M, Jalalpoor MH, Lari SY, Eghtedari M. Autologous activated omental versus allogeneic adipose tissue-derived mesenchymal stem cells in corneal alkaline injury: an experimental study. J Curr Ophthalmol. 2021;33:136.","journal-title":"J Curr Ophthalmol"},{"key":"3619_CR102","first-page":"5662","volume":"56","author":"K Gumus","year":"2015","unstructured":"Gumus K. A new matrix therapy agent (CACICOL20\u00ae) for corneal healing following the corneal crosslinking with ultraviolet A and riboflavin in progressive keratoconus. Invest Ophthalmol Vis Sci. 2015;56:5662.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3619_CR103","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/ICL.0b013e3182a2f8fa","volume":"39","author":"K Suri","year":"2013","unstructured":"Suri K, Kosker M, Raber IM, Hammersmith KM, Nagra PK, Ayres BD, et al. Sutureless Amniotic Membrane ProKera for Ocular Surface Disorders: Short-Term Results. Eye Contact Lens. 2013;39:341.","journal-title":"Eye Contact Lens"},{"key":"3619_CR104","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/ICO.0b013e31823f8b2a","volume":"31","author":"A Ghaffarieh","year":"2012","unstructured":"Ghaffarieh A, Ghaffarpasand F, Dehghankhalili M, Honarpisheh N, Nirumandi S, Tanideh N. Effect of transcutaneous electrical stimulation on rabbit corneal epithelial cell migration. Cornea. 2012;31:559\u201363.","journal-title":"Cornea"},{"key":"3619_CR105","unstructured":"Shadmani A, Khalili MR, Sanie-Jahromi F Application of electrostimulation and magnetic stimulation in patients with optic neuropathy: A mechanistic review. Dev Neurobiol."},{"key":"3619_CR106","doi-asserted-by":"crossref","unstructured":"Liu Y, Di G, Wang Y, Chong D, Cao X, Chen P Aquaporin 5 Facilitates Corneal Epithelial Wound Healing and Nerve Regeneration by Reactivating Akt Signaling Pathway. Am J Pathol. 2021 Nov 1 [cited 2024 Nov 19];191:1974\u201385. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002944021003473","DOI":"10.1016\/j.ajpath.2021.07.010"},{"key":"3619_CR107","unstructured":"Liu XF, Zhou DD, Xie T, Malik TH, Lu CB, Li HJ, et al. Nrf2, a Potential Therapeutic Target against Oxidative Stress in Corneal Diseases. [cited 2024 Nov 19]; Available from: https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/2326178"},{"key":"3619_CR108","doi-asserted-by":"publisher","first-page":"107998","DOI":"10.1177\/09603271211063165","volume":"41","author":"DK Shukal","year":"2022","unstructured":"Shukal DK, Malaviya PB, Sharma T. Role of the AMPK signalling pathway in the aetiopathogenesis of ocular diseases. Hum Exp Toxicol. 2022;41:107998.","journal-title":"Hum Exp Toxicol"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-03619-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-03619-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-03619-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T13:15:27Z","timestamp":1744204527000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-03619-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,12]]},"references-count":108,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["3619"],"URL":"https:\/\/doi.org\/10.1038\/s41433-025-03619-2","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,12]]},"assertion":[{"value":"28 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}