{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:06:46Z","timestamp":1763424406304,"version":"3.45.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"17","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1038\/s41433-025-04036-1","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:28:12Z","timestamp":1758875292000},"page":"3070-3075","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional and microvascular sequelae of type 1 retinopathy of prematurity: insights from OCT-A and microperimetry"],"prefix":"10.1038","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-8357","authenticated-orcid":false,"given":"Barbaros Hayrettin","family":"Unlu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-5429","authenticated-orcid":false,"given":"Ozlem Ural","family":"Fatihoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5894-0220","authenticated-orcid":false,"given":"Ayse Bozkurt","family":"Oflaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6633-0553","authenticated-orcid":false,"given":"Taylan","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4364-934X","authenticated-orcid":false,"given":"Aylin","family":"Yaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-6161","authenticated-orcid":false,"given":"Ayse Tulin","family":"Berk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"4036_CR1","doi-asserted-by":"crossref","unstructured":"Multicenter trial of cryotherapy for retinopathy of prematurity: three-month outcome. Arch Ophthalmol. 1990;108:195\u2013204.","DOI":"10.1001\/archopht.1990.01070040047029"},{"key":"4036_CR2","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1001\/archopht.124.6.871","volume":"124","author":"D Robaei","year":"2006","unstructured":"Robaei D. The impact of modest prematurity on visual function at age 6 years: findings from a population-based study. Arch Ophthalmol. 2006;124:871.","journal-title":"Arch Ophthalmol"},{"key":"4036_CR3","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1136\/bjophthalmol-2012-301612","volume":"96","author":"SE Yanni","year":"2012","unstructured":"Yanni SE, Wang J, Chan M, Carroll J, Farsiu S, Leffler JN, et al. Foveal avascular zone and foveal pit formation after preterm birth. Br J Ophthalmol. 2012;96:961\u20136.","journal-title":"Br J Ophthalmol"},{"key":"4036_CR4","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/0042-6989(86)90143-4","volume":"26","author":"C Yuodelis","year":"1986","unstructured":"Yuodelis C, Hendrickson A. A qualitative and quantitative analysis of the human fovea during development. Vision Res. 1986;26:847\u201355.","journal-title":"Vision Res"},{"key":"4036_CR5","doi-asserted-by":"publisher","first-page":"4948","DOI":"10.1167\/iovs.17-22333","volume":"58","author":"J Sj\u00f6strand","year":"2017","unstructured":"Sj\u00f6strand J, Ros\u00e9n R, Nilsson M, Popovic Z. Arrested foveal development in preterm eyes: thickening of the outer nuclear layer and structural redistribution within the fovea. Investig Ophthalmol Vis Sci. 2017;58:4948.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"4036_CR6","doi-asserted-by":"crossref","unstructured":"Lago AD, Matieli L, Gomes M, Baba NT, Farah ME, Belfort Junior R, et al. Stratus optical coherence tomography findings in patients with retinopathy of prematurity. Arq Bras Oftalmol. 2007;70. Available from: http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-27492007000100004&lng=en&nrm=iso&tlng=en.","DOI":"10.1590\/S0004-27492007000100004"},{"key":"4036_CR7","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1080\/08820538.2021.1893760","volume":"36","author":"MN Jabroun","year":"2021","unstructured":"Jabroun MN, AlWattar BK, Fulton AB. Optical coherence tomography angiography in prematurity. Semin Ophthalmol. 2021;36:264\u20139.","journal-title":"Semin Ophthalmol"},{"key":"4036_CR8","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/j.oret.2018.02.004","volume":"2","author":"W Bowl","year":"2018","unstructured":"Bowl W, Bowl M, Schweinfurth S, Holve K, Knobloch R, Stieger K, et al. OCT angiography in young children with a history of retinopathy of prematurity. Ophthalmol Retin. 2018;2:972\u20138.","journal-title":"Ophthalmol Retin"},{"key":"4036_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-024-03773-3","volume":"24","author":"A Eftekhari Milani","year":"2024","unstructured":"Eftekhari Milani A, Ahoor MH, Etemad F, Kharrazi Ghadim B, Arasteh A. The macular microvascular changes in children with a history of retinopathy of prematurity treated with intravitreal Bevacizumab injection using optical coherence tomography angiography: a retrospective cohort. BMC Ophthalmol. 2024;24:505.","journal-title":"BMC Ophthalmol"},{"key":"4036_CR10","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.21037\/qims.2019.09.01","volume":"9","author":"Y Moshiri","year":"2019","unstructured":"Moshiri Y, Legocki AT, Zhou K, Cabrera MT, Rezaei KA, Tarczy-Hornoch K, et al. Handheld swept-source optical coherence tomography with angiography in awake premature neonates. Quant Imaging Med Surg. 2019;9:1495\u2013502.","journal-title":"Quant Imaging Med Surg"},{"key":"4036_CR11","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1080\/08820538.2017.1375125","volume":"33","author":"A Molina-Mart\u00edn","year":"2018","unstructured":"Molina-Mart\u00edn A, P\u00e9rez-Cambrod\u00ed RJ, Pi\u00f1ero DP. Current clinical application of microperimetry: a review. Semin Ophthalmol. 2018;33:620\u20138.","journal-title":"Semin Ophthalmol"},{"key":"4036_CR12","doi-asserted-by":"publisher","first-page":"607","DOI":"10.5301\/ejo.5000930","volume":"27","author":"A Molina-Mart\u00edn","year":"2017","unstructured":"Molina-Mart\u00edn A, Pi\u00f1ero DP, P\u00e9rez-Cambrod\u00ed RJ. Normal values for microperimetry with the MAIA microperimeter: sensitivity and fixation analysis in healthy adults and children. Eur J Ophthalmol. 2017;27:607\u201313.","journal-title":"Eur J Ophthalmol"},{"key":"4036_CR13","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.sjopt.2011.01.010","volume":"25","author":"E Midena","year":"2011","unstructured":"Midena E, Vujosevic S. Microperimetry in diabetic retinopathy. Saudi J Ophthalmol. 2011;25:131\u20135.","journal-title":"Saudi J Ophthalmol"},{"key":"4036_CR14","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1136\/bjophthalmol-2021-319352","volume":"106","author":"Z Ozen Tunay","year":"2022","unstructured":"Ozen Tunay Z, Idil A. Macular sensitivity assessment and fixation analysis using microperimetry in children with retinopathy of prematurity. Br J Ophthalmol. 2022;106:1767\u201371.","journal-title":"Br J Ophthalmol"},{"key":"4036_CR15","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1007\/s00417-021-05090-7","volume":"259","author":"A Vinekar","year":"2021","unstructured":"Vinekar A, Sinha S, Mangalesh S, Jayadev C, Shetty B. Optical coherence tomography angiography in preterm-born children with retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2021;259:2131\u20137.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4036_CR16","doi-asserted-by":"crossref","unstructured":"Periti F, Toma C, Plaitano C, Guagliano R, Bertone C, Barill\u00e0 D, et al. Microvascular parameters evaluated with optical coherence tomography-angiography in children: comparison between preterm and full-term patients. Acta Ophthalmologica. 2019;97. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14131.","DOI":"10.1111\/aos.14131"},{"key":"4036_CR17","unstructured":"Ko\u00e7 DE, Ba\u015f DAY, Oval\u0131 DF. T\u00fcrkiye premat\u00fcre retinopatisi rehberi 2021 g\u00fcncellemesi. 2021. https:\/\/neonatology.org.tr\/."},{"key":"4036_CR18","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1080\/02713683.2021.1896740","volume":"46","author":"D Altinbay","year":"2021","unstructured":"Altinbay D, Idil A, Sahli E. How much do clinical and microperimetric findings affect reading speed in low vision patients with age-related macular degeneration?. Curr Eye Res. 2021;46:1581\u20138.","journal-title":"Curr Eye Res"},{"key":"4036_CR19","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1097\/IAE.0000000000001897","volume":"38","author":"M Erbezci","year":"2018","unstructured":"Erbezci M, Ozturk T. Preferred retinal locus locations in age-related macular degeneration. Retina. 2018;38:2372\u20138.","journal-title":"Retina"},{"key":"4036_CR20","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1001\/archophthalmol.2011.143","volume":"129","author":"V Dobson","year":"2011","unstructured":"The Early Treatment for Retinopathy of Prematurity Cooperative Group, Dobson V, Quinn GE, Summers CG, Hardy RJ, Tung B, et al. Grating visual acuity results in the early treatment for retinopathy of prematurity study. Archives Ophthalmol. 2011;129:840\u20136.","journal-title":"Archives Ophthalmol"},{"key":"4036_CR21","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1542\/peds.113.4.790","volume":"113","author":"ME Msall","year":"2004","unstructured":"Msall ME, Phelps DL, Hardy RJ, Dobson V, Quinn GE, Summers CG, et al. Educational and social competencies at 8 years in children with threshold retinopathy of prematurity in the CRYO-ROP multicenter study. Pediatrics. 2004;113:790\u20139.","journal-title":"Pediatrics"},{"key":"4036_CR22","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.ajo.2012.05.004","volume":"154","author":"L Vajzovic","year":"2012","unstructured":"Vajzovic L, Hendrickson AE, O\u2019Connell RV, Clark LA, Tran-Viet D, Possin D, et al. Maturation of the human fovea: correlation of spectral-domain optical coherence tomography findings with histology. Am J Ophthalmol. 2012;154:779\u2013789.e2.","journal-title":"Am J Ophthalmol"},{"key":"4036_CR23","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1016\/j.ophtha.2012.02.040","volume":"119","author":"WC Wu","year":"2012","unstructured":"Wu WC, Lin RI, Shih CP, Wang NK, Chen YP, Chao AN, et al. Visual acuity, optical components, and macular abnormalities in patients with a history of retinopathy of prematurity. Ophthalmology. 2012;119:1907\u201316.","journal-title":"Ophthalmology"},{"key":"4036_CR24","doi-asserted-by":"publisher","first-page":"6349","DOI":"10.1167\/iovs.16-20037","volume":"57","author":"PR Jones","year":"2016","unstructured":"Jones PR, Yasoubi N, Nardini M, Rubin GS. Feasibility of macular integrity assessment (MAIA) microperimetry in children: sensitivity, reliability, and fixation stability in healthy observers. Investig Ophthalmol Vis Sci. 2016;57:6349.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"4036_CR25","doi-asserted-by":"publisher","first-page":"232","DOI":"10.4103\/IJO.IJO_3382_22","volume":"72","author":"N \u00c7i\u00e7ek","year":"2024","unstructured":"\u00c7i\u00e7ek N, Demirayak B, Yigit FU. Evaluation of the macular sensitivity and retinal ganglion cell layer in unilateral amblyopia. Indian J Ophthalmol. 2024;72:232\u20135.","journal-title":"Indian J Ophthalmol"},{"key":"4036_CR26","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1080\/08820538.2022.2085513","volume":"37","author":"M Milla-Barrios","year":"2022","unstructured":"Milla-Barrios M, Pi\u00f1ero DP, Molina-Mart\u00edn A. Fixation pattern analysis with microperimetry in strabismic subjects: a pilot study. Semin Ophthalmol. 2022;37:699\u2013706.","journal-title":"Semin Ophthalmol"},{"key":"4036_CR27","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1167\/iovs.66.1.14","volume":"66","author":"Y Zhou","year":"2025","unstructured":"Zhou Y, Yu W, Ye Q, Xu Z, He Y, Yao Y, et al. Fixation stability deficits in anisometropic amblyopia. Investig Ophthalmol Vis Sci. 2025;66:14.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"4036_CR28","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1080\/08820538.2021.1890142","volume":"36","author":"S Wang","year":"2021","unstructured":"Wang S, Tian T, Zou L, Wu S, Liu Y, Wen W, et al. Fixation characteristics of severe amblyopia with eccentric fixation and central fixation assessed by the MP-1 microperimeter. Semin Ophthalmol. 2021;36:360\u20135.","journal-title":"Semin Ophthalmol"},{"key":"4036_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/8340729","volume":"2019","author":"A Miki","year":"2019","unstructured":"Miki A, Yamada Y, Nakamura M. The size of the foveal avascular zone is associated with foveal thickness and structure in premature children. J Ophthalmol. 2019;2019:1\u20135.","journal-title":"J Ophthalmol"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-04036-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-04036-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-04036-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:04:14Z","timestamp":1763424254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-04036-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":29,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["4036"],"URL":"https:\/\/doi.org\/10.1038\/s41433-025-04036-1","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"type":"print","value":"0950-222X"},{"type":"electronic","value":"1476-5454"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"18 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}