{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T21:16:45Z","timestamp":1769289405677,"version":"3.49.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1038\/s41433-025-04115-3","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:09:22Z","timestamp":1764090562000},"page":"201-206","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomechanical changes and associated factors of preserved SMILE-derived corneal stromal lenticules"],"prefix":"10.1038","volume":"40","author":[{"given":"Xiaosong","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2450-4137","authenticated-orcid":false,"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haipeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-1579","authenticated-orcid":false,"given":"Xingtao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-0980","authenticated-orcid":false,"given":"Meiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"4115_CR1","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1007\/s00417-019-04481-1","volume":"257","author":"T Han","year":"2019","unstructured":"Han T, Zhao F, Chen X, Miao H, Chen Z, Zhou X. Evaluation of disk halo size after small incision lenticule extraction (SMILE). Graefes Arch Clin Exp Ophthalmol. 2019;257:2789\u201393.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4115_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-016-0331-0","volume":"16","author":"T Han","year":"2016","unstructured":"Han T, Zheng K, Chen Y, Gao Y, He L, Zhou X. Four-year observation of predictability and stability of small incision lenticule extraction. BMC Ophthalmol. 2016;16:149.","journal-title":"BMC Ophthalmol"},{"key":"4115_CR3","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3928\/1081597X-20151021-01","volume":"31","author":"H Miao","year":"2015","unstructured":"Miao H, Tian M, Xu Y, Chen Y, Zhou X. Visual outcomes and optical quality after femtosecond laser small incision lenticule extraction: an 18-month prospective study. J Refract Surg. 2015;31:726\u201331.","journal-title":"J Refract Surg"},{"key":"4115_CR4","first-page":"753","volume":"23","author":"YC Liu","year":"2017","unstructured":"Liu YC, Williams GP, George BL, Soh YQ, Seah XY, Peh GSL, et al. Corneal lenticule storage before reimplantation. Mol Vis. 2017;23:753\u201364.","journal-title":"Mol Vis"},{"key":"4115_CR5","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1007\/s00417-017-3645-6","volume":"255","author":"MS Abd Elaziz","year":"2017","unstructured":"Abd Elaziz MS, Zaky AG, El SaebaySarhan AR. Stromal lenticule transplantation for management of corneal perforations; one year results. Graefes Arch Clin Exp Ophthalmol. 2017;255:1179\u201384.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4115_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/srep33848","volume":"6","author":"H Yin","year":"2016","unstructured":"Yin H, Qiu P, Wu F, Zhang W, Teng W, Qin Z, et al. Construction of a corneal stromal equivalent with SMILE-derived lenticules and fibrin glue. Sci Rep. 2016;6:33848.","journal-title":"Sci Rep"},{"key":"4115_CR7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3928\/1081597X-20211117-01","volume":"38","author":"S Liu","year":"2022","unstructured":"Liu S, Zhang X, Zhou X. Toric lenticule implantation for correction of hyperopia and astigmatism following small incision lenticule intrastromal keratoplasty with the triple marking method. J Refract Surg. 2022;38:82\u20138.","journal-title":"J Refract Surg"},{"key":"4115_CR8","doi-asserted-by":"publisher","first-page":"780","DOI":"10.3928\/1081597X-20160726-01","volume":"32","author":"A Lazaridis","year":"2016","unstructured":"Lazaridis A, Reinstein DZ, Archer TJ, Schulze S, Sekundo W. Refractive lenticule transplantation for correction of iatrogenic hyperopia and high astigmatism after LASIK. J Refract Surg. 2016;32:780\u20136.","journal-title":"J Refract Surg"},{"key":"4115_CR9","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1080\/02713683.2019.1597890","volume":"44","author":"G Liang","year":"2019","unstructured":"Liang G, Wang L, Pan Z, Zhang F. Comparison of the different preservative methods for refractive lenticules following SMILE. Curr Eye Res. 2019;44:832\u20139.","journal-title":"Curr Eye Res"},{"key":"4115_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108357","volume":"201","author":"F Xia","year":"2020","unstructured":"Xia F, Zhao J, Fu D, Xu Y, Yao P, Li M, et al. Optical transmittance and ultrastructure of SMILE-derived lenticules subjected to three different preservative methods. Exp Eye Res. 2020;201:108357.","journal-title":"Exp Eye Res"},{"key":"4115_CR11","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3928\/1081597X-20201030-03","volume":"37","author":"Y Shang","year":"2021","unstructured":"Shang Y, Li Y, Wang Z, Sun X, Zhang F. Risk evaluation of human corneal stromal lenticules from SMILE for reuse. J Refract Surg. 2021;37:32\u201340.","journal-title":"J Refract Surg"},{"key":"4115_CR12","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1097\/ICO.0000000000002846","volume":"41","author":"F Xia","year":"2022","unstructured":"Xia F, Zhao J, Fu D, Qin B, Chen Z, Zhao Y, et al. Comparison of the effects of temperature and dehydration mode on glycerin-based approaches to SMILE-derived lenticule preservation. Cornea. 2022;41:470\u20137.","journal-title":"Cornea"},{"key":"4115_CR13","volume":"2018","author":"C Xue","year":"2018","unstructured":"Xue C, Xiang Y, Shen M, Wu D, Wang Y. Preliminary investigation of the mechanical anisotropy of the normal human corneal stroma. J Ophthalmol. 2018;2018:5392041.","journal-title":"J Ophthalmol"},{"key":"4115_CR14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jmbbm.2018.05.042","volume":"85","author":"Y Xiang","year":"2018","unstructured":"Xiang Y, Shen M, Xue C, Wu D, Wang Y. Tensile biomechanical properties and constitutive parameters of human corneal stroma extracted by SMILE procedure. J Mech Behav Biomed Mater. 2018;85:102\u20138.","journal-title":"J Mech Behav Biomed Mater"},{"key":"4115_CR15","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3928\/1081597X-20140415-02","volume":"30","author":"H Miao","year":"2014","unstructured":"Miao H, He L, Shen Y, Li M, Yu Y, Zhou X. Optical quality and intraocular scattering after femtosecond laser small incision lenticule extraction. J Refract Surg. 2014;30:296\u2013302.","journal-title":"J Refract Surg"},{"key":"4115_CR16","doi-asserted-by":"crossref","unstructured":"Xu P, Londregan A, Rich C, Trinkaus-Randall V. Changes in epithelial and stromal corneal stiffness occur with age and obesity. Bioengineering. 2020;7:14\u201324.","DOI":"10.3390\/bioengineering7010014"},{"key":"4115_CR17","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.2147\/OPTH.S409014","volume":"17","author":"H Zhang","year":"2023","unstructured":"Zhang H, Deng Y, Li Z, Tang J. Update of research progress on small incision lenticule extraction (SMILE) lenticule reuse. Clin Ophthalmol. 2023;17:1423\u201331.","journal-title":"Clin Ophthalmol"},{"key":"4115_CR18","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1002\/jbm.a.36337","volume":"106","author":"J Nohava","year":"2018","unstructured":"Nohava J, Swain M, Lang SJ, Maier P, Heinzelmann S, Reinhard T, et al. Instrumented indentation for determination of mechanical properties of human cornea after ultraviolet-A crosslinking. J Biomed Mater Res A. 2018;106:1413\u201320.","journal-title":"J Biomed Mater Res A"},{"key":"4115_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2023.105802","volume":"142","author":"C Wang","year":"2023","unstructured":"Wang C, Shen M, Song Y, Chang L, Yang Y, Li Y, et al. Biaxial hyperelastic and anisotropic behaviors of the corneal anterior central stroma along the preferential fibril orientations. Part II: quantitative computational analysis of mechanical response of stromal components. J Mech Behav Biomed Mater. 2023;142:105802.","journal-title":"J Mech Behav Biomed Mater"},{"key":"4115_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-023-03048-3","volume":"23","author":"M Polachova","year":"2023","unstructured":"Polachova M, Netukova M, Benada O, Kucera T, Kolin V, Baxant AD, et al. The new future perspective in corneal tissue utilisation - methods of preparation and preservation. BMC Ophthalmol. 2023;23:294.","journal-title":"BMC Ophthalmol"},{"key":"4115_CR21","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s10561-021-09990-0","volume":"23","author":"M Nemcokova","year":"2022","unstructured":"Nemcokova M, Dite J, Klimesova YM, Netukova M, Studeny P. Preservation of corneal stromal lenticule: review. Cell Tissue Bank. 2022;23:627\u201339.","journal-title":"Cell Tissue Bank"},{"key":"4115_CR22","first-page":"3437","volume":"17","author":"K Mohamed-Noriega","year":"2011","unstructured":"Mohamed-Noriega K, Toh KP, Poh R, Balehosur D, Riau A, Htoon HM, et al. Cornea lenticule viability and structural integrity after refractive lenticule extraction (ReLEx) and cryopreservation. Mol Vis. 2011;17:3437\u201349.","journal-title":"Mol Vis"},{"key":"4115_CR23","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1097\/ICO.0000000000001876","volume":"38","author":"V Romano","year":"2019","unstructured":"Romano V, Levis HJ, Gallon P, Lace R, Borroni D, Ponzin D, et al. Biobanking of dehydrated human donor corneal stroma to increase the supply of anterior lamellar grafts. Cornea. 2019;38:480\u20134.","journal-title":"Cornea"},{"key":"4115_CR24","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1007\/s00417-018-4069-7","volume":"256","author":"TG Seiler","year":"2018","unstructured":"Seiler TG, Shao P, Frueh BE, Yun SH, Seiler T. The influence of hydration on different mechanical moduli of the cornea. Graefes Arch Clin Exp Ophthalmol. 2018;256:1653\u201360.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4115_CR25","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.exer.2013.07.016","volume":"116","author":"H Hatami-Marbini","year":"2013","unstructured":"Hatami-Marbini H, Etebu E. Hydration dependent biomechanical properties of the corneal stroma. Exp Eye Res. 2013;116:47\u201354.","journal-title":"Exp Eye Res"},{"key":"4115_CR26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1364\/BOE.9.000173","volume":"9","author":"JA Germann","year":"2018","unstructured":"Germann JA, Martinez-Enriquez E, Marcos S. Quantization of collagen organization in the stroma with a new order coefficient. Biomed Opt Express. 2018;9:173\u201389.","journal-title":"Biomed Opt Express"},{"key":"4115_CR27","doi-asserted-by":"crossref","unstructured":"Zhao J, Zhang Z, Xia F, Li G, Saiding Q, Xiang L, et al. Nutrient capsules maintain tear film homeostasis for human corneal lenticule transplantation. Chem Eng J. 2022;450;138078.","DOI":"10.1016\/j.cej.2022.138078"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-04115-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-04115-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-04115-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:37:52Z","timestamp":1769168272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41433-025-04115-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["4115"],"URL":"https:\/\/doi.org\/10.1038\/s41433-025-04115-3","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"26 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}