{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:05:22Z","timestamp":1793675122512,"version":"4.5.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1038\/s41433-026-04489-y","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T06:27:31Z","timestamp":1777012051000},"page":"1477-1482","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-term clinical outcomes in chronic ocular graft-versus-host disease: a retrospective cohort study"],"prefix":"10.1038","volume":"40","author":[{"given":"Karanvir","family":"Gill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-6164","authenticated-orcid":false,"given":"Barbara","family":"Burgos-Blasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaryamaan","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Iovieno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-8026","authenticated-orcid":false,"given":"Sonia N.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"4489_CR1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1053\/bbmt.2003.50026","volume":"9","author":"SJ Lee","year":"2003","unstructured":"Lee SJ, Vogelsang G, Flowers ME. Chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2003;9:215\u201333. https:\/\/doi.org\/10.1053\/bbmt.2003.50026.","journal-title":"Biol Blood Marrow Transplant"},{"key":"4489_CR2","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.jtct.2020.12.027","volume":"27","author":"CR Bachier","year":"2021","unstructured":"Bachier CR, Aggarwal SK, Hennegan K, Milgroom A, Francis K, Dehipawala S, et al. Epidemiology and treatment of chronic graft-versus-host disease post-allogeneic hematopoietic cell transplantation: a US claims analysis. Transplant Cell Ther. 2021;27:504. https:\/\/doi.org\/10.1016\/j.jtct.2020.12.027.","journal-title":"Transplant Cell Ther"},{"key":"4489_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaad.2022.12.024","volume":"90","author":"E Baumrin","year":"2024","unstructured":"Baumrin E, Loren AW, Falk SJ, Mays JW, Cowen EW. Chronic graft-versus-host disease. Part I: Epidemiology, pathogenesis, and clinical manifestations. J Am Acad Dermatol. 2024;90:1\u201316. https:\/\/doi.org\/10.1016\/j.jaad.2022.12.024.","journal-title":"J Am Acad Dermatol"},{"key":"4489_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.blre.2005.01.007","volume":"20","author":"ME Horwitz","year":"2006","unstructured":"Horwitz ME, Sullivan KM. Chronic graft-versus-host disease. Blood Rev. 2006;20:15\u201327. https:\/\/doi.org\/10.1016\/j.blre.2005.01.007.","journal-title":"Blood Rev"},{"key":"4489_CR5","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1056\/NEJMra1703472","volume":"377","author":"R Zeiser","year":"2017","unstructured":"Zeiser R, Blazar BR. Pathophysiology of chronic graft-versus-host disease and therapeutic targets. N Engl J Med. 2017;377:2565\u201379. https:\/\/doi.org\/10.1056\/NEJMra1703472.","journal-title":"N Engl J Med"},{"key":"4489_CR6","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","volume":"21","author":"MH Jagasia","year":"2015","unstructured":"Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant. 2015;21:389\u2013401. https:\/\/doi.org\/10.1016\/j.bbmt.2014.12.001.","journal-title":"Biol Blood Marrow Transplant"},{"key":"4489_CR7","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1016\/j.ophtha.2009.04.054","volume":"116","author":"KF Tabbara","year":"2009","unstructured":"Tabbara KF, Al-Ghamdi A, Al-Mohareb F, Ayas M, Chaudhri N, Al-Sharif F, et al. Ocular findings after allogeneic hematopoietic stem cell transplantation. Ophthalmology. 2009;116:1624\u20139. https:\/\/doi.org\/10.1016\/j.ophtha.2009.04.054.","journal-title":"Ophthalmology"},{"key":"4489_CR8","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/s41409-018-0090-z","volume":"53","author":"M Pathak","year":"2018","unstructured":"Pathak M, Diep PP, Lai X, Brinch L, Ruud E, Drolsum L. Ocular findings and ocular graft-versus-host disease after allogeneic stem cell transplantation without total body irradiation. Bone Marrow Transplant. 2018;53:863\u201372. https:\/\/doi.org\/10.1038\/s41409-018-0090-z.","journal-title":"Bone Marrow Transplant"},{"key":"4489_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ajo.2021.02.022","volume":"227","author":"M Pellegrini","year":"2021","unstructured":"Pellegrini M, Bernabei F, Barbato F, Arpinati M, Giannaccare G, Versura P, et al. Incidence, risk factors and complications of ocular graft-versus-host disease following hematopoietic stem cell transplantation. Am J Ophthalmol. 2021;227:25\u201334. https:\/\/doi.org\/10.1016\/j.ajo.2021.02.022.","journal-title":"Am J Ophthalmol"},{"key":"4489_CR10","doi-asserted-by":"publisher","first-page":"e0324703","DOI":"10.1371\/journal.pone.0324703","volume":"20","author":"Y Wang","year":"2025","unstructured":"Wang Y, Min Y, Sun Y, Xue M, Li F. Risk factors for ocular graft-versus-host disease: a systematic review and meta-analysis. PLoS One. 2025;20:e0324703. https:\/\/doi.org\/10.1371\/journal.pone.0324703.","journal-title":"PLoS One"},{"key":"4489_CR11","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1080\/09273948.2021.1939390","volume":"29","author":"JT Carreno-Galeano","year":"2021","unstructured":"Carreno-Galeano JT, Dohlman TH, Kim S, Yin J, Dana R. A review of ocular graft-versus-host disease: pathophysiology, clinical presentation and management. Ocul Immunol Inflamm. 2021;29:1190\u20139. https:\/\/doi.org\/10.1080\/09273948.2021.1939390.","journal-title":"Ocul Immunol Inflamm"},{"key":"4489_CR12","doi-asserted-by":"publisher","first-page":"6114","DOI":"10.3390\/ijms22116114","volume":"22","author":"Y Ogawa","year":"2021","unstructured":"Ogawa Y, Kawakami Y, Tsubota K. Cascade of inflammatory, fibrotic processes, and stress-induced senescence in chronic GVHD-related dry eye disease. Int J Mol Sci. 2021;22:6114. https:\/\/doi.org\/10.3390\/ijms22116114.","journal-title":"Int J Mol Sci"},{"key":"4489_CR13","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1016\/j.bbmt.2015.05.020","volume":"21","author":"YC Sun","year":"2015","unstructured":"Sun YC, Chai X, Inamoto Y, Pidala J, Martin PJ, Flowers MED, et al. Impact of Ocular chronic graft-versus-host disease on quality of life. Biol Blood Marrow Transplant. 2015;21:1687\u201391. https:\/\/doi.org\/10.1016\/j.bbmt.2015.05.020.","journal-title":"Biol Blood Marrow Transplant"},{"key":"4489_CR14","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00417-022-05812-5","volume":"261","author":"Y Liao","year":"2023","unstructured":"Liao Y, Zhao W, Yang J, Wu S, Jin L, Huang F, et al. Vision-specific and cancer-specific quality of life in ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Graefes Arch Clin Exp Ophthalmol. 2023;261:453\u201365. https:\/\/doi.org\/10.1007\/s00417-022-05812-5.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4489_CR15","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.jcjo.2020.04.013","volume":"55","author":"JCC Wang","year":"2020","unstructured":"Wang JCC, Mustafa M, Teichman JC, O\u2019Donnell H, Broady R, Yeung SN. Risk factors associated with severity of dry eye syndrome in ocular graft-versus-host disease. Can J Ophthalmol. 2020;55:366\u201372. https:\/\/doi.org\/10.1016\/j.jcjo.2020.04.013.","journal-title":"Can J Ophthalmol"},{"key":"4489_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17032-2","volume":"12","author":"HJ Yoon","year":"2022","unstructured":"Yoon HJ, Song GY, Yoon KC. Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease. Sci Rep. 2022;12:12985. https:\/\/doi.org\/10.1038\/s41598-022-17032-2.","journal-title":"Sci Rep"},{"key":"4489_CR17","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1016\/j.transproceed.2011.03.027","volume":"43","author":"P de la Parra-Col\u00edn","year":"2011","unstructured":"de la Parra-Col\u00edn P, Agahan AL, P\u00e9rez-Sim\u00f3n JA, L\u00f3pez A, Caballero D, Hern\u00e1ndez E, et al. Dry eye disease in chronic graft-versus-host disease: results from a Spanish retrospective cohort study. Transplant Proc. 2011;43:1934\u20138. https:\/\/doi.org\/10.1016\/j.transproceed.2011.03.027.","journal-title":"Transplant Proc"},{"key":"4489_CR18","doi-asserted-by":"publisher","first-page":"1133381","DOI":"10.3389\/fmed.2023.1133381","volume":"10","author":"C Tappeiner","year":"2023","unstructured":"Tappeiner C, Heiligenhaus A, Halter JP, Miserocchi E, Bandello F, Goldblum D. Challenges and concepts in the diagnosis and management of ocular graft-versus-host disease. Front Med. 2023;10:1133381. https:\/\/doi.org\/10.3389\/fmed.2023.1133381.","journal-title":"Front Med"},{"key":"4489_CR19","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.survophthal.2023.02.006","volume":"68","author":"M Soleimani","year":"2023","unstructured":"Soleimani M, Mahdavi Sharif P, Cheraqpour K, Koganti R, Masoumi A, Baharnoori SM, et al. Ocular graft-versus-host disease (oGVHD): from A to Z. Surv Ophthalmol. 2023;68:697\u2013712. https:\/\/doi.org\/10.1016\/j.survophthal.2023.02.006.","journal-title":"Surv Ophthalmol"},{"key":"4489_CR20","doi-asserted-by":"publisher","first-page":"S570","DOI":"10.1016\/j.jtct.2024.06.031","volume":"30","author":"PL Surico","year":"2024","unstructured":"Surico PL, Luo ZK. Understanding ocular graft-versus-host disease to facilitate an integrated multidisciplinary approach. Transplant Cell Ther. 2024;30:S570\u2013S84. https:\/\/doi.org\/10.1016\/j.jtct.2024.06.031.","journal-title":"Transplant Cell Ther"},{"key":"4489_CR21","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jtos.2025.04.006","volume":"37","author":"ZG Dabre","year":"2025","unstructured":"Dabre ZG, Sheth T, Hernandez E, Mun J, Hernandez D, Ascencio N, et al. Ocular graft-versus-host disease: experience, incidence, and treatment outcomes at a university-based tertiary care ophthalmology center. Ocul Surf. 2025;37:219\u201326. https:\/\/doi.org\/10.1016\/j.jtos.2025.04.006.","journal-title":"Ocul Surf"},{"key":"4489_CR22","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/s41409-020-0993-3","volume":"56","author":"H Jeppesen","year":"2021","unstructured":"Jeppesen H, Sengel\u00f8v H, Eriksson F, Kiilgaard JF, Andersen ST, Lindegaard J, et al. Chronic ocular graft-versus-host disease after allogeneic haematopoietic stem cell transplantation in Denmark - factors associated with risks and rates in adults according to conditioning regimen. Bone Marrow Transplant. 2021;56:144\u201354. https:\/\/doi.org\/10.1038\/s41409-020-0993-3.","journal-title":"Bone Marrow Transplant"},{"key":"4489_CR23","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1016\/j.jcjo.2024.04.005","volume":"60","author":"BG Pearson","year":"2025","unstructured":"Pearson BG, Cortez RS, Khimani KS, Gupta PK. Ocular screening for chronic graft-versus-host disease in patients with allogeneic hematopoietic stem cell transplant. Can J Ophthalmol. 2025;60:e11\u2013e5. https:\/\/doi.org\/10.1016\/j.jcjo.2024.04.005.","journal-title":"Can J Ophthalmol"},{"key":"4489_CR24","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1097\/ICO.0000000000002659","volume":"40","author":"M H\u00e9bert","year":"2021","unstructured":"H\u00e9bert M, Archambault C, Doyon C, Ospina LH, Robert MC. Risk factors for ocular involvement in pediatric graft-versus-host disease. Cornea. 2021;40:1158\u201364. https:\/\/doi.org\/10.1097\/ICO.0000000000002659.","journal-title":"Cornea"},{"key":"4489_CR25","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.2147\/OPTH.S463526","volume":"18","author":"MB Qureshi","year":"2024","unstructured":"Qureshi MB, Garcia JO, Quillen J, Mead-Harvey C, Wentz C, Nau CB, et al. Chronic ocular GVHD treatment at two locations of a tertiary referral center. Clin Ophthalmol. 2024;18:2731\u20139. https:\/\/doi.org\/10.2147\/OPTH.S463526.","journal-title":"Clin Ophthalmol"},{"key":"4489_CR26","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.18240\/ijo.2022.07.16","volume":"15","author":"T Aldebasi","year":"2022","unstructured":"Aldebasi T, Bashir R, Gangadharan S, Shaheen NA, Alhussain B, Almudhaiyan T, et al. Incidence of ocular manifestations in patients with graft versus host disease after allogeneic stem cell transplant in Riyadh, Saudi Arabia. Int J Ophthalmol. 2022;15:1149\u201356. https:\/\/doi.org\/10.18240\/ijo.2022.07.16.","journal-title":"Int J Ophthalmol"},{"key":"4489_CR27","doi-asserted-by":"publisher","first-page":"782.e1","DOI":"10.1016\/j.jtct.2022.07.027","volume":"28","author":"U Gehlsen","year":"2022","unstructured":"Gehlsen U, Stern ME, Franklin J, Tahmaz V, Hallek M, Holtick U, et al. Desiccating stress significantly increases the risk for chronic ocular graft-versus-host-disease. Transplant Cell Ther. 2022;28:782.e1\u2013782. https:\/\/doi.org\/10.1016\/j.jtct.2022.07.027.","journal-title":"Transplant Cell Ther"},{"key":"4489_CR28","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.ajo.2020.05.035","volume":"218","author":"S Sinha","year":"2020","unstructured":"Sinha S, Singh RB, Dohlman TH, Wang M, Taketani Y, Yin J, et al. Prevalence of persistent corneal epithelial defects in chronic ocular graft-versus-host disease. Am J Ophthalmol. 2020;218:296\u2013303. https:\/\/doi.org\/10.1016\/j.ajo.2020.05.035.","journal-title":"Am J Ophthalmol"},{"key":"4489_CR29","doi-asserted-by":"publisher","first-page":"962250","DOI":"10.3389\/fonc.2022.962250","volume":"12","author":"Y Xu","year":"2022","unstructured":"Xu Y, Wang YM, Sun ZT, Yang XL, Zhuang XY, Ren YR, et al. Corneal perforation associated with ocular graft-versus-host disease. Front Oncol. 2022;12:962250. https:\/\/doi.org\/10.3389\/fonc.2022.962250.","journal-title":"Front Oncol"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04489-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04489-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04489-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:21:28Z","timestamp":1783434088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04489-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["4489"],"URL":"https:\/\/doi.org\/10.1038\/s41433-026-04489-y","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"26 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}