{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:20:42Z","timestamp":1785522042378,"version":"3.56.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1038\/s41433-026-04616-9","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:39:11Z","timestamp":1780731551000},"page":"1598-1599","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Straatsma plus syndrome: beyond the classic triad"],"prefix":"10.1038","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6538-2033","authenticated-orcid":false,"given":"Hashim Ali","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Geetha","family":"Sravani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Aamir","family":"Shahzad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"4616_CR1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.survophthal.2007.08.016","volume":"52","author":"AB Tarabishy","year":"2007","unstructured":"Tarabishy AB, Alexandrou TJ, Traboulsi EI. Syndrome of myelinated retinal nerve fibers, myopia, and amblyopia: a review. Surv Ophthalmol. 2007;52:588\u201396.","journal-title":"Surv Ophthalmol"},{"key":"4616_CR2","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1177\/11206721241272182","volume":"35","author":"A Choudhary","year":"2025","unstructured":"Choudhary A, Kathare R, Gandhi P, Yadav NK, Prabhu V, Bavaskar S, et al. Characteristics of myelinated retinal nerve fibres in associated straatsma syndrome. Eur J Ophthalmol. 2025;35:689\u201394.","journal-title":"Eur J Ophthalmol"},{"key":"4616_CR3","first-page":"2672","volume":"36","author":"MX Repka","year":"1995","unstructured":"Repka MX, Tusa RJ. Refractive error and axial length in a primate model of strabismus and congenital nystagmus. Investig Ophthalmol Vis Sci. 1995;36:2672\u20137.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"4616_CR4","first-page":"416","volume":"67","author":"CP Blanca","year":"2023","unstructured":"Blanca CP, Isabel PC, Sergio IM, Candela CL, Honorio BG, Enrique EG. Straatsma Syndrome and cataract: case report and review of the literature. Rom J Ophthalmol. 2023;67:416\u20138.","journal-title":"Rom J Ophthalmol"},{"key":"4616_CR5","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1097\/OPX.0000000000000951","volume":"93","author":"SJ Bass","year":"2016","unstructured":"Bass SJ, Westcott J, Sherman J. OCT in a myelinated retinal nerve fiber syndrome with reduced vision. Optom Vis Sci. 2016;93:1285\u201391.","journal-title":"Optom Vis Sci"},{"key":"4616_CR6","doi-asserted-by":"publisher","first-page":"104794","DOI":"10.1016\/j.jaapos.2026.104794","volume":"30","author":"C Liu","year":"2026","unstructured":"Liu C, Lu H, Li S, Deng G, Ma J, Dong J, et al. Cooccurrence of myelinated retinal nerve fibers in pediatric unilateral persistent fetal vasculature: report of three cases. J AAPOS. 2026;30:104794.","journal-title":"J AAPOS"},{"key":"4616_CR7","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/pin.13270","volume":"72","author":"S Nojima","year":"2022","unstructured":"Nojima S. Class IV semaphorins in disease pathogenesis. Pathol Int. 2022;72:471\u201387.","journal-title":"Pathol Int"},{"key":"4616_CR8","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.ydbio.2005.11.007","volume":"290","author":"L Gao","year":"2006","unstructured":"Gao L, Macklin W, Gerson J, Miller RH. Intrinsic and extrinsic inhibition of oligodendrocyte development by rat retina. Dev Biol. 2006;290:277\u201386.","journal-title":"Dev Biol"},{"key":"4616_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101837","volume":"8","author":"I Elorza Ridaura","year":"2021","unstructured":"Elorza Ridaura I, Sorrentino S, Moroni L. Parallels between the developing vascular and neural systems: signaling pathways and future perspectives for regenerative medicine. Adv Sci. 2021;8:e2101837.","journal-title":"Adv Sci"},{"key":"4616_CR10","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ajoc.2017.10.003","volume":"8","author":"A Vide-Escada","year":"2017","unstructured":"Vide-Escada A, Prior Filipe H. Unusual Straatsma syndrome - how dogmatic is a bad prognosis? Am J Ophthalmol Case Rep. 2017;8:71\u20133.","journal-title":"Am J Ophthalmol Case Rep"},{"key":"4616_CR11","doi-asserted-by":"publisher","first-page":"952","DOI":"10.4103\/ijo.IJO_1518_18","volume":"67","author":"S Gupta","year":"2019","unstructured":"Gupta S, Shiny H, Bhukya RK, Jain S, Kumar V. Myelinated retinal nerve fibers and persistent hyperplastic primary vitreous. Indian J Ophthalmol. 2019;67:952.","journal-title":"Indian J Ophthalmol"},{"key":"4616_CR12","doi-asserted-by":"publisher","first-page":"e261","DOI":"10.1111\/aos.15228","volume":"101","author":"G Hallali","year":"2023","unstructured":"Hallali G, Loudon SE, Robson AG, Mohand-Said S, Zanlonghi X, Sahel JA, et al. Extensive myelinated retinal nerve fibres and bilateral foveal hypoplasia: a specific clinical entity. Acta Ophthalmol. 2023;101:e261\u2013e263.","journal-title":"Acta Ophthalmol"},{"key":"4616_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2024.102168","volume":"36","author":"A Usui-Ouchi","year":"2024","unstructured":"Usui-Ouchi A, Ebihara N, Nakao S. Macular hole retinal detachment in extensive myelinated retinal nerve fiber and high myopia with Straatsma syndrome: a case report. Am J Ophthalmol Case Rep. 2024;36:102168.","journal-title":"Am J Ophthalmol Case Rep"},{"key":"4616_CR14","doi-asserted-by":"publisher","first-page":"e244355","DOI":"10.1136\/bcr-2021-244355","volume":"14","author":"S Parida","year":"2021","unstructured":"Parida S, Padhy SK, Majhi D, Kelgaonkar A. Dome-shaped maculopathy in the setting of Straatsma syndrome. BMJ Case Rep. 2021;14:e244355.","journal-title":"BMJ Case Rep"},{"key":"4616_CR15","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/ICB.0000000000000137","volume":"9","author":"AT Juhn","year":"2015","unstructured":"Juhn AT, Houston SK, Mehta S. Bilateral Straatsma syndrome with nystagmus. Retina Cases Brief Rep. 2015;9:198\u2013200.","journal-title":"Retina Cases Brief Rep"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04616-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04616-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04616-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:10:54Z","timestamp":1785517854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04616-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["4616"],"URL":"https:\/\/doi.org\/10.1038\/s41433-026-04616-9","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]},"assertion":[{"value":"30 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}