{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:57:45Z","timestamp":1790780265161,"version":"4.1.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000272","name":"DH | National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eye"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate patient-reported outcome measures (PROMs) in biopsy-confirmed and treated conjunctival melanoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, cross-sectional observational case series assessing PROMs 1 year after initial treatment. A total of\u00a013 consecutive patients who underwent excision of newly diagnosed conjunctival melanoma between June and December 2023 in a single UK specialized tertiary center met the inclusion criteria. Of these, 11 patients (85%) completed the EORTC QLQ-C30 (Quality of Life of Cancer Patients) and QLQ-OPT30 (Quality of Life of Ophthalmic Cancer Patients) questionnaires. The 60 items assessed general health, ocular symptoms, functional status, psychosocial impacts, overall quality of life and health within the last week. Responses were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean scores across the 58 items ranged from 1.00 to 2.18\/4 (\u2018not at all 'to \u2018a little\u2019), indicating an overall mild impact. Patients were slightly limited in activities of daily living but more restricted in pursuing hobbies and social activities, which most did not attribute to their eyesight. Patients reported some symptoms of depression and worry, both generally and related to their health. Common ocular symptoms included: dry eye, watering, difficulty driving in the dark and difficulty judging distances. Overall health in the last week was rated 4.91\/7 and overall quality of life was 5.18\/7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is a paucity of research exploring quality of life in treated conjunctival melanoma. These findings can help inform patients and clinicians about potential long-term symptoms, functional difficulties and psychological effects, thereby managing expectations. Consequently, further endeavours can be directed to better support patients with conjunctival melanoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41433-026-04872-9","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:18:16Z","timestamp":1790777896000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient-reported outcome measures 1 year after conjunctival melanoma treatment using EORTC QLQ-C30 and QLQ-OPT30 questionnaires"],"prefix":"10.1038","author":[{"given":"Catharine","family":"Kwok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helya","family":"Aghazadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6193-7276","authenticated-orcid":false,"given":"Amr","family":"Wassef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1530-3824","authenticated-orcid":false,"given":"Mandeep S.","family":"Sagoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"4872_CR1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1001\/jamaophthalmol.2020.0531","volume":"138","author":"G Virgili","year":"2020","unstructured":"Virgili G, Parravano M, Gatta G, Capocaccia R, Mazzini C, Mallone S, et al. Incidence and survival of patients with conjunctival melanoma in Europe. JAMA Ophthalmol. 2020;138:601\u20138.","journal-title":"JAMA Ophthalmol"},{"key":"4872_CR2","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1001\/archopht.118.11.1497","volume":"118","author":"CL Shields","year":"2000","unstructured":"Shields CL, Shields JA, G\u00fcnd\u00fcz K, Cater J, Mercado GV, Gross N, et al. Conjunctival melanoma: risk factors for recurrence, exenteration, metastasis, and death in 150 consecutive patients. Arch Ophthalmol. 2000;118:1497\u2013507.","journal-title":"Arch Ophthalmol"},{"key":"4872_CR3","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1586\/17469899.2014.921119","volume":"9","author":"JR Wong","year":"2014","unstructured":"Wong JR, Nanji AA, Galor A, Karp CL. Management of conjunctival malignant melanoma: a review and update. Expert Rev Ophthalmol. 2014;9:185\u2013204.","journal-title":"Expert Rev Ophthalmol"},{"key":"4872_CR4","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1159\/000485189","volume":"4","author":"AR Afshar","year":"2018","unstructured":"Afshar AR, Deiner M, Allen G, Damato BE. The patient\u2019s experience of ocular melanoma in the US: a survey of the Ocular Melanoma Foundation. Ocul Oncol Pathol. 2018;4:280\u201390.","journal-title":"Ocul Oncol Pathol"},{"key":"4872_CR5","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/sj.eye.6700639","volume":"18","author":"Y Brandberg","year":"2004","unstructured":"Brandberg Y, Damato B, Kivel\u00e4 T, Kock E, Seregard S, et al. The EORTC ophthalmic oncology quality of life questionnaire module (EORTC QLQ-OPT30). Development and pre-testing (Phase I-III). Eye. 2004;18:283\u20139.","journal-title":"Eye"},{"key":"4872_CR6","unstructured":"Amin MB, Edge SB, Greene FL, Byrd DR, Brookland RK, Washington MK, et al. AJCC cancer staging manual: Springer, 2017. New York, NY, USA."},{"key":"4872_CR7","doi-asserted-by":"publisher","first-page":"116","DOI":"10.34172\/hpp.2020.19","volume":"10","author":"J Kim","year":"2020","unstructured":"Kim J, Kim J, Han A. The impact of leisure time physical activity on mental health and health perception among people with cancer. Health Promot Perspect. 2020;10:116\u201322.","journal-title":"Health Promot Perspect"},{"key":"4872_CR8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11764-016-0580-1","volume":"11","author":"S Catt","year":"2017","unstructured":"Catt S, Starkings R, Shilling V, Fallowfield L. Patient-reported outcome measures of the impact of cancer on patients\u2019 everyday lives: a systematic review. J Cancer Survivorship. 2017;11:211\u201332.","journal-title":"J Cancer Survivorship"},{"key":"4872_CR9","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s40257-019-00500-3","volume":"21","author":"JM Grimes","year":"2020","unstructured":"Grimes JM, Shah NV, Samie FH, Carvajal RD, Marr BP. Conjunctival melanoma: current treatments and future options. Am J Clin Dermatol. 2020;21:371\u201381.","journal-title":"Am J Clin Dermatol"},{"key":"4872_CR10","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/S0161-6420(88)33058-7","volume":"95","author":"FA Jakobiec","year":"1988","unstructured":"Jakobiec FA, Rini FJ, Fraunfelder FT, Brownstein S. Cryotherapy for conjunctival primary acquired melanosis and malignant melanoma: experience with 62 cases. Ophthalmology. 1988;95:1058\u201370.","journal-title":"Ophthalmology"},{"key":"4872_CR11","doi-asserted-by":"publisher","first-page":"P286","DOI":"10.1016\/j.ophtha.2018.10.023","volume":"126","author":"EK Akpek","year":"2019","unstructured":"Akpek EK, Amescua G, Farid M, Garcia-Ferrer FJ, Lin A, Rhee MK, et al. Dry eye syndrome preferred practice pattern\u00ae. Ophthalmology. 2019;126:P286\u2013P334.","journal-title":"Ophthalmology"},{"key":"4872_CR12","doi-asserted-by":"publisher","first-page":"181","DOI":"10.13181\/mji.oa.258027","volume":"34","author":"S Indrakila","year":"2025","unstructured":"Indrakila S, Soewoto W, Purnomo J, Malindha E, Asmara YV. Quality of life in Indonesian conjunctival tumor patients. Med J Indones. 2025;34:181\u20138.","journal-title":"Med J Indones"},{"key":"4872_CR13","doi-asserted-by":"publisher","first-page":"833","DOI":"10.2147\/OPTH.S155631","volume":"12","author":"ACV Wanzeler","year":"2018","unstructured":"Wanzeler ACV, Duarte B, de Andrade VDM, Alves M. Impact of conjunctival autograft on pterygium treatment: evaluation of related symptoms and patients\u2019 satisfaction after surgery. Clin Ophthalmol. 2018;12:833\u20137.","journal-title":"Clin Ophthalmol"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04872-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04872-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04872-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:18:18Z","timestamp":1790777898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41433-026-04872-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":13,"alternative-id":["4872"],"URL":"https:\/\/doi.org\/10.1038\/s41433-026-04872-9","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"26 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}