{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:25:00Z","timestamp":1793247900245,"version":"4.5.0"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"7-8","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01RX001940"],"award-info":[{"award-number":["I01RX001940"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01RX001940"],"award-info":[{"award-number":["I01RX001940"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Gene Ther"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1038\/s41434-019-0082-7","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T12:03:25Z","timestamp":1558526605000},"page":"308-323","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["AAV-encoded CaV2.2 peptide aptamer CBD3A6K for primary sensory neuron-targeted treatment of established neuropathic pain"],"prefix":"10.1038","volume":"26","author":[{"given":"Hongwei","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Min","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongman","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn H.","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"82_CR1","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1001\/jama.2014.12986","volume":"312","author":"VJ Dzau","year":"2014","unstructured":"Dzau VJ, Pizzo PA. Relieving pain in America: insights from an Institute of Medicine committee. JAMA. 2014;312:1507\u20138. \n                    https:\/\/doi.org\/10.1001\/jama.2014.12986","journal-title":"JAMA"},{"key":"82_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/AJP.0b013e318230f6c1","volume":"28","author":"JD Loeser","year":"2012","unstructured":"Loeser JD. Relieving pain in America. Clin J Pain. 2012;28:185\u20136. \n                    https:\/\/doi.org\/10.1097\/AJP.0b013e318230f6c1","journal-title":"Clin J Pain"},{"key":"82_CR3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139:267\u201384. \n                    https:\/\/doi.org\/10.1016\/j.cell.2009.09.028","journal-title":"Cell"},{"key":"82_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.neuro.051508.135531","volume":"32","author":"M Costigan","year":"2009","unstructured":"Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci. 2009;32:1\u201332. \n                    https:\/\/doi.org\/10.1146\/annurev.neuro.051508.135531","journal-title":"Annu Rev Neurosci"},{"key":"82_CR5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuron.2006.09.021","volume":"52","author":"JN Campbell","year":"2006","unstructured":"Campbell JN, Meyer RA. Mechanisms of neuropathic pain. Neuron. 2006;52:77\u201392. \n                    https:\/\/doi.org\/10.1016\/j.neuron.2006.09.021","journal-title":"Neuron"},{"key":"82_CR6","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1113\/jphysiol.2010.204735","volume":"589","author":"G Bucci","year":"2011","unstructured":"Bucci G, Mochida S, Stephens GJ. Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca(2)+ channel peptides. J Physiol. 2011;589:3085\u2013101. \n                    https:\/\/doi.org\/10.1113\/jphysiol.2010.204735","journal-title":"J Physiol"},{"key":"82_CR7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0896-6273(03)00801-8","volume":"41","author":"TJ Bell","year":"2004","unstructured":"Bell TJ, Thaler C, Castiglioni AJ, Helton TD, Lipscombe D. Cell-specific alternative splicing increases calcium channel current density in the pain pathway. Neuron. 2004;41:127\u201338.","journal-title":"Neuron"},{"key":"82_CR8","doi-asserted-by":"publisher","first-page":"6363","DOI":"10.1523\/JNEUROSCI.0307-07.2007","volume":"27","author":"C Altier","year":"2007","unstructured":"Altier C, Dale CS, Kisilevsky AE, Chapman K, Castiglioni AJ, Matthews EA, et al. Differential role of N-type calcium channel splice isoforms in pain. J Neurosci. 2007;27:6363\u201373. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.0307-07.2007","journal-title":"J Neurosci"},{"key":"82_CR9","doi-asserted-by":"publisher","first-page":"4076","DOI":"10.1523\/JNEUROSCI.0356-09.2009","volume":"29","author":"CS Bauer","year":"2009","unstructured":"Bauer CS, Nieto-Rostro M, Rahman W, Tran-Van-Minh A, Ferron L, Douglas L, et al. The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin. J Neurosci. 2009;29:4076\u201388. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.0356-09.2009","journal-title":"J Neurosci"},{"key":"82_CR10","doi-asserted-by":"publisher","first-page":"reE14","DOI":"10.1126\/stke.2522004re14","volume":"2004","author":"RR Ji","year":"2004","unstructured":"Ji RR, Strichartz G. Cell signaling and the genesis of neuropathic pain. Sci STKE. 2004;2004:reE14 \n                    https:\/\/doi.org\/10.1126\/stke.2522004re14","journal-title":"Sci STKE"},{"key":"82_CR11","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.bmcl.2010.11.067","volume":"21","author":"S Tyagarajan","year":"2011","unstructured":"Tyagarajan S, Chakravarty PK, Park M, Zhou B, Herrington JB, Ratliff K, et al. A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain. Bioorg Med Chem Lett. 2011;21:869\u201373. \n                    https:\/\/doi.org\/10.1016\/j.bmcl.2010.11.067","journal-title":"Bioorg Med Chem Lett"},{"key":"82_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00275-9","volume":"7","author":"M Liang","year":"2017","unstructured":"Liang M, Yin XL, Shi HB, Li CY, Li XY, Song NY, et al. Bilirubin augments Ca(2+) load of developing bushy neurons by targeting specific subtype of voltage-gated calcium channels. Sci Rep. 2017;7:431 \n                    https:\/\/doi.org\/10.1038\/s41598-017-00275-9","journal-title":"Sci Rep"},{"key":"82_CR13","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.2174\/138161208785777478","volume":"14","author":"RS Norton","year":"2008","unstructured":"Norton RS, McDonough SI. Peptides targeting voltage-gated calcium channels. Curr Pharm Des. 2008;14:2480\u201391.","journal-title":"Curr Pharm Des"},{"key":"82_CR14","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.nurt.2009.07.006","volume":"6","author":"D Perret","year":"2009","unstructured":"Perret D, Luo ZD. Targeting voltage-gated calcium channels for neuropathic pain management. Neurotherapeutics. 2009;6:679\u201392. \n                    https:\/\/doi.org\/10.1016\/j.nurt.2009.07.006","journal-title":"Neurotherapeutics"},{"key":"82_CR15","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1517\/13543784.2011.600686","volume":"20","author":"T Pexton","year":"2011","unstructured":"Pexton T, Moeller-Bertram T, Schilling JM, Wallace MS. Targeting voltage-gated calcium channels for the treatment of neuropathic pain: a review of drug development. Expert Opin Investig Drugs. 2011;20:1277\u201384. \n                    https:\/\/doi.org\/10.1517\/13543784.2011.600686","journal-title":"Expert Opin Investig Drugs"},{"key":"82_CR16","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/j.1476-5381.2012.02082.x","volume":"167","author":"S Vink","year":"2012","unstructured":"Vink S, Alewood PF. Targeting voltage-gated calcium channels: developments in peptide and small-molecule inhibitors for the treatment of neuropathic pain. Br J Pharmacol. 2012;167:970\u201389. \n                    https:\/\/doi.org\/10.1111\/j.1476-5381.2012.02082.x","journal-title":"Br J Pharmacol"},{"key":"82_CR17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nrd.2015.5","volume":"15","author":"GW Zamponi","year":"2016","unstructured":"Zamponi GW. Targeting voltage-gated calcium channels in neurological and psychiatric diseases. Nat Rev Drug Discov. 2016;15:19\u201334. \n                    https:\/\/doi.org\/10.1038\/nrd.2015.5","journal-title":"Nat Rev Drug Discov"},{"key":"82_CR18","doi-asserted-by":"publisher","first-page":"510","DOI":"10.4161\/chan.4.6.12869","volume":"4","author":"J Park","year":"2010","unstructured":"Park J, Luo ZD. Calcium channel functions in pain processing. Channels. 2010;4:510\u20137.","journal-title":"Channels"},{"key":"82_CR19","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1111\/bph.13789","volume":"175","author":"R Patel","year":"2018","unstructured":"Patel R, Montagut-Bordas C, Dickenson AH. Calcium channel modulation as a target in chronic pain control. Br J Pharmacol. 2018;175:2173\u201384. \n                    https:\/\/doi.org\/10.1111\/bph.13789","journal-title":"Br J Pharmacol"},{"key":"82_CR20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S1359-6446(05)03662-7","volume":"11","author":"JG McGivern","year":"2006","unstructured":"McGivern JG. Targeting N-type and T-type calcium channels for the treatment of pain. Drug Discov Today. 2006;11:245\u201353. \n                    https:\/\/doi.org\/10.1016\/S1359-6446(05)03662-7","journal-title":"Drug Discov Today"},{"key":"82_CR21","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/nm.2345","volume":"17","author":"JM Brittain","year":"2011","unstructured":"Brittain JM, Duarte DB, Wilson SM, Zhu W, Ballard C, Johnson PL, et al. Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca(2)(+) channel complex. Nat Med. 2011;17:822\u20139. \n                    https:\/\/doi.org\/10.1038\/nm.2345","journal-title":"Nat Med"},{"key":"82_CR22","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1097\/j.pain.0000000000001026","volume":"158","author":"A Moutal","year":"2017","unstructured":"Moutal A, Wang Y, Yang X, Ji Y, Luo S, Dorame A, et al. Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors. Pain. 2017;158:2203\u201321. \n                    https:\/\/doi.org\/10.1097\/j.pain.0000000000001026","journal-title":"Pain"},{"key":"82_CR23","doi-asserted-by":"publisher","first-page":"529","DOI":"10.2174\/1566524043360519","volume":"4","author":"F Hoppe-Seyler","year":"2004","unstructured":"Hoppe-Seyler F, Crnkovic-Mertens I, Tomai E, Butz K. Peptide aptamers: specific inhibitors of protein function. Curr Mol Med. 2004;4:529\u201338.","journal-title":"Curr Mol Med"},{"key":"82_CR24","doi-asserted-by":"publisher","first-page":"31375","DOI":"10.1074\/jbc.M109.009951","volume":"284","author":"JM Brittain","year":"2009","unstructured":"Brittain JM, Piekarz AD, Wang Y, Kondo T, Cummins TR, Khanna R. An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels. J Biol Chem. 2009;284:31375\u201390. \n                    https:\/\/doi.org\/10.1074\/jbc.M109.009951","journal-title":"J Biol Chem"},{"key":"82_CR25","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1097\/j.pain.0000000000000147","volume":"156","author":"L Francois-Moutal","year":"2015","unstructured":"Francois-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, et al. A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain. 2015;156:1247\u201364. \n                    https:\/\/doi.org\/10.1097\/j.pain.0000000000000147","journal-title":"Pain"},{"key":"82_CR26","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1097\/j.pain.0000000000000628","volume":"157","author":"JY Xie","year":"2016","unstructured":"Xie JY, Chew LA, Yang X, Wang Y, Qu C, Wang Y, et al. Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential. Pain. 2016;157:2124\u201340. \n                    https:\/\/doi.org\/10.1097\/j.pain.0000000000000628","journal-title":"Pain"},{"key":"82_CR27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.neuron.2014.03.016","volume":"82","author":"BA Simms","year":"2014","unstructured":"Simms BA, Zamponi GW. Neuronal voltage-gated calcium channels: structure, function, and dysfunction. Neuron. 2014;82:24\u201345. \n                    https:\/\/doi.org\/10.1016\/j.neuron.2014.03.016","journal-title":"Neuron"},{"key":"82_CR28","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1242\/jcs.053280","volume":"122","author":"XX Chi","year":"2009","unstructured":"Chi XX, Schmutzler BS, Brittain JM, Wang Y, Hingtgen CM, Nicol GD, et al. Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons. J Cell Sci. 2009;122:4351\u201362. \n                    https:\/\/doi.org\/10.1242\/jcs.053280","journal-title":"J Cell Sci"},{"key":"82_CR29","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/gt.2013.56","volume":"21","author":"G Fischer","year":"2014","unstructured":"Fischer G, Pan B, Vilceanu D, Hogan QH, Yu H. Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion. Gene Ther. 2014;21:44\u201351. \n                    https:\/\/doi.org\/10.1038\/gt.2013.56","journal-title":"Gene Ther"},{"key":"82_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-8-54","volume":"8","author":"AD Piekarz","year":"2012","unstructured":"Piekarz AD, Due MR, Khanna M, Wang B, Ripsch MS, Wang R, et al. CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy. Mol Pain. 2012;8:54 \n                    https:\/\/doi.org\/10.1186\/1744-8069-8-54","journal-title":"Mol Pain"},{"key":"82_CR31","doi-asserted-by":"publisher","first-page":"e61266","DOI":"10.1371\/journal.pone.0061266","volume":"8","author":"H Yu","year":"2013","unstructured":"Yu H, Fischer G, Ferhatovic L, Fan F, Light AR, Weihrauch D, et al. Intraganglionic AAV6 results in efficient and long-term gene transfer to peripheral sensory nervous system in adult rats. PLoS ONE. 2013;8:e61266 \n                    https:\/\/doi.org\/10.1371\/journal.pone.0061266","journal-title":"PLoS One"},{"key":"82_CR32","doi-asserted-by":"publisher","first-page":"9491","DOI":"10.1523\/JNEUROSCI.23-29-09491.2003","volume":"23","author":"DI Hughes","year":"2003","unstructured":"Hughes DI, Scott DT, Todd AJ, Riddell JS. Lack of evidence for sprouting of Abeta afferents into the superficial laminas of the spinal cord dorsal horn after nerve section. J Neurosci. 2003;23:9491\u20139.","journal-title":"J Neurosci"},{"key":"82_CR33","doi-asserted-by":"publisher","first-page":"14086","DOI":"10.1523\/JNEUROSCI.1969-15.2015","volume":"35","author":"H Yu","year":"2015","unstructured":"Yu H, Pan B, Weyer A, Wu HE, Meng J, Fischer G, et al. CaMKII controls whether touch is painful. J Neurosci. 2015;35:14086\u2013102. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.1969-15.2015","journal-title":"J Neurosci"},{"key":"82_CR34","doi-asserted-by":"publisher","first-page":"5891","DOI":"10.1523\/JNEUROSCI.3997-14.2015","volume":"35","author":"M D\u2019Arco","year":"2015","unstructured":"D\u2019Arco M, Margas W, Cassidy JS, Dolphin AC. The upregulation of alpha2delta-1 subunit modulates activity-dependent Ca2+signals in sensory neurons. J Neurosci. 2015;35:5891\u2013903. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.3997-14.2015","journal-title":"J Neurosci"},{"key":"82_CR35","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.pain.2010.08.030","volume":"151","author":"SG Lu","year":"2010","unstructured":"Lu SG, Zhang XL, Luo ZD, Gold MS. Persistent inflammation alters the density and distribution of voltage-activated calcium channels in subpopulations of rat cutaneous DRG neurons. Pain. 2010;151:633\u201343. \n                    https:\/\/doi.org\/10.1016\/j.pain.2010.08.030","journal-title":"Pain"},{"key":"82_CR36","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/nature11033","volume":"486","author":"MB Hoppa","year":"2012","unstructured":"Hoppa MB, Lana B, Margas W, Dolphin AC, Ryan T. A. alpha2delta expression sets presynaptic calcium channel abundance and release probability. Nature. 2012;486:122\u20135. \n                    https:\/\/doi.org\/10.1038\/nature11033","journal-title":"Nature"},{"key":"82_CR37","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/0896-6273(92)90069-P","volume":"9","author":"RE Westenbroek","year":"1992","unstructured":"Westenbroek RE, Hell JW, Warner C, Dubel SJ, Snutch TP, Catterall WA. Biochemical properties and subcellular distribution of an N-type calcium channel alpha 1 subunit. Neuron. 1992;9:1099\u2013115.","journal-title":"Neuron"},{"key":"82_CR38","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1007\/s00221-002-1217-3","volume":"147","author":"D Cizkova","year":"2002","unstructured":"Cizkova D, Marsala J, Lukacova N, Marsala M, Jergova S, Orendacova J, et al. Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury. Exp Brain Res. 2002;147:456\u201363. \n                    https:\/\/doi.org\/10.1007\/s00221-002-1217-3","journal-title":"Exp Brain Res"},{"key":"82_CR39","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nrn2947","volume":"11","author":"AJ Todd","year":"2010","unstructured":"Todd AJ. Neuronal circuitry for pain processing in the dorsal horn. Nat Rev Neurosci. 2010;11:823\u201336. \n                    https:\/\/doi.org\/10.1038\/nrn2947","journal-title":"Nat Rev Neurosci"},{"key":"82_CR40","doi-asserted-by":"publisher","first-page":"449","DOI":"10.4161\/chan.5.5.17363","volume":"5","author":"SM Wilson","year":"2011","unstructured":"Wilson SM, Brittain JM, Piekarz AD, Ballard CJ, Ripsch MS, Cummins TR, et al. Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex. Channels. 2011;5:449\u201356. \n                    https:\/\/doi.org\/10.4161\/chan.5.5.17363","journal-title":"Channels"},{"key":"82_CR41","doi-asserted-by":"publisher","DOI":"10.1177\/1744806917717040","volume":"13","author":"H Xiang","year":"2017","unstructured":"Xiang H, Liu Z, Wang F, Xu H, Roberts C, Fischer G, et al. Primary sensory neuron-specific interference of TRPV1 signaling by AAV-encoded TRPV1 peptide aptamer attenuates neuropathic pain. Mol Pain. 2017;13:1744806917717040 \n                    https:\/\/doi.org\/10.1177\/1744806917717040","journal-title":"Mol Pain"},{"key":"82_CR42","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/0014-4886(91)90087-S","volume":"114","author":"JE Swett","year":"1991","unstructured":"Swett JE, Torigoe Y, Elie VR, Bourassa CM, Miller PG. Sensory neurons of the rat sciatic nerve. Exp Neurol. 1991;114:82\u2013103.","journal-title":"Exp Neurol"},{"key":"82_CR43","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1046\/j.1460-9568.2003.03083.x","volume":"19","author":"B Heinke","year":"2004","unstructured":"Heinke B, Balzer E, Sandkuhler J. Pre- and postsynaptic contributions of voltage-dependent Ca2+channels to nociceptive transmission in rat spinal lamina I neurons. Eur J Neurosci. 2004;19:103\u201311.","journal-title":"Eur J Neurosci"},{"key":"82_CR44","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1113\/jphysiol.2006.125880","volume":"580","author":"BK Rycroft","year":"2007","unstructured":"Rycroft BK, Vikman KS, Christie MJ. Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn. J Physiol. 2007;580:883\u201394. \n                    https:\/\/doi.org\/10.1113\/jphysiol.2006.125880","journal-title":"J Physiol"},{"key":"82_CR45","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.neuron.2017.10.028","volume":"96","author":"Z Chai","year":"2017","unstructured":"Chai Z, Wang C, Huang R, Wang Y, Zhang X, Wu Q, et al. CaV2.2 gates calcium-independent but voltage-dependent secretion in mammalian sensory neurons. Neuron. 2017;96:1317\u201326. \n                    https:\/\/doi.org\/10.1016\/j.neuron.2017.10.028\n                    \n                  . e1314","journal-title":"Neuron"},{"key":"82_CR46","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1016\/j.celrep.2018.01.073","volume":"22","author":"FX Zhang","year":"2018","unstructured":"Zhang FX, Gadotti VM, Souza IA, Chen L, Zamponi GW. BK potassium channels suppress cavalpha2delta subunit function to reduce inflammatory and neuropathic pain. Cell Rep. 2018;22:1956\u201364. \n                    https:\/\/doi.org\/10.1016\/j.celrep.2018.01.073","journal-title":"Cell Rep"},{"key":"82_CR47","doi-asserted-by":"publisher","first-page":"13943","DOI":"10.1073\/pnas.220389697","volume":"97","author":"I Bezprozvanny","year":"2000","unstructured":"Bezprozvanny I, Zhong P, Scheller RH, Tsien RW. Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating. Proc Natl Acad Sci USA. 2000;97:13943\u20138. \n                    https:\/\/doi.org\/10.1073\/pnas.220389697","journal-title":"Proc Natl Acad Sci USA"},{"key":"82_CR48","doi-asserted-by":"publisher","first-page":"8979","DOI":"10.1073\/pnas.1403731111","volume":"111","author":"JS Cassidy","year":"2014","unstructured":"Cassidy JS, Ferron L, Kadurin I, Pratt WS, Dolphin AC. Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary alpha2delta-1 subunits. Proc Natl Acad Sci USA. 2014;111:8979\u201384. \n                    https:\/\/doi.org\/10.1073\/pnas.1403731111","journal-title":"Proc Natl Acad Sci USA"},{"key":"82_CR49","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/0306-4522(94)00476-L","volume":"65","author":"M Diverse-Pierluissi","year":"1995","unstructured":"Diverse-Pierluissi M, Dunlap K. Interaction of convergent pathways that inhibit N-type calcium currents in sensory neurons. Neuroscience. 1995;65:477\u201383.","journal-title":"Neuroscience"},{"key":"82_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/srep43802","volume":"7","author":"I Kadurin","year":"2017","unstructured":"Kadurin I, Rothwell SW, Lana B, Nieto-Rostro M, Dolphin AC. LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary alpha2delta-1 subunit. Sci Rep. 2017;7:43802 \n                    https:\/\/doi.org\/10.1038\/srep43802","journal-title":"Sci Rep"},{"key":"82_CR51","doi-asserted-by":"publisher","first-page":"6984","DOI":"10.1523\/JNEUROSCI.1137-05.2005","volume":"25","author":"J Leroy","year":"2005","unstructured":"Leroy J, Richards MW, Butcher AJ, Nieto-Rostro M, Pratt WS, Davies A, et al. Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties. J Neurosci. 2005;25:6984\u201396. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.1137-05.2005","journal-title":"J Neurosci"},{"key":"82_CR52","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1097\/00000542-199603000-00019","volume":"84","author":"K Omote","year":"1996","unstructured":"Omote K, Kawamata M, Satoh O, Iwasaki H, Namiki A. Spinal antinociceptive action of an N-Type voltage-dependent calcium channel blocker and the synergistic interaction with morphine. Anesthesiology. 1996;84:636\u201343.","journal-title":"Anesthesiology"},{"key":"82_CR53","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/379451a0","volume":"379","author":"ZH Sheng","year":"1996","unstructured":"Sheng ZH, Rettig J, Cook T, Catterall WA. Calcium-dependent interaction of N-type calcium channels with the synaptic core complex. Nature. 1996;379:451\u20134. \n                    https:\/\/doi.org\/10.1038\/379451a0","journal-title":"Nature"},{"issue":"6","key":"82_CR54","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1111\/jnc.12070","volume":"124","author":"Weina Ju","year":"2013","unstructured":"Ju W, Li Q, Allette YM, Ripsch MS, White FA & Khanna R. Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide. J Neurochem. \n                    https:\/\/doi.org\/10.1111\/jnc.12070\n                    \n                   (2012).","journal-title":"Journal of Neurochemistry"},{"key":"82_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2478\/s13380-012-0002-4","volume":"3","author":"MS Ripsch","year":"2012","unstructured":"Ripsch MS, Ballard CJ, Khanna M, Hurley JH, White FA, Khanna R. A Peptide uncoupling crmp-2 from the presynaptic ca(2+) channel complex demonstrates efficacy in animal models of migraine and aids therapy-induced neuropathy. Transl Neurosci. 2012;3:1\u20138. \n                    https:\/\/doi.org\/10.2478\/s13380-012-0002-4","journal-title":"Transl Neurosci"},{"key":"82_CR56","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1177\/1073858413514278","volume":"20","author":"JP Ip","year":"2014","unstructured":"Ip JP, Fu AK, Ip NY. CRMP2: functional roles in neural development and therapeutic potential in neurological diseases. Neuroscientist. 2014;20:589\u201398. \n                    https:\/\/doi.org\/10.1177\/1073858413514278","journal-title":"Neuroscientist"},{"key":"82_CR57","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1046\/j.1471-4159.2003.01920.x","volume":"86","author":"Y Suzuki","year":"2003","unstructured":"Suzuki Y, Nakagomi S, Namikawa K, Kiryu-Seo S, Inagaki N, Kaibuchi K, et al. Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat. J Neurochem. 2003;86:1042\u201350.","journal-title":"J Neurochem"},{"key":"82_CR58","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1097\/00003643-201306001-00669","volume":"30","author":"Y Kamiya","year":"2013","unstructured":"Kamiya Y, Saeki K, Takiguchi M. CDK5, CRMP2 and NR2B in spinal dorsal horn and dorsal root ganglion have different role in pain signaling between neuropathic pain model and inflammatory pain model. Eur J Anaesthesiol. 2013;30:214.","journal-title":"Eur J Anaesthesiol"},{"key":"82_CR59","doi-asserted-by":"publisher","first-page":"692","DOI":"10.4103\/1673-5374.206631","volume":"12","author":"JN Zhang","year":"2017","unstructured":"Zhang JN, Koch JC. Collapsin response mediator protein-2 plays a major protective role in acute axonal degeneration. Neural Regen Res. 2017;12:692\u20135. \n                    https:\/\/doi.org\/10.4103\/1673-5374.206631","journal-title":"Neural Regen Res"},{"key":"82_CR60","doi-asserted-by":"publisher","unstructured":"Moutal A, Luo S, Largent-Milnes, TM, Vanderah TW, Khanna R. Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain. Neurobiol Pain. In press, \n                    https:\/\/doi.org\/10.1016\/j.ynpai.2018.1007.1003\n                    \n                   (2018).","DOI":"10.1016\/j.ynpai.2018.1007.1003"},{"key":"82_CR61","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1111\/j.1469-7793.1998.881bs.x","volume":"507","author":"V Chapman","year":"1998","unstructured":"Chapman V, Suzuki R, Dickenson AH. Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5-L6. J Physiol. 1998;507:881\u201394.","journal-title":"J Physiol"},{"key":"82_CR62","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0304-3959(96)03023-0","volume":"66","author":"K Takaishi","year":"1996","unstructured":"Takaishi K, Eisele JH Jr., Carstens E. Behavioral and electrophysiological assessment of hyperalgesia and changes in dorsal horn responses following partial sciatic nerve ligation in rats. Pain. 1996;66:297\u2013306.","journal-title":"Pain"},{"key":"82_CR63","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1152\/jn.1992.67.6.1562","volume":"67","author":"J Palecek","year":"1992","unstructured":"Palecek J, Paleckova V, Dougherty PM, Carlton SM, Willis WD. Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy. J Neurophysiol. 1992;67:1562\u201373. \n                    https:\/\/doi.org\/10.1152\/jn.1992.67.6.1562","journal-title":"J Neurophysiol"},{"key":"82_CR64","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1152\/jn.1993.69.6.2072","volume":"69","author":"JM Laird","year":"1993","unstructured":"Laird JM, Bennett GJ. An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy. J Neurophysiol. 1993;69:2072\u201385. \n                    https:\/\/doi.org\/10.1152\/jn.1993.69.6.2072","journal-title":"J Neurophysiol"},{"key":"82_CR65","doi-asserted-by":"publisher","first-page":"7470","DOI":"10.1074\/jbc.M113.518472","volume":"289","author":"T Brustovetsky","year":"2014","unstructured":"Brustovetsky T, Pellman JJ, Yang XF, Khanna R, Brustovetsky N. Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+\/Ca2+exchanger and regulates their functional activity. J Biol Chem. 2014;289:7470\u201382. \n                    https:\/\/doi.org\/10.1074\/jbc.M113.518472","journal-title":"J Biol Chem"},{"key":"82_CR66","doi-asserted-by":"publisher","first-page":"24316","DOI":"10.1074\/jbc.M113.474924","volume":"288","author":"ET Dustrude","year":"2013","unstructured":"Dustrude ET, Wilson SM, Ju W, Xiao Y, Khanna R. CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking. J Biol Chem. 2013;288:24316\u201331. \n                    https:\/\/doi.org\/10.1074\/jbc.M113.474924","journal-title":"J Biol Chem"},{"issue":"1","key":"82_CR67","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4161\/chan.18919","volume":"6","author":"Joel M. Brittain","year":"2012","unstructured":"Brittain JM, Pan R, You H, Brustovetsky T, Brustovetsky N, Zamponi GW, et al. Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model. Channels (Austin) 2012;6:52\u201359.","journal-title":"Channels"},{"key":"82_CR68","doi-asserted-by":"publisher","first-page":"427","DOI":"10.15252\/embj.201796692","volume":"37","author":"AH Kanellopoulos","year":"2018","unstructured":"Kanellopoulos AH, Koenig J, Huang H, Pyrski M, Millet Q, Lolignier S, et al. Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice. Embo J. 2018;37:427\u201345. \n                    https:\/\/doi.org\/10.15252\/embj.201796692","journal-title":"Embo J"},{"key":"82_CR69","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1247\/csf.17025","volume":"43","author":"T Sumi","year":"2018","unstructured":"Sumi T, Imasaki T, Aoki M, Sakai N, Nitta E, Shirouzu M, et al. Structural insights into the altering function of CRMP2 by phosphorylation. Cell Struct Funct. 2018;43:15\u201323. \n                    https:\/\/doi.org\/10.1247\/csf.17025","journal-title":"Cell Struct Funct"},{"key":"82_CR70","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3389\/fncel.2014.00135","volume":"8","author":"SM Wilson","year":"2014","unstructured":"Wilson SM, Ki Yeon S, Yang XF, Park KD, Khanna R. Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ss and CDK5 following traumatic brain injury. Front Cell Neurosci. 2014;8:135 \n                    https:\/\/doi.org\/10.3389\/fncel.2014.00135","journal-title":"Front Cell Neurosci"},{"key":"82_CR71","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.1016\/j.febslet.2012.09.022","volume":"586","author":"JM Brittain","year":"2012","unstructured":"Brittain JM, Wang Y, Eruvwetere O, Khanna R. Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2. FEBS Lett. 2012;586:3813\u20138. \n                    https:\/\/doi.org\/10.1016\/j.febslet.2012.09.022","journal-title":"FEBS Lett"},{"key":"82_CR72","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/papr.12602","volume":"18","author":"RB Bolash","year":"2018","unstructured":"Bolash RB, Niazi T, Kumari M, Azer G, Mekhail N. Efficacy of a targeted drug delivery on-demand bolus option for chronic pain. Pain Pract. 2018;18:305\u201313. \n                    https:\/\/doi.org\/10.1111\/papr.12602","journal-title":"Pain Pract"},{"key":"82_CR73","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1093\/pm\/pnv058","volume":"17","author":"SM Hayek","year":"2016","unstructured":"Hayek SM, Sweet JA, Miller JP, Sayegh RR. Successful management of corneal neuropathic pain with intrathecal targeted drug delivery. Pain Med. 2016;17:1302\u20137. \n                    https:\/\/doi.org\/10.1093\/pm\/pnv058","journal-title":"Pain Med"},{"key":"82_CR74","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1080\/14728222.2017.1328057","volume":"21","author":"T Berta","year":"2017","unstructured":"Berta T, Qadri Y, Tan PH, Ji RR. Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain. Expert Opin Ther Targets. 2017;21:695\u2013703. \n                    https:\/\/doi.org\/10.1080\/14728222.2017.1328057","journal-title":"Expert Opin Ther Targets"},{"key":"82_CR75","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1227\/NEU.0000000000001255","volume":"63","author":"D Guha","year":"2016","unstructured":"Guha D, Shamji MF. The dorsal root Ganglion in the pathogenesis of chronic neuropathic pain. Neurosurgery. 2016;63:118\u201326. \n                    https:\/\/doi.org\/10.1227\/NEU.0000000000001255","journal-title":"Neurosurgery"},{"key":"82_CR76","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1097\/AAP.0b013e3181d2375e","volume":"35","author":"QH Hogan","year":"2010","unstructured":"Hogan QH. Labat lecture: the primary sensory neuron: where it is, what it does, and why it matters. Reg Anesth Pain Med. 2010;35:306\u201311. \n                    https:\/\/doi.org\/10.1097\/AAP.0b013e3181d2375e","journal-title":"Reg Anesth Pain Med"},{"key":"82_CR77","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.omtn.2018.02.007","volume":"11","author":"T Terashima","year":"2018","unstructured":"Terashima T, Ogawa N, Nakae Y, Sato T, Katagi M, Okano J, et al. Gene therapy for neuropathic pain through siRNA-IRF5 gene delivery with homing peptides to microglia. Mol Ther Nucleic Acids. 2018;11:203\u201315. \n                    https:\/\/doi.org\/10.1016\/j.omtn.2018.02.007","journal-title":"Mol Ther Nucleic Acids"},{"key":"82_CR78","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02811-7","volume":"9","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Sethi R, Mangala LS, Taylor C, Goldsmith J, Wang M, et al. Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation. Nat Commun. 2018;9:476 \n                    https:\/\/doi.org\/10.1038\/s41467-017-02811-7","journal-title":"Nat Commun"},{"key":"82_CR79","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jneumeth.2011.04.021","volume":"199","author":"G Fischer","year":"2011","unstructured":"Fischer G, Kostic S, Nakai H, Park F, Sapunar D, Yu H, et al. Direct injection into the dorsal root ganglion: technical, behavioral, and histological observations. J Neurosci Methods. 2011;199:43\u201355.","journal-title":"J Neurosci Methods"},{"key":"82_CR80","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","volume":"53","author":"SR Chaplan","year":"1994","unstructured":"Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53:55\u201363.","journal-title":"J Neurosci Methods"},{"key":"82_CR81","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jpain.2009.07.011","volume":"11","author":"HE Wu","year":"2010","unstructured":"Wu HE, Gemes G, Zoga V, Kawano T, Hogan QH. Learned avoidance from noxious mechanical simulation but not threshold semmes weinstein filament stimulation after nerve injury in rats. J Pain. 2010;11:280\u20136. \n                    https:\/\/doi.org\/10.1016\/j.jpain.2009.07.011","journal-title":"J Pain"},{"key":"82_CR82","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-7-63","volume":"7","author":"H Yu","year":"2011","unstructured":"Yu H, Fischer G, Jia G, Reiser J, Park F, Hogan QH. Lentiviral gene transfer into the dorsal root ganglion of adult rats. Mol Pain. 2011;7:63.","journal-title":"Mol Pain"},{"key":"82_CR83","doi-asserted-by":"publisher","first-page":"174480691664638","DOI":"10.1177\/1744806916646380","volume":"12","author":"Zhen Liu","year":"2016","unstructured":"Liu Z, Wang F, Fischer G, Hogan QH & Yu H. Peripheral nerve injury induces loss of nociceptive neuron-specific Galphai-interacting protein in neuropathic pain rat. Mol Pain. \n                    https:\/\/doi.org\/10.1177\/1744806916646380\n                    \n                   (2016).","journal-title":"Molecular Pain"},{"key":"82_CR84","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1523\/JNEUROSCI.21-08-02651.2001","volume":"21","author":"MS Ramer","year":"2001","unstructured":"Ramer MS, Duraisingam I, Priestley JV, McMahon SB. Two-tiered inhibition of axon regeneration at the dorsal root entry zone. J Neurosci. 2001;21:2651\u201360.","journal-title":"J Neurosci"},{"issue":"3","key":"82_CR85","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1002\/jnr.24183","volume":"96","author":"Hongfei Xiang","year":"2017","unstructured":"Xiang H, Xu H, Fan F, Shin SM, Hogan QH & Yu H. Glial fibrillary acidic protein promoter determines transgene expression in satellite glial cells following intraganglionic adeno-associated virus delivery in adult rats. J Neurosci Res. \n                    https:\/\/doi.org\/10.1002\/jnr.24183\n                    \n                   (2017).","journal-title":"Journal of Neuroscience Research"}],"container-title":["Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41434-019-0082-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41434-019-0082-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41434-019-0082-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:14:00Z","timestamp":1684617240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41434-019-0082-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":85,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["82"],"URL":"https:\/\/doi.org\/10.1038\/s41434-019-0082-7","relation":{},"ISSN":["0969-7128","1476-5462"],"issn-type":[{"value":"0969-7128","type":"print"},{"value":"1476-5462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"5 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}