{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:15:51Z","timestamp":1780661751181,"version":"3.54.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Immun"],"DOI":"10.1038\/s41435-026-00381-7","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T09:55:35Z","timestamp":1772531735000},"page":"261-275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibition of cGAS in dendritic cells suppresses maturation and prolongs allograft survival in mice"],"prefix":"10.1038","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4786-2113","authenticated-orcid":false,"given":"Hanyuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4125-9698","authenticated-orcid":false,"given":"Yi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"381_CR1","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.jhep.2018.12.009","volume":"70","author":"F Durand","year":"2019","unstructured":"Durand F, Levitsky J, Cauchy F, Gilgenkrantz H, Soubrane O, Francoz C. Age and liver transplantation. J Hepatol. 2019;70:745\u201358.","journal-title":"J Hepatol"},{"key":"381_CR2","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/nrendo.2016.178","volume":"13","author":"AM Shapiro","year":"2017","unstructured":"Shapiro AM, Pokrywczynska M, Ricordi C. Clinical pancreatic islet transplantation. Nat Rev Endocrinol. 2017;13:268\u201377.","journal-title":"Nat Rev Endocrinol"},{"key":"381_CR3","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1053\/j.gastro.2021.09.012","volume":"162","author":"Y Bekki","year":"2022","unstructured":"Bekki Y, Fenig Y. Evaluation of early liver transplantation for alcohol-related cirrhosis. Gastroenterology. 2022;162:2127\u20138.","journal-title":"Gastroenterology"},{"key":"381_CR4","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrneph.2015.159","volume":"11","author":"B Kaplan","year":"2015","unstructured":"Kaplan B. Decade in review-renal transplantation: a spectrum of advances in renal transplantation. Nat Rev Nephrol. 2015;11:639\u201341.","journal-title":"Nat Rev Nephrol"},{"key":"381_CR5","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.jhep.2016.06.023","volume":"65","author":"JD Yang","year":"2016","unstructured":"Yang JD, Aqel BA, Pungpapong S, Gores GJ, Roberts LR, Leise MD. Direct acting antiviral therapy and tumor recurrence after liver transplantation for hepatitis C-associated hepatocellular carcinoma. J Hepatol. 2016;65:859\u201360.","journal-title":"J Hepatol"},{"key":"381_CR6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/bs.ircmb.2019.10.002","volume":"349","author":"R Leylek","year":"2019","unstructured":"Leylek R, Idoyaga J. The versatile plasmacytoid dendritic cell: Function, heterogeneity, and plasticity. Int Rev Cell Mol Biol. 2019;349:177\u2013211.","journal-title":"Int Rev Cell Mol Biol"},{"key":"381_CR7","first-page":"1","volume":"348","author":"S Balan","year":"2019","unstructured":"Balan S, Saxena M, Bhardwaj N. Dendritic cell subsets and locations. Int Rev Cell Mol Biol. 2019;348:1\u201368.","journal-title":"Int Rev Cell Mol Biol"},{"key":"381_CR8","doi-asserted-by":"crossref","unstructured":"Xia H, Wang Y, Dai J, Zhang X, Zhou J, Zeng Z, et al. Selenoprotein K is essential for the migration and phagocytosis of immature dendritic cells. Antioxidants 2022;11:1264.","DOI":"10.3390\/antiox11071264"},{"key":"381_CR9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.molimm.2016.10.004","volume":"79","author":"W He","year":"2016","unstructured":"He W, Chen L, Zheng L, Luo L, Gao L. Prolonged survival effects induced by immature dendritic cells and regulatory T cells in a rat liver transplantation model. Mol Immunol. 2016;79:92\u201397.","journal-title":"Mol Immunol"},{"key":"381_CR10","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.cell.2013.04.046","volume":"153","author":"P Gao","year":"2013","unstructured":"Gao P, Ascano M, Wu Y, Barchet W, Gaffney BL, Zillinger T, et al. Cyclic [G(2\u2019,5\u2019)pA(3\u2019,5\u2019)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell. 2013;153:1094\u2013107.","journal-title":"Cell"},{"key":"381_CR11","doi-asserted-by":"publisher","unstructured":"Lu T, Zhang Z, Bi Z, Lan T, Zeng H, Liu Y, et al. TFAM deficiency in dendritic cells leads to mitochondrial dysfunction and enhanced antitumor immunity through cGAS-STING pathway. J Immunother Cancer, 2023;11. https:\/\/doi.org\/10.1136\/jitc-2022-005430.","DOI":"10.1136\/jitc-2022-005430"},{"key":"381_CR12","doi-asserted-by":"publisher","first-page":"102305","DOI":"10.1016\/j.redox.2022.102305","volume":"52","author":"Z Liu","year":"2022","unstructured":"Liu Z, Wang M, Wang X, Bu Q, Wang Q, Su W, et al. XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury. Redox Biol. 2022;52:102305.","journal-title":"Redox Biol"},{"key":"381_CR13","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","volume":"21","author":"A Decout","year":"2021","unstructured":"Decout A, Katz JD, Venkatraman S, Ablasser A. The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol. 2021;21:548\u201369.","journal-title":"Nat Rev Immunol"},{"key":"381_CR14","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/s43018-022-00468-w","volume":"3","author":"N Samson","year":"2022","unstructured":"Samson N, Ablasser A. The cGAS-STING pathway and cancer. Nat Cancer. 2022;3:1452\u201363.","journal-title":"Nat Cancer"},{"key":"381_CR15","doi-asserted-by":"publisher","first-page":"9644","DOI":"10.7150\/thno.47651","volume":"10","author":"Y Liao","year":"2020","unstructured":"Liao Y, Cheng J, Kong X, Li S, Li X, Zhang M, et al. HDAC3 inhibition ameliorates ischemia\/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway. Theranostics. 2020;10:9644\u201362.","journal-title":"Theranostics"},{"key":"381_CR16","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","volume":"21","author":"KP Hopfner","year":"2020","unstructured":"Hopfner KP, Hornung V. Molecular mechanisms and cellular functions of cGAS-STING signalling. Nat Rev Mol Cell Biol. 2020;21:501\u201321.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"381_CR17","doi-asserted-by":"publisher","first-page":"1231057","DOI":"10.3389\/fimmu.2023.1231057","volume":"14","author":"Z Chen","year":"2023","unstructured":"Chen Z, Liu Y, Lin Z, Huang W. cGAS-STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes. Front Immunol. 2023;14:1231057.","journal-title":"Front Immunol"},{"key":"381_CR18","doi-asserted-by":"crossref","unstructured":"Yu X, Cai L, Yao J, Li C, Wang X. Agonists and Inhibitors of the cGAS-STING Pathway. Molecules 2024;29:3121.","DOI":"10.3390\/molecules29133121"},{"key":"381_CR19","doi-asserted-by":"crossref","unstructured":"Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE 2017;12:e0184843.","DOI":"10.1371\/journal.pone.0184843"},{"key":"381_CR20","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.4049\/jimmunol.1402793","volume":"194","author":"J An","year":"2015","unstructured":"An J, Woodward JJ, Sasaki T, Minie M, Elkon KB. Cutting edge: antimalarial drugs inhibit IFN-\u03b2 production through blockade of cyclic GMP-AMP synthase\u2013DNA interaction. J Immunol. 2015;194:4089\u201393.","journal-title":"J Immunol"},{"key":"381_CR21","doi-asserted-by":"publisher","first-page":"117069","DOI":"10.1016\/j.jep.2023.117069","volume":"319","author":"Y Jiang","year":"2024","unstructured":"Jiang Y, Hu Y, Yang Y, Yan R, Zheng L, Fu X, et al. Tong-Xie-Yao-Fang promotes dendritic cells maturation and retards tumor growth in colorectal cancer mice with chronic restraint stress. J Ethnopharmacol. 2024;319:117069.","journal-title":"J Ethnopharmacol"},{"key":"381_CR22","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.immuni.2020.03.016","volume":"52","author":"C Zhou","year":"2020","unstructured":"Zhou C, Xia, Chen, Planells-Cases R, Chu J, Li Wang, et al. Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity. Immunity. 2020;52:767\u201381.e6.","journal-title":"Immunity"},{"key":"381_CR23","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/nature12640","volume":"503","author":"A Ablasser","year":"2013","unstructured":"Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013;503:530\u20134.","journal-title":"Nature"},{"key":"381_CR24","doi-asserted-by":"publisher","first-page":"3399","DOI":"10.1182\/blood-2010-12-325746","volume":"118","author":"RJ Robb","year":"2011","unstructured":"Robb RJ, Kreijveld E, Kuns RD, Wilson YA, Olver SD, Don ALJ, et al. Type I-IFNs control GVHD and GVL responses after transplantation. Blood. 2011;118:3399\u2013409.","journal-title":"Blood"},{"key":"381_CR25","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/s41586-022-04847-2","volume":"607","author":"C Hong","year":"2022","unstructured":"Hong C, Schubert M, Tijhuis AE, Requesens M, Roorda M, van den Brink A, et al. cGAS-STING drives the IL-6-dependent survival of chromosomally instable cancers. Nature. 2022;607:366\u201373.","journal-title":"Nature"},{"key":"381_CR26","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1136\/gutjnl-2020-323426","volume":"71","author":"W Si","year":"2022","unstructured":"Si W, Liang H, Bugno J, Xu Q, Ding X, Yang K, et al. Lactobacillus rhamnosus GG induces cGAS\/STING- dependent type I interferon and improves response to immune checkpoint blockade. Gut. 2022;71:521\u201333.","journal-title":"Gut"},{"key":"381_CR27","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1128\/JVI.02702-13","volume":"88","author":"E Lam","year":"2014","unstructured":"Lam E, Stein S, Falck-Pedersen E. Adenovirus detection by the cGAS\/STING\/TBK1 DNA sensing cascade. J Virol. 2014;88:974\u201381.","journal-title":"J Virol"},{"key":"381_CR28","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.chom.2016.10.007","volume":"20","author":"E Bayer-Santos","year":"2016","unstructured":"Bayer-Santos E, Durkin CH, Rigano LA, Kupz A, Alix E, Cerny O, et al. The Salmonella effector SteD mediates MARCH8-dependent ubiquitination of MHC II molecules and inhibits T cell activation. Cell Host Microbe. 2016;20:584\u201395.","journal-title":"Cell Host Microbe"},{"key":"381_CR29","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/imr.13050","volume":"306","author":"B Bo\u0161njak","year":"2022","unstructured":"Bo\u0161njak B, Do KTH, F\u00f6rster R, Hammerschmidt SI. Imaging dendritic cell functions. Immunol Rev. 2022;306:137\u201363.","journal-title":"Immunol Rev"},{"key":"381_CR30","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.alit.2024.07.003","volume":"74","author":"M Peyneau","year":"2025","unstructured":"Peyneau M, Zeller M, Paulet V, No\u00ebl B, Damiens MH, Szely N, et al. Quaternary ammoniums activate human dendritic cells and induce a specific T-cell response in vitro. Allergol Int. 2025;74:105\u201314.","journal-title":"Allergol Int"},{"key":"381_CR31","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/nature07781","volume":"458","author":"MB Torchinsky","year":"2009","unstructured":"Torchinsky MB, Garaude J, Martin AP, Blander JM. Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation. Nature. 2009;458:78\u201382.","journal-title":"Nature"},{"key":"381_CR32","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/nm1580","volume":"13","author":"G Xanthou","year":"2007","unstructured":"Xanthou G, Alissafi T, Semitekolou M, Simoes DCM, Economidou E, Gaga M, et al. Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Nat Med. 2007;13:570\u20138.","journal-title":"Nat Med"},{"key":"381_CR33","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.immuni.2023.01.004","volume":"56","author":"S Dikiy","year":"2023","unstructured":"Dikiy S, Rudensky AY. Principles of regulatory T cell function. Immunity. 2023;56:240\u201355.","journal-title":"Immunity"}],"container-title":["Genes &amp; Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41435-026-00381-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41435-026-00381-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41435-026-00381-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:47:38Z","timestamp":1780660058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41435-026-00381-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["381"],"URL":"https:\/\/doi.org\/10.1038\/s41435-026-00381-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7302546\/v1","asserted-by":"object"}]},"ISSN":["1476-5470"],"issn-type":[{"value":"1476-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]},"assertion":[{"value":"5 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}