{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:24:59Z","timestamp":1791559499525,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":871,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["gimjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1038\/s41436-019-0442-0","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T19:03:42Z","timestamp":1548183822000},"page":"1977-1986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Untargeted metabolomic profiling reveals multiple pathway perturbations and new clinical biomarkers in urea cycle disorders"],"prefix":"10.1016","volume":"21","author":[{"given":"Lindsay C.","family":"Burrage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Thistlethwaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget M.","family":"Stroup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus J.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandesh C.S.","family":"Nagamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Craigen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Scaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Reid","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam D.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Milosavljevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Elsea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41436-019-0442-0_bb0010","author":"Jang"},{"key":"10.1038\/s41436-019-0442-0_bb0015","author":"Haberle"},{"key":"10.1038\/s41436-019-0442-0_bb0020","author":"Miller"},{"key":"10.1038\/s41436-019-0442-0_bb0025","author":"Coene"},{"key":"10.1038\/s41436-019-0442-0_bb0030","author":"Kennedy"},{"key":"10.1038\/s41436-019-0442-0_bb0035","author":"Kennedy"},{"key":"10.1038\/s41436-019-0442-0_bb0040","author":"Atwal"},{"key":"10.1038\/s41436-019-0442-0_bb0045","author":"Cappuccio"},{"key":"10.1038\/s41436-019-0442-0_bb0050","author":"Sandlers"},{"key":"10.1038\/s41436-019-0442-0_bb0055","article-title":"High resolution mass spectrometry improves data quantity and quality as compared to unit mass resolution mass spectrometry in high-throughput profiling metabolomics","volume":"4","author":"Evans","year":"2014","journal-title":"Metabolomics"},{"key":"10.1038\/s41436-019-0442-0_bb0060","author":"Batshaw"},{"key":"10.1038\/s41436-019-0442-0_bb0065","author":"Shannon"},{"key":"10.1038\/s41436-019-0442-0_bb0070","first-page":"1695","article-title":"The igraph software package for complex network research","author":"Cs\u00e1rdi","year":"2006","journal-title":"InterJournal Complex Systems"},{"key":"10.1038\/s41436-019-0442-0_bb0075","author":"Burrage"},{"key":"10.1038\/s41436-019-0442-0_bb0080","author":"Diez-Fernandez"},{"key":"10.1038\/s41436-019-0442-0_bb0085","author":"Amayreh"},{"key":"10.1038\/s41436-019-0442-0_bb0090","author":"Nagamani"},{"key":"10.1038\/s41436-019-0442-0_bb0095","author":"Burrage"},{"key":"10.1038\/s41436-019-0442-0_bb0100","author":"Scaglia"},{"key":"10.1038\/s41436-019-0442-0_bb0105","author":"Brunetti-Pierri"},{"key":"10.1038\/s41436-019-0442-0_bb0110","author":"Yamaguchi"},{"key":"10.1038\/s41436-019-0442-0_bb0115","author":"Webster"},{"key":"10.1038\/s41436-019-0442-0_bb0120","author":"Marescau"},{"key":"10.1038\/s41436-019-0442-0_bb0125","author":"Deignan"},{"key":"10.1038\/s41436-019-0442-0_bb0130","author":"Stockler"},{"key":"10.1038\/s41436-019-0442-0_bb0135","author":"Neu"},{"key":"10.1038\/s41436-019-0442-0_bb0140","author":"Schulze"},{"key":"10.1038\/s41436-019-0442-0_bb0145","author":"Zugno"},{"key":"10.1038\/s41436-019-0442-0_bb0150","author":"Mori"},{"key":"10.1038\/s41436-019-0442-0_bb0155","author":"Wyse"},{"key":"10.1038\/s41436-019-0442-0_bb0160","author":"da Silva"},{"key":"10.1038\/s41436-019-0442-0_bb0165","author":"Balz"},{"key":"10.1038\/s41436-019-0442-0_bb0170","author":"Delwing-de Lima"},{"key":"10.1038\/s41436-019-0442-0_bb0175","author":"Diez-Fernandez"},{"key":"10.1038\/s41436-019-0442-0_bb0180","author":"Silva"},{"key":"10.1038\/s41436-019-0442-0_bb0185","author":"Naylor"},{"key":"10.1038\/s41436-019-0442-0_bb0190","author":"Jung"},{"key":"10.1038\/s41436-019-0442-0_bb0195","author":"Tarlungeanu"},{"key":"10.1038\/s41436-019-0442-0_bb0200","author":"Novarino"}],"container-title":["Genetics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41436-019-0442-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41436-019-0442-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109836002104990X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109836002104990X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41436-019-0442-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T01:48:13Z","timestamp":1761097693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109836002104990X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S109836002104990X"],"URL":"https:\/\/doi.org\/10.1038\/s41436-019-0442-0","relation":{},"ISSN":["1098-3600"],"issn-type":[{"value":"1098-3600","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Untargeted metabolomic profiling reveals multiple pathway perturbations and new clinical biomarkers in urea cycle disorders","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41436-019-0442-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019, The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics","name":"copyright","label":"Copyright"}]}}