{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:52:15Z","timestamp":1790376735130,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":871,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["gimjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1038\/s41436-019-0449-6","type":"journal-article","created":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T19:02:29Z","timestamp":1549825349000},"page":"2151-2155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["SERPINA1 Z allele is associated with cystic fibrosis liver disease"],"prefix":"10.1016","volume":"21","author":[{"given":"Pierre-Yves","family":"Bo\u00eblle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Debray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic","family":"Guillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Corvol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41436-019-0449-6_bb0010","author":"Riordan"},{"key":"10.1038\/s41436-019-0449-6_bb0015","author":"Debray"},{"key":"10.1038\/s41436-019-0449-6_bb0020","author":"Stonebraker"},{"key":"10.1038\/s41436-019-0449-6_bb0025","author":"Rowland"},{"key":"10.1038\/s41436-019-0449-6_bb0030","author":"Cutting"},{"key":"10.1038\/s41436-019-0449-6_bb0035","author":"Guillot"},{"key":"10.1038\/s41436-019-0449-6_bb0040","author":"McKone"},{"key":"10.1038\/s41436-019-0449-6_bb0045","doi-asserted-by":"crossref","unstructured":"Boelle PY, Debray D, Guillot L, Clement A, Corvol H, French CFMGSI. Cystic fibrosis liver disease: outcomes and risk factors in a large cohort of French patients. Hepatology. 30 2018.","DOI":"10.1002\/hep.30148"},{"key":"10.1038\/s41436-019-0449-6_bb0050","author":"Bartlett"},{"key":"10.1038\/s41436-019-0449-6_bb0055","author":"Bartels"},{"key":"10.1038\/s41436-019-0449-6_bb0060","author":"Zorzetto"},{"key":"10.1038\/s41436-019-0449-6_bb0065","author":"Stoller"},{"key":"10.1038\/s41436-019-0449-6_bb0070","author":"Teckman"},{"key":"10.1038\/s41436-019-0449-6_bb0075","unstructured":"Vaincre-la-Mucoviscidose, Ined. Registre Fran\u00e7ais de la mucoviscidose - Bilan des donn\u00e9es 2016. National report, 2017."},{"key":"10.1038\/s41436-019-0449-6_bb0080","author":"Debray"},{"key":"10.1038\/s41436-019-0449-6_bb0085","author":"Fay"},{"key":"10.1038\/s41436-019-0449-6_bb0090","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/10618600.1999.10474804","article-title":"Extending the iterative convex minorant algorithm to the Cox model for interval-censored data","volume":"8","author":"Pan","year":"1999","journal-title":"J Comput Graph Stat"},{"key":"10.1038\/s41436-019-0449-6_bb0095","author":"Torres-Duran"},{"key":"10.1038\/s41436-019-0449-6_bb0100","author":"Cheng"}],"container-title":["Genetics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41436-019-0449-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41436-019-0449-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021049960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021049960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41436-019-0449-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T01:48:48Z","timestamp":1761097728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1098360021049960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1098360021049960"],"URL":"https:\/\/doi.org\/10.1038\/s41436-019-0449-6","relation":{},"ISSN":["1098-3600"],"issn-type":[{"value":"1098-3600","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SERPINA1 Z allele is associated with cystic fibrosis liver disease","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41436-019-0449-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019, The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics","name":"copyright","label":"Copyright"}]}}