{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:49:05Z","timestamp":1792784945534,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":572,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Stichting Neurofibromatose","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["gimjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1038\/s41436-020-0752-2","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T19:07:32Z","timestamp":1580756852000},"page":"889-897","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Examination of the genetic factors underlying the cognitive variability associated with neurofibromatosis type 1"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1934-7752","authenticated-orcid":false,"given":"Myrthe J.","family":"Ottenhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 B.","family":"Rietman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine E.","family":"Mous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Plasschaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Gawehns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Brems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne","family":"Oostenbrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"van Minkelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nellist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Schorry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Legius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette A.","family":"Moll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3758-1297","authenticated-orcid":false,"given":"Ype","family":"Elgersma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claire Y.","family":"de Wit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter F.A.","family":"de Nijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen S.","family":"Legerstee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn C.","family":"Dieleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontine W.","family":"ten Hoopen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41436-020-0752-2_bb0010","author":"Kallionpaa"},{"key":"10.1038\/s41436-020-0752-2_bb0015","author":"Gutmann"},{"key":"10.1038\/s41436-020-0752-2_bb0020","author":"Torres Nupan"},{"key":"10.1038\/s41436-020-0752-2_bb0025","author":"Rietman"},{"key":"10.1038\/s41436-020-0752-2_bb0030","author":"Hyman"},{"key":"10.1038\/s41436-020-0752-2_bb0035","author":"Krab"},{"key":"10.1038\/s41436-020-0752-2_bb0040","author":"Wolkenstein"},{"key":"10.1038\/s41436-020-0752-2_bb0045","author":"Garg"},{"key":"10.1038\/s41436-020-0752-2_bb0050","author":"Eijk"},{"key":"10.1038\/s41436-020-0752-2_bb0055","author":"Sabbagh"},{"key":"10.1038\/s41436-020-0752-2_bb0060","author":"Easton"},{"key":"10.1038\/s41436-020-0752-2_bb0065","author":"Rieley"},{"key":"10.1038\/s41436-020-0752-2_bb0070","first-page":"1","article-title":"Analysis of copy number variants in 11 pairs of monozygotic twins with neurofibromatosis type 1","volume":"1","author":"Sites","year":"2016","journal-title":"Am J Med Genet A"},{"key":"10.1038\/s41436-020-0752-2_bb0075","author":"Laycock-van Spyk"},{"key":"10.1038\/s41436-020-0752-2_bb0080","author":"Acosta"},{"key":"10.1038\/s41436-020-0752-2_bb0085","author":"Diggs-Andrews"},{"key":"10.1038\/s41436-020-0752-2_bb0090","author":"Legius"},{"key":"10.1038\/s41436-020-0752-2_bb0095","author":"Payne"},{"key":"10.1038\/s41436-020-0752-2_bb0100","author":"Anastasaki"},{"key":"10.1038\/s41436-020-0752-2_bb0105","author":"Jentarra"},{"key":"10.1038\/s41436-020-0752-2_bb0110","author":"Anastasaki"},{"key":"10.1038\/s41436-020-0752-2_bb0115","author":"Hoffmeyer"},{"key":"10.1038\/s41436-020-0752-2_bb0120","author":"Descheemaeker"},{"key":"10.1038\/s41436-020-0752-2_bb0125","author":"Mautner"},{"key":"10.1038\/s41436-020-0752-2_bb0130","author":"Alkindy"},{"key":"10.1038\/s41436-020-0752-2_bb0135","author":"Upadhyaya"},{"key":"10.1038\/s41436-020-0752-2_bb0140","author":"Rojnueangnit"},{"key":"10.1038\/s41436-020-0752-2_bb0145","author":"Koczkowska"},{"key":"10.1038\/s41436-020-0752-2_bb0150","author":"Koczkowska"},{"key":"10.1038\/s41436-020-0752-2_bb0155","author":"Szudek"},{"key":"10.1038\/s41436-020-0752-2_bb0160","author":"Krab"},{"key":"10.1038\/s41436-020-0752-2_bb0165","first-page":"11","article-title":"Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial","volume":"1","author":"van der Vaart","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1038\/s41436-020-0752-2_bb0170","author":"Devlin"},{"key":"10.1038\/s41436-020-0752-2_bb0175","series-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"10.1038\/s41436-020-0752-2_bb0180","unstructured":"Pinheiro JBD, DebRoy S, Sarkar D, and R Core Team. nlme: linear and nonlinear mixed effects models. 2017. https:\/\/CRAN.R-project.org\/package=nlme."},{"key":"10.1038\/s41436-020-0752-2_bb0185","unstructured":"Lenth R, Singmann H, Love J, Buerkner P, Herve M. emmeans: estimated marginal means, aka least-squares means. 2019. https:\/\/CRAN.R-project.org\/package=emmeans. Accessed 28 October 2019."},{"key":"10.1038\/s41436-020-0752-2_bb0190","unstructured":"Pigeon G. GabrielPigeon\/gabtool. 2016. https:\/\/github.com\/GabrielPigeon\/gabtool. Accessed 28 October 2019."},{"key":"10.1038\/s41436-020-0752-2_bb0195","author":"Morris"},{"key":"10.1038\/s41436-020-0752-2_bb0200","author":"Chabernaud"},{"key":"10.1038\/s41436-020-0752-2_bb0205","author":"Piscitelli"},{"key":"10.1038\/s41436-020-0752-2_bb0210","author":"Roy"},{"key":"10.1038\/s41436-020-0752-2_bb0215","author":"Parmeggiani"},{"key":"10.1038\/s41436-020-0752-2_bb0220","author":"Bouchard"},{"key":"10.1038\/s41436-020-0752-2_bb0225","author":"Kehrer-Sawatzki"},{"key":"10.1038\/s41436-020-0752-2_bb0230","author":"Koczkowska"}],"container-title":["Genetics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41436-020-0752-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41436-020-0752-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021008649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021008649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41436-020-0752-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T01:50:51Z","timestamp":1761097851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1098360021008649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S1098360021008649"],"URL":"https:\/\/doi.org\/10.1038\/s41436-020-0752-2","relation":{},"ISSN":["1098-3600"],"issn-type":[{"value":"1098-3600","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Examination of the genetic factors underlying the cognitive variability associated with neurofibromatosis type 1","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41436-020-0752-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020, The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics","name":"copyright","label":"Copyright"}]}}