{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:48:25Z","timestamp":1781758105668,"version":"3.54.5"},"reference-count":18,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["gimjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Genetics in Medicine"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1038\/s41436-021-01258-y","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T07:11:24Z","timestamp":1625555484000},"page":"2114-2121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Potential of polygenic risk scores for improving population estimates of women\u2019s breast cancer genetic risks"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-955X","authenticated-orcid":false,"given":"Michael","family":"Wolfson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Gribble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Pashayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas F.","family":"Easton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis C.","family":"Antoniou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"van Katwyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Simard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/s41436-021-01258-y_bb0010","author":"Mavaddat"},{"key":"10.1038\/s41436-021-01258-y_bb0015","author":"Pashayan"},{"key":"10.1038\/s41436-021-01258-y_bb0020","author":"Geuzinge"},{"key":"10.1038\/s41436-021-01258-y_bb0025","author":"van den Broek"},{"key":"10.1038\/s41436-021-01258-y_bb0030","author":"Sankatsing"},{"key":"10.1038\/s41436-021-01258-y_bb0035","author":"Pashayan"},{"key":"10.1038\/s41436-021-01258-y_bb0040","author":"Lee"},{"key":"10.1038\/s41436-021-01258-y_bb0045","author":"Pal Choudhury"},{"key":"10.1038\/s41436-021-01258-y_bb0050","author":"Lee"},{"key":"10.1038\/s41436-021-01258-y_bb0055","year":"2021","journal-title":"Statistics Canada. The LifePaths microsimulation model: an overview"},{"key":"10.1038\/s41436-021-01258-y_bb0060","year":"2019","journal-title":"Canadian Partnership Against Cancer. OncoSim cervical"},{"key":"10.1038\/s41436-021-01258-y_bb0065","author":"Ginsburg"},{"key":"10.1038\/s41436-021-01258-y_bb0070","author":"Terkelsen"},{"key":"10.1038\/s41436-021-01258-y_bb0075","author":"Dorling"},{"key":"10.1038\/s41436-021-01258-y_bb0080","author":"Ho"},{"key":"10.1038\/s41436-021-01258-y_bb0085","author":"Esserman"},{"key":"10.1038\/s41436-021-01258-y_bb0090","unstructured":"QuebecGenome. Personalized risk assessment for prevention and early detection of breast cancer: integration and implementation (PERSPECTIVE I&I). http:\/\/www.genomequebec.com\/211-en\/project\/personalized-risk-assessment-for-prevention-and-early-detection-of-breast-cancer-integration-and-implementation [Accessed June 25, 2021]."},{"key":"10.1038\/s41436-021-01258-y_bb0095","author":"Klarenbach"}],"container-title":["Genetics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41436-021-01258-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41436-021-01258-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021051820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098360021051820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41436-021-01258-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T01:54:59Z","timestamp":1761098099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1098360021051820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S1098360021051820"],"URL":"https:\/\/doi.org\/10.1038\/s41436-021-01258-y","relation":{},"ISSN":["1098-3600"],"issn-type":[{"value":"1098-3600","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential of polygenic risk scores for improving population estimates of women\u2019s breast cancer genetic risks","name":"articletitle","label":"Article Title"},{"value":"Genetics in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/s41436-021-01258-y","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021, The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics","name":"copyright","label":"Copyright"}]}}