{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T16:57:25Z","timestamp":1758473845705,"version":"3.41.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T00:00:00Z","timestamp":1515974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1038\/s41440-017-0004-2","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T08:04:52Z","timestamp":1516003492000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Roles of angiotensin II type 2 receptor in mice with fetal growth restriction"],"prefix":"10.1038","volume":"41","author":[{"given":"Toshifumi","family":"Yamauchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Mogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Kan-no","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Shuai","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Higaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Juan","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Higaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Iwanami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ei-ichi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Horiuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"4_CR1","unstructured":"Organization UNCsFaWH. Low birth weight: country, regional and global estimates. UNICEF, WHO: New York, 2004."},{"key":"4_CR2","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1056\/NEJM199904223401603","volume":"340","author":"DD McIntire","year":"1999","unstructured":"McIntire DD, Bloom SL, Casey BM, Leveno KJ. Birth weight in relation to morbidity and mortality among newborn infants. N Engl J Med. 1999;340:1234\u20138.","journal-title":"N Engl J Med"},{"key":"4_CR3","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1136\/bmj.298.6673.564","volume":"298","author":"DJ Barker","year":"1989","unstructured":"Barker DJ, Osmond C, Golding J, Kuh D, Wadsworth ME. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989;298:564\u20137.","journal-title":"BMJ"},{"key":"4_CR4","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1161\/01.CIR.94.12.3246","volume":"94","author":"GC Curhan","year":"1996","unstructured":"Curhan GC, Willett WC, Rimm EB, Spiegelman D, Ascherio AL, Stampfer MJ. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation. 1996;94:3246\u201350.","journal-title":"Circulation"},{"key":"4_CR5","doi-asserted-by":"publisher","first-page":"1344S","DOI":"10.1093\/ajcn\/71.5.1344s","volume":"71","author":"KM Godfrey","year":"2000","unstructured":"Godfrey KM, Barker DJ. Fetal nutrition and adult disease. Am J Clin Nutr. 2000;71:1344S\u201352S.","journal-title":"Am J Clin Nutr"},{"key":"4_CR6","doi-asserted-by":"publisher","first-page":"1846S","DOI":"10.3945\/ajcn.110.001651","volume":"94","author":"C Remacle","year":"2011","unstructured":"Remacle C, Bieswal F, Bol V, Reusens B. Developmental programming of adult obesity and cardiovascular disease in rodents by maternal nutrition imbalance. Am J Clin Nutr. 2011;94:1846S\u201352S.","journal-title":"Am J Clin Nutr"},{"key":"4_CR7","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/S0140-6736(05)66419-7","volume":"365","author":"MR Skilton","year":"2005","unstructured":"Skilton MR, Evans N, Griffiths KA, Harmer JA, Celermajer DS. Aortic wall thickness in newborns with intrauterine growth restriction. Lancet. 2005;365:1484\u20136.","journal-title":"Lancet"},{"key":"4_CR8","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0140-6736(97)10404-4","volume":"352","author":"CN Martyn","year":"1998","unstructured":"Martyn CN, Gale CR, Jespersen S, Sherriff SB. Impaired fetal growth and atherosclerosis of carotid and peripheral arteries. Lancet. 1998;352:173\u20138.","journal-title":"Lancet"},{"key":"4_CR9","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1095\/biolreprod.102.012120","volume":"69","author":"KA Vonnahme","year":"2003","unstructured":"Vonnahme KA, Hess BW, Hansen TR, McCormick RJ, Rule DC, Moss GE, Murdoch WJ, Nijland MJ, Skinner DC, Nathanielsz PW, Ford SP. Maternal undernutrition from early- to mid-gestation leads to growth retardation, cardiac ventricular hypertrophy, and increased liver weight in the fetal sheep. Biol Reprod. 2003;69:133\u201340.","journal-title":"Biol Reprod"},{"key":"4_CR10","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1093\/ajh\/hpv072","volume":"29","author":"T Chisaka","year":"2016","unstructured":"Chisaka T, Mogi M, Nakaoka H, Kan-No H, Tsukuda K, Wang XL, Bai HY, Shan BS, Kukida M, Iwanami J, Higaki T, Ishii E, Horiuchi M. Low-protein diet-induced fetal growth restriction leads to exaggerated proliferative response to vascular injury in postnatal life. Am J Hypertens. 2016;29:54\u201362.","journal-title":"Am J Hypertens"},{"key":"4_CR11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0031-6997(24)01458-3","volume":"52","author":"M Gasparo de","year":"2000","unstructured":"de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000;52:415\u201372.","journal-title":"Pharmacol Rev"},{"key":"4_CR12","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1172\/JCI115395","volume":"88","author":"EF Grady","year":"1991","unstructured":"Grady EF, Sechi LA, Griffin CA, Schambelan M, Kalinyak JE. Expression of AT2 receptors in the developing rat fetus. J Clin Invest. 1991;88:921\u201333.","journal-title":"J Clin Invest"},{"key":"4_CR13","doi-asserted-by":"crossref","unstructured":"Wang YP, Chen X, Zhang ZK, Cui HY, Wang P, Wang Y. Increased renal apoptosis and reduced renin-angiotensin system in fetal growth restriction. J Renin Angiotensin Aldosterone Syst. 2016;17:1\u20137.","DOI":"10.1177\/1470320316654810"},{"key":"4_CR14","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jash.2012.07.001","volume":"6","author":"K Tsukuda","year":"2012","unstructured":"Tsukuda K, Mogi M, Iwanami J, Min LJ, Jing F, Ohshima K, Horiuchi M. Influence of angiotensin II type 1 receptor-associated protein on prenatal development and adult hypertension after maternal dietary protein restriction during pregnancy. J Am Soc Hypertens. 2012;6:324\u201330.","journal-title":"J Am Soc Hypertens"},{"key":"4_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1152\/physiolgenomics.2000.2.1.13","volume":"2","author":"M Akishita","year":"2000","unstructured":"Akishita M, Horiuchi M, Yamada H, Zhang L, Shirakami G, Tamura K, Ouchi Y, Dzau VJ. Inflammation influences vascular remodeling through AT2 receptor expression and signaling. Physiol Genom. 2000;2:13\u201320.","journal-title":"Physiol Genom"},{"key":"4_CR16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.regpep.2004.09.004","volume":"126","author":"H Utsunomiya","year":"2005","unstructured":"Utsunomiya H, Nakamura M, Kakudo K, Inagami T, Tamura M. Angiotensin II AT2 receptor localization in cardiovascular tissues by its antibody developed in AT2 gene-deleted mice. Regul Pept. 2005;126:155\u201361.","journal-title":"Regul Pept"},{"key":"4_CR17","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.jash.2013.03.002","volume":"7","author":"T Moritani","year":"2013","unstructured":"Moritani T, Iwai M, Kanno H, Nakaoka H, Iwanami J, Higaki T, Ishii E, Horiuchi M. ACE2 deficiency induced perivascular fibrosis and cardiac hypertrophy during postnatal development in mice. J Am Soc Hypertens. 2013;7:259\u201366.","journal-title":"J Am Soc Hypertens"},{"key":"4_CR18","doi-asserted-by":"publisher","first-page":"e0150255","DOI":"10.1371\/journal.pone.0150255","volume":"11","author":"LA Rabelo","year":"2016","unstructured":"Rabelo LA, Todiras M, Nunes-Souza V, Qadri F, Szijarto IA, Gollasch M, Penninger JM, Bader M, Santos RA, Alenina N. Genetic deletion of ACE2 induces vascular dysfunction in C57BL\/6 mice: role of nitric oxide imbalance and oxidative stress. PLoS One. 2016;11:e0150255.","journal-title":"PLoS One"},{"key":"4_CR19","doi-asserted-by":"publisher","first-page":"H134","DOI":"10.1152\/ajpheart.00595.2013","volume":"307","author":"P Shukla","year":"2014","unstructured":"Shukla P, Ghatta S, Dubey N, Lemley CO, Johnson ML, Modgil A, Vonnahme K, Caton JS, Reynolds LP, Sun C, O\u2019Rourke ST. Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries. Am J Physiol Heart Circ Physiol. 2014;307:H134\u2013142.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4_CR20","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.vph.2005.01.005","volume":"42","author":"WW Batenburg","year":"2005","unstructured":"Batenburg WW, Tom B, Schuijt MP, Danser AH. Angiotensin II type 2 receptor-mediated vasodilation. Focus on bradykinin, no and endothelium-derived hyperpolarizing factor(s). Vasc Pharmacol. 2005;42:109\u201318.","journal-title":"Vasc Pharmacol"},{"key":"4_CR21","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/1440-1681.12067","volume":"40","author":"LM Hilliard","year":"2013","unstructured":"Hilliard LM, Mirabito KM, Denton KM. Unmasking the potential of the angiotensin AT2 receptor as a therapeutic target in hypertension in men and women: what we know and what we still need to find out. Clin Exp Pharmacol Physiol. 2013;40:542\u201350.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"4_CR22","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jash.2011.01.007","volume":"5","author":"M Okumura","year":"2011","unstructured":"Okumura M, Iwai M, Nakaoka H, Sone H, Kanno H, Senba I, Ito M, Horiuchi M. Possible involvement of AT2 receptor dysfunction in age-related gender difference in vascular remodeling. J Am Soc Hypertens. 2011;5:76\u201384.","journal-title":"J Am Soc Hypertens"},{"key":"4_CR23","doi-asserted-by":"crossref","unstructured":"Redman CW, Sargent IL. Placental stress and pre-eclampsia: a revised view. Placenta. 2009;Suppl A:S38\u201342.","DOI":"10.1016\/j.placenta.2008.11.021"},{"key":"4_CR24","doi-asserted-by":"publisher","first-page":"R86","DOI":"10.1152\/ajpregu.00600.2011","volume":"303","author":"LC Kusinski","year":"2012","unstructured":"Kusinski LC, Stanley JL, Dilworth MR, Hirt CJ, Andersson IJ, Renshall LJ, Baker BC, Baker PN, Sibley CP, Wareing M, Glazier JD. Enos knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype. Am J Physiol Regul Integr Comp Physiol. 2012;303:R86\u201393.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"4_CR25","doi-asserted-by":"crossref","unstructured":"Wolf G. Angiotensin II and tubular development. Nephrol Dial Transplant. 2002;Suppl9:48\u201351.","DOI":"10.1093\/ndt\/17.suppl_9.48"},{"key":"4_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1097-2765(00)80169-0","volume":"3","author":"H Nishimura","year":"1999","unstructured":"Nishimura H, Yerkes E, Hohenfellner K, Miyazaki Y, Ma J, Hunley TE, Yoshida H, Ichiki T, Threadgill D, Phillips JA, 3rd, Hogan BM, Fogo A, Brock JW, 3rd, Inagami T, Ichikawa I, Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell. 1999;3:1\u201310.","journal-title":"Mol Cell"},{"key":"4_CR27","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.celrep.2014.02.033","volume":"7","author":"C Cebrian","year":"2014","unstructured":"Cebrian C, Asai N, D\u2019Agati V, Costantini F. The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment. Cell Rep. 2014;7:127\u201337.","journal-title":"Cell Rep"},{"key":"4_CR28","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/hr.2015.12","volume":"38","author":"C Shimada","year":"2015","unstructured":"Shimada C, Akaishi R, Cho K, Morikawa M, Kaneshi Y, Yamda T, Minakami H. Outcomes of 83 fetuses exposed to angiotensin receptor blockers during the second or third trimesters: a literature review. Hypertens Res. 2015;38:308\u201313.","journal-title":"Hypertens Res"},{"key":"4_CR29","first-page":"153","volume":"6","author":"LA Danyel","year":"2013","unstructured":"Danyel LA, Schmerler P, Paulis L, Unger T, Steckelings UM. Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure. Integr Blood Press Control. 2013;6:153\u201361.","journal-title":"Integr Blood Press Control"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41440-017-0004-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41440-017-0004-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41440-017-0004-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T21:11:24Z","timestamp":1751231484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41440-017-0004-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,15]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["4"],"URL":"https:\/\/doi.org\/10.1038\/s41440-017-0004-2","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"type":"print","value":"0916-9636"},{"type":"electronic","value":"1348-4214"}],"subject":[],"published":{"date-parts":[[2018,1,15]]},"assertion":[{"value":"25 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}