{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T11:50:25Z","timestamp":1744199425088},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1038\/s41440-018-0147-9","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T09:58:47Z","timestamp":1544435927000},"page":"306-318","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Renal nerves contribute to hypertension in Schlager BPH\/2J mice"],"prefix":"10.1038","volume":"42","author":[{"given":"Cindy","family":"Gueguen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy L.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine Z.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Eikelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily R.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi J.","family":"Charchar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin W.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela J.","family":"Davern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey A.","family":"Head","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"147_CR1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/genetics\/76.3.537","volume":"76","author":"G Schlager","year":"1974","unstructured":"Schlager G. Selection for blood pressure levels in mice. Genetics. 1974;76:537\u201349.","journal-title":"Genetics"},{"key":"147_CR2","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1161\/HYPERTENSIONAHA.109.136069","volume":"54","author":"PJ Davern","year":"2009","unstructured":"Davern PJ, Nguyen-Huu T, La Greca L, Head GA. Role of the sympathetic nervous system in Schlager genetically hypertensive mice. Hypertension. 2009;54:852\u20139.","journal-title":"Hypertension"},{"key":"147_CR3","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1161\/HYPERTENSIONAHA.113.02020","volume":"63","author":"KL Jackson","year":"2014","unstructured":"Jackson KL, Palma-Rigo K, Nguyen-Huu T-P, Davern PJ, Head GA. Major contribution of the medial amygdala to hypertension in BPH\/2J genetically hypertensive mice. Hypertension. 2014;63:811\u20138.","journal-title":"Hypertension"},{"key":"147_CR4","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1161\/HYPERTENSIONAHA.113.01701","volume":"62","author":"KL Jackson","year":"2013","unstructured":"Jackson KL, Marques FZ, Watson AMD, Palma Rigo K, Nguyen-Huu T-P, Morris BJ, et al. A novel interaction between sympathetic overactivity and aberrant regulation of renin by mir-181a in BPH\/2J genetically hypertensive mice. Hypertension. 2013;62:775\u201381.","journal-title":"Hypertension"},{"key":"147_CR5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/BF02002815","volume":"33","author":"JF Liard","year":"1977","unstructured":"Liard JF. Renal denervation delays blood pressure increase in the spontaneously hypertensive rat. Experientia. 1977;33:339\u201340.","journal-title":"Experientia"},{"key":"147_CR6","doi-asserted-by":"publisher","first-page":"H1519","DOI":"10.1152\/ajpheart.00206.2005","volume":"289","author":"F Jacob","year":"2005","unstructured":"Jacob F, Clark LA, Guzman PA, Osborn JW. Role of renal nerves in development of hypertension in DOCA-salt model in rats: a telemetric approach. Am J Physiol Heart Circ Physiol. 2005;289:H1519\u201329.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6 Pt 1","key":"147_CR7","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1161\/01.HYP.11.6.523","volume":"11","author":"JL Osborn","year":"1988","unstructured":"Osborn JL, Roman RJ, Ewens JD. Renal nerves and the development of Dahl salt-sensitive hypertension. Hypertension. 1988;11(6 Pt 1):523\u20138.","journal-title":"Hypertension"},{"key":"147_CR8","doi-asserted-by":"publisher","first-page":"H1781","DOI":"10.1152\/ajpheart.00972.2010","volume":"300","author":"SS Kandlikar","year":"2011","unstructured":"Kandlikar SS, Fink GD. Mild DOCA-salt hypertension: sympathetic system and role of renal nerves. Am J Physiol Heart Circ Physiol. 2011;300:H1781\u201387.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"147_CR9","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1097\/HJH.0b013e32832dd0d8","volume":"27","author":"JL Moretti","year":"2009","unstructured":"Moretti J-L, Burke SL, Evans RG, Lambert GW, Head GA. Enhanced responses to ganglion blockade do not reflect sympathetic nervous system contribution to Angiotensin II-induced hypertension. J Hypertens. 2009;27:1838\u201348.","journal-title":"J Hypertens"},{"key":"147_CR10","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s11906-014-0519-8","volume":"17","author":"M Esler","year":"2015","unstructured":"Esler M. The sympathetic nervous system in hypertension: back to the future? Curr Hypertens Rep. 2015;17:519.","journal-title":"Curr Hypertens Rep"},{"key":"147_CR11","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/S0140-6736(13)62192-3","volume":"383","author":"H Krum","year":"2014","unstructured":"Krum H, Schlaich MP, Sobotka PA, Bohm M, Mahfoud F, Rocha-Singh K, et al. Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study. Lancet. 2014;383:622\u20139.","journal-title":"Lancet"},{"key":"147_CR12","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1016\/S0140-6736(17)32281-X","volume":"390","author":"RR Townsend","year":"2017","unstructured":"Townsend RR, Mahfoud F, Kandzari DE, Kario K, Pocock S, Weber MA, et al. Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial. Lancet. 2017;390:2160\u201370.","journal-title":"Lancet"},{"key":"147_CR13","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1152\/physiolgenomics.2001.5.2.89","volume":"5","author":"GM Butz","year":"2001","unstructured":"Butz GM, Davisson RL. Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool. Physiol Genom. 2001;5:89\u201397.","journal-title":"Physiol Genom"},{"key":"147_CR14","doi-asserted-by":"publisher","first-page":"F583","DOI":"10.1152\/ajprenal.00270.2001","volume":"283","author":"W Wang","year":"2002","unstructured":"Wang W, Falk SA, Jittikanont S, Gengaro PE, Edelstein CL, Schrier RW. Protective effect of renal denervation on normotensive endotoxemia-induced acute renal failure in mice. Am J Physiol Ren Physiol. 2002;283:F583\u201387.","journal-title":"Am J Physiol Ren Physiol"},{"key":"147_CR15","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.amjhyper.2007.02.010","volume":"20","author":"KL Jackson","year":"2007","unstructured":"Jackson KL, Head GA, Morris BJ, Chin-Dusting J, Jones E, La Greca L, et al. Reduced cardiovascular reactivity to stress but not feeding in renin enhancer knockout mice. Am J Hypertens. 2007;20:893\u20139.","journal-title":"Am J Hypertens"},{"key":"147_CR16","doi-asserted-by":"publisher","first-page":"R1394","DOI":"10.1152\/ajpregu.00306.2004","volume":"287","author":"DL Lee","year":"2004","unstructured":"Lee DL, Webb RC, Brands MW. Sympathetic and angiotensin-dependent hypertension during cage-switch stress in mice. Am J Physiol Regul Integr Comp Physiol. 2004;287:R1394\u201398.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"147_CR17","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1152\/jappl.1998.85.3.962","volume":"85","author":"GW Lambert","year":"1998","unstructured":"Lambert GW, Jonsdottir IH. Influence of voluntary exercise on hypothalamic norepinephrine. J Appl Physiol. 1998;85:962\u20136.","journal-title":"J Appl Physiol"},{"key":"147_CR18","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/cvr\/28.3.303","volume":"28","author":"J Ludbrook","year":"1994","unstructured":"Ludbrook J. Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc Res. 1994;28:303\u201311.","journal-title":"Cardiovasc Res"},{"key":"147_CR19","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/hr.2013.156","volume":"37","author":"KL Jackson","year":"2014","unstructured":"Jackson KL, Nguyen-Huu T-P, Davern PJ, Head GA. Energy metabolism in BPH\/2J genetically hypertensive mice. Hypertens Res. 2014;37:413\u201321.","journal-title":"Hypertens Res"},{"key":"147_CR20","doi-asserted-by":"publisher","first-page":"739","DOI":"10.2119\/molmed.2015.00096","volume":"21","author":"FZ Marques","year":"2015","unstructured":"Marques FZ, Romaine SP, Denniff M, Eales J, Dormer J, Garrelds IM, et al. Signatures of miR-181a on renal transcriptome and blood pressure. Mol Med. 2015;21:739\u201348.","journal-title":"Mol Med"},{"key":"147_CR21","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1172\/JCI108069","volume":"56","author":"E Bello-Reuss","year":"1975","unstructured":"Bello-Reuss E, Colindres RE, Pastoriza-Munoz E, Mueller RA, Gottschalk CW. Effects of acute unilateral renal denervation in the rat. J Clin Investig. 1975;56:208\u201317.","journal-title":"J Clin Investig"},{"key":"147_CR22","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1161\/HYPERTENSIONAHA.113.01261","volume":"62","author":"EC Hart","year":"2013","unstructured":"Hart EC, McBryde FD, Burchell AE, Ratcliffe LE, Stewart LQ, Baumbach A, et al. Translational examination of changes in baroreflex function after renal denervation in hypertensive rats and humans. Hypertension. 2013;62:533\u201341.","journal-title":"Hypertension"},{"key":"147_CR23","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1161\/01.HYP.32.2.249","volume":"32","author":"WC Huang","year":"1998","unstructured":"Huang WC, Fang TC, Cheng JT. Renal denervation prevents and reverses hyperinsulinemia-induced hypertension in rats. Hypertension. 1998;32:249\u201354.","journal-title":"Hypertension"},{"key":"147_CR24","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1161\/01.HYP.2.3.266","volume":"2","author":"RE Katholi","year":"1980","unstructured":"Katholi RE, Naftilan AJ, Oparil S. Importance of renal sympathetic tone in the development of DOCA-salt hypertension in the rat. Hypertension. 1980;2:266\u201373.","journal-title":"Hypertension"},{"key":"147_CR25","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1161\/01.HYP.0000153319.20340.2a","volume":"45","author":"BT Alexander","year":"2005","unstructured":"Alexander BT, Hendon AE, Ferril G, Dwyer TM. Renal denervation abolishes hypertension in low-birth-weight offspring from pregnant rats with reduced uterine perfusion. Hypertension. 2005;45:754\u20138.","journal-title":"Hypertension"},{"key":"147_CR26","doi-asserted-by":"publisher","first-page":"R262","DOI":"10.1152\/ajpregu.00408.2015","volume":"310","author":"JD Foss","year":"2016","unstructured":"Foss JD, Fink GD, Osborn JW. Differential role of afferent and efferent renal nerves in the maintenance of early- and late-phase Dahl S hypertension. Am J Physiol Regul Integr Comp Physiol. 2016;310:R262\u201367.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"147_CR27","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1161\/HYPERTENSIONAHA.111.00474","volume":"61","author":"JD Foss","year":"2013","unstructured":"Foss JD, Fink GD, Osborn JW. Reversal of genetic salt-sensitive hypertension by targeted sympathetic ablation. Hypertension. 2013;61:806\u201311.","journal-title":"Hypertension"},{"key":"147_CR28","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.lfs.2014.06.015","volume":"110","author":"T Machino","year":"2014","unstructured":"Machino T, Murakoshi N, Sato A, Xu D, Hoshi T, Kimura T, et al. Anti-hypertensive effect of radiofrequency renal denervation in spontaneously hypertensive rats. Life Sci. 2014;110:86\u201392.","journal-title":"Life Sci"},{"key":"147_CR29","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/ki.2014.220","volume":"87","author":"M Eriguchi","year":"2015","unstructured":"Eriguchi M, Tsuruya K, Haruyama N, Yamada S, Tanaka S, Suehiro T, et al. Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease. Kidney Int. 2015;87:116\u201327.","journal-title":"Kidney Int"},{"key":"147_CR30","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1161\/01.HYP.4.3.369","volume":"4","author":"SR Winternitz","year":"1982","unstructured":"Winternitz SR, Katholi RE, Oparil S. Decrease in hypothalamic norepinephrine content following renal denervation in the one-kidney, one clip Goldblatt hypertensive rat. Hypertension. 1982;4:369\u201373.","journal-title":"Hypertension"},{"key":"147_CR31","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/S0140-6736(10)62039-9","volume":"376","author":"MD Esler","year":"2010","unstructured":"Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376:1903\u20139.","journal-title":"Lancet"},{"key":"147_CR32","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1291\/hypres.31.561","volume":"31","author":"T Wang","year":"2008","unstructured":"Wang T, Nabika T, Notsu Y, Takabatake T. Sympathetic regulation of the renal functions in rats reciprocally congenic for chromosome 1 blood pressure quantitative trait locus. Hypertens Res. 2008;31:561\u20138.","journal-title":"Hypertens Res"},{"key":"147_CR33","doi-asserted-by":"publisher","first-page":"F251","DOI":"10.1152\/ajprenal.00578.2013","volume":"307","author":"Y Yao","year":"2014","unstructured":"Yao Y, Fomison-Nurse IC, Harrison JC, Walker RJ, Davis G, Sammut IA. Chronic bilateral renal denervation attenuates renal injury in a transgenic rat model of diabetic nephropathy. Am J Physiol Ren Physiol. 2014;307:F251\u201362.","journal-title":"Am J Physiol Ren Physiol"},{"key":"147_CR34","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/S0140-6736(09)60566-3","volume":"373","author":"H Krum","year":"2009","unstructured":"Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373:1275\u201381.","journal-title":"Lancet"},{"key":"147_CR35","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1681\/ASN.2012070678","volume":"24","author":"J Kim","year":"2013","unstructured":"Kim J, Padanilam BJ. Renal nerves drive interstitial fibrogenesis in obstructive nephropathy. J Am Soc Nephrol. 2013;24:229\u201342.","journal-title":"J Am Soc Nephrol"},{"key":"147_CR36","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1152\/jappl.1997.83.1.95","volume":"83","author":"G Bao","year":"1997","unstructured":"Bao G, Metreveli N, Li R, Taylor A, Fletcher EC. Blood pressure response to chronic episodic hypoxia: role of the sympathetic nervous system. J Appl Physiol. 1997;83:95\u2013101.","journal-title":"J Appl Physiol"},{"key":"147_CR37","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1590\/S0100-879X2009000200010","volume":"42","author":"JV Franquini","year":"2009","unstructured":"Franquini JV, Medeiros AR, Andrade TU, Araujo MT, Moyses MR, Abreu GR, et al. Influence of renal denervation on blood pressure, sodium and water excretion in acute total obstructive apnea in rats. Braz J Med Biol Res. 2009;42:214\u20139.","journal-title":"Braz J Med Biol Res"},{"key":"147_CR38","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1161\/HYPERTENSIONAHA.107.100800","volume":"51","author":"SL Burke","year":"2008","unstructured":"Burke SL, Evans RG, Moretti J-L, Head GA. Levels of renal and extrarenal sympathetic drive in Ang II-induced hypertension. Hypertension. 2008;51:878\u201383.","journal-title":"Hypertension"},{"key":"147_CR39","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1161\/HYPERTENSIONAHA.107.096891","volume":"50","author":"MA Markus","year":"2007","unstructured":"Markus MA, Goy C, Adams DJ, Lovicu FJ, Morris BJ. Renin enhancer is crucial for full response in Renin expression to an in vivo stimulus. Hypertension. 2007;50:933\u20138.","journal-title":"Hypertension"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41440-018-0147-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41440-018-0147-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41440-018-0147-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:19:50Z","timestamp":1684617590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41440-018-0147-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,10]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["147"],"URL":"https:\/\/doi.org\/10.1038\/s41440-018-0147-9","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,10]]},"assertion":[{"value":"13 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"G.W.L. received research support from Medtronic and has acted as a consultant for Medtronic.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}