{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:57:40Z","timestamp":1785527860724,"version":"3.56.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study aimed to investigate the effects of the combination of Marukome Nenrin miso, which has natriuretic effects, and Marukome MK-34-1 miso, which has potent angiotensin converting enzyme inhibitory effects, on blood pressure (BP) in humans. A total of 40 subjects aged 40\u201369 years with high-normal BP or stage I hypertension were randomly assigned to two groups: 1) the miso group (32\u2009g 2:1 w\/w Nenrin and MK-34-1 with 3.8\u2009g salt\/day) or 2) the control soy food group (14.4\u2009g soy food with 0.2\u2009g salt\/day). The levels of major nutrients were equal in the miso and control food servings, except for the fiber and Na levels, which were higher in the miso food serving. Daytime and nighttime BP were measured with an automated BP monitor. Compared with the soy food intake, miso intake for 8 weeks did not affect daytime clinical BP but significantly decreased nighttime BP without affecting pulse rate (PR). Moreover, miso shifted the nighttime BP profile to lower levels than those at baseline. Soy food intake did not change the nighttime BP profile after 8 weeks. Miso intake also tended to reduce nighttime BP in a subgroup with stage 1 hypertension compared with the results of the soy food group participants and shifted the nighttime BP profile toward lower levels than those recorded at baseline. Miso intake did not influence lipid or glucose metabolism. In conclusion, this is the first report showing that miso reduces nighttime BP in humans. Miso may do so by shrinking the fluid spaces in the body and\/or deactivating the adrenergic nervous system.<\/jats:p>","DOI":"10.1038\/s41440-019-0304-9","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T10:49:55Z","timestamp":1564742995000},"page":"1757-1767","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Long-term intake of miso soup decreases nighttime blood pressure in subjects with high-normal blood pressure or stage I hypertension"],"prefix":"10.1038","volume":"42","author":[{"given":"Hiroaki","family":"Kondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroe","family":"Sakuyama Tomari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minami","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiki","family":"Itou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"304_CR1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1056\/NEJMoa1311989","volume":"371","author":"A Mente","year":"2014","unstructured":"Mente A, O\u2019Donnell MJ, Rangarajan S, McQueen MJ, Poirier P, Wielgosz A, et al. PURE Investigators. Association of Urinary Sodium and Potassium Excretion with blood pressure. N Engl J Med. 2014;371:601\u201311.","journal-title":"N Engl J Med"},{"key":"304_CR2","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/s41440-018-0091-8","volume":"41","author":"H Liu","year":"2018","unstructured":"Liu H, Gao X, Zhou L, Wu Y, Li Y, Mai J, et al. Urinary sodium excretion and risk of cardiovascular disease in the Chinese population: a prospective study. Hypertens Res. 2018;41:849\u201355.","journal-title":"Hypertens Res"},{"key":"304_CR3","first-page":"361","volume":"10","author":"H Sakuyama","year":"2017","unstructured":"Sakuyama H, Tachizaki N, Nanmo A, Yamada K, Uehara Y. The influence of intake of daily Miso soup on blood pressure in humans-The results of 5-year observational study-. J Jpn Soc Med Use Func Foods. 2017;10:361\u20138.","journal-title":"J Jpn Soc Med Use Func Foods"},{"key":"304_CR4","first-page":"1601","volume":"44","author":"M Kitagawa","year":"2016","unstructured":"Kitagawa M, Itoh K, Yamada M, Koike S, Yamamoto T, Uehara Y. Long term intake of Miso soup unaffected blood pressure in subjects with normal or stage I hypertension-Double blind comparative intervention trial-. Jpn Pharm Ther. 2016;44:1601\u201312.","journal-title":"Jpn Pharm Ther"},{"key":"304_CR5","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.nut.2011.09.010","volume":"28","author":"M Yoshinaga","year":"2012","unstructured":"Yoshinaga M, Toda N, Tamura Y, Terakado S, Ueno M, Otsuka K, et al. Japanese traditional miso soup attenuates salt-induced hypertension and its organ damage in Dahl salt-sensitive rats. 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Toyama\/Japan. 2016."},{"key":"304_CR8","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/s41440-018-0197-z","volume":"42","author":"H Sakuyama-Tomari","year":"2019","unstructured":"Sakuyama-Tomari H, Uchikawa M, Yamazaki A, Hirabayashi S, Yamakawa S, Kitagawa M, et al. Newly manufactured Marukome MK-34-1 miso with angiotensin-converting enzyme inhibitory activity and its antihypertensive effects in genetic hypertensive rat models. Hypertens Res. 2019;42:790\u2013800.","journal-title":"Hypertens Res"},{"key":"304_CR9","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1291\/hypres.26.771","volume":"26","author":"Y Imai","year":"2003","unstructured":"Imai Y, Otsuka K, Kawano Y, Shimada K, Hayashi H, Tochikubo O, et al. Japanese society of hypertension (JSH) guidelines for self-monitoring of blood pressure at home. 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Circulation. 1999;100:1635\u20138.","journal-title":"Circulation"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41440-019-0304-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41440-019-0304-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41440-019-0304-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:21:06Z","timestamp":1684617666000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41440-019-0304-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,2]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["304"],"URL":"https:\/\/doi.org\/10.1038\/s41440-019-0304-9","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,2]]},"assertion":[{"value":"3 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The Marukome Nenrin and Marukome MK-34-1 combination miso was originally manufactured and offered by Marukome Co., Ltd., Nagano. The study was designed by TTC, Co., Ltd., Tokyo and performed by Meiseikai Higashi Shinjuku Clinic, Tokyo, Japan under the supervision of Yoshio Uehara. Manabu Kitagawa, Minami Yamada, and Seiki Itou were responsible for supplying the test miso. They were not involved in the execution of the clinical study, data analysis or writing the article. Tetsuro Yamamoto was responsible for controlling the study. The collected data were analyzed by Hiroe Sakuyama Tomari and Shoko Yamakawa. The article was independently written by Yoshio Uehara.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}