{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T13:12:58Z","timestamp":1744204378486},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1038\/s41440-021-00759-2","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T05:10:47Z","timestamp":1633065047000},"page":"1668-1670","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exosomes and exosomal cargo in urinary extracellular vesicles: novel potential biomarkers for mineralocorticoid-receptor-associated hypertension"],"prefix":"10.1038","volume":"44","author":[{"given":"Hirotaka","family":"Shibata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"759_CR1","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1038\/s41440-019-0284-9","volume":"42","author":"S Umemura","year":"2019","unstructured":"Umemura S, Arima H, Arima S, Asayama K, Dohi Y, Hirooka Y, et al. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019). Hypertens Res. 2019;42:1235\u2013481.","journal-title":"Hypertens Res"},{"key":"759_CR2","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1161\/HYPERTENSIONAHA.117.10263","volume":"71","author":"Y Ohno","year":"2018","unstructured":"Ohno Y, Sone M, Inagaki N, Yamasaki T, Ogawa O, Takeda Y, et al. Prevalence of cardiovascular disease and its risk factors in primary aldosteronism: a multicenter study in Japan. Hypertension. 2018;71:530\u20137.","journal-title":"Hypertension"},{"key":"759_CR3","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/s41440-019-0244-4","volume":"42","author":"M Satoh","year":"2019","unstructured":"Satoh M, Maruhashi T, Yoshida Y, Shibata H. Systematic review of the clinical outcomes of mineralocorticoid receptor antagonist treatment versus adrenalectomy in patients with primary aldosteronism. Hypertens Res. 2019;42:817\u201324.","journal-title":"Hypertens Res"},{"key":"759_CR4","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/ajh.2011.245","volume":"25","author":"H Shibata","year":"2012","unstructured":"Shibata H, Itoh H. Mineralocorticoid receptor-associated hypertension and its organ damage: clinical relevance for resistant hypertension. Am J Hypertens. 2012;25:514\u201323.","journal-title":"Am J Hypertens"},{"key":"759_CR5","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3389\/fendo.2017.00230","volume":"8","author":"ER Barros","year":"2017","unstructured":"Barros ER, Carvajal CA. Urinary exosomes and their cargo: potential biomarkers for mineralocorticoid arterial hypertension? Front Endocrinol. 2017;8:230 https:\/\/doi.org\/10.3389\/fendo.2017.00230","journal-title":"Front Endocrinol"},{"key":"759_CR6","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1161\/HYPERTENSIONAHA.121.17136","volume":"78","author":"J Burrello","year":"2021","unstructured":"Burrello J, Tetti M, Forestiero V, Biemmi V, Bolis S, Pomatto MAC, et al. Characterization of circulating extracellular vesicle surface antigens in patients with primary aldosteronism. Hypertension. 2021;78:726\u201337.","journal-title":"Hypertension"},{"key":"759_CR7","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1161\/HYPERTENSIONAHA.112.198135","volume":"60","author":"N van der Lubbe","year":"2012","unstructured":"van der Lubbe N, Jansen PM, Salih M, Fenton RA, van den Meiracker AH, Danser AH, et al. The phosphorylated sodium chloride cotransporter in urinary exosomes is superior to prostasin as a marker for aldosteronism. Hypertension. 2012;60:741\u20138.","journal-title":"Hypertension"},{"key":"759_CR8","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1681\/ASN.2015111221","volume":"28","author":"MJ Wolley","year":"2017","unstructured":"Wolley MJ, Wu A, Zu S, Gordon RD, Fenton RA, Stowasser M. In primary aldosteronism, mineralocorticoids influence exosomal sodium-chloride cotransporter abundance. J Am Soc Nephrol. 2017;28:56\u201363.","journal-title":"J Am Soc Nephrol"},{"key":"759_CR9","doi-asserted-by":"publisher","unstructured":"Ochiai-Homma F, Kuribayashi-Okuma E, Tsurutani Y, Ishizawa K, Fujii W, Odajima K, et al. Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism. Hypertens Res. 2021. https:\/\/doi.org\/10.1038\/s41440-021-00710-5.","DOI":"10.1038\/s41440-021-00710-5"},{"key":"759_CR10","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.jacc.2020.05.071","volume":"76","author":"A Tanaka","year":"2020","unstructured":"Tanaka A, Shibata H, Node K. Suspected borderline aldosteronism in hypertension. The next target? J Am Coll Cardiol. 2020;76:759\u201360.","journal-title":"J Am Coll Cardiol"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41440-021-00759-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-021-00759-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-021-00759-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:10:08Z","timestamp":1638749408000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41440-021-00759-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["759"],"URL":"https:\/\/doi.org\/10.1038\/s41440-021-00759-2","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,1]]},"assertion":[{"value":"22 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The author received honoraria from Daiichi Sankyo Co., Limited, and scholarship from Chugai Pharmaceuticals, Limited, and Bayer Pharmaceuticals, Limited.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}