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RDN was performed one week after creation of ACF or sham-operation. Animals were prepared for evaluation of autoregulatory capacity of renal blood flow (RBF) and glomerular filtration rate (GFR), and of the pressure-natriuresis characteristics after stepwise changes in renal arterial pressure (RAP) induced by aortic clamping. Their basal values of blood pressure and renal function were significantly lower than with innervated sham-operated TGR (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 in all cases): mean arterial pressure (MAP) (115\u2009\u00b1\u20092 vs. 160\u2009\u00b1\u20093\u2009mmHg), RBF (6.91\u2009\u00b1\u20090.33 vs. 10.87\u2009\u00b1\u20090.38\u2009ml.min<jats:sup>\u20131<\/jats:sup>.g<jats:sup>\u20131<\/jats:sup>), urine flow (UF) (11.3\u2009\u00b1\u20091.79 vs. 43.17\u2009\u00b1\u20093.24\u2009\u00b5l.min<jats:sup>\u20131<\/jats:sup>.g<jats:sup>\u20131<\/jats:sup>) and absolute sodium excretion (U<jats:sub>Na<\/jats:sub>V) (1.08\u2009\u00b1\u20090.27 vs, 6.38\u2009\u00b1\u20090.76 \u00b5mol.min<jats:sup>\u20131<\/jats:sup>.g<jats:sup>\u20131<\/jats:sup>). After denervation ACF TGR showed improved autoregulation of RBF: at lowest RAP level (80\u2009mmHg) the value was higher than in innervated ACF TGR (6.92\u2009\u00b1\u20090.26 vs. 4.54\u2009\u00b1\u20090.22\u2009ml.min<jats:sup>\u20131<\/jats:sup>.g<jats:sup>\u20131<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Also, the pressure-natriuresis relationship was markedly improved after RDN: at the RAP of 80\u2009mmHg UF equaled 4.31\u2009\u00b1\u20090.99 vs. 0.26\u2009\u00b1\u20090.09\u2009\u00b5l.min<jats:sup>\u20131<\/jats:sup>.g<jats:sup>\u20131<\/jats:sup> recorded in innervated ACF TGR, U<jats:sub>Na<\/jats:sub>V was 0.31\u2009\u00b1\u20090.05 vs. 0.04\u2009\u00b1\u20090.01 \u00b5mol\u2009min<jats:sup>\u20131<\/jats:sup>.g<jats:sup>\u20131<\/jats:sup> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 in all cases). In conclusion, in our model of hypertensive rat with ACF-induced HF, RDN improved autoregulatory capacity of RBF and the pressure-natriuresis relationship when measured at the stage of HF decompensation.<\/jats:p>","DOI":"10.1038\/s41440-024-01583-0","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T03:03:04Z","timestamp":1706842984000},"page":"998-1016","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Renal sympathetic denervation improves pressure-natriuresis relationship in cardiorenal syndrome: insight from studies with Ren-2 transgenic hypertensive rats with volume overload induced using aorto-caval fistula"],"prefix":"10.1038","volume":"47","author":[{"given":"Zuzana","family":"Honetschl\u00e4gerov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Huskov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u0148a","family":"Kikerlov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Sadowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Kompanowska-Jezierska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo\u0161","family":"T\u00e1borsk\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenka","family":"Va\u0148ourkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Kujal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lud\u011bk","family":"\u010cervenka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"1583_CR1","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","volume":"118","author":"G Savarese","year":"2023","unstructured":"Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GMC, Coats AJS. 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