{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:23:57Z","timestamp":1790796237617,"version":"4.1.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1038\/s41440-024-01701-y","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T02:01:44Z","timestamp":1716256904000},"page":"2157-2171","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adrenomedullin improved endothelial dysfunction via receptor-Akt pathway in rats with obesity-related hypertension"],"prefix":"10.1038","volume":"47","author":[{"given":"Si-Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9465-1338","authenticated-orcid":false,"given":"Ye-Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"1701_CR1","volume":"12","author":"X Lin","year":"2021","unstructured":"Lin X, Li H. Obesity: Epidemiology, Pathophysiology, and Therapeutics. Front Endocrinol (Lausanne). 2021;12:706978.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1701_CR2","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.120.316101","volume":"126","author":"ME Piche","year":"2020","unstructured":"Piche ME, Tchernof A, Despres JP. Obesity Phenotypes, Diabetes, and Cardiovascular Diseases. Circ Res. 2020;126:1477\u20131500.","journal-title":"Circ Res"},{"key":"1701_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2017.05.013","volume":"122","author":"G Seravalle","year":"2017","unstructured":"Seravalle G, Grassi G. Obesity and hypertension. Pharm Res. 2017;122:1\u20137.","journal-title":"Pharm Res"},{"key":"1701_CR4","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3502","volume":"38","author":"JL Silveira Rossi","year":"2022","unstructured":"Silveira Rossi JL, Barbalho SM, Reverete de Araujo R, Bechara MD, Sloan KP, Sloan LA. Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors. Diabetes Metab Res Rev. 2022;38:e3502.","journal-title":"Diabetes Metab Res Rev"},{"key":"1701_CR5","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.2174\/1381612811319130006","volume":"19","author":"A Virdis","year":"2013","unstructured":"Virdis A, Neves MF, Duranti E, Bernini G, Taddei S. Microvascular endothelial dysfunction in obesity and hypertension. Curr Pharm Des. 2013;19:2382\u20139.","journal-title":"Curr Pharm Des"},{"key":"1701_CR6","volume":"8","author":"G Gallo","year":"2021","unstructured":"Gallo G, Volpe M, Savoia C. Endothelial Dysfunction in Hypertension: Current Concepts and Clinical Implications. Front Med (Lausanne). 2021;8:798958.","journal-title":"Front Med (Lausanne)"},{"key":"1701_CR7","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s12265-021-10171-3","volume":"15","author":"J Gao","year":"2022","unstructured":"Gao J, Pan X, Li G, Chatterjee E, Xiao J. Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases. J Cardiovasc Transl Res. 2022;15:604\u201320.","journal-title":"J Cardiovasc Transl Res"},{"key":"1701_CR8","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.3390\/ijms23063346","volume":"23","author":"S Jebari-Benslaiman","year":"2022","unstructured":"Jebari-Benslaiman S, Galicia-Garcia U, Larrea-Sebal A, Olaetxea JR, Alloza I, Vandenbroeck K, et al. Pathophysiology of Atherosclerosis. Int J Mol Sci. 2022;23:3346.","journal-title":"Int J Mol Sci"},{"key":"1701_CR9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ccc.2019.12.009","volume":"36","author":"AR Cyr","year":"2020","unstructured":"Cyr AR, Huckaby LV, Shiva SS, Zuckerbraun BS. Nitric Oxide and Endothelial Dysfunction. Crit Care Clin. 2020;36:307\u201321.","journal-title":"Crit Care Clin"},{"key":"1701_CR10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11010-021-04260-9","volume":"477","author":"R Mallick","year":"2022","unstructured":"Mallick R, Duttaroy AK. Modulation of endothelium function by fatty acids. Mol Cell Biochem. 2022;477:15\u201338.","journal-title":"Mol Cell Biochem"},{"key":"1701_CR11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11892-021-01446-9","volume":"22","author":"MN Rana","year":"2022","unstructured":"Rana MN, Neeland IJ. Adipose Tissue Inflammation and Cardiovascular Disease: An Update. Curr Diab Rep. 2022;22:27\u201337.","journal-title":"Curr Diab Rep."},{"key":"1701_CR12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/978-3-319-48382-5_15","volume":"960","author":"A Engin","year":"2017","unstructured":"Engin A. Endothelial Dysfunction in Obesity. Adv Exp Med Biol. 2017;960:345\u201379.","journal-title":"Adv Exp Med Biol"},{"key":"1701_CR13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10456-021-09785-7","volume":"24","author":"C Marziano","year":"2021","unstructured":"Marziano C, Genet G, Hirschi KK. Vascular endothelial cell specification in health and disease. Angiogenesis. 2021;24:213\u201336.","journal-title":"Angiogenesis"},{"key":"1701_CR14","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.3390\/ijms12053117","volume":"12","author":"A Fernandez-Sanchez","year":"2011","unstructured":"Fernandez-Sanchez A, Madrigal-Santillan E, Bautista M, Esquivel-Soto J, Morales-Gonzalez A, Esquivel-Chirino C, et al. Inflammation, oxidative stress, and obesity. Int J Mol Sci. 2011;12:3117\u201332.","journal-title":"Int J Mol Sci"},{"key":"1701_CR15","unstructured":"Iantorno, M; Campia, U; Di Daniele, N; Nistico, S; Forleo, GB; Cardillo, C; et al. Obesity, inflammation and endothelial dysfunction. (0393-974X (Print))."},{"key":"1701_CR16","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/jch.13518","volume":"21","author":"SG Chrysant","year":"2019","unstructured":"Chrysant SG. Pathophysiology and treatment of obesity-related hypertension. J Clin Hypertens (Greenwich). 2019;21:555\u20139.","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"1701_CR17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11906-019-0915-1","volume":"21","author":"JB Cohen","year":"2019","unstructured":"Cohen JB, Gadde KM. Weight Loss Medications in the Treatment of Obesity and Hypertension. Curr Hypertens Rep. 2019;21:16.","journal-title":"Curr Hypertens Rep."},{"key":"1701_CR18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/187221412799015263","volume":"6","author":"BM Cheung","year":"2012","unstructured":"Cheung BM, Tang F. Adrenomedullin: exciting new horizons. Recent Pat Endocr Metab Immune Drug Discov. 2012;6:4\u201317.","journal-title":"Recent Pat Endocr Metab Immune Drug Discov"},{"key":"1701_CR19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bph.14075","volume":"175","author":"DL Hay","year":"2018","unstructured":"Hay DL, Garelja ML, Poyner DR, Walker CS. Update on the pharmacology of calcitonin\/CGRP family of peptides: IUPHAR Review 25. Br J Pharm. 2018;175:3\u201317.","journal-title":"Br J Pharm"},{"key":"1701_CR20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejphar.2015.06.061","volume":"764","author":"J Kato","year":"2015","unstructured":"Kato J, Kitamura K. Bench-to-bedside pharmacology of adrenomedullin. Eur J Pharm. 2015;764:140\u20138.","journal-title":"Eur J Pharm"},{"key":"1701_CR21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12519-017-0106-6","volume":"14","author":"KA Metwalley","year":"2018","unstructured":"Metwalley KA, Farghaly HS, Sherief T. Plasma adrenomedullin level in children with obesity: relationship to left ventricular function. World J Pediatr. 2018;14:84\u201391.","journal-title":"World J Pediatr"},{"key":"1701_CR22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.regpep.2009.08.003","volume":"158","author":"I Nomura","year":"2009","unstructured":"Nomura I, Kato J, Tokashiki M, Kitamura K. Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity. Regul Pept. 2009;158:127\u201331.","journal-title":"Regul Pept"},{"key":"1701_CR23","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijcard.2019.04.008","volume":"291","author":"J Theuerle","year":"2019","unstructured":"Theuerle J, Farouque O, Vasanthakumar S, Patel SK, Burrell LM, Clark DJ, et al. Plasma endothelin-1 and adrenomedullin are associated with coronary artery function and cardiovascular outcomes in humans. Int J Cardiol. 2019;291:168\u201372.","journal-title":"Int J Cardiol"},{"key":"1701_CR24","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1097\/00004872-200410000-00017","volume":"22","author":"N Hosomi","year":"2004","unstructured":"Hosomi N, Ohyama H, Takahashi T, Shinomiya K, Naya T, Ban CR, et al. Plasma adrenomedullin and carotid atherosclerosis in atherothrombotic ischemic stroke. J Hypertens. 2004;22:1945\u201351.","journal-title":"J Hypertens"},{"key":"1701_CR25","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2459\/JCM.0000000000000299","volume":"18","author":"MF Yuyun","year":"2017","unstructured":"Yuyun MF, Narayan HK, Quinn PA, Struck J, Bergmann A, Hartmann O, et al. Prognostic value of human mature adrenomedullin in patients with acute myocardial infarction. J Cardiovasc Med (Hagerstown). 2017;18:42\u201350.","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"1701_CR26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ejhf.1366","volume":"21","author":"AA Voors","year":"2019","unstructured":"Voors AA, Kremer D, Geven C, Ter Maaten JM, Struck J, Bergmann A, et al. Adrenomedullin in heart failure: pathophysiology and therapeutic application. Eur J Heart Fail. 2019;21:163\u201371.","journal-title":"Eur J Heart Fail"},{"key":"1701_CR27","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2174\/1570161112666141014145735","volume":"13","author":"M Yuan","year":"2015","unstructured":"Yuan M, Wang Q, Li C, Tao L, Zhang H, Wang H, et al. Adrenomedullin in Vascular Endothelial Injury and Combination Therapy: Time for a New Paradigm. Curr Vasc Pharm. 2015;13:459\u201366.","journal-title":"Curr Vasc Pharm"},{"key":"1701_CR28","unstructured":"Murakami S, Kimura H, Kangawa K, Nagaya N, Physiological significance and therapeutic potential of adrenomedullin in pulmonary hypertension. (1871-529X (Print))."},{"key":"1701_CR29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0014-2999(99)00151-X","volume":"371","author":"I Makino","year":"1999","unstructured":"Makino I, Shibata K, Makino Y, Kangawa K, Kawarabayashi T. Adrenomedullin attenuates the hypertension in hypertensive pregnant rats induced by N(G)-nitro-L-arginine methyl ester. Eur J Pharm. 1999;371:159\u201367.","journal-title":"Eur J Pharm"},{"key":"1701_CR30","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/SHK.0000000000001103","volume":"50","author":"C Geven","year":"2018","unstructured":"Geven C, Bergmann A, Kox M, Pickkers P. Vascular Effects of Adrenomedullin and the Anti-Adrenomedullin Antibody Adrecizumab in Sepsis. Shock. 2018;50:132\u201340.","journal-title":"Shock"},{"key":"1701_CR31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00726-005-0279-5","volume":"32","author":"B Yanagawa","year":"2007","unstructured":"Yanagawa B, Nagaya N. Adrenomedullin: molecular mechanisms and its role in cardiac disease. Amino Acids. 2007;32:157\u201364.","journal-title":"Amino Acids"},{"key":"1701_CR32","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.yjmcc.2006.05.017","volume":"41","author":"SA Hamid","year":"2006","unstructured":"Hamid SA, Baxter GF. A critical cytoprotective role of endogenous adrenomedullin in acute myocardial infarction. J Mol Cell Cardiol. 2006;41:360\u20133.","journal-title":"J Mol Cell Cardiol"},{"key":"1701_CR33","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/00005344-200306000-00004","volume":"41","author":"E Fung","year":"2003","unstructured":"Fung E, Fiscus RR. Adrenomedullin induces direct (endothelium-independent) vasorelaxations and cyclic adenosine monophosphate elevations that are synergistically enhanced by brain natriuretic peptide in isolated rings of rat thoracic aorta. J Cardiovasc Pharm. 2003;41:849\u201355.","journal-title":"J Cardiovasc Pharm"},{"key":"1701_CR34","first-page":"719","volume":"15","author":"P Qian","year":"2022","unstructured":"Qian P, Wang Q, Wang FZ, Dai HB, Wang HY, Gao Q, et al. Adrenomedullin Improves Cardiac Remodeling and Function in Obese Rats with Hypertension. Pharm (Basel). 2022;15:719.","journal-title":"Pharm (Basel)"},{"key":"1701_CR35","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1161\/CIRCRESAHA.112.275743","volume":"111","author":"IA Estrada","year":"2012","unstructured":"Estrada IA, Donthamsetty R, Debski P, Zhou MH, Zhang SL, Yuan JX, et al. STIM1 restores coronary endothelial function in type 1 diabetic mice. Circ Res. 2012;111:1166\u201375.","journal-title":"Circ Res"},{"key":"1701_CR36","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1089\/ars.2013.5607","volume":"20","author":"A Konior","year":"2014","unstructured":"Konior A, Schramm A, Czesnikiewicz-Guzik M, Guzik TJ. NADPH oxidases in vascular pathology. Antioxid Redox Signal. 2014;20:2794\u2013814.","journal-title":"Antioxid Redox Signal"},{"key":"1701_CR37","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ecl.2008.06.007","volume":"37","author":"G Boden","year":"2008","unstructured":"Boden G. Obesity and free fatty acids. Endocrinol Metab Clin North Am. 2008;37:635\u201346. viii-ix","journal-title":"Endocrinol Metab Clin North Am"},{"key":"1701_CR38","doi-asserted-by":"crossref","first-page":"9165","DOI":"10.3892\/mmr.2017.7710","volume":"16","author":"M Wang","year":"2017","unstructured":"Wang M, Chen Y, Xiong Z, Yu S, Zhou B, Ling Y, et al. Ginsenoside Rb1 inhibits free fatty acids\u2011induced oxidative stress and inflammation in 3T3\u2011L1 adipocytes. Mol Med Rep. 2017;16:9165\u201372.","journal-title":"Mol Med Rep"},{"key":"1701_CR39","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.bbrc.2015.07.067","volume":"464","author":"S Zhang","year":"2015","unstructured":"Zhang S, Patel A, Moorthy B, Shivanna B. Adrenomedullin deficiency potentiates hyperoxic injury in fetal human pulmonary microvascular endothelial cells. Biochem Biophys Res Commun. 2015;464:1048\u201353.","journal-title":"Biochem Biophys Res Commun"},{"key":"1701_CR40","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/hc0102.101399","volume":"105","author":"T Shimosawa","year":"2002","unstructured":"Shimosawa T, Shibagaki Y, Ishibashi K, Kitamura K, Kangawa K, Kato S, et al. Adrenomedullin, an\u2002endogenous\u2002peptide, counteracts cardiovascular damage. Circulation. 2002;105:106\u201311.","journal-title":"Circulation"},{"key":"1701_CR41","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1161\/01.HYP.0000066846.46422.2C","volume":"41","author":"T Shimosawa","year":"2003","unstructured":"Shimosawa T, Ogihara T, Matsui H, Asano T, Ando K, Fujita T. Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress. Hypertension. 2003;41:1080\u20135.","journal-title":"Hypertension"},{"key":"1701_CR42","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3390\/biomedicines9081068","volume":"9","author":"S Ashizuka","year":"2021","unstructured":"Ashizuka S, Kita T, Inatsu H, Kitamura K. Adrenomedullin: A Novel Therapeutic for the Treatment of Inflammatory Bowel Disease. Biomedicines. 2021;9:1068.","journal-title":"Biomedicines"},{"key":"1701_CR43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.niox.2013.08.005","volume":"35","author":"TV Gadkari","year":"2013","unstructured":"Gadkari TV, Cortes N, Madrasi K, Tsoukias NM, Joshi MS. Agmatine induced NO dependent rat mesenteric artery relaxation and its impairment in salt-sensitive hypertension. Nitric Oxide. 2013;35:65\u201371.","journal-title":"Nitric Oxide"},{"key":"1701_CR44","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-30646-4","volume":"13","author":"MA Cottam","year":"2022","unstructured":"Cottam MA, Caslin HL, Winn NC, Hasty AH. Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice. Nat Commun. 2022;13:2950.","journal-title":"Nat Commun"},{"key":"1701_CR45","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3390\/cells11081327","volume":"11","author":"S Kiran","year":"2022","unstructured":"Kiran S, Rakib A, Kodidela S, Kumar S, Singh UP. High-Fat Diet-Induced Dysregulation of Immune Cells Correlates with Macrophage Phenotypes and Chronic Inflammation in Adipose Tissue. Cells. 2022;11:1327.","journal-title":"Cells"},{"key":"1701_CR46","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/cvr\/cvx197","volume":"114","author":"S Steven","year":"2018","unstructured":"Steven S, Dib M, Hausding M, Kashani F, Oelze M, Kr\u00f6ller-Sch\u00f6n S, et al. CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db\/db mice. Cardiovasc Res. 2018;114:312\u201323.","journal-title":"Cardiovasc Res"},{"key":"1701_CR47","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/cmi.2014.71","volume":"11","author":"BC Matson","year":"2014","unstructured":"Matson BC, Caron KM. Adrenomedullin and endocrine control of immune cells during pregnancy. Cell Mol Immunol. 2014;11:456\u20139.","journal-title":"Cell Mol Immunol"},{"key":"1701_CR48","volume":"219","author":"J Han","year":"2022","unstructured":"Han J, Wan Q, Seo GY, Kim K, El Baghdady S, Lee JH, et al. Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity. J Exp Med. 2022;219:e20211985.","journal-title":"J Exp Med"},{"key":"1701_CR49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1203\/01.PDR.0000147745.52711.DD","volume":"57","author":"I Nomura","year":"2005","unstructured":"Nomura I, Abe J, Noma S, Saito H, Gao B, Wheeler G, et al. Adrenomedullin is highly expressed in blood monocytes associated with acute Kawasaki disease: a microarray gene expression study. Pediatr Res. 2005;57:49\u201355.","journal-title":"Pediatr Res"},{"key":"1701_CR50","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12929-017-0357-5","volume":"24","author":"A Ghosh","year":"2017","unstructured":"Ghosh A, Gao L, Thakur A, Siu PM, Lai CWK. Role of free fatty acids in endothelial dysfunction. J Biomed Sci. 2017;24:50.","journal-title":"J Biomed Sci"},{"key":"1701_CR51","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1161\/01.ATV.0000184759.91369.f8","volume":"25","author":"J Kato","year":"2005","unstructured":"Kato J, Tsuruda T, Kita T, Kitamura K, Eto T. Adrenomedullin: a protective factor for blood vessels. Arterioscler Thromb Vasc Biol. 2005;25:2480\u20137.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1701_CR52","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1161\/01.ATV.0000024685.92243.E7","volume":"22","author":"Y Imai","year":"2002","unstructured":"Imai Y, Shindo T, Maemura K, Sata M, Saito Y, Kurihara Y, et al. Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression. Arterioscler Thromb Vasc Biol. 2002;22:1310\u20135.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1701_CR53","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.yjmcc.2011.09.014","volume":"52","author":"P Balakumar","year":"2012","unstructured":"Balakumar P, Kathuria S, Taneja G, Kalra S, Mahadevan N. Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins? J Mol Cell Cardiol. 2012;52:83\u201392.","journal-title":"J Mol Cell Cardiol"},{"key":"1701_CR54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40292-017-0245-9","volume":"25","author":"RM Bruno","year":"2018","unstructured":"Bruno RM, Masi S, Taddei M, Taddei S, Virdis A. Essential Hypertension and Functional Microvascular Ageing. High Blood Press Cardiovasc Prev. 2018;25:35\u201340.","journal-title":"High Blood Press Cardiovasc Prev"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41440-024-01701-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-024-01701-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-024-01701-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T23:05:37Z","timestamp":1722812737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41440-024-01701-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["1701"],"URL":"https:\/\/doi.org\/10.1038\/s41440-024-01701-y","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,21]]},"assertion":[{"value":"4 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study is comprised of animal data without any human data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}