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This analysis evaluates longer-term outcomes of patients randomized to uRDN. Patients with resistant hypertension to a 3-drug combination pill were randomized to uRDN (<jats:italic>n<\/jats:italic>\u2009=\u200969) or sham (<jats:italic>n<\/jats:italic>\u2009=\u200967). From 2-5 months, patients followed a standardized anti-hypertensive medication (AHM) titration protocol. At 6 months, patients were unblinded and received AHM per standard of care. In the uRDN group, 71% (49\/69) completed 36-month follow-up. Screening office BP was 159\/103 on 3.9 AHM. Baseline office BP on the single-pill combination was 153\/99\u2009mmHg. At 36 months, office BP changed by \u221214.5\u2009\u00b1\u200926.1\/\u22129.0\u2009\u00b1\u200914.8\u2009mmHg from screening (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for both) and \u22128.0\u2009\u00b1\u200924.5\/\u22125.0\u2009\u00b1\u200914.6\u2009mmHg from baseline (<jats:italic>p<\/jats:italic>\u2009=\u20090.007; <jats:italic>p<\/jats:italic>\u2009=\u20090.022) on 3.7 AHM. 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AJK reports institutional funding to Columbia University and\/or Cardiovascular Research Foundation from Medtronic, Boston Scientific, Abbott Vascular, Amgen, CSI, Philips, Recor Medical, Neurotronic, Biotronik, Chiesi, Bolt Medical, Magenta Medical, Canon, SoniVie, and Merck. In addition to research grants, institutional funding includes fees paid to Columbia University and\/or Cardiovascular Research Foundation for consulting and\/or speaking engagements in which AJK controlled the content. Personal: Consulting from IMDS; Travel Expenses\/Meals from Medtronic, Boston Scientific, Abbott Vascular, CSI, Siemens, Philips, Recor Medical, Chiesi, OpSens, Zoll, and Regeneron. MA has received research grants from the European Horizon 2020 programme; has received grant support and non-financial support from Recor Medical, Novartis, and Idorsia; and has received personal fees from Alnylam Pharmaceutical, Novartis, Medtronic, Astra Zeneca. FM is supported by Deutsche Gesellschaft f\u00fcr Kardiologie (DGK), Deutsche Forschungsgemeinschaft (SFB TRR219, Project-ID 322900939), and Deutsche Herzstiftung. He has received scientific support from Ablative Solutions, Medtronic and Recor Medical and speaker honoraria\/consulting fees from Ablative Solutions, Amgen, Astra Zeneca, Bayer, Boehringer Ingelheim, Inari, Medtronic, Merck, Recor Medical, Servier, and Terumo. JB has reported receiving grants from Recor Medical and Ablative Solutions. JD has received institutional grant\/research support from Abbott Vascular, Boston Scientific, ACIST Medical, Medtronic, Microport, Pie Medical, and Recor Medical, and consultancy and speaker fees from Abbott Vascular, Abiomed, ACIST medical, Boston Scientific, Cardialysis BV, CardiacBooster, Kaminari Medical, Recor Medical, PulseCath, Pie Medical, Sanofi, Siemens Health Care and Medtronic. MS has received grant support from Recor Medical, Ablative Solutions, Applied Therapeutics, Vascular Dynamics, and MSD; and has received consulting fees from Recor Medical, Esperion Inc., Daiichi Sankyo Inc., Novartis, and Vifor Pharma. LT is an employee of NAMSA, a contractor for Recor Medical. MM and LC are employees of Recor Medical. RES has received research grants and personal fees from Recor Medical, Medtronic, and Ablative Solutions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}