{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:08:57Z","timestamp":1793365737845,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1038\/s41440-024-01988-x","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T10:45:17Z","timestamp":1731581117000},"page":"49-59","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognosis of apparent treatment-resistant hypertension and poor adherence: a nationwide cohort study"],"prefix":"10.1038","volume":"48","author":[{"given":"Chan Joo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hokyou","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinseub","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayoung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Taek","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungha","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"1988_CR1","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/S0140-6736(21)01330-1","volume":"398","author":"NCD Risk Factor Collaboration (NCD-RisC","year":"2021","unstructured":"NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021;398:957\u201380.","journal-title":"Lancet"},{"key":"1988_CR2","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1161\/CIRCULATIONAHA.113.008506","volume":"130","author":"S Cheng","year":"2014","unstructured":"Cheng S, Claggett B, Correia AW, Shah AM, Gupta DK, Skali H, et al. Temporal trends in the population attributable risk for cardiovascular disease: the Atherosclerosis Risk in Communities Study. Circulation. 2014;130:820\u20138.","journal-title":"Circulation"},{"key":"1988_CR3","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1161\/CIRCULATIONAHA.112.096156","volume":"126","author":"Q Gu","year":"2012","unstructured":"Gu Q, Burt VL, Dillon CF, Yoon S. Trends in antihypertensive medication use and blood pressure control among United States adults with hypertension: the National Health And Nutrition Examination Survey, 2001 to 2010. Circulation. 2012;126:2105\u201314.","journal-title":"Circulation"},{"key":"1988_CR4","doi-asserted-by":"publisher","first-page":"e057510","DOI":"10.1136\/bmjopen-2021-057510","volume":"12","author":"J Rouette","year":"2022","unstructured":"Rouette J, McDonald EG, Schuster T, Brophy JM, Azoulay L. Treatment and prescribing trends of antihypertensive drugs in 2.7 million UK primary care patients over 31 years: a population-based cohort study. BMJ Open. 2022;12:e057510.","journal-title":"BMJ Open"},{"key":"1988_CR5","doi-asserted-by":"publisher","first-page":"e53","DOI":"10.1161\/HYP.0000000000000084","volume":"72","author":"RM Carey","year":"2018","unstructured":"Carey RM, Calhoun DA, Bakris GL, Brook RD, Daugherty SL, Dennison-Himmelfarb CR, et al. Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association. Hypertension. 2018;72:e53\u2013e90.","journal-title":"Hypertension"},{"key":"1988_CR6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40885-019-0124-x","volume":"25","author":"HY Lee","year":"2019","unstructured":"Lee HY, Shin J, Kim GH, Park S, Ihm SH, Kim HC, et al. 2018 Korean Society of Hypertension Guidelines for the management of hypertension: part II-diagnosis and treatment of hypertension. Clin Hypertens. 2019;25:20.","journal-title":"Clin Hypertens"},{"key":"1988_CR7","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40885-023-00255-4","volume":"29","author":"S Park","year":"2023","unstructured":"Park S, Shin J, Ihm SH, Kim KI, Kim HL, Kim HC, et al. Resistant hypertension: consensus document from the Korean society of hypertension. Clin Hypertens. 2023;29:30.","journal-title":"Clin Hypertens"},{"key":"1988_CR8","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/ki.2015.142","volume":"88","author":"JJ Sim","year":"2015","unstructured":"Sim JJ, Bhandari SK, Shi J, Reynolds K, Calhoun DA, Kalantar-Zadeh K, et al. Comparative risk of renal, cardiovascular, and mortality outcomes in controlled, uncontrolled resistant, and nonresistant hypertension. Kidney Int. 2015;88:622\u201332.","journal-title":"Kidney Int"},{"key":"1988_CR9","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1161\/CIRCULATIONAHA.111.068064","volume":"125","author":"SL Daugherty","year":"2012","unstructured":"Daugherty SL, Powers JD, Magid DJ, Tavel HM, Masoudi FA, Margolis KL, et al. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012;125:1635\u201342.","journal-title":"Circulation"},{"key":"1988_CR10","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1001\/archinte.165.10.1147","volume":"165","author":"RH Chapman","year":"2005","unstructured":"Chapman RH, Benner JS, Petrilla AA, Tierce JC, Collins SR, Battleman DS, et al. Predictors of adherence with antihypertensive and lipid-lowering therapy. Arch Intern Med. 2005;165:1147\u201352.","journal-title":"Arch Intern Med"},{"key":"1988_CR11","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s11096-021-01236-z","volume":"43","author":"S Mahmood","year":"2021","unstructured":"Mahmood S, Jalal Z, Hadi MA, Khan TM, Haque MS, Shah KU. Prevalence of non-adherence to antihypertensive medication in Asia: a systematic review and meta-analysis. Int J Clin Pharm. 2021;43:486\u2013501.","journal-title":"Int J Clin Pharm"},{"key":"1988_CR12","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1161\/HYPERTENSIONAHA.115.06731","volume":"67","author":"S Kim","year":"2016","unstructured":"Kim S, Shin DW, Yun JM, Hwang Y, Park SK, Ko YJ, et al. Medication Adherence and the Risk of Cardiovascular Mortality and Hospitalization Among Patients With Newly Prescribed Antihypertensive Medications. Hypertension. 2016;67:506\u201312.","journal-title":"Hypertension"},{"key":"1988_CR13","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1161\/HYP.0000000000000203","volume":"79","author":"NK Choudhry","year":"2022","unstructured":"Choudhry NK, Kronish IM, Vongpatanasin W, Ferdinand KC, Pavlik VN, Egan BM, et al. Medication Adherence and Blood Pressure Control: A Scientific Statement From the American Heart Association. Hypertension. 2022;79:e1\u2013e14.","journal-title":"Hypertension"},{"key":"1988_CR14","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.1097\/HJH.0000000000001502","volume":"35","author":"H Durand","year":"2017","unstructured":"Durand H, Hayes P, Morrissey EC, Newell J, Casey M, Murphy AW, et al. Medication adherence among patients with apparent treatment-resistant hypertension: systematic review and meta-analysis. J Hypertens. 2017;35:2346\u201357.","journal-title":"J Hypertens"},{"key":"1988_CR15","doi-asserted-by":"publisher","first-page":"e016640","DOI":"10.1136\/bmjopen-2017-016640","volume":"7","author":"SC Seong","year":"2017","unstructured":"Seong SC, Kim YY, Park SK, Khang YH, Kim HC, Park JH, et al. Cohort profile: the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) in Korea. BMJ Open. 2017;7:e016640.","journal-title":"BMJ Open"},{"key":"1988_CR16","first-page":"799","volume":"46","author":"S Cheol Seong","year":"2016","unstructured":"Cheol Seong S, Kim Y-Y, Khang Y-H, Heon Park J, Kang H-J, Lee H, et al. Data Resource Profile: The National Health Information Database of the National Health Insurance Service in South Korea. Int J Epidemiol. 2016;46:799\u2013800.","journal-title":"Int J Epidemiol"},{"key":"1988_CR17","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1161\/HYPERTENSIONAHA.118.11787","volume":"72","author":"CJ Lee","year":"2018","unstructured":"Lee CJ, Ryu J, Kim HC, Ryu DR, Ihm SH, Kim YJ, et al. Clinical Benefit of Treatment of Stage-1, Low-Risk Hypertension. Hypertension. 2018;72:1285\u201393.","journal-title":"Hypertension"},{"key":"1988_CR18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jaccao.2021.03.006","volume":"3","author":"JP Yun","year":"2021","unstructured":"Yun JP, Choi EK, Han KD, Park SH, Jung JH, Park SH, et al. Risk of Atrial Fibrillation According to Cancer Type: A Nationwide Population-Based Study. JACC CardioOncol. 2021;3:221\u201332.","journal-title":"JACC CardioOncol."},{"key":"1988_CR19","doi-asserted-by":"publisher","first-page":"382","DOI":"10.23876\/j.krcp.18.0128","volume":"38","author":"KM Kim","year":"2019","unstructured":"Kim KM, Oh HJ, Choi HY, Lee H, Ryu DR. Impact of chronic kidney disease on mortality: A nationwide cohort study. Kidney Res Clin Pr. 2019;38:382\u201390.","journal-title":"Kidney Res Clin Pr"},{"key":"1988_CR20","first-page":"1146","volume":"24","author":"H Kumamaru","year":"2018","unstructured":"Kumamaru H, Lee MP, Choudhry NK, Dong YH, Krumme AA, Khan N, et al. Using Previous Medication Adherence to Predict Future Adherence. J Manag Care Spec Pharm. 2018;24:1146\u201355.","journal-title":"J Manag Care Spec Pharm"},{"key":"1988_CR21","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1161\/HYPERTENSIONAHA.118.12191","volume":"73","author":"RM Carey","year":"2019","unstructured":"Carey RM, Sakhuja S, Calhoun DA, Whelton PK, Muntner P. Prevalence of Apparent Treatment-Resistant Hypertension in the United States. Hypertension. 2019;73:424\u201331.","journal-title":"Hypertension"},{"key":"1988_CR22","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1038\/s41440-021-00845-5","volume":"45","author":"M Yoon","year":"2022","unstructured":"Yoon M, You SC, Oh J, Lee CJ, Lee SH, Kang SM, et al. Prevalence and prognosis of refractory hypertension diagnosed using ambulatory blood pressure measurements. Hypertens Res. 2022;45:1353\u201362.","journal-title":"Hypertens Res"},{"key":"1988_CR23","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1136\/heartjnl-2018-313599","volume":"105","author":"JJ Noubiap","year":"2019","unstructured":"Noubiap JJ, Nansseu JR, Nyaga UF, Sime PS, Francis I, Bigna JJ. Global prevalence of resistant hypertension: a meta-analysis of data from 3.2 million patients. Heart. 2019;105:98\u2013105.","journal-title":"Heart"},{"key":"1988_CR24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40885-016-0043-z","volume":"22","author":"KN Lee","year":"2015","unstructured":"Lee KN, Na JO, Choi CU, Lim HE, Kim JW, Kim EJ, et al. Prevalence and characteristics of resistant hypertension at primary clinics in Korea: a nationwide cross-sectional study. Clin Hypertens. 2015;22:4.","journal-title":"Clin Hypertens"},{"key":"1988_CR25","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1161\/HYPERTENSIONAHA.114.03850","volume":"64","author":"P Muntner","year":"2014","unstructured":"Muntner P, Davis BR, Cushman WC, Bangalore S, Calhoun DA, Pressel SL, et al. Treatment-resistant hypertension and the incidence of cardiovascular disease and end-stage renal disease: results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Hypertension. 2014;64:1012\u201321.","journal-title":"Hypertension"},{"key":"1988_CR26","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1093\/eurjpc\/zwad066","volume":"30","author":"JE Ebinger","year":"2023","unstructured":"Ebinger JE, Kauko A, Bello NA, Cheng S, Niiranen T. Apparent treatment-resistant hypertension associated lifetime cardiovascular risk in a longitudinal national registry. Eur J Prev Cardiol. 2023;30:960\u20138.","journal-title":"Eur J Prev Cardiol"},{"key":"1988_CR27","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1001\/jama.1996.03530440037034","volume":"275","author":"LevyD Larson","year":"1996","unstructured":"Larson LevyD, Vasan MG, Kannel RS, Ho WB. KK. The progression from hypertension to congestive heart failure. JAMA. 1996;275:1557\u201362.","journal-title":"JAMA"},{"key":"1988_CR28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1053\/j.ajkd.2009.11.004","volume":"55","author":"DE Weiner","year":"2010","unstructured":"Weiner DE. Risk factors for ESRD: lessons from a community study and implications for public health. Am J Kidney Dis. 2010;55:5\u20137.","journal-title":"Am J Kidney Dis"},{"key":"1988_CR29","doi-asserted-by":"crossref","unstructured":"Coccina F, Pierdomenico AM, Cuccurullo C, Pizzicannella J, Trubiani O, Pierdomenico SD. Ambulatory Resistant Hypertension and Risk of Heart Failure in the Elderly. Diagnostics. 2023;13:1631.","DOI":"10.3390\/diagnostics13091631"},{"key":"1988_CR30","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1002\/clc.24135","volume":"46","author":"PK Garg","year":"2023","unstructured":"Garg PK, Wilson N, Yuan Y, Howard VJ, Judd S, Howard G, et al. Association of hypertension severity and control with risk of incident atrial fibrillation: The REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Clin Cardiol. 2023;46:1418\u201325.","journal-title":"Clin Cardiol"},{"key":"1988_CR31","first-page":"2083","volume":"289","author":"LJ Appel","year":"2003","unstructured":"Appel LJ, Champagne CM, Harsha DW, Cooper LS, Obarzanek E, Elmer PJ, et al. Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA. 2003;289:2083\u201393.","journal-title":"JAMA"},{"key":"1988_CR32","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1161\/CIRCULATIONAHA.121.055329","volume":"144","author":"JA Blumenthal","year":"2021","unstructured":"Blumenthal JA, Hinderliter AL, Smith PJ, Mabe S, Watkins LL, Craighead L, et al. Effects of Lifestyle Modification on Patients With Resistant Hypertension: Results of the TRIUMPH Randomized Clinical Trial. Circulation. 2021;144:1212\u201326.","journal-title":"Circulation"},{"key":"1988_CR33","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1161\/HYPERTENSIONAHA.120.16784","volume":"77","author":"H Lee","year":"2021","unstructured":"Lee H, Yano Y, Cho SMJ, Heo JE, Kim DW, Park S, et al. Adherence to Antihypertensive Medication and Incident Cardiovascular Events in Young Adults With Hypertension. Hypertension. 2021;77:1341\u20139.","journal-title":"Hypertension"},{"key":"1988_CR34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.121.008150","volume":"15","author":"ME Wilder","year":"2022","unstructured":"Wilder ME, Zheng Z, Zeger SL, Elmi A, Katz RJ, Li Y, et al. Relationship Between Social Determinants of Health and Antihypertensive Medication Adherence in a Medicaid Cohort. Circ Cardiovasc Qual Outcomes. 2022;15:e008150.","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"1988_CR35","doi-asserted-by":"publisher","first-page":"e62775","DOI":"10.1371\/journal.pone.0062775","volume":"8","author":"GK Lee","year":"2013","unstructured":"Lee GK, Wang HH, Liu KQ, Cheung Y, Morisky DE, Wong MC. Determinants of medication adherence to antihypertensive medications among a Chinese population using Morisky Medication Adherence Scale. PLoS One. 2013;8:e62775.","journal-title":"PLoS One"},{"key":"1988_CR36","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1161\/HYPERTENSIONAHA.121.18198","volume":"78","author":"K Kario","year":"2021","unstructured":"Kario K, Hoshide S, Narita K, Okawara Y, Kanegae H. Cardiovascular Prognosis in Drug-Resistant Hypertension Stratified by 24-Hour Ambulatory Blood Pressure: The JAMP Study. Hypertension. 2021;78:1781\u201390.","journal-title":"Hypertension"},{"key":"1988_CR37","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1161\/HYPERTENSIONAHA.117.08929","volume":"70","author":"A Cai","year":"2017","unstructured":"Cai A, Calhoun DA. Resistant Hypertension: An Update of Experimental and Clinical Findings. Hypertension. 2017;70:5\u20139.","journal-title":"Hypertension"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41440-024-01988-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-024-01988-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-024-01988-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T06:38:52Z","timestamp":1736923132000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41440-024-01988-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["1988"],"URL":"https:\/\/doi.org\/10.1038\/s41440-024-01988-x","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,14]]},"assertion":[{"value":"19 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"CJL has received honoraria from Novartis, Organon, Viatris, Boryung, Daiichi Sankyo, Chong Kun Dang, Daewoong, and JW Pharmaceutical. CJL has received stock option from Mediwhale. SP received honoraria from Viatris, Organon, Boryoung, Hanmi, Daewoong, Donga, Celltrion, Servier, Daiichi Sankyo, Chong Kun Dang, and Daewon, and a research grant from Daiichi Sankyo. SP has received consultation fees from Skylab. In addition, SP received stock options from Mediwhale. The other authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study complied with the Declaration of Helsinki, and its design was approved by Yonsei University Health System\u2019s Institutional Review Board (institutional review board number: 4-2022-0325). The requirement for informed consent was waived because the data were deidentified and anonymized. We followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guidelines for cohort studies.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}]}}