{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:15:49Z","timestamp":1793578549319,"version":"4.5.0"},"reference-count":260,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1038\/s41440-025-02417-3","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T09:00:26Z","timestamp":1762333226000},"page":"237-271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Current updates on latest basic research of scientific relevance in hypertensive dementia"],"prefix":"10.1038","volume":"49","author":[{"given":"Masaki","family":"Mogi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Takami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Node","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuomi","family":"Kario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Prevention of Cognitive Impairment by Hypertension Management (PCIHM) Working Group of the Japanese Society of Hypertension","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisatomi","family":"Arima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Kawazoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yori","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sakima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Komori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Nozato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Kubozono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Akasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yume","family":"Nohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichiro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Takami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"2417_CR1","unstructured":"House of Councillors, The National Diet of Japan. Basic Act for Dementia to promote the realisation of a symbiotic society. 2023. https:\/\/www.sangiin.go.jp\/japanese\/joho1\/kousei\/gian\/211\/meisai\/m211090211024.htm."},{"key":"2417_CR2","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","volume":"404","author":"G Livingston","year":"2024","unstructured":"Livingston G, Huntley J, Liu KY, Costafreda SG, Selbaek G, Alladi S, et al. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet. 2024;404:572\u2013628.","journal-title":"Lancet"},{"key":"2417_CR3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1161\/HYPERTENSIONAHA.122.18085","volume":"80","author":"MM Santisteban","year":"2023","unstructured":"Santisteban MM, Iadecola C, Carnevale D. Hypertension, neurovascular dysfunction, and cognitive impairment. Hypertension. 2023;80:22\u201334.","journal-title":"Hypertension"},{"key":"2417_CR4","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nrcardio.2014.223","volume":"12","author":"C Qiu","year":"2015","unstructured":"Qiu C, Fratiglioni L. A major role for cardiovascular burden in age-related cognitive decline. Nat Rev Cardiol. 2015;12:267\u201377.","journal-title":"Nat Rev Cardiol"},{"key":"2417_CR5","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1161\/HYP.0000000000000053","volume":"68","author":"C Iadecola","year":"2016","unstructured":"Iadecola C, Yaffe K, Biller J, Bratzke LC, Faraci FM, Gorelick PB, et al. Impact of hypertension on cognitive function: a scientific statement from the American Heart Association. Hypertension. 2016;68:e67\u2013e94.","journal-title":"Hypertension"},{"key":"2417_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1161\/HYPERTENSIONAHA.110.163055","volume":"58","author":"T Ninomiya","year":"2011","unstructured":"Ninomiya T, Ohara T, Hirakawa Y, Yoshida D, Doi Y, Hata J, et al. Midlife and late-life blood pressure and dementia in Japanese elderly: the Hisayama study. Hypertension. 2011;58:22\u20138.","journal-title":"Hypertension"},{"key":"2417_CR7","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1161\/HYPERTENSIONAHA.120.14993","volume":"76","author":"YN Ou","year":"2020","unstructured":"Ou YN, Tan CC, Shen XN, Xu W, Hou XH, Dong Q, et al. Blood pressure and risks of cognitive impairment and dementia: a systematic review and meta-analysis of 209 prospective studies. Hypertension. 2020;76:217\u201325.","journal-title":"Hypertension"},{"key":"2417_CR8","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1001\/jama.2020.4249","volume":"323","author":"D Hughes","year":"2020","unstructured":"Hughes D, Judge C, Murphy R, Loughlin E, Costello M, Whiteley W, et al. Association of blood pressure lowering with incident dementia or cognitive impairment: a systematic review and meta-analysis. JAMA. 2020;323:1934\u201344.","journal-title":"JAMA"},{"key":"2417_CR9","doi-asserted-by":"publisher","first-page":"e2333353","DOI":"10.1001\/jamanetworkopen.2023.33353","volume":"6","author":"MJ Lennon","year":"2023","unstructured":"Lennon MJ, Lam BCP, Lipnicki DM, Crawford JD, Peters R, Schutte AE, et al. Use of antihypertensives, blood pressure, and estimated risk of dementia in late life: an individual participant data meta-analysis. JAMA Netw Open. 2023;6:e2333353.","journal-title":"JAMA Netw Open"},{"key":"2417_CR10","doi-asserted-by":"publisher","first-page":"4980","DOI":"10.1093\/eurheartj\/ehac584","volume":"43","author":"R Peters","year":"2022","unstructured":"Peters R, Xu Y, Fitzgerald O, Aung HL, Beckett N, Bulpitt C, et al. Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis. Eur Heart J. 2022;43:4980\u201390.","journal-title":"Eur Heart J"},{"key":"2417_CR11","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1161\/HYPERTENSIONAHA.121.17797","volume":"78","author":"RAA de Heus","year":"2021","unstructured":"de Heus RAA, Tzourio C, Lee EJL, Opozda M, Vincent AD, Anstey KJ, et al. Association between blood pressure variability with dementia and cognitive impairment: a systematic review and meta-analysis. Hypertension. 2021;78:1478\u201389.","journal-title":"Hypertension"},{"key":"2417_CR12","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1111\/jgs.13596","volume":"63","author":"T Hayakawa","year":"2015","unstructured":"Hayakawa T, McGarrigle CA, Coen RF, Soraghan CJ, Foran T, Lawlor BA, et al. Orthostatic blood pressure behavior in people with mild cognitive impairment predicts conversion to dementia. J Am Geriatr Soc. 2015;63:1868\u201373.","journal-title":"J Am Geriatr Soc"},{"key":"2417_CR13","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1161\/HYPERTENSIONAHA.121.17788","volume":"78","author":"P Jia","year":"2021","unstructured":"Jia P, Lee HWY, Chan JYC, Yiu KKL, Tsoi KKF. Long-term blood pressure variability increases risks of dementia and cognitive decline: a meta-analysis of longitudinal studies. Hypertension. 2021;78:996\u20131004.","journal-title":"Hypertension"},{"key":"2417_CR14","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1161\/STROKEAHA.120.033697","volume":"52","author":"C Li","year":"2021","unstructured":"Li C, Ma Y, Hua R, Yang Z, Zhong B, Wang H, et al. Dose-response relationship between long-term blood pressure variability and cognitive decline. Stroke. 2021;52:3249\u201357.","journal-title":"Stroke"},{"key":"2417_CR15","doi-asserted-by":"publisher","first-page":"851","DOI":"10.3233\/JAD-190485","volume":"71","author":"K Javanshiri","year":"2019","unstructured":"Javanshiri K, Haglund M, Englund E. Cardiovascular disease, diabetes mellitus, and hypertension in Lewy body disease: a comparison with other dementia disorders. J Alzheimers Dis. 2019;71:851\u20139.","journal-title":"J Alzheimers Dis"},{"key":"2417_CR16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.neurobiolaging.2023.11.006","volume":"134","author":"KS Chin","year":"2024","unstructured":"Chin KS, Holper S, Loveland P, Churilov L, Yassi N, Watson R. Prevalence of cerebral microbleeds in Alzheimer\u2019s disease, dementia with Lewy bodies and Parkinson\u2019s disease dementia: a systematic review and meta-analysis. Neurobiol Aging. 2024;134:74\u201383.","journal-title":"Neurobiol Aging"},{"key":"2417_CR17","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1161\/HYPERTENSIONAHA.123.21356","volume":"81","author":"A Pacholko","year":"2024","unstructured":"Pacholko A, Iadecola C. Hypertension, neurodegeneration, and cognitive decline. Hypertension. 2024;81:991\u20131007.","journal-title":"Hypertension"},{"key":"2417_CR18","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jash.2013.07.011","volume":"7","author":"MA Pannozzo","year":"2013","unstructured":"Pannozzo MA, Holland PR, Scullion G, Talbot R, Mullins JJ, Horsburgh K. Controlled hypertension induces cerebrovascular and gene alterations in Cyp1a1-Ren2 transgenic rats. J Am Soc Hypertens. 2013;7:411\u20139.","journal-title":"J Am Soc Hypertens"},{"key":"2417_CR19","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1161\/HYPERTENSIONAHA.118.11147","volume":"72","author":"MD Leo","year":"2018","unstructured":"Leo MD, Zhai X, Yin W, Jaggar JH. Impaired trafficking of beta1 subunits inhibits BK channels in cerebral arteries of hypertensive rats. Hypertension. 2018;72:765\u201375.","journal-title":"Hypertension"},{"key":"2417_CR20","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1161\/01.STR.0000163080.82766.eb","volume":"36","author":"P Lacombe","year":"2005","unstructured":"Lacombe P, Oligo C, Domenga V, Tournier-Lasserve E, Joutel A. Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy. Stroke. 2005;36:1053\u20138.","journal-title":"Stroke"},{"key":"2417_CR21","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/jcbfm.2015.31","volume":"35","author":"JA Iddings","year":"2015","unstructured":"Iddings JA, Kim KJ, Zhou Y, Higashimori H, Filosa JA. Enhanced parenchymal arteriole tone and astrocyte signaling protect neurovascular coupling mediated parenchymal arteriole vasodilation in the spontaneously hypertensive rat. J Cereb Blood Flow Metab. 2015;35:1127\u201336.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","volume":"96","author":"C Iadecola","year":"2017","unstructured":"Iadecola C. The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease. Neuron. 2017;96:17\u201342.","journal-title":"Neuron"},{"key":"2417_CR23","doi-asserted-by":"publisher","first-page":"H1304","DOI":"10.1152\/ajpheart.00207.2018","volume":"315","author":"JM Diaz-Otero","year":"2018","unstructured":"Diaz-Otero JM, Yen TC, Fisher C, Bota D, Jackson WF, Dorrance AM. Mineralocorticoid receptor antagonism improves parenchymal arteriole dilation via a TRPV4-dependent mechanism and prevents cognitive dysfunction in hypertension. Am J Physiol Heart Circ Physiol. 2018;315:H1304\u2013H15.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2417_CR24","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12535","volume":"26","author":"JM Diaz-Otero","year":"2019","unstructured":"Diaz-Otero JM, Yen TC, Ahmad A, Laimon-Thomson E, Abolibdeh B, Kelly K, et al. Transient receptor potential vanilloid 4 channels are important regulators of parenchymal arteriole dilation and cognitive function. Microcirculation. 2019;26:e12535.","journal-title":"Microcirculation"},{"key":"2417_CR25","doi-asserted-by":"publisher","first-page":"e41602","DOI":"10.1371\/journal.pone.0041602","volume":"7","author":"P Karczewski","year":"2012","unstructured":"Karczewski P, Pohlmann A, Wagenhaus B, Wisbrun N, Hempel P, Lemke B, et al. Antibodies to the alpha1-adrenergic receptor cause vascular impairments in rat brain as demonstrated by magnetic resonance angiography. PLoS One. 2012;7:e41602.","journal-title":"PLoS One"},{"key":"2417_CR26","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/nn.4533","volume":"20","author":"TA Longden","year":"2017","unstructured":"Longden TA, Dabertrand F, Koide M, Gonzales AL, Tykocki NR, Brayden JE, et al. Capillary K(+)-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow. Nat Neurosci. 2017;20:717\u201326.","journal-title":"Nat Neurosci"},{"key":"2417_CR27","doi-asserted-by":"crossref","unstructured":"Koide M, Harraz OF, Dabertrand F, Longden TA, Ferris HR, Wellman GC, et al. Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease. J Clin Investig. 2021;131","DOI":"10.1172\/JCI149029"},{"key":"2417_CR28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1161\/HYPERTENSIONAHA.123.19939","volume":"81","author":"CE Baggeroer","year":"2024","unstructured":"Baggeroer CE, Cambronero FE, Savan NA, Jefferson AL, Santisteban MM. Basic mechanisms of brain injury and cognitive decline in hypertension. Hypertension. 2024;81:34\u201344.","journal-title":"Hypertension"},{"key":"2417_CR29","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1007\/s00424-016-1849-y","volume":"468","author":"N Toda","year":"2016","unstructured":"Toda N, Okamura T. Hyperhomocysteinemia impairs regional blood flow: involvements of endothelial and neuronal nitric oxide. Pflugers Arch. 2016;468:1517\u201325.","journal-title":"Pflugers Arch"},{"key":"2417_CR30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1161\/HYPERTENSIONAHA.114.03040","volume":"64","author":"C Iadecola","year":"2014","unstructured":"Iadecola C. Hypertension and dementia. Hypertension. 2014;64:3\u20135.","journal-title":"Hypertension"},{"key":"2417_CR31","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41591-018-0297-y","volume":"25","author":"DA Nation","year":"2019","unstructured":"Nation DA, Sweeney MD, Montagne A, Sagare AP, D\u2019Orazio LM, Pachicano M, et al. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med. 2019;25:270\u20136.","journal-title":"Nat Med"},{"key":"2417_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/neup.12262","volume":"36","author":"M Ueno","year":"2016","unstructured":"Ueno M, Chiba Y, Matsumoto K, Murakami R, Fujihara R, Kawauchi M, et al. Blood-brain barrier damage in vascular dementia. Neuropathology. 2016;36:115\u201324.","journal-title":"Neuropathology"},{"key":"2417_CR33","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-015-0557-x","volume":"15","author":"L Ostergaard","year":"2015","unstructured":"Ostergaard L, Jespersen SN, Engedahl T, Gutierrez Jimenez E, Ashkanian M, Hansen MB, et al. Capillary dysfunction: its detection and causative role in dementias and stroke. Curr Neurol Neurosci Rep. 2015;15:37.","journal-title":"Curr Neurol Neurosci Rep"},{"key":"2417_CR34","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.nlm.2013.01.002","volume":"101","author":"X Zhang","year":"2013","unstructured":"Zhang X, Yeung PK, McAlonan GM, Chung SS, Chung SK. Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion. Neurobiol Learn Mem. 2013;101:46\u201354.","journal-title":"Neurobiol Learn Mem"},{"key":"2417_CR35","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1161\/HYPERTENSIONAHA.120.15581","volume":"76","author":"MM Santisteban","year":"2020","unstructured":"Santisteban MM, Ahn SJ, Lane D, Faraco G, Garcia-Bonilla L, Racchumi G, et al. Endothelium-macrophage crosstalk mediates blood-brain barrier dysfunction in hypertension. Hypertension. 2020;76:795\u2013807.","journal-title":"Hypertension"},{"key":"2417_CR36","doi-asserted-by":"publisher","first-page":"9512","DOI":"10.7150\/thno.44394","volume":"10","author":"D Kerkhofs","year":"2020","unstructured":"Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, et al. Pharmacological depletion of microglia and perivascular macrophages prevents vascular cognitive impairment in Ang II-induced hypertension. Theranostics. 2020;10:9512\u201327.","journal-title":"Theranostics"},{"key":"2417_CR37","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1161\/CIRCRESAHA.121.320183","volume":"130","author":"H Zhou","year":"2022","unstructured":"Zhou H, Gao F, Yang X, Lin T, Li Z, Wang Q, et al. Endothelial BACE1 impairs cerebral small vessels via tight junctions and eNOS. Circ Res. 2022;130:1321\u201341.","journal-title":"Circ Res"},{"key":"2417_CR38","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0006-8993(03)02632-5","volume":"975","author":"H Al-Sarraf","year":"2003","unstructured":"Al-Sarraf H, Philip L. Effect of hypertension on the integrity of blood brain and blood CSF barriers, cerebral blood flow and CSF secretion in the rat. Brain Res. 2003;975:179\u201388.","journal-title":"Brain Res"},{"key":"2417_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134626","volume":"715","author":"X Lu","year":"2020","unstructured":"Lu X, Moeini M, Li B, Thorin E, Lesage F. Hypertension accelerates cerebral tissue PO(2) disruption in Alzheimer\u2019s disease. Neurosci Lett. 2020;715:134626.","journal-title":"Neurosci Lett"},{"key":"2417_CR40","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s11357-016-9931-0","volume":"38","author":"S Tarantini","year":"2016","unstructured":"Tarantini S, Tucsek Z, Valcarcel-Ares MN, Toth P, Gautam T, Giles CB, et al. Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age (Dordr). 2016;38:273\u201389.","journal-title":"Age (Dordr)"},{"key":"2417_CR41","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1038\/jcbfm.2014.156","volume":"34","author":"P Toth","year":"2014","unstructured":"Toth P, Tucsek Z, Tarantini S, Sosnowska D, Gautam T, Mitschelen M, et al. IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice. J Cereb Blood Flow Metab. 2014;34:1887\u201397.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR42","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/acel.12583","volume":"16","author":"S Tarantini","year":"2017","unstructured":"Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Springo Z, Fulop GA, Ashpole N, et al. Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype. Aging Cell. 2017;16:469\u201379.","journal-title":"Aging Cell"},{"key":"2417_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1320808","volume":"16","author":"LR Miller","year":"2024","unstructured":"Miller LR, Bickel MA, Tarantini S, Runion ME, Matacchiera Z, Vance ML, et al. IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice. Front Aging Neurosci. 2024;16:1320808.","journal-title":"Front Aging Neurosci"},{"key":"2417_CR44","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/s41440-018-0033-5","volume":"41","author":"L Zhang","year":"2018","unstructured":"Zhang L, Zheng H, Luo J, Li L, Pan X, Jiang T, et al. Inhibition of endothelial nitric oxide synthase reverses the effect of exercise on improving cognitive function in hypertensive rats. Hypertens Res. 2018;41:414\u201325.","journal-title":"Hypertens Res"},{"key":"2417_CR45","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1093\/cvr\/cvad110","volume":"119","author":"N Zhu","year":"2023","unstructured":"Zhu N, Guo ZF, Kazama K, Yi B, Tongmuang N, Yao H, et al. Epigenetic regulation of vascular smooth muscle cell phenotypic switch and neointimal formation by PRMT5. Cardiovasc Res. 2023;119:2244\u201355.","journal-title":"Cardiovasc Res"},{"key":"2417_CR46","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm3471","volume":"8","author":"P Swiatlowska","year":"2022","unstructured":"Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, et al. Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching. Sci Adv. 2022;8:eabm3471.","journal-title":"Sci Adv"},{"key":"2417_CR47","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1152\/physiolgenomics.00119.2021","volume":"54","author":"E Gonzalez-Fernandez","year":"2022","unstructured":"Gonzalez-Fernandez E, Fan L, Wang S, Liu Y, Gao W, Thomas KN, et al. The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases. Physiol Genomics. 2022;54:58\u201370.","journal-title":"Physiol Genomics"},{"key":"2417_CR48","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.pbb.2012.11.011","volume":"103","author":"B Sharma","year":"2013","unstructured":"Sharma B, Singh N. Pharmacological inhibition of inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, convalesce behavior and biochemistry of hypertension induced vascular dementia in rats. Pharmacol Biochem Behav. 2013;103:821\u201330.","journal-title":"Pharmacol Biochem Behav"},{"key":"2417_CR49","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s10571-017-0521-1","volume":"38","author":"B Mravec","year":"2018","unstructured":"Mravec B, Horvathova L, Padova A. Brain under stress and Alzheimer\u2019s disease. Cell Mol Neurobiol. 2018;38:73\u201384.","journal-title":"Cell Mol Neurobiol"},{"key":"2417_CR50","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.mehy.2011.02.034","volume":"76","author":"DA Nation","year":"2011","unstructured":"Nation DA, Hong S, Jak AJ, Delano-Wood L, Mills PJ, Bondi MW, et al. Stress, exercise, and Alzheimer\u2019s disease: a neurovascular pathway. Med Hypotheses. 2011;76:847\u201354.","journal-title":"Med Hypotheses"},{"key":"2417_CR51","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.jns.2012.05.047","volume":"322","author":"SK Tayebati","year":"2012","unstructured":"Tayebati SK, Tomassoni D, Amenta F. Spontaneously hypertensive rat as a model of vascular brain disorder: microanatomy, neurochemistry and behavior. J Neurol Sci. 2012;322:241\u20139.","journal-title":"J Neurol Sci"},{"key":"2417_CR52","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1081\/CEH-120034138","volume":"26","author":"D Tomassoni","year":"2004","unstructured":"Tomassoni D, Avola R, Di Tullio MA, Sabbatini M, Vitaioli L, Amenta F. Increased expression of glial fibrillary acidic protein in the brain of spontaneously hypertensive rats. Clin Exp Hypertens. 2004;26:335\u201350.","journal-title":"Clin Exp Hypertens"},{"key":"2417_CR53","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1007\/s11357-020-00256-3","volume":"42","author":"A Nyul-Toth","year":"2020","unstructured":"Nyul-Toth A, Tarantini S, Kiss T, Toth P, Galvan V, Tarantini A, et al. Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer\u2019s disease. Geroscience. 2020;42:1685\u201398.","journal-title":"Geroscience"},{"key":"2417_CR54","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1177\/0271678X15606720","volume":"36","author":"GF Passos","year":"2016","unstructured":"Passos GF, Kilday K, Gillen DL, Cribbs DH, Vasilevko V. Experimental hypertension increases spontaneous intracerebral hemorrhages in a mouse model of cerebral amyloidosis. J Cereb Blood Flow Metab. 2016;36:399\u2013404.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR55","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/jnen\/nlac057","volume":"81","author":"JM Schrader","year":"2022","unstructured":"Schrader JM, Stanisavljevic A, Xu F, Van Nostrand WE. Distinct brain proteomic signatures in cerebral small vessel disease rat models of hypertension and cerebral amyloid angiopathy. J Neuropathol Exp Neurol. 2022;81:731\u201345.","journal-title":"J Neuropathol Exp Neurol"},{"key":"2417_CR56","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/acn3.27","volume":"1","author":"CZ Bueche","year":"2014","unstructured":"Bueche CZ, Hawkes C, Garz C, Vielhaber S, Attems J, Knight RT, et al. Hypertension drives parenchymal beta-amyloid accumulation in the brain parenchyma. Ann Clin Transl Neurol. 2014;1:124\u20139.","journal-title":"Ann Clin Transl Neurol"},{"key":"2417_CR57","doi-asserted-by":"publisher","first-page":"S205","DOI":"10.3233\/JAD-132618","volume":"42","author":"S Schreiber","year":"2014","unstructured":"Schreiber S, Drukarch B, Garz C, Niklass S, Stanaszek L, Kropf S, et al. Interplay between age, cerebral small vessel disease, parenchymal amyloid-beta, and tau pathology: longitudinal studies in hypertensive stroke-prone rats. J Alzheimers Dis. 2014;42:S205\u201315.","journal-title":"J Alzheimers Dis"},{"key":"2417_CR58","doi-asserted-by":"publisher","first-page":"S305","DOI":"10.3233\/JAD-132615","volume":"42","author":"CZ Bueche","year":"2014","unstructured":"Bueche CZ, Garz C, Stanaszek L, Niklass S, Kropf S, Bittner D, et al. Impact of N-acetylcysteine on cerebral amyloid-beta plaques and kidney damage in spontaneously hypertensive stroke-prone rats. J Alzheimers Dis. 2014;42:S305\u201313.","journal-title":"J Alzheimers Dis"},{"key":"2417_CR59","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1111\/nan.12116","volume":"40","author":"EL Bailey","year":"2014","unstructured":"Bailey EL, McBride MW, Beattie W, McClure JD, Graham D, Dominiczak AF, et al. Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke. Neuropathol Appl Neurobiol. 2014;40:855\u201372.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2417_CR60","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1161\/HYPERTENSIONAHA.123.21940","volume":"81","author":"L Carnevale","year":"2024","unstructured":"Carnevale L, Perrotta M, Mastroiacovo F, Perrotta S, Migliaccio A, Fardella V, et al. Advanced magnetic resonance imaging to define the microvascular injury driven by neuroinflammation in the brain of a mouse model of hypertension. Hypertension. 2024;81:636\u201347.","journal-title":"Hypertension"},{"key":"2417_CR61","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s00109-017-1573-x","volume":"95","author":"G Faraco","year":"2017","unstructured":"Faraco G, Park L, Anrather J, Iadecola C. Brain perivascular macrophages: characterization and functional roles in health and disease. J Mol Med (Berl). 2017;95:1143\u201352.","journal-title":"J Mol Med (Berl)"},{"key":"2417_CR62","doi-asserted-by":"publisher","first-page":"H1120","DOI":"10.1152\/ajpheart.00288.2013","volume":"305","author":"A Csiszar","year":"2013","unstructured":"Csiszar A, Tucsek Z, Toth P, Sosnowska D, Gautam T, Koller A, et al. Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in beta-amyloid generation and Alzheimer\u2019s disease. Am J Physiol Heart Circ Physiol. 2013;305:H1120\u201330.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2417_CR63","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/jcbfm.2015.79","volume":"36","author":"G Faraco","year":"2016","unstructured":"Faraco G, Park L, Zhou P, Luo W, Paul SM, Anrather J, et al. Hypertension enhances Abeta-induced neurovascular dysfunction, promotes beta-secretase activity, and leads to amyloidogenic processing of APP. J Cereb Blood Flow Metab. 2016;36:241\u201352.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR64","doi-asserted-by":"publisher","DOI":"10.1038\/srep12059","volume":"5","author":"J Liu","year":"2015","unstructured":"Liu J, Liu S, Matsumoto Y, Murakami S, Sugakawa Y, Kami A, et al. Angiotensin type 1a receptor deficiency decreases amyloid beta-protein generation and ameliorates brain amyloid pathology. Sci Rep. 2015;5:12059.","journal-title":"Sci Rep"},{"key":"2417_CR65","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.neurobiolaging.2007.06.005","volume":"30","author":"MT Gentile","year":"2009","unstructured":"Gentile MT, Poulet R, Di Pardo A, Cifelli G, Maffei A, Vecchione C, et al. Beta-amyloid deposition in brain is enhanced in mouse models of arterial hypertension. Neurobiol Aging. 2009;30:222\u20138.","journal-title":"Neurobiol Aging"},{"key":"2417_CR66","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12987-020-00203-6","volume":"17","author":"DMP Naessens","year":"2020","unstructured":"Naessens DMP, Coolen BF, de Vos J, VanBavel E, Strijkers GJ, Bakker E. Altered brain fluid management in a rat model of arterial hypertension. Fluids Barriers CNS. 2020;17:41.","journal-title":"Fluids Barriers CNS"},{"key":"2417_CR67","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00861-x","volume":"7","author":"B Bedussi","year":"2017","unstructured":"Bedussi B, Naessens DMP, de Vos J, Olde Engberink R, Wilhelmus MMM, Richard E, et al. Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats. Sci Rep. 2017;7:744.","journal-title":"Sci Rep"},{"key":"2417_CR68","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3348\/kjr.2018.19.3.498","volume":"19","author":"Y Wang","year":"2018","unstructured":"Wang Y, Zhang R, Tao C, Xu Z, Chen W, Wang C, et al. Blood-brain barrier disruption and perivascular beta-amyloid accumulation in the brain of aged rats with spontaneous hypertension: evaluation with dynamic contrast-enhanced magnetic resonance imaging. Korean J Radio. 2018;19:498\u2013507.","journal-title":"Korean J Radio"},{"key":"2417_CR69","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1161\/HYPERTENSIONAHA.112.195511","volume":"60","author":"D Carnevale","year":"2012","unstructured":"Carnevale D, Mascio G, D\u2019Andrea I, Fardella V, Bell RD, Branchi I, et al. Hypertension induces brain beta-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature. Hypertension. 2012;60:188\u201397.","journal-title":"Hypertension"},{"key":"2417_CR70","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1161\/HYPERTENSIONAHA.115.05524","volume":"66","author":"A Kruyer","year":"2015","unstructured":"Kruyer A, Soplop N, Strickland S, Norris EH. Chronic hypertension leads to neurodegeneration in the TgSwDI mouse model of Alzheimer\u2019s disease. Hypertension. 2015;66:175\u201382.","journal-title":"Hypertension"},{"key":"2417_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147369","volume":"1758","author":"AY Lai","year":"2021","unstructured":"Lai AY, Joo IL, Trivedi AU, Dorr A, Hill ME, Stefanovic B, et al. Cerebrovascular damage after midlife transient hypertension in non-transgenic and Alzheimer\u2019s disease rats. Brain Res. 2021;1758:147369.","journal-title":"Brain Res"},{"key":"2417_CR72","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-64","volume":"7","author":"Z Stozicka","year":"2010","unstructured":"Stozicka Z, Zilka N, Novak P, Kovacech B, Bugos O, Novak M. Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer\u2019s disease. J Neuroinflammation. 2010;7:64.","journal-title":"J Neuroinflammation"},{"key":"2417_CR73","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1159\/000333125","volume":"10","author":"N Zilka","year":"2012","unstructured":"Zilka N, Stozicka Z, Cente M, Kazmerova Z, Kovacech B, Novak M. Immunomodulation of memory-impairing protein tau in Alzheimer\u2019s disease. Neurodegener Dis. 2012;10:242\u20135.","journal-title":"Neurodegener Dis"},{"key":"2417_CR74","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s40478-023-01672-0","volume":"11","author":"L Morton","year":"2023","unstructured":"Morton L, Arndt P, Garza AP, Henneicke S, Mattern H, Gonzalez M, et al. Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states. Acta Neuropathol Commun. 2023;11:204.","journal-title":"Acta Neuropathol Commun"},{"key":"2417_CR75","doi-asserted-by":"publisher","first-page":"205 e19","DOI":"10.1016\/j.neurobiolaging.2010.08.013","volume":"33","author":"D Carnevale","year":"2012","unstructured":"Carnevale D, Mascio G, Ajmone-Cat MA, D\u2019Andrea I, Cifelli G, Madonna M, et al. Role of neuroinflammation in hypertension-induced brain amyloid pathology. Neurobiol Aging. 2012;33:205 e19\u201329.","journal-title":"Neurobiol Aging"},{"key":"2417_CR76","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3233\/JAD-190240","volume":"70","author":"F Gao","year":"2019","unstructured":"Gao F, Jing Y, Zang P, Hu X, Gu C, Wu R, et al. Vascular cognitive impairment caused by cerebral small vessel disease is associated with the TLR4 in the hippocampus. J Alzheimers Dis. 2019;70:563\u201372.","journal-title":"J Alzheimers Dis"},{"key":"2417_CR77","doi-asserted-by":"publisher","first-page":"995","DOI":"10.2174\/1871527315666160527155014","volume":"15","author":"SK Tayebati","year":"2016","unstructured":"Tayebati SK, Tomassoni D, Amenta F. Neuroinflammatory markers in spontaneously hypertensive rat brain: an immunohistochemical study. CNS Neurol Disord Drug Targets. 2016;15:995\u20131000.","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"2417_CR78","first-page":"2575","volume":"117","author":"LE Evans","year":"2021","unstructured":"Evans LE, Taylor JL, Smith CJ, Pritchard HAT, Greenstein AS, Allan SM. Cardiovascular comorbidities, inflammation, and cerebral small vessel disease. Cardiovasc Res. 2021;117:2575\u201388.","journal-title":"Cardiovasc Res"},{"key":"2417_CR79","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.mehy.2013.11.023","volume":"82","author":"JZ Wang","year":"2014","unstructured":"Wang JZ, Zhu WD, Xu ZX, Du WT, Zhang HY, Sun XW, et al. Pin1, endothelial nitric oxide synthase, and amyloid-beta form a feedback signaling loop involved in the pathogenesis of Alzheimer\u2019s disease, hypertension, and cerebral amyloid angiopathy. Med Hypotheses. 2014;82:145\u201350.","journal-title":"Med Hypotheses"},{"key":"2417_CR80","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1161\/HYPERTENSIONAHA.117.09742","volume":"70","author":"D Cifuentes","year":"2017","unstructured":"Cifuentes D, Poittevin M, Bonnin P, Ngkelo A, Kubis N, Merkulova-Rainon T, et al. Inactivation of nitric oxide synthesis exacerbates the development of Alzheimer disease pathology in APPPS1 mice (amyloid precursor protein\/presenilin-1). Hypertension. 2017;70:613\u201323.","journal-title":"Hypertension"},{"key":"2417_CR81","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1093\/gerona\/glab376","volume":"77","author":"C Cosarderelioglu","year":"2022","unstructured":"Cosarderelioglu C, Nidadavolu LS, George CJ, Marx-Rattner R, Powell L, Xue QL, et al. Higher angiotensin II type 1 receptor levels and activity in the postmortem brains of older persons with Alzheimer\u2019s dementia. J Gerontol A Biol Sci Med Sci. 2022;77:664\u201372.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2417_CR82","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1161\/HYPERTENSIONAHA.112.192401","volume":"59","author":"LJ Min","year":"2012","unstructured":"Min LJ, Mogi M, Shudou M, Jing F, Tsukuda K, Ohshima K, et al. Peroxisome proliferator-activated receptor-gamma activation with angiotensin II type 1 receptor blockade is pivotal for the prevention of blood-brain barrier impairment and cognitive decline in type 2 diabetic mice. Hypertension. 2012;59:1079\u201388.","journal-title":"Hypertension"},{"key":"2417_CR83","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/micc.12193","volume":"22","author":"S Bloch","year":"2015","unstructured":"Bloch S, Obari D, Girouard H. Angiotensin and neurovascular coupling: beyond hypertension. Microcirculation. 2015;22:159\u201367.","journal-title":"Microcirculation"},{"key":"2417_CR84","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1161\/01.ATV.0000205849.22807.6e","volume":"26","author":"H Girouard","year":"2006","unstructured":"Girouard H, Park L, Anrather J, Zhou P, Iadecola C. Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through NOX-2-derived radicals. Arterioscler Thromb Vasc Biol. 2006;26:826\u201332.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2417_CR85","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1177\/0271678X16667364","volume":"37","author":"M Wiesmann","year":"2017","unstructured":"Wiesmann M, Roelofs M, van der Lugt R, Heerschap A, Kiliaan AJ, Claassen JA. Angiotensin II, hypertension and angiotensin II receptor antagonism: roles in the behavioural and brain pathology of a mouse model of Alzheimer\u2019s disease. J Cereb Blood Flow Metab. 2017;37:2396\u2013413.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106222","volume":"184","author":"Y Xue","year":"2023","unstructured":"Xue Y, Tang J, Zhang M, He Y, Fu J, Ding F. Durative sleep fragmentation with or without hypertension suppress rapid eye movement sleep and generate cerebrovascular dysfunction. Neurobiol Dis. 2023;184:106222.","journal-title":"Neurobiol Dis"},{"key":"2417_CR87","doi-asserted-by":"publisher","first-page":"H397","DOI":"10.1152\/ajpheart.00679.2010","volume":"300","author":"C Capone","year":"2011","unstructured":"Capone C, Faraco G, Park L, Cao X, Davisson RL, Iadecola C. The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension. Am J Physiol Heart Circ Physiol. 2011;300:H397\u2013407.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2417_CR88","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.1523\/JNEUROSCI.6262-11.2012","volume":"32","author":"C Capone","year":"2012","unstructured":"Capone C, Faraco G, Peterson JR, Coleman C, Anrather J, Milner TA, et al. Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension. J Neurosci. 2012;32:4878\u201386.","journal-title":"J Neurosci"},{"key":"2417_CR89","doi-asserted-by":"publisher","first-page":"4674","DOI":"10.1172\/JCI86950","volume":"126","author":"G Faraco","year":"2016","unstructured":"Faraco G, Sugiyama Y, Lane D, Garcia-Bonilla L, Chang H, Santisteban MM, et al. Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension. J Clin Invest. 2016;126:4674\u201389.","journal-title":"J Clin Invest"},{"key":"2417_CR90","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1161\/CIRCRESAHA.118.313260","volume":"124","author":"C Iadecola","year":"2019","unstructured":"Iadecola C, Gottesman RF. Neurovascular and cognitive dysfunction in hypertension. Circ Res. 2019;124:1025\u201344.","journal-title":"Circ Res"},{"key":"2417_CR91","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2023.102489","volume":"228","author":"X Chen","year":"2023","unstructured":"Chen X, Gao R, Song Y, Xu T, Jin L, Zhang W, et al. Astrocytic AT1R deficiency ameliorates Abeta-induced cognitive deficits and synaptotoxicity through beta-arrestin2 signaling. Prog Neurobiol. 2023;228:102489.","journal-title":"Prog Neurobiol"},{"key":"2417_CR92","doi-asserted-by":"crossref","unstructured":"Hendrickx JO, Calus E, De Deyn PP, Van Dam D, De Meyer GRY Short-term pharmacological induction of arterial stiffness and hypertension with angiotensin II does not affect learning and memory and cerebral amyloid load in two murine models of Alzheimer\u2019s disease. Int J Mol Sci. 2022;23","DOI":"10.3390\/ijms23052738"},{"key":"2417_CR93","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1089\/rej.2009.0944","volume":"13","author":"L Danielyan","year":"2010","unstructured":"Danielyan L, Klein R, Hanson LR, Buadze M, Schwab M, Gleiter CH, et al. Protective effects of intranasal losartan in the APP\/PS1 transgenic mouse model of Alzheimer disease. Rejuvenation Res. 2010;13:195\u2013201.","journal-title":"Rejuvenation Res"},{"key":"2417_CR94","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s13311-019-00723-6","volume":"16","author":"HJ Drews","year":"2019","unstructured":"Drews HJ, Yenkoyan K, Lourhmati A, Buadze M, Kabisch D, Verleysdonk S, et al. Intranasal losartan decreases perivascular beta amyloid, inflammation, and the decline of neurogenesis in hypertensive rats. Neurotherapeutics. 2019;16:725\u201340.","journal-title":"Neurotherapeutics"},{"key":"2417_CR95","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2021.102061","volume":"120","author":"H Coatl-Cuaya","year":"2022","unstructured":"Coatl-Cuaya H, Tendilla-Beltran H, de Jesus-Vasquez LM, Garces-Ramirez L, Gomez-Villalobos MJ, Flores G. Losartan enhances cognitive and structural neuroplasticity impairments in spontaneously hypertensive rats. J Chem Neuroanat. 2022;120:102061.","journal-title":"J Chem Neuroanat"},{"key":"2417_CR96","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s10571-019-00744-x","volume":"40","author":"GV Campos","year":"2020","unstructured":"Campos GV, de Souza AMA, Ji H, West CA, Wu X, Lee DL, et al. The angiotensin type 1 receptor antagonist losartan prevents ovariectomy-induced cognitive dysfunction and anxiety-like behavior in Long Evans rats. Cell Mol Neurobiol. 2020;40:407\u201320.","journal-title":"Cell Mol Neurobiol"},{"key":"2417_CR97","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1161\/HYPERTENSIONAHA.109.138586","volume":"54","author":"S Takeda","year":"2009","unstructured":"Takeda S, Sato N, Takeuchi D, Kurinami H, Shinohara M, Niisato K, et al. Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling. Hypertension. 2009;54:1345\u201352.","journal-title":"Hypertension"},{"key":"2417_CR98","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/ajh\/hpw099","volume":"30","author":"T Nakagawa","year":"2017","unstructured":"Nakagawa T, Hasegawa Y, Uekawa K, Senju S, Nakagata N, Matsui K, et al. Transient mild cerebral ischemia significantly deteriorated cognitive impairment in a mouse model of Alzheimer\u2019s disease via angiotensin AT1 receptor. Am J Hypertens. 2017;30:141\u201350.","journal-title":"Am J Hypertens"},{"key":"2417_CR99","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.pbb.2012.03.029","volume":"102","author":"B Sharma","year":"2012","unstructured":"Sharma B, Singh N. Experimental hypertension induced vascular dementia: pharmacological, biochemical and behavioral recuperation by angiotensin receptor blocker and acetylcholinesterase inhibitor. Pharmacol Biochem Behav. 2012;102:101\u20138.","journal-title":"Pharmacol Biochem Behav"},{"key":"2417_CR100","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1248\/bpb.b12-00387","volume":"35","author":"T Shindo","year":"2012","unstructured":"Shindo T, Takasaki K, Uchida K, Onimura R, Kubota K, Uchida N, et al. Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer\u2019s disease incorporating additional cerebrovascular disease factors. Biol Pharm Bull. 2012;35:2141\u20137.","journal-title":"Biol Pharm Bull"},{"key":"2417_CR101","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neulet.2014.03.030","volume":"567","author":"J Liu","year":"2014","unstructured":"Liu J, Liu S, Tanabe C, Maeda T, Zou K, Komano H. Differential effects of angiotensin II receptor blockers on Abeta generation. Neurosci Lett. 2014;567:51\u20136.","journal-title":"Neurosci Lett"},{"key":"2417_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117388","volume":"245","author":"NF Abdelkader","year":"2020","unstructured":"Abdelkader NF, Abd El-Latif AM, Khattab MM. Telmisartan\/17beta-estradiol mitigated cognitive deficit in an ovariectomized rat model of Alzheimer\u2019s disease: Modulation of ACE1\/ACE2 and AT1\/AT2 ratio. Life Sci. 2020;245:117388.","journal-title":"Life Sci"},{"key":"2417_CR103","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.bbrc.2013.08.091","volume":"439","author":"YI Sohn","year":"2013","unstructured":"Sohn YI, Lee NJ, Chung A, Saavedra JM, Scott Turner R, Pak DT, et al. Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking. Biochem Biophys Res Commun. 2013;439:464\u201370.","journal-title":"Biochem Biophys Res Commun"},{"key":"2417_CR104","doi-asserted-by":"publisher","first-page":"5282","DOI":"10.1007\/s12035-017-0754-5","volume":"55","author":"SA Bhat","year":"2018","unstructured":"Bhat SA, Goel R, Shukla S, Shukla R, Hanif K. Angiotensin receptor blockade by inhibiting glial activation promotes hippocampal neurogenesis via activation of Wnt\/beta-catenin signaling in hypertension. Mol Neurobiol. 2018;55:5282\u201398.","journal-title":"Mol Neurobiol"},{"key":"2417_CR105","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111471","volume":"128","author":"F Gouveia","year":"2024","unstructured":"Gouveia F, Fonseca C, Silva A, Camins A, Teresa Cruz M, Ettcheto M, et al. Intranasal irbesartan reverts cognitive decline and activates the PI3K\/AKT pathway in an LPS-induced neuroinflammation mice model. Int Immunopharmacol. 2024;128:111471.","journal-title":"Int Immunopharmacol"},{"key":"2417_CR106","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/MNH.0b013e328350261b","volume":"21","author":"UM Steckelings","year":"2012","unstructured":"Steckelings UM, Paulis L, Namsolleck P, Unger T. AT2 receptor agonists: hypertension and beyond. Curr Opin Nephrol Hypertens. 2012;21:142\u20136.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2417_CR107","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1111\/j.1476-5381.2010.01167.x","volume":"163","author":"M Horiuchi","year":"2011","unstructured":"Horiuchi M, Mogi M. Role of angiotensin II receptor subtype activation in cognitive function and ischaemic brain damage. Br J Pharm. 2011;163:1122\u201330.","journal-title":"Br J Pharm"},{"key":"2417_CR108","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jash.2015.01.010","volume":"9","author":"J Iwanami","year":"2015","unstructured":"Iwanami J, Mogi M, Tsukuda K, Wang XL, Nakaoka H, Kan-no H, et al. Direct angiotensin II type 2 receptor stimulation by compound 21 prevents vascular dementia. J Am Soc Hypertens. 2015;9:250\u20136.","journal-title":"J Am Soc Hypertens"},{"key":"2417_CR109","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/jcbfm.2011.133","volume":"32","author":"F Jing","year":"2012","unstructured":"Jing F, Mogi M, Sakata A, Iwanami J, Tsukuda K, Ohshima K, et al. Direct stimulation of angiotensin II type 2 receptor enhances spatial memory. J Cereb Blood Flow Metab. 2012;32:248\u201355.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR110","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1262-x","volume":"15","author":"HA Ahmed","year":"2018","unstructured":"Ahmed HA, Ishrat T, Pillai B, Fouda AY, Sayed MA, Eldahshan W, et al. RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial. J Neuroinflammation. 2018;15:229.","journal-title":"J Neuroinflammation"},{"key":"2417_CR111","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0261-4","volume":"12","author":"SY Dai","year":"2015","unstructured":"Dai SY, Peng W, Zhang YP, Li JD, Shen Y, Sun XF. Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA\/salt-induced hypertension in female rats. J Neuroinflammation. 2015;12:47.","journal-title":"J Neuroinflammation"},{"key":"2417_CR112","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.brainres.2009.08.068","volume":"1300","author":"A Sakata","year":"2009","unstructured":"Sakata A, Mogi M, Iwanami J, Tsukuda K, Min LJ, Fujita T, et al. Sex-different effect of angiotensin II type 2 receptor on ischemic brain injury and cognitive function. Brain Res. 2009;1300:14\u201323.","journal-title":"Brain Res"},{"key":"2417_CR113","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2021.106904","volume":"141","author":"W Eldahshan","year":"2021","unstructured":"Eldahshan W, Sayed MA, Awad ME, Ahmed HA, Gillis E, Althomali W, et al. Stimulation of angiotensin II receptor 2 preserves cognitive function and is associated with an enhanced cerebral vascular density after stroke. Vasc Pharm. 2021;141:106904.","journal-title":"Vasc Pharm"},{"key":"2417_CR114","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1007\/s12975-024-01232-1","volume":"16","author":"A Alshammari","year":"2025","unstructured":"Alshammari A, Pillai B, Kamat P, Jones TW, Bosomtwi A, Khan MB, et al. Angiotensin II type 2 receptor agonism alleviates progressive post-stroke cognitive impairment in aged spontaneously hypertensive rats. Transl Stroke Res. 2025;16:584\u201399.","journal-title":"Transl Stroke Res"},{"key":"2417_CR115","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1161\/HYPERTENSIONAHA.119.14431","volume":"75","author":"J Royea","year":"2020","unstructured":"Royea J, Lacalle-Aurioles M, Trigiani LJ, Fermigier A, Hamel E. AT2R\u2019s (angiotensin II type 2 receptor\u2019s) role in cognitive and cerebrovascular deficits in a mouse model of Alzheimer disease. Hypertension. 2020;75:1464\u201374.","journal-title":"Hypertension"},{"key":"2417_CR116","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1111\/j.1460-9568.2008.06347.x","volume":"28","author":"RN Fernando","year":"2008","unstructured":"Fernando RN, Albiston AL, Chai SY. The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus-potential role in modulation of glucose uptake in neurones?. Eur J Neurosci. 2008;28:588\u201398.","journal-title":"Eur J Neurosci"},{"key":"2417_CR117","doi-asserted-by":"publisher","first-page":"939","DOI":"10.2174\/1570159X18666201111103024","volume":"19","author":"MJ Ramirez-Exposito","year":"2021","unstructured":"Ramirez-Exposito MJ, Martinez-Martos JM, Canton-Habas V, Del Pilar Carrera-Gonzalez M. Putative involvement of endocrine disruptors in the Alzheimer\u2019s disease via the insulin-regulated aminopeptidase\/GLUT4 pathway. Curr Neuropharmacol. 2021;19:939\u201356.","journal-title":"Curr Neuropharmacol"},{"key":"2417_CR118","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11906-023-01266-0","volume":"26","author":"Z Zhou","year":"2024","unstructured":"Zhou Z, Orchard SG, Nelson MR, Fravel MA, Ernst ME. Angiotensin receptor blockers and cognition: a scoping review. Curr Hypertens Rep. 2024;26:1\u201319.","journal-title":"Curr Hypertens Rep"},{"key":"2417_CR119","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101612","volume":"77","author":"F Gouveia","year":"2022","unstructured":"Gouveia F, Camins A, Ettcheto M, Bicker J, Falcao A, Cruz MT, et al. Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer\u2019s disease: past, present and future. Ageing Res Rev. 2022;77:101612.","journal-title":"Ageing Res Rev"},{"key":"2417_CR120","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1161\/HYPERTENSIONAHA.121.17595","volume":"78","author":"L Glodzik","year":"2021","unstructured":"Glodzik L, Santisteban MM. Blood-brain barrier crossing renin-angiotensin system drugs: considerations for dementia and cognitive decline. Hypertension. 2021;78:644\u20136.","journal-title":"Hypertension"},{"key":"2417_CR121","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1007\/s12035-015-9260-9","volume":"53","author":"T Jiang","year":"2016","unstructured":"Jiang T, Zhang YD, Zhou JS, Zhu XC, Tian YY, Zhao HD, et al. Angiotensin-(1-7) is reduced and inversely correlates with tau hyperphosphorylation in animal models of Alzheimer\u2019s disease. Mol Neurobiol. 2016;53:2489\u201397.","journal-title":"Mol Neurobiol"},{"key":"2417_CR122","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s00401-019-02098-6","volume":"139","author":"CE Evans","year":"2020","unstructured":"Evans CE, Miners JS, Piva G, Willis CL, Heard DM, Kidd EJ, et al. ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer\u2019s disease. Acta Neuropathol. 2020;139:485\u2013502.","journal-title":"Acta Neuropathol"},{"key":"2417_CR123","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3233\/JAD-181000","volume":"69","author":"C Cao","year":"2019","unstructured":"Cao C, Hasegawa Y, Hayashi K, Takemoto Y, Kim-Mitsuyama S. Chronic angiotensin 1-7 infusion prevents angiotensin-II-induced cognitive dysfunction and skeletal muscle injury in a mouse model of Alzheimer\u2019s disease. J Alzheimers Dis. 2019;69:297\u2013309.","journal-title":"J Alzheimers Dis"},{"key":"2417_CR124","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1124\/jpet.118.254854","volume":"369","author":"M Hay","year":"2019","unstructured":"Hay M, Polt R, Heien ML, Vanderah TW, Largent-Milnes TM, Rodgers K, et al. A Novel angiotensin-(1-7) glycosylated Mas receptor agonist for treating vascular cognitive impairment and inflammation-related memory dysfunction. J Pharm Exp Ther. 2019;369:9\u201325.","journal-title":"J Pharm Exp Ther"},{"key":"2417_CR125","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14812","volume":"9","author":"FF Stoyell-Conti","year":"2021","unstructured":"Stoyell-Conti FF, Chabbra A, Puthentharayil J, Rigatto K, Speth RC. Chronic administration of pharmacological doses of angiotensin 1-7 and iodoangiotensin 1-7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats. Physiol Rep. 2021;9:e14812.","journal-title":"Physiol Rep"},{"key":"2417_CR126","doi-asserted-by":"crossref","unstructured":"Higaki A, Mogi M, Iwanami J, Min LJ, Bai HY, Shan BS, et al. Beneficial effect of Mas receptor deficiency on vascular cognitive impairment in the presence of angiotensin II type 2 receptor. J Am Heart Assoc. 2018;7","DOI":"10.1161\/JAHA.117.008121"},{"key":"2417_CR127","doi-asserted-by":"publisher","first-page":"943","DOI":"10.3233\/JAD-215231","volume":"85","author":"S Tran","year":"2022","unstructured":"Tran S, Kuruppu S, Rajapakse NW. Chronic renin-angiotensin system activation induced neuroinflammation: common mechanisms underlying hypertension and dementia?. J Alzheimers Dis. 2022;85:943\u201355.","journal-title":"J Alzheimers Dis"},{"key":"2417_CR128","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00213-012-2718-9","volume":"223","author":"B Sharma","year":"2012","unstructured":"Sharma B, Singh N. Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA-salt hypertension-induced vascular dementia in rats. Psychopharmacology (Berl). 2012;223:307\u201317.","journal-title":"Psychopharmacology (Berl)"},{"key":"2417_CR129","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115756","volume":"168","author":"R Collu","year":"2023","unstructured":"Collu R, Giunti E, Daley S, Chen M, Xia W. Angiotensin-converting enzyme inhibitors and statins therapies-induced changes in omics profiles in humans and transgenic tau mice. Biomed Pharmacother. 2023;168:115756.","journal-title":"Biomed Pharmacother"},{"key":"2417_CR130","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/s11906-014-0444-x","volume":"16","author":"M Koronyo-Hamaoui","year":"2014","unstructured":"Koronyo-Hamaoui M, Shah K, Koronyo Y, Bernstein E, Giani JF, Janjulia T, et al. ACE overexpression in myelomonocytic cells: effect on a mouse model of Alzheimer\u2019s disease. Curr Hypertens Rep. 2014;16:444.","journal-title":"Curr Hypertens Rep"},{"key":"2417_CR131","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s11906-019-1008-x","volume":"22","author":"LC Veiras","year":"2020","unstructured":"Veiras LC, Cao D, Saito S, Peng Z, Bernstein EA, Shen JZY, et al. Overexpression of ACE in myeloid cells increases immune effectiveness and leads to a new way of considering inflammation in acute and chronic diseases. Curr Hypertens Rep. 2020;22:4.","journal-title":"Curr Hypertens Rep"},{"key":"2417_CR132","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2022.170769","volume":"152","author":"D Cao","year":"2022","unstructured":"Cao D, Veiras L, Ahmed F, Shibata T, Bernstein EA, Okwan-Duodu D, et al. The non-cardiovascular actions of ACE. Peptides. 2022;152:170769.","journal-title":"Peptides"},{"key":"2417_CR133","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1080\/10641963.2020.1723615","volume":"42","author":"X Wang","year":"2020","unstructured":"Wang X, Zhu Y, Wang S, Wang Z, Sun H, He Y, et al. Effects of eplerenone on cerebral aldosterone levels and brain lesions in spontaneously hypertensive rats. Clin Exp Hypertens. 2020;42:531\u20138.","journal-title":"Clin Exp Hypertens"},{"key":"2417_CR134","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.ijbiomac.2016.02.069","volume":"91","author":"TN Shamsi","year":"2016","unstructured":"Shamsi TN, Parveen R, Fatima S. Characterization, biomedical and agricultural applications of protease inhibitors: a review. Int J Biol Macromol. 2016;91:1120\u201333.","journal-title":"Int J Biol Macromol"},{"key":"2417_CR135","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111363","volume":"192","author":"NN Nalivaeva","year":"2020","unstructured":"Nalivaeva NN, Zhuravin IA, Turner AJ. Neprilysin expression and functions in development, ageing and disease. Mech Ageing Dev. 2020;192:111363.","journal-title":"Mech Ageing Dev"},{"key":"2417_CR136","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1126\/science.1059946","volume":"292","author":"N Iwata","year":"2001","unstructured":"Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, et al. Metabolic regulation of brain Abeta by neprilysin. Science. 2001;292:1550\u20132.","journal-title":"Science"},{"key":"2417_CR137","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.neulet.2017.07.060","volume":"657","author":"H Zhang","year":"2017","unstructured":"Zhang H, Liu D, Wang Y, Huang H, Zhao Y, Zhou H. Meta-analysis of expression and function of neprilysin in Alzheimer\u2019s disease. Neurosci Lett. 2017;657:69\u201376.","journal-title":"Neurosci Lett"},{"key":"2417_CR138","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1111\/bcp.12861","volume":"81","author":"TH Langenickel","year":"2016","unstructured":"Langenickel TH, Tsubouchi C, Ayalasomayajula S, Pal P, Valentin MA, Hinder M, et al. The effect of LCZ696 (sacubitril\/valsartan) on amyloid-beta concentrations in cerebrospinal fluid in healthy subjects. Br J Clin Pharm. 2016;81:878\u201390.","journal-title":"Br J Clin Pharm"},{"key":"2417_CR139","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1001\/jamaneurol.2023.4719","volume":"81","author":"WS Brum","year":"2024","unstructured":"Brum WS, Docherty KF, Ashton NJ, Zetterberg H, Hansson O, McMurray JJV, et al. Effect of neprilysin inhibition on Alzheimer disease plasma biomarkers: a secondary analysis of a randomized clinical trial. JAMA Neurol. 2024;81:197\u2013200.","journal-title":"JAMA Neurol"},{"key":"2417_CR140","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1161\/CIRCULATIONAHA.124.068774","volume":"150","author":"P Dewan","year":"2024","unstructured":"Dewan P, Shen L, Pedro Ferreira J, Jhund PS, Anand IS, Chandra A, et al. Effect of sacubitril\/valsartan on cognitive function in patients with heart failure with preserved ejection fraction: a prespecified analysis of PARAGON-HF. Circulation. 2024;150:272\u201382.","journal-title":"Circulation"},{"key":"2417_CR141","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.07.084","volume":"309","author":"T Bartsch","year":"2015","unstructured":"Bartsch T, Wulff P. The hippocampus in aging and disease: from plasticity to vulnerability. Neuroscience. 2015;309:1\u201316.","journal-title":"Neuroscience"},{"key":"2417_CR142","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1038\/jcbfm.2013.140","volume":"33","author":"DI Bink","year":"2013","unstructured":"Bink DI, Ritz K, Aronica E, van der Weerd L, Daemen MJ. Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition. J Cereb Blood Flow Metab. 2013;33:1666\u201384.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR143","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0079-6123(08)63261-6","volume":"96","author":"NH Diemer","year":"1993","unstructured":"Diemer NH, Valente E, Bruhn T, Berg M, Jorgensen MB, Johansen FF. Glutamate receptor transmission and ischemic nerve cell damage: evidence for involvement of excitotoxic mechanisms. Prog Brain Res. 1993;96:105\u201323.","journal-title":"Prog Brain Res"},{"key":"2417_CR144","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101938","volume":"199","author":"AC Johnson","year":"2021","unstructured":"Johnson AC, Li Z, Orfila JE, Herson PS, Cipolla MJ. Hippocampal network dysfunction as a mechanism of early-onset dementia after preeclampsia and eclampsia. Prog Neurobiol. 2021;199:101938.","journal-title":"Prog Neurobiol"},{"key":"2417_CR145","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.931536","volume":"14","author":"J Lee","year":"2022","unstructured":"Lee J, Kim HJ. Normal aging induces changes in the brain and neurodegeneration progress: review of the structural, biochemical, metabolic, cellular, and molecular changes. Front Aging Neurosci. 2022;14:931536.","journal-title":"Front Aging Neurosci"},{"key":"2417_CR146","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/acel.12315","volume":"14","author":"P Toth","year":"2015","unstructured":"Toth P, Tarantini S, Springo Z, Tucsek Z, Gautam T, Giles CB, et al. Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. Aging Cell. 2015;14:400\u20138.","journal-title":"Aging Cell"},{"key":"2417_CR147","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50559-8","volume":"15","author":"HC Bennett","year":"2024","unstructured":"Bennett HC, Zhang Q, Wu YT, Manjila SB, Chon U, Shin D, et al. Aging drives cerebrovascular network remodeling and functional changes in the mouse brain. Nat Commun. 2024;15:6398.","journal-title":"Nat Commun"},{"key":"2417_CR148","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s11357-018-0037-8","volume":"40","author":"VN Sure","year":"2018","unstructured":"Sure VN, Sakamuri S, Sperling JA, Evans WR, Merdzo I, Mostany R, et al. A novel high-throughput assay for respiration in isolated brain microvessels reveals impaired mitochondrial function in the aged mice. Geroscience. 2018;40:365\u201375.","journal-title":"Geroscience"},{"key":"2417_CR149","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s004010000278","volume":"101","author":"TL Kemper","year":"2001","unstructured":"Kemper TL, Blatt GJ, Killiany RJ, Moss MB. Neuropathology of progressive cognitive decline in chronically hypertensive rhesus monkeys. Acta Neuropathol. 2001;101:145\u201353.","journal-title":"Acta Neuropathol"},{"key":"2417_CR150","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s40478-014-0169-8","volume":"2","author":"D Kaiser","year":"2014","unstructured":"Kaiser D, Weise G, Moller K, Scheibe J, Posel C, Baasch S, et al. Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease. Acta Neuropathol Commun. 2014;2:169.","journal-title":"Acta Neuropathol Commun"},{"key":"2417_CR151","doi-asserted-by":"publisher","first-page":"10","DOI":"10.2174\/156720212799297074","volume":"9","author":"MF Ritz","year":"2012","unstructured":"Ritz MF, Grond-Ginsbach C, Engelter S, Lyrer P. Gene expression suggests spontaneously hypertensive rats may have altered metabolism and reduced hypoxic tolerance. Curr Neurovasc Res. 2012;9:10\u20139.","journal-title":"Curr Neurovasc Res"},{"key":"2417_CR152","doi-asserted-by":"publisher","first-page":"6365","DOI":"10.1523\/JNEUROSCI.1974-18.2019","volume":"39","author":"KN Mortensen","year":"2019","unstructured":"Mortensen KN, Sanggaard S, Mestre H, Lee H, Kostrikov S, Xavier ALR, et al. Impaired glymphatic transport in spontaneously hypertensive rats. J Neurosci. 2019;39:6365\u201377.","journal-title":"J Neurosci"},{"key":"2417_CR153","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1177\/0271678X221105668","volume":"42","author":"B Monte","year":"2022","unstructured":"Monte B, Constantinou S, Koundal S, Lee H, Dai F, Gursky Z, et al. Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging. J Cereb Blood Flow Metab. 2022;42:1813\u201326.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR154","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.neuroscience.2019.01.030","volume":"404","author":"S Koundal","year":"2019","unstructured":"Koundal S, Liu X, Sanggaard S, Mortensen K, Wardlaw J, Nedergaard M, et al. Brain morphometry and longitudinal relaxation time of spontaneously hypertensive rats (SHRs) in early and intermediate stages of hypertension investigated by 3D VFA-SPGR MRI. Neuroscience. 2019;404:14\u201326.","journal-title":"Neuroscience"},{"key":"2417_CR155","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.expneurol.2015.05.006","volume":"272","author":"P Venkat","year":"2015","unstructured":"Venkat P, Chopp M, Chen J. Models and mechanisms of vascular dementia. Exp Neurol. 2015;272:97\u2013108.","journal-title":"Exp Neurol"},{"key":"2417_CR156","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1007\/s00401-004-0845-z","volume":"107","author":"M Ueno","year":"2004","unstructured":"Ueno M, Sakamoto H, Tomimoto H, Akiguchi I, Onodera M, Huang CL, et al. Blood-brain barrier is impaired in the hippocampus of young adult spontaneously hypertensive rats. Acta Neuropathol. 2004;107:532\u20138.","journal-title":"Acta Neuropathol"},{"key":"2417_CR157","doi-asserted-by":"publisher","unstructured":"Xu X, Xiao C, Yi M, Yang J, Liao M, Zhou K, et al. Cerebral perfusion characteristics and dynamic brain structural changes in stroke-prone renovascular hypertensive rats: a preclinical model for cerebral small vessel disease. Transl Stroke Res. 2024, (e-pub ahead of print 20240305;https:\/\/doi.org\/10.1007\/s12975-024-01239-8).","DOI":"10.1007\/s12975-024-01239-8)"},{"key":"2417_CR158","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1161\/STROKEAHA.123.044732","volume":"54","author":"R Roberts","year":"2023","unstructured":"Roberts R, Huckstepp RTR. Innate sleep apnea in spontaneously hypertensive rats is associated with microvascular rarefaction and neuronal loss in the preBotzinger complex. Stroke. 2023;54:3141\u201352.","journal-title":"Stroke"},{"key":"2417_CR159","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.bbadis.2015.12.009","volume":"1862","author":"AM Helman","year":"2016","unstructured":"Helman AM, Murphy MP. Vascular cognitive impairment: Modeling a critical neurologic disease in vitro and in vivo. Biochim Biophys Acta. 2016;1862:975\u201382.","journal-title":"Biochim Biophys Acta"},{"key":"2417_CR160","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.neuroscience.2015.06.056","volume":"303","author":"JY Choi","year":"2015","unstructured":"Choi JY, Cui Y, Kim BG. Interaction between hypertension and cerebral hypoperfusion in the development of cognitive dysfunction and white matter pathology in rats. Neuroscience. 2015;303:115\u201325.","journal-title":"Neuroscience"},{"key":"2417_CR161","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.bbr.2013.05.043","volume":"252","author":"C Valerio Romanini","year":"2013","unstructured":"Valerio Romanini C, Dias Fiuza Ferreira E, Correia Bacarin C, Verussa MH, Weffort de Oliveira RM, Milani H. Neurohistological and behavioral changes following the four-vessel occlusion\/internal carotid artery model of chronic cerebral hypoperfusion: comparison between normotensive and spontaneously hypertensive rats. Behav Brain Res. 2013;252:214\u201321.","journal-title":"Behav Brain Res"},{"key":"2417_CR162","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.nbd.2018.02.012","volume":"114","author":"Y Yang","year":"2018","unstructured":"Yang Y, Kimura-Ohba S, Thompson JF, Salayandia VM, Cosse M, Raz L, et al. Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury. Neurobiol Dis. 2018;114:95\u2013110.","journal-title":"Neurobiol Dis"},{"key":"2417_CR163","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1177\/0271678X15606717","volume":"36","author":"A Kitamura","year":"2016","unstructured":"Kitamura A, Saito S, Maki T, Oishi N, Ayaki T, Hattori Y, et al. Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory. J Cereb Blood Flow Metab. 2016;36:1592\u2013602.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR164","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.nbd.2018.07.009","volume":"126","author":"L Raz","year":"2019","unstructured":"Raz L, Bhaskar K, Weaver J, Marini S, Zhang Q, Thompson JF, et al. Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction. Neurobiol Dis. 2019;126:124\u201336.","journal-title":"Neurobiol Dis"},{"key":"2417_CR165","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.nbd.2018.07.021","volume":"126","author":"S Guo","year":"2019","unstructured":"Guo S, Deng W, Xing C, Zhou Y, Ning M, Lo EH. Effects of aging, hypertension and diabetes on the mouse brain and heart vasculomes. Neurobiol Dis. 2019;126:117\u201323.","journal-title":"Neurobiol Dis"},{"key":"2417_CR166","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0793-9","volume":"15","author":"AH Hainsworth","year":"2017","unstructured":"Hainsworth AH, Allan SM, Boltze J, Cunningham C, Farris C, Head E, et al. Translational models for vascular cognitive impairment: a review including larger species. BMC Med. 2017;15:16.","journal-title":"BMC Med"},{"key":"2417_CR167","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.7150\/thno.18509","volume":"7","author":"M Wiesmann","year":"2017","unstructured":"Wiesmann M, Zerbi V, Jansen D, Lutjohann D, Veltien A, Heerschap A, et al. Hypertension, cerebrovascular impairment, and cognitive decline in aged AbetaPP\/PS1 mice. Theranostics. 2017;7:1277\u201389.","journal-title":"Theranostics"},{"key":"2417_CR168","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1161\/HYPERTENSIONAHA.114.04139","volume":"65","author":"D Cifuentes","year":"2015","unstructured":"Cifuentes D, Poittevin M, Dere E, Broqueres-You D, Bonnin P, Benessiano J, et al. Hypertension accelerates the progression of Alzheimer-like pathology in a mouse model of the disease. Hypertension. 2015;65:218\u201324.","journal-title":"Hypertension"},{"key":"2417_CR169","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1161\/HYPERTENSIONAHA.118.12048","volume":"73","author":"O de Montgolfier","year":"2019","unstructured":"de Montgolfier O, Pincon A, Pouliot P, Gillis MA, Bishop J, Sled JG, et al. High systolic blood pressure induces cerebral microvascular endothelial dysfunction, neurovascular unit damage, and cognitive decline in mice. Hypertension. 2019;73:217\u201328.","journal-title":"Hypertension"},{"key":"2417_CR170","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1177\/0271678X16630991","volume":"36","author":"HC Helms","year":"2016","unstructured":"Helms HC, Abbott NJ, Burek M, Cecchelli R, Couraud PO, Deli MA, et al. In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use. J Cereb Blood Flow Metab. 2016;36:862\u201390.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR171","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s44164-022-00015-y","volume":"1","author":"E Ko","year":"2022","unstructured":"Ko E, Kamm RD. Neurovascular models for organ-on-a-chips. vitro models. 2022;1:125\u20137.","journal-title":"vitro models"},{"key":"2417_CR172","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/j.1749-6632.2000.tb06363.x","volume":"903","author":"Z Suo","year":"2000","unstructured":"Suo Z, Su G, Placzek A, Kundtz A, Humphrey J, Crawford F, et al. A beta vasoactivity in vivo. Ann N. Y Acad Sci. 2000;903:156\u201363.","journal-title":"Ann N. Y Acad Sci"},{"key":"2417_CR173","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1179\/016164103101201940","volume":"25","author":"D Paris","year":"2003","unstructured":"Paris D, Humphrey J, Quadros A, Patel N, Crescentini R, Crawford F, et al. Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer\u2019s disease: role of inflammation. Neurol Res. 2003;25:642\u201351.","journal-title":"Neurol Res"},{"key":"2417_CR174","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1161\/HYPERTENSIONAHA.113.01348","volume":"62","author":"N Haase","year":"2013","unstructured":"Haase N, Herse F, Spallek B, Haase H, Morano I, Qadri F, et al. Amyloid-beta peptides activate alpha1-adrenergic cardiovascular receptors. Hypertension. 2013;62:966\u201372.","journal-title":"Hypertension"},{"key":"2417_CR175","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1177\/0271678X17724930","volume":"38","author":"HM Tayler","year":"2018","unstructured":"Tayler HM, Palmer JC, Thomas TL, Kehoe PG, Paton JF, Love S. Cerebral Abeta(40) and systemic hypertension. J Cereb Blood Flow Metab. 2018;38:1993\u20132005.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR176","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.brainresbull.2010.11.004","volume":"84","author":"JT Yu","year":"2011","unstructured":"Yu JT, Wang ND, Ma T, Jiang H, Guan J, Tan L. Roles of beta-adrenergic receptors in Alzheimer\u2019s disease: implications for novel therapeutics. Brain Res Bull. 2011;84:111\u20137.","journal-title":"Brain Res Bull"},{"key":"2417_CR177","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.3233\/JAD-190630","volume":"73","author":"JC Palmer","year":"2020","unstructured":"Palmer JC, Tayler HM, Dyer L, Kehoe PG, Paton JFR, Love S. Zibotentan, an endothelin A receptor antagonist, prevents amyloid-beta-induced hypertension and maintains cerebral perfusion. J Alzheimers Dis. 2020;73:1185\u201399.","journal-title":"J Alzheimers Dis"},{"key":"2417_CR178","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.brainres.2010.07.006","volume":"1352","author":"K Yamada","year":"2010","unstructured":"Yamada K, Uchida S, Takahashi S, Takayama M, Nagata Y, Suzuki N, et al. Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer\u2019s disease. Brain Res. 2010;1352:176\u201386.","journal-title":"Brain Res"},{"key":"2417_CR179","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1007\/s11481-016-9703-8","volume":"11","author":"N Torika","year":"2016","unstructured":"Torika N, Asraf K, Roasso E, Danon A, Fleisher-Berkovich S. Angiotensin converting enzyme inhibitors ameliorate brain inflammation associated with microglial activation: possible implications for Alzheimer\u2019s disease. J Neuroimmune Pharm. 2016;11:774\u201385.","journal-title":"J Neuroimmune Pharm"},{"key":"2417_CR180","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1161\/HYPERTENSIONAHA.118.11775","volume":"72","author":"LJ Trigiani","year":"2018","unstructured":"Trigiani LJ, Royea J, Lacalle-Aurioles M, Tong XK, Hamel E. Pleiotropic benefits of the angiotensin receptor blocker candesartan in a mouse model of Alzheimer disease. Hypertension. 2018;72:1217\u201326.","journal-title":"Hypertension"},{"key":"2417_CR181","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1161\/HYPERTENSIONAHA.109.136879","volume":"54","author":"K Tsukuda","year":"2009","unstructured":"Tsukuda K, Mogi M, Iwanami J, Min LJ, Sakata A, Jing F, et al. Cognitive deficit in amyloid-beta-injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome proliferator-activated receptor-gamma activation. Hypertension. 2009;54:782\u20137.","journal-title":"Hypertension"},{"key":"2417_CR182","doi-asserted-by":"publisher","first-page":"919","DOI":"10.3233\/JAD-230133","volume":"94","author":"XX Fu","year":"2023","unstructured":"Fu XX, Wei B, Cao HM, Duan R, Deng Y, Lian HW, et al. Telmisartan alleviates Alzheimer\u2019s disease-related neuropathologies and cognitive impairments. J Alzheimers Dis. 2023;94:919\u201333.","journal-title":"J Alzheimers Dis"},{"key":"2417_CR183","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.jjcc.2012.08.004","volume":"60","author":"T Kishi","year":"2012","unstructured":"Kishi T, Hirooka Y, Sunagawa K. Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor\/tropomyosin-related kinase B in hippocampus of hypertensive rats. J Cardiol. 2012;60:489\u201394.","journal-title":"J Cardiol"},{"key":"2417_CR184","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.05.023","volume":"23","author":"T Kurata","year":"2014","unstructured":"Kurata T, Lukic V, Kozuki M, Wada D, Miyazaki K, Morimoto N, et al. Telmisartan reduces progressive accumulation of cellular amyloid beta and phosphorylated tau with inflammatory responses in aged spontaneously hypertensive stroke resistant rat. J Stroke Cerebrovasc Dis. 2014;23:2580\u201390.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2417_CR185","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1179\/1743132815Y.0000000002","volume":"37","author":"W Liu","year":"2015","unstructured":"Liu W, Yamashita T, Kurata T, Kono S, Hishikawa N, Deguchi K, et al. Protective effect of telmisartan on neurovascular unit and inflammasome in stroke-resistant spontaneously hypertensive rats. Neurol Res. 2015;37:491\u2013501.","journal-title":"Neurol Res"},{"key":"2417_CR186","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.05.033","volume":"23","author":"Y Zhai","year":"2014","unstructured":"Zhai Y, Yamashita T, Kurata T, Fukui Y, Sato K, Kono S, et al. Strong reduction of low-density lipoprotein receptor\/apolipoprotein E expressions by telmisartan in cerebral cortex and hippocampus of stroke resistant spontaneously hypertensive rats. J Stroke Cerebrovasc Dis. 2014;23:2350\u201361.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2417_CR187","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.brainres.2011.09.016","volume":"1421","author":"K Yamada","year":"2011","unstructured":"Yamada K, Horita T, Takayama M, Takahashi S, Takaba K, Nagata Y, et al. Effect of a centrally active angiotensin converting enzyme inhibitor, perindopril, on cognitive performance in chronic cerebral hypo-perfusion rats. Brain Res. 2011;1421:110\u201320.","journal-title":"Brain Res"},{"key":"2417_CR188","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.09.037","volume":"24","author":"S Kono","year":"2015","unstructured":"Kono S, Kurata T, Sato K, Omote Y, Hishikawa N, Yamashita T, et al. Neurovascular protection by telmisartan via reducing neuroinflammation in stroke-resistant spontaneously hypertensive rat brain after ischemic stroke. J Stroke Cerebrovasc Dis. 2015;24:537\u201347.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2417_CR189","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12975-013-0321-y","volume":"6","author":"T Kurata","year":"2015","unstructured":"Kurata T, Lukic V, Kozuki M, Wada D, Miyazaki K, Morimoto N, et al. Long-term effect of telmisartan on Alzheimer\u2019s amyloid genesis in SHR-SR after tMCAO. Transl Stroke Res. 2015;6:107\u201315.","journal-title":"Transl Stroke Res"},{"key":"2417_CR190","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.01.025","volume":"27","author":"Y Gao","year":"2018","unstructured":"Gao Y, Li W, Liu Y, Wang Y, Zhang J, Li M, et al. Effect of telmisartan on preventing learning and memory deficits via peroxisome proliferator-activated receptor-gamma in vascular dementia spontaneously hypertensive rats. J Stroke Cerebrovasc Dis. 2018;27:277\u201385.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2417_CR191","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/1440-1681.13738","volume":"50","author":"CJ Rodriguez-Ortiz","year":"2023","unstructured":"Rodriguez-Ortiz CJ, Thorwald MA, Rodriguez R, Mejias-Ortega M, Kieu Z, Maitra N, et al. Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats. Clin Exp Pharm Physiol. 2023;50:228\u201337.","journal-title":"Clin Exp Pharm Physiol"},{"key":"2417_CR192","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1021\/acschemneuro.5b00274","volume":"7","author":"R Goel","year":"2016","unstructured":"Goel R, Bhat SA, Hanif K, Nath C, Shukla R. Perindopril attenuates lipopolysaccharide-induced amyloidogenesis and memory impairment by suppression of oxidative stress and RAGE activation. ACS Chem Neurosci. 2016;7:206\u201317.","journal-title":"ACS Chem Neurosci"},{"key":"2417_CR193","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.3390\/cells10071778","volume":"10","author":"S Yoo","year":"2021","unstructured":"Yoo S, Stremlau M, Pinto A, Woo H, Curtis O, van Praag H. Effects of combined anti-hypertensive and statin treatment on memory, fear extinction, adult neurogenesis, and angiogenesis in adult and middle-aged mice. Cells. 2021;10:1778.","journal-title":"Cells"},{"key":"2417_CR194","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/ijo.2017.57","volume":"41","author":"JCL Mamo","year":"2017","unstructured":"Mamo JCL, Lam V, Giles C, Coulson SH, Fimognari N, Mooranian A, et al. Antihypertensive agents do not prevent blood-brain barrier dysfunction and cognitive deficits in dietary-induced obese mice. Int J Obes (Lond). 2017;41:926\u201334.","journal-title":"Int J Obes (Lond)"},{"key":"2417_CR195","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3233\/JAD-131679","volume":"40","author":"X Liu","year":"2014","unstructured":"Liu X, Wang Z, Xia Y, Yu G, Zeng K, Luo H, et al. Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit. J Alzheimers Dis. 2014;40:419\u201327.","journal-title":"J Alzheimers Dis"},{"key":"2417_CR196","doi-asserted-by":"publisher","first-page":"9760","DOI":"10.1074\/jbc.RA118.006420","volume":"294","author":"S Liu","year":"2019","unstructured":"Liu S, Ando F, Fujita Y, Liu J, Maeda T, Shen X, et al. A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer\u2019s disease pathology in mice. J Biol Chem. 2019;294:9760\u201370.","journal-title":"J Biol Chem"},{"key":"2417_CR197","doi-asserted-by":"publisher","first-page":"e65232","DOI":"10.1371\/journal.pone.0065232","volume":"8","author":"J Wang","year":"2013","unstructured":"Wang J, Zhao Z, Lin E, Zhao W, Qian X, Freire D, et al. Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer\u2019s disease. PLoS One. 2013;8:e65232.","journal-title":"PLoS One"},{"key":"2417_CR198","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.nbd.2007.01.004","volume":"26","author":"ML Hemming","year":"2007","unstructured":"Hemming ML, Selkoe DJ, Farris W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease. Neurobiol Dis. 2007;26:273\u201381.","journal-title":"Neurobiol Dis"},{"key":"2417_CR199","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2119\/molmed.2010.00180","volume":"17","author":"D Paris","year":"2011","unstructured":"Paris D, Bachmeier C, Patel N, Quadros A, Volmar CH, Laporte V, et al. Selective antihypertensive dihydropyridines lower A\u03b2 accumulation by targeting both the production and the clearance of A\u03b2 across the blood-brain barrier. Mol Med. 2011;17:149\u201362.","journal-title":"Mol Med"},{"key":"2417_CR200","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1081\/CEH-120034139","volume":"26","author":"F Amenta","year":"2004","unstructured":"Amenta F, Tomassoni D. Treatment with nicardipine protects brain in an animal model of hypertension-induced damage. Clin Exp Hypertens. 2004;26:351\u201361.","journal-title":"Clin Exp Hypertens"},{"key":"2417_CR201","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1097\/HJH.0000000000003445","volume":"41","author":"D Kerkhofs","year":"2023","unstructured":"Kerkhofs D, Helgers R, Hermes D, Steinbusch HPJ, Van Essen H, Leenders P, et al. Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. J Hypertens. 2023;41:1159\u201367.","journal-title":"J Hypertens"},{"key":"2417_CR202","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1016\/S0047-6374(01)00318-9","volume":"122","author":"M Sabbatini","year":"2001","unstructured":"Sabbatini M, Tomassoni D, Amenta F. Hypertensive brain damage: comparative evaluation of protective effect of treatment with dihydropyridine derivatives in spontaneously hypertensive rats. Mech Ageing Dev. 2001;122:2085\u2013105.","journal-title":"Mech Ageing Dev"},{"key":"2417_CR203","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s40478-020-01045-x","volume":"8","author":"A Morin","year":"2020","unstructured":"Morin A, Mouzon B, Ferguson S, Paris D, Browning M, Stewart W, et al. Nilvadipine suppresses inflammation via inhibition of P-SYK and restores spatial memory deficits in a mouse model of repetitive mild TBI. Acta Neuropathol Commun. 2020;8:166.","journal-title":"Acta Neuropathol Commun"},{"key":"2417_CR204","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s10571-011-9649-6","volume":"31","author":"Y Sakurai-Yamashita","year":"2011","unstructured":"Sakurai-Yamashita Y, Harada N, Niwa M. Lercanidipine rescues hippocampus pyramidal neurons from mild ischemia-induced delayed neuronal death in SHRSP. Cell Mol Neurobiol. 2011;31:561\u20137.","journal-title":"Cell Mol Neurobiol"},{"key":"2417_CR205","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30515-0","volume":"13","author":"DMP Naessens","year":"2023","unstructured":"Naessens DMP, de Vos J, Richard E, Wilhelmus MMM, Jongenelen CAM, Scholl ER, et al. Effect of long-term antihypertensive treatment on cerebrovascular structure and function in hypertensive rats. Sci Rep. 2023;13:3481.","journal-title":"Sci Rep"},{"key":"2417_CR206","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1017\/S1461145712001393","volume":"16","author":"M Dobarro","year":"2013","unstructured":"Dobarro M, Orejana L, Aguirre N, Ramirez MJ. Propranolol reduces cognitive deficits, amyloid beta levels, tau phosphorylation and insulin resistance in response to chronic corticosterone administration. Int J Neuropsychopharmacol. 2013;16:1351\u201360.","journal-title":"Int J Neuropsychopharmacol"},{"key":"2417_CR207","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.3233\/JAD-2012-120904","volume":"33","author":"J Wang","year":"2013","unstructured":"Wang J, Wright HM, Vempati P, Li H, Wangsa J, Dzhuan A, et al. Investigation of nebivolol as a novel therapeutic agent for the treatment of Alzheimer\u2019s disease. J Alzheimers Dis. 2013;33:1147\u201356.","journal-title":"J Alzheimers Dis"},{"key":"2417_CR208","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105089","volume":"146","author":"AK Evans","year":"2020","unstructured":"Evans AK, Ardestani PM, Yi B, Park HH, Lam RK, Shamloo M. Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer\u2019s Disease. Neurobiol Dis. 2020;146:105089.","journal-title":"Neurobiol Dis"},{"key":"2417_CR209","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s11064-011-0663-3","volume":"37","author":"L Zhang","year":"2012","unstructured":"Zhang L, Chan LuL, Huang WM, Wai Y, Yew MS. DT. Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis. Neurochem Res. 2012;37:911\u20139.","journal-title":"Neurochem Res"},{"key":"2417_CR210","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1142\/S0192415X08006004","volume":"36","author":"SC Ho","year":"2008","unstructured":"Ho SC, Ho YF, Lai TH, Liu TH, Su SY, Wu RY. Effect of Tianma Gouteng Decoction with subtractive ingredients and its active constituents on memory acquisition. Am J Chin Med. 2008;36:593\u2013602.","journal-title":"Am J Chin Med"},{"key":"2417_CR211","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.phymed.2016.03.009","volume":"23","author":"SW Huang","year":"2016","unstructured":"Huang SW, Wang W, Zhang MY, Liu QB, Luo SY, Peng Y, et al. The effect of ethyl acetate extract from persimmon leaves on Alzheimer\u2019s disease and its underlying mechanism. Phytomedicine. 2016;23:694\u2013704.","journal-title":"Phytomedicine"},{"key":"2417_CR212","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.brainres.2017.03.005","volume":"1663","author":"YL Fei","year":"2017","unstructured":"Fei YL, Lv HJ, Li YB, Liu J, Qian YH, Yang WN, et al. Tongxinluo improves cognition by decreasing beta-amyloid in spontaneous hypertensive rats. Brain Res. 2017;1663:151\u201360.","journal-title":"Brain Res"},{"key":"2417_CR213","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0091-3057(03)00109-6","volume":"75","author":"H Watanabe","year":"2003","unstructured":"Watanabe H, Zhao Q, Matsumoto K, Tohda M, Murakami Y, Zhang SH, et al. Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine. Pharmacol Biochem Behav. 2003;75:635\u201343.","journal-title":"Pharmacol Biochem Behav"},{"key":"2417_CR214","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.neulet.2016.02.019","volume":"617","author":"M Wei","year":"2016","unstructured":"Wei M, Chen L, Liu J, Zhao J, Liu W, Feng F. Protective effects of a Chotosan Fraction and its active components on beta-amyloid-induced neurotoxicity. Neurosci Lett. 2016;617:143\u20139.","journal-title":"Neurosci Lett"},{"key":"2417_CR215","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1248\/bpb.28.47","volume":"28","author":"G Hussein","year":"2005","unstructured":"Hussein G, Nakamura M, Zhao Q, Iguchi T, Goto H, Sankawa U, et al. Antihypertensive and neuroprotective effects of astaxanthin in experimental animals. Biol Pharm Bull. 2005;28:47\u201352.","journal-title":"Biol Pharm Bull"},{"key":"2417_CR216","doi-asserted-by":"publisher","first-page":"3444","DOI":"10.1039\/C6FO00223D","volume":"7","author":"TH Liu","year":"2016","unstructured":"Liu TH, Tsai TY. Effects of equol on deoxycorticosterone acetate salt-induced hypertension and associated vascular dementia in rats. Food Funct. 2016;7:3444\u201357.","journal-title":"Food Funct"},{"key":"2417_CR217","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.1172\/JCI31547","volume":"117","author":"J Wang","year":"2007","unstructured":"Wang J, Ho L, Chen L, Zhao Z, Zhao W, Qian X, et al. Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. J Clin Invest. 2007;117:3393\u2013402.","journal-title":"J Clin Invest"},{"key":"2417_CR218","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-00983-y","volume":"13","author":"E Pauls","year":"2021","unstructured":"Pauls E, Bayod S, Mateo L, Alcalde V, Juan-Blanco T, Sanchez-Soto M, et al. Identification and drug-induced reversion of molecular signatures of Alzheimer\u2019s disease onset and progression in App(NL-G-F), App(NL-F), and 3xTg-AD mouse models. Genome Med. 2021;13:168.","journal-title":"Genome Med"},{"key":"2417_CR219","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09494-2","volume":"10","author":"FH Siddiqi","year":"2019","unstructured":"Siddiqi FH, Menzies FM, Lopez A, Stamatakou E, Karabiyik C, Ureshino R, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nat Commun. 2019;10:1817.","journal-title":"Nat Commun"},{"key":"2417_CR220","doi-asserted-by":"publisher","first-page":"8587","DOI":"10.1523\/JNEUROSCI.1098-20.2020","volume":"40","author":"NJ Michaels","year":"2020","unstructured":"Michaels NJ, Lemmon K, Plemel JR, Jensen SK, Mishra MK, Brown D, et al. Aging-exacerbated acute axon and myelin injury is associated with microglia-derived reactive oxygen species and is alleviated by the generic medication indapamide. J Neurosci. 2020;40:8587\u2013600.","journal-title":"J Neurosci"},{"key":"2417_CR221","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1021\/acschemneuro.8b00368","volume":"10","author":"T Teng","year":"2019","unstructured":"Teng T, Ridgley DM, Tsoy A, Sun GY, Askarova S, Lee JC. Azelnidipine attenuates the oxidative and NFkappaB pathways in amyloid-beta-stimulated cerebral endothelial cells. ACS Chem Neurosci. 2019;10:209\u201315.","journal-title":"ACS Chem Neurosci"},{"key":"2417_CR222","doi-asserted-by":"crossref","unstructured":"Choi DH, Lee J. A mini-review of the NADPH oxidases in vascular dementia: correlation with NOXs and risk factors for VaD. Int J Mol Sci. 2017;18","DOI":"10.3390\/ijms18112500"},{"key":"2417_CR223","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1080\/1028415X.2022.2062925","volume":"26","author":"TA Olasehinde","year":"2023","unstructured":"Olasehinde TA, Oladapo SFAK, Oyeleye IF. SI. Effect of diet supplemented with African Star Apple Fruit Pulp on purinergic, cholinergic and monoaminergic enzymes, TNF-alpha expression and redox imbalance in the brain of hypertensive rats. Nutr Neurosci. 2023;26:496\u2013510.","journal-title":"Nutr Neurosci"},{"key":"2417_CR224","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2307513120","volume":"120","author":"JL Taylor","year":"2023","unstructured":"Taylor JL, Walsh KR, Mosneag IE, Danby TGE, Luka N, Chanda B, et al. Uncoupling of Ca(2+) sparks from BK channels in cerebral arteries underlies hypoperfusion in hypertension-induced vascular dementia. Proc Natl Acad Sci USA. 2023;120:e2307513120.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2417_CR225","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0306-4522(00)00377-8","volume":"101","author":"AV Terry Jr.","year":"2000","unstructured":"Terry AV Jr., Hernandez CM, Buccafusco JJ, Gattu M. Deficits in spatial learning and nicotinic-acetylcholine receptors in older, spontaneously hypertensive rats. Neuroscience. 2000;101:357\u201368.","journal-title":"Neuroscience"},{"key":"2417_CR226","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1081\/CEH-120034140","volume":"26","author":"SK Tayebati","year":"2004","unstructured":"Tayebati SK, Di Tullio MA, Amenta F. Effect of treatment with the cholinesterase inhibitor rivastigmine on vesicular acetylcholine transporter and choline acetyltransferase in rat brain. Clin Exp Hypertens. 2004;26:363\u201373.","journal-title":"Clin Exp Hypertens"},{"key":"2417_CR227","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jns.2009.02.349","volume":"283","author":"SK Tayebati","year":"2009","unstructured":"Tayebati SK, Di Tullio MA, Tomassoni D, Amenta F. Neuroprotective effect of treatment with galantamine and choline alphoscerate on brain microanatomy in spontaneously hypertensive rats. J Neurol Sci. 2009;283:187\u201394.","journal-title":"J Neurol Sci"},{"key":"2417_CR228","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.brainres.2006.08.068","volume":"1120","author":"D Tomassoni","year":"2006","unstructured":"Tomassoni D, Avola R, Mignini F, Parnetti L, Amenta F. Effect of treatment with choline alphoscerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive rats. Brain Res. 2006;1120:183\u201390.","journal-title":"Brain Res"},{"key":"2417_CR229","doi-asserted-by":"publisher","first-page":"120","DOI":"10.2174\/156720512799015118","volume":"9","author":"D Tomassoni","year":"2012","unstructured":"Tomassoni D, Catalani A, Cinque C, Di Tullio MA, Tayebati SK, Cadoni A, et al. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats. Curr Alzheimer Res. 2012;9:120\u20137.","journal-title":"Curr Alzheimer Res"},{"key":"2417_CR230","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuroscience.2014.04.001","volume":"270","author":"E Avolio","year":"2014","unstructured":"Avolio E, Mahata SK, Mantuano E, Mele M, Alo R, Facciolo RM, et al. Antihypertensive and neuroprotective effects of catestatin in spontaneously hypertensive rats: interaction with GABAergic transmission in amygdala and brainstem. Neuroscience. 2014;270:48\u201357.","journal-title":"Neuroscience"},{"key":"2417_CR231","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.neuroscience.2019.04.018","volume":"408","author":"M Nakazaki","year":"2019","unstructured":"Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Oka S, Suzuki J, Sasaki Y, et al. Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease model. Neuroscience. 2019;408:361\u201377.","journal-title":"Neuroscience"},{"key":"2417_CR232","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nature10180","volume":"475","author":"E Karakas","year":"2011","unstructured":"Karakas E, Simorowski N, Furukawa H. Subunit arrangement and phenylethanolamine binding in GluN1\/GluN2B NMDA receptors. Nature. 2011;475:249\u201353.","journal-title":"Nature"},{"key":"2417_CR233","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/npp.2010.225","volume":"36","author":"J Benicky","year":"2011","unstructured":"Benicky J, Sanchez-Lemus E, Honda M, Pang T, Orecna M, Wang J, et al. Angiotensin II AT1 receptor blockade ameliorates brain inflammation. Neuropsychopharmacology. 2011;36:857\u201370.","journal-title":"Neuropsychopharmacology"},{"key":"2417_CR234","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.716917","volume":"13","author":"X Xu","year":"2021","unstructured":"Xu X, Du L, Jiang J, Yang M, Wang Z, Wang Y, et al. Microglial TREM2 mitigates inflammatory responses and neuronal apoptosis in angiotensin II-induced hypertension in middle-aged mice. Front Aging Neurosci. 2021;13:716917.","journal-title":"Front Aging Neurosci"},{"key":"2417_CR235","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1021\/acschemneuro.2c00712","volume":"14","author":"Y Tang","year":"2023","unstructured":"Tang Y, Zhang D, Chang Y, Zheng J. Atrial natriuretic peptide associated with cardiovascular diseases inhibits amyloid-beta aggregation via cross-seeding. ACS Chem Neurosci. 2023;14:312\u201322.","journal-title":"ACS Chem Neurosci"},{"key":"2417_CR236","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1111\/nan.12711","volume":"47","author":"KA Bretland","year":"2021","unstructured":"Bretland KA, Lin L, Bretland KM, Smith MA, Fleming SM, Dengler-Crish CM. Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice. Neuropathol Appl Neurobiol. 2021;47:967\u201378.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2417_CR237","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1190402","volume":"14","author":"B Boyarko","year":"2023","unstructured":"Boyarko B, Podvin S, Greenberg B, Momper JD, Huang Y, Gerwick WH, et al. Evaluation of bumetanide as a potential therapeutic agent for Alzheimer\u2019s disease. Front Pharm. 2023;14:1190402.","journal-title":"Front Pharm"},{"key":"2417_CR238","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s43440-022-00364-1","volume":"74","author":"P Sharma","year":"2022","unstructured":"Sharma P, Gaur N, Jayant S, Sharma BM, Singh B, Kharkwal H, et al. Salubrious effects of ulinastatin and quercetin alone or in combination in endothelial dysfunction and vascular dementia. Pharmacol Rep. 2022;74:481\u201392.","journal-title":"Pharmacol Rep"},{"key":"2417_CR239","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.physbeh.2015.02.009","volume":"142","author":"P Singh","year":"2015","unstructured":"Singh P, Gupta S, Sharma B. Melatonin receptor and KATP channel modulation in experimental vascular dementia. Physiol Behav. 2015;142:66\u201378.","journal-title":"Physiol Behav"},{"key":"2417_CR240","doi-asserted-by":"publisher","first-page":"219","DOI":"10.2174\/1567202613666160518122534","volume":"13","author":"P Singh","year":"2016","unstructured":"Singh P, Gupta S, Sharma B. Antagonism of endothelin (ETA and ETB) receptors during renovascular hypertension-induced vascular dementia improves cognition. Curr Neurovasc Res. 2016;13:219\u201329.","journal-title":"Curr Neurovasc Res"},{"key":"2417_CR241","doi-asserted-by":"publisher","first-page":"135","DOI":"10.2174\/1567202613666160226152549","volume":"13","author":"P Singh","year":"2016","unstructured":"Singh P, Sharma B. Selective sserotonin-norepinephrine re-uptake inhibition limits renovascular-hypertension induced cognitive impairment, endothelial dysfunction, and oxidative stress injury. Curr Neurovasc Res. 2016;13:135\u201346.","journal-title":"Curr Neurovasc Res"},{"key":"2417_CR242","doi-asserted-by":"publisher","first-page":"S101","DOI":"10.3233\/JAD-2012-129043","volume":"33","author":"J Pacheco-Quinto","year":"2013","unstructured":"Pacheco-Quinto J, Herdt A, Eckman CB, Eckman EA. Endothelin-converting enzymes and related metalloproteases in Alzheimer\u2019s disease. J Alzheimers Dis. 2013;33:S101\u201310.","journal-title":"J Alzheimers Dis"},{"key":"2417_CR243","doi-asserted-by":"publisher","first-page":"317","DOI":"10.2174\/1567202043362117","volume":"1","author":"M Panchal","year":"2004","unstructured":"Panchal M, Rholam M, Brakch N. Abnormalities of peptide metabolism in Alzheimer disease. Curr Neurovasc Res. 2004;1:317\u201323.","journal-title":"Curr Neurovasc Res"},{"key":"2417_CR244","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.173851","volume":"894","author":"E Poorgolizadeh","year":"2021","unstructured":"Poorgolizadeh E, Homayouni Moghadam F, Dormiani K, Rezaei N, Nasr-Esfahani MH. Do neprilysin inhibitors walk the line? Heart ameliorative but brain threatening!. Eur J Pharm. 2021;894:173851.","journal-title":"Eur J Pharm"},{"key":"2417_CR245","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.2174\/1568026621666211201150217","volume":"21","author":"DK Yadav","year":"2021","unstructured":"Yadav DK. Potential therapeutic strategies of phytochemicals in neurodegenerative disorders. Curr Top Med Chem. 2021;21:2814\u201338.","journal-title":"Curr Top Med Chem"},{"key":"2417_CR246","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.1111\/bph.14116","volume":"175","author":"N Zisapel","year":"2018","unstructured":"Zisapel N. New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Br J Pharm. 2018;175:3190\u20139.","journal-title":"Br J Pharm"},{"key":"2417_CR247","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111198","volume":"135","author":"S Ghafouri-Fard","year":"2021","unstructured":"Ghafouri-Fard S, Shoorei H, Bahroudi Z, Abak A, Majidpoor J, Taheri M. An update on the role of miR-124 in the pathogenesis of human disorders. Biomed Pharmacother. 2021;135:111198.","journal-title":"Biomed Pharmacother"},{"key":"2417_CR248","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1042\/CS20171572","volume":"132","author":"EL Bailey","year":"2018","unstructured":"Bailey EL, McBride MW, McClure JD, Beattie W, Graham D, Dominiczak AF, et al. Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. Clin Sci (Lond). 2018;132:1315\u201328.","journal-title":"Clin Sci (Lond)"},{"key":"2417_CR249","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nature11868","volume":"496","author":"M Kleinewietfeld","year":"2013","unstructured":"Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013;496:518\u201322.","journal-title":"Nature"},{"key":"2417_CR250","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nature24628","volume":"551","author":"N Wilck","year":"2017","unstructured":"Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, et al. Salt-responsive gut commensal modulates T(H)17 axis and disease. Nature. 2017;551:585\u20139.","journal-title":"Nature"},{"key":"2417_CR251","doi-asserted-by":"crossref","unstructured":"Lin B, Hasegawa Y, Takane K, Koibuchi N, Cao C, Kim-Mitsuyama S High-fat-diet intake enhances cerebral amyloid angiopathy and cognitive impairment in a mouse model of Alzheimer\u2019s disease, independently of metabolic disorders. J Am Heart Assoc. 2016;5","DOI":"10.1161\/JAHA.115.003154"},{"key":"2417_CR252","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1177\/0271678X17739219","volume":"38","author":"KD Langdon","year":"2018","unstructured":"Langdon KD, Cordova CA, Granter-Button S, Boyd JD, Peeling J, Murphy TH, et al. Executive dysfunction and blockage of brain microvessels in a rat model of vascular cognitive impairment. J Cereb Blood Flow Metab. 2018;38:1727\u201340.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2417_CR253","doi-asserted-by":"publisher","first-page":"6460","DOI":"10.1523\/JNEUROSCI.0724-23.2023","volume":"43","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Xie L, Schroder J, Schuster IS, Nakai M, Sun G, et al. Dietary fiber and microbiota metabolite receptors enhance cognition and alleviate disease in the 5xFAD mouse model of Alzheimer\u2019s disease. J Neurosci. 2023;43:6460\u201375.","journal-title":"J Neurosci"},{"key":"2417_CR254","doi-asserted-by":"crossref","unstructured":"Sochocka M, Karska J, Pszczolowska M, Ochnik M, Fulek M, Fulek K, et al. Cognitive decline in early and premature menopause. Int J Mol Sci. 2023;24","DOI":"10.3390\/ijms24076566"},{"key":"2417_CR255","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2023.105521","volume":"165","author":"H Pradhyumnan","year":"2023","unstructured":"Pradhyumnan H, Reddy V, Bassett ZQ, Patel SH, Zhao W, Dave KR, et al. Post-stroke periodic estrogen receptor-beta agonist improves cognition in aged female rats. Neurochem Int. 2023;165:105521.","journal-title":"Neurochem Int"},{"key":"2417_CR256","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.cmet.2018.03.001","volume":"27","author":"DJ Drucker","year":"2018","unstructured":"Drucker DJ. Mechanisms of action and therapeutic application of glucagon-like peptide-1. Cell Metab. 2018;27:740\u201356.","journal-title":"Cell Metab"},{"key":"2417_CR257","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101180","volume":"47","author":"J Zheng","year":"2021","unstructured":"Zheng J, Xie Y, Ren L, Qi L, Wu L, Pan X, et al. GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer\u2019s disease. Mol Metab. 2021;47:101180.","journal-title":"Mol Metab"},{"key":"2417_CR258","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.588044","volume":"12","author":"JY Chung","year":"2020","unstructured":"Chung JY, Jeong JH, Song J. Resveratrol modulates the gut-brain axis: Focus on glucagon-like peptide-1, 5-HT, and gut microbiota. Front Aging Neurosci. 2020;12:588044.","journal-title":"Front Aging Neurosci"},{"key":"2417_CR259","doi-asserted-by":"publisher","first-page":"S198","DOI":"10.1038\/nature16036","volume":"527","author":"V Ravindranath","year":"2015","unstructured":"Ravindranath V, Dang HM, Goya RG, Mansour H, Nimgaonkar VL, Russell VA, et al. Regional research priorities in brain and nervous system disorders. Nature. 2015;527:S198\u2013206.","journal-title":"Nature"},{"key":"2417_CR260","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1097\/HJH.0000000000003706","volume":"42","author":"G Loo","year":"2024","unstructured":"Loo G, Puar T, Foo R, Ong TK, Wang TD, Nguyen QN, et al. Unique characteristics of Asians with hypertension: what is known and what can be done?. J Hypertens. 2024;42:1482.","journal-title":"J Hypertens"}],"updated-by":[{"DOI":"10.1038\/s41440-025-02529-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000}}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02417-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02417-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02417-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:01:49Z","timestamp":1768982509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02417-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":260,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["2417"],"URL":"https:\/\/doi.org\/10.1038\/s41440-025-02417-3","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]},"assertion":[{"value":"21 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2025","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original version of this article unfortunately contained errors in Graphical Abstract. The correct figures can be found as below.The original article has been corrected.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2026","order":9,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":10,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41440-025-02529-w","URL":"https:\/\/doi.org\/10.1038\/s41440-025-02529-w","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}