{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T23:53:31Z","timestamp":1772668411310,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1038\/s41440-025-02460-0","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:38:52Z","timestamp":1763627932000},"page":"874-882","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The application of partial pressure of oxygen adjusted indirect Fick method in vasoreactivity testing by inhaling oxygen in congenital heart disease"],"prefix":"10.1038","volume":"49","author":[{"given":"Lu-Hong","family":"Qiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Ran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Hui","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi-Qi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"2460_CR1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41569-022-00749-y","volume":"20","author":"A Liu","year":"2023","unstructured":"Liu A, Diller GP, Moons P, Daniels CJ, Jenkins KJ, Marelli A. Changing epidemiology of congenital heart disease: effect on outcomes and quality of care in adults. Nat Rev Cardiol. 2023;20:126\u201337.","journal-title":"Nat Rev Cardiol"},{"key":"2460_CR2","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1161\/CIRCULATIONAHA.113.008396","volume":"130","author":"AJ Marelli","year":"2014","unstructured":"Marelli AJ, Ionescu-Ittu R, Mackie AS, Guo L, Dendukuri N, Kaouache M. Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010. Circulation. 2014;130:749\u201356.","journal-title":"Circulation"},{"key":"2460_CR3","first-page":"949","volume":"37","author":"Center For Cardiovascular Diseases The Writing Committee Of The Report On Cardiovascular H, Diseases In China N","year":"2024","unstructured":"Center For Cardiovascular Diseases The Writing Committee Of The Report On Cardiovascular H, Diseases In China N. Report on Cardiovascular Health and Diseases in China 2023: an updated summary. Biomed Environ Sci. 2024;37:949\u201392.","journal-title":"Biomed Environ Sci"},{"key":"2460_CR4","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ijcard.2006.09.017","volume":"120","author":"MG Duffels","year":"2007","unstructured":"Duffels MG, Engelfriet PM, Berger RM, van Loon RL, Hoendermis E, Vriend JW, et al. Pulmonary arterial hypertension in congenital heart disease: an epidemiologic perspective from a Dutch registry. Int J Cardiol. 2007;120:198\u2013204.","journal-title":"Int J Cardiol"},{"key":"2460_CR5","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.jacc.2011.03.033","volume":"58","author":"BS Lowe","year":"2011","unstructured":"Lowe BS, Therrien J, Ionescu-Ittu R, Pilote L, Martucci G, Marelli AJ. Diagnosis of pulmonary hypertension in the congenital heart disease adult population impact on outcomes. J Am Coll Cardiol. 2011;58:538\u201346.","journal-title":"J Am Coll Cardiol"},{"key":"2460_CR6","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s12872-020-01434-z","volume":"20","author":"LK Dinarti","year":"2020","unstructured":"Dinarti LK, Hartopo AB, Kusuma AD, Satwiko MG, Hadwiono MR, Pradana AD, et al. The COngenital HeARt Disease in adult and Pulmonary Hypertension (COHARD-PH) registry: a descriptive study from single-center hospital registry of adult congenital heart disease and pulmonary hypertension in Indonesia. BMC Cardiovasc Disord. 2020;20:163.","journal-title":"BMC Cardiovasc Disord"},{"key":"2460_CR7","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1378\/chest.10-2327","volume":"140","author":"R Zhang","year":"2011","unstructured":"Zhang R, Dai LZ, Xie WP, Yu ZX, Wu BX, Pan L, et al. Survival of Chinese patients with pulmonary arterial hypertension in the modern treatment era. Chest. 2011;140:301\u20139.","journal-title":"Chest"},{"key":"2460_CR8","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1093\/eurheartj\/ehaa554","volume":"42","author":"H Baumgartner","year":"2021","unstructured":"Baumgartner H, De Backer J, Babu-Narayan SV, Budts W, Chessa M, Diller GP, et al. 2020 ESC Guidelines for the management of adult congenital heart disease. Eur Heart J. 2021;42:563\u2013645.","journal-title":"Eur Heart J"},{"key":"2460_CR9","doi-asserted-by":"crossref","unstructured":"Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, et al. 2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. 2023;61:2200879.","DOI":"10.1183\/13993003.00879-2022"},{"key":"2460_CR10","doi-asserted-by":"publisher","unstructured":"Jones JPS, Benson L Hemodynamics: Pressures and Flows. In: Butera G, Chessa M, Eicken A, Thomson J (eds). Cardiac Catheterization for Congenital Heart Disease: From Fetal Life to Adulthood. https:\/\/doi.org\/10.1007\/978-88-470-5681-7_9) Springer Milan: Milano, 2015, 125-48.","DOI":"10.1007\/978-88-470-5681-7_9)"},{"key":"2460_CR11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1136\/heart.85.1.113","volume":"85","author":"JL Wilkinson","year":"2001","unstructured":"Wilkinson JL. Haemodynamic calculations in the catheter laboratory. Heart. 2001;85:113\u201320.","journal-title":"Heart"},{"key":"2460_CR12","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/0002-9149(69)90075-7","volume":"23","author":"MD Flamm","year":"1969","unstructured":"Flamm MD, Cohn KE, Hancock EW. Measurement of systemic cardiac output at rest and exercise in patients with atrial septal defect. Am J Cardiol. 1969;23:258\u201365.","journal-title":"Am J Cardiol"},{"key":"2460_CR13","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/BF02082331","volume":"3","author":"JE Lock","year":"1982","unstructured":"Lock JE, Einzig S, Bass JL, Moller JH. The pulmonary vascular response to oxygen and its influence on operative results in children with ventricular septal defect. Pediatr Cardiol. 1982;3:41\u20136.","journal-title":"Pediatr Cardiol"},{"key":"2460_CR14","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032412","volume":"13","author":"Z Zhou","year":"2024","unstructured":"Zhou Z, Gu Y, Tian L, Zheng H, Li S. Development and validation of a nomogram of persistent pulmonary hypertension in adult pretricuspid shunts after correction. J Am Heart Assoc. 2024;13:e032412.","journal-title":"J Am Heart Assoc"},{"key":"2460_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2024.100887","volume":"3","author":"S Akagi","year":"2024","unstructured":"Akagi S, Kasahara S, Akagi T, Ejiri K, Mitsuhashi T, Nakagawa K, et al. Feasibility of treat and repair strategy in congenital heart defects with pulmonary arterial hypertension. JACC Adv. 2024;3:100887.","journal-title":"JACC Adv"},{"key":"2460_CR16","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jacc.2012.04.010","volume":"60","author":"C Apitz","year":"2012","unstructured":"Apitz C, Zimmermann R, Kreuder J, Jux C, Latus H, Pons-K\u00fchnemann J, et al. Assessment of pulmonary endothelial function during invasive testing in children and adolescents with idiopathic pulmonary arterial hypertension. J Am Coll Cardiol. 2012;60:157\u201364.","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl 2","key":"2460_CR17","doi-asserted-by":"publisher","first-page":"ii23","DOI":"10.1136\/heartjnl-2014-307340","volume":"102","author":"C Apitz","year":"2016","unstructured":"Apitz C, Hansmann G, Schranz D. Hemodynamic assessment and acute pulmonary vasoreactivity testing in the evaluation of children with pulmonary vascular disease. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016;102(Suppl 2):ii23\u20139.","journal-title":"Heart"},{"key":"2460_CR18","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.106.630715","volume":"114","author":"N Gali\u00e8","year":"2006","unstructured":"Gali\u00e8 N, Beghetti M, Gatzoulis MA, Granton J, Berger RM, Lauer A, et al. Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study. Circulation. 2006;114:48\u201354.","journal-title":"Circulation"},{"key":"2460_CR19","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1056\/NEJMoa1213917","volume":"369","author":"T Pulido","year":"2013","unstructured":"Pulido T, Adzerikho I, Channick RN, Delcroix M, Gali\u00e8 N, Ghofrani HA, et al. Macitentan and morbidity and mortality in pulmonary arterial hypertension. N Engl J Med. 2013;369:809\u201318.","journal-title":"N Engl J Med"},{"key":"2460_CR20","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1111\/j.1747-0803.2011.00561.x","volume":"6","author":"S Mukhopadhyay","year":"2011","unstructured":"Mukhopadhyay S, Nathani S, Yusuf J, Shrimal D, Tyagi S. Clinical efficacy of phosphodiesterase-5 inhibitor tadalafil in Eisenmenger syndrome-a randomized, placebo-controlled, double-blind crossover study. Congenit Heart Dis. 2011;6:424\u201331.","journal-title":"Congenit Heart Dis"},{"key":"2460_CR21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1161\/CIRCULATIONAHA.118.033575","volume":"139","author":"MA Gatzoulis","year":"2019","unstructured":"Gatzoulis MA, Landzberg M, Beghetti M, Berger RM, Efficace M, Gesang S, et al. Evaluation of macitentan in patients with Eisenmenger syndrome. Circulation. 2019;139:51\u201363.","journal-title":"Circulation"},{"key":"2460_CR22","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1093\/eurheartj\/ehaf322","volume":"46","author":"K Zeder","year":"2025","unstructured":"Zeder K, Mak S, Galie N, Rosenkranz S, Maron BA. Right heart catheterization in heart failure: indications, interpretation, and pitfalls. Eur Heart J. 2025;46:3354\u201372.","journal-title":"Eur Heart J"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02460-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02460-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02460-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T23:01:55Z","timestamp":1772665315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02460-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["2460"],"URL":"https:\/\/doi.org\/10.1038\/s41440-025-02460-0","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"7 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}