{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:11:24Z","timestamp":1783977084873,"version":"3.55.0"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1038\/s41440-025-02541-0","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:29:44Z","timestamp":1767842984000},"page":"1261-1264","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of brain conductivity changes after three-month antihypertensive medication in patients with essential hypertension"],"prefix":"10.1038","volume":"49","author":[{"given":"Il Suk","family":"Sohn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minseo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mun Bae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunche","family":"Hyeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Young","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungseok","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh In","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soonchan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Woo","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geon-Ho","family":"Jahng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"2541_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12987-024-00509-9","volume":"21","author":"J Jukkola","year":"2024","unstructured":"Jukkola J, Kaakinen M, Singh A, Moradi S, Ferdinando H, Myllyla T, et al. Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature. Fluids Barriers CNS. 2024;21:12.","journal-title":"Fluids Barriers CNS"},{"key":"2541_CR2","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/jcbfm.2015.64","volume":"36","author":"AK Heye","year":"2016","unstructured":"Heye AK, Thrippleton MJ, Chappell FM, Hernandez Mdel C, Armitage PA, Makin SD, et al. Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease. J Cereb Blood Flow Metab. 2016;36:264\u201374.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2541_CR3","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1161\/HYPERTENSIONAHA.120.16217","volume":"77","author":"MV Fernandes","year":"2021","unstructured":"Fernandes MV, Rosso Melo M, Mowry FE, Lucera GM, Lauar MR, Frigieri G et al. Intracranial Pressure During the Development of Renovascular Hypertension. Hypertension. 2021;77:1311\u201322.","journal-title":"Hypertension"},{"key":"2541_CR4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/mrm.26097","volume":"77","author":"N Gurler","year":"2017","unstructured":"Gurler N, Ider YZ. Gradient-based electrical conductivity imaging using MR phase. Magn Reson Med. 2017;77:137\u201350.","journal-title":"Magn Reson Med"},{"key":"2541_CR5","doi-asserted-by":"crossref","unstructured":"Park S, Jung SM, Lee MB, Rhee HY, Ryu CW, Cho AR, et al. Application of High-Frequency Conductivity Map Using MRI to Evaluate It in the Brain of Alzheimer\u2019s Disease Patients. Front Neurol. 2022;13:1\u201310.","DOI":"10.3389\/fneur.2022.872878"},{"key":"2541_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/jch.14440","volume":"24","author":"K Kario","year":"2022","unstructured":"Kario K, Chia YC, Siddique S, Turana Y, Li Y, Chen CH, et al. Seven-action approaches for the management of hypertension in Asia - The HOPE Asia network. J Clin Hypertens (Greenwich). 2022;24:213\u201323.","journal-title":"J Clin Hypertens (Greenwich)"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02541-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02541-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02541-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T22:05:11Z","timestamp":1775426711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41440-025-02541-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2541"],"URL":"https:\/\/doi.org\/10.1038\/s41440-025-02541-0","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"9 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki. The Institutional Review Board (IRB) of Kyung Hee University Hospital at Gangdong in Seoul, Republic of Korea, approved this cross-sectional prospective study (IRB khnmc2022-10-036), and written informed consent was obtained from the participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. The written informed consent was obtained from all patients for being included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}