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Although the contribution of the sympathetic nervous system to an elevation of blood pressure is well established, the determinants of persistent sympathetic overactivity remain incompletely understood. This review summarizes the findings of recent basic research that have expanded the understanding of sympathetic regulation in hypertension, highlighting emerging mechanisms and providing insights into the development of novel therapeutic strategies.<\/jats:p>","DOI":"10.1038\/s41440-026-02589-6","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:34:30Z","timestamp":1771500870000},"page":"1324-1328","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The sympathetic nervous system in the pathophysiology of hypertension: Mechanistic insights and therapeutic implications"],"prefix":"10.1038","volume":"49","author":[{"given":"Naoyoshi","family":"Sakitani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"2589_CR1","doi-asserted-by":"publisher","first-page":"III49","DOI":"10.1161\/01.HYP.18.5_Suppl.III49","volume":"18","author":"A Guyton","year":"1991","unstructured":"Guyton A. 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