{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:41:19Z","timestamp":1792424479994,"version":"4.5.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We investigated cross-sectional associations between body mass index (BMI) and brachial\u2013ankle pulse wave velocity (baPWV) and longitudinal associations between body weight change and baPWV over 3 years in 874 patients with treated hypertension or diabetes mellitus without coronary artery disease (475 men; mean age, 61.9\u2009\u00b1\u20099.5 years). baPWV was measured at baseline, 1.5 years, and 3 years. At baseline, BMI was inversely correlated with baPWV (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.14,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001), and multivariate analysis confirmed this association (\u03b2\u2009=\u2009\u221212.5,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). In generalized linear mixed-effects models adjusted for concurrent systolic blood pressure, heart rate, and other covariates, neither continuous percentage change in body weight (\u03b2\u2009=\u2009\u22121.2,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.08) nor categorical body weight change (\u22655% increase: \u03b2\u2009=\u2009\u221210.6,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.45; \u22655% decrease: \u03b2\u2009=\u200918.0,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.15) was associated with longitudinal changes in baPWV, with no interaction across baseline BMI categories. The modest body weight changes observed in this cohort were not significantly associated with longitudinal changes in baPWV.\n                  <\/jats:p>","DOI":"10.1038\/s41440-026-02849-5","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:56:03Z","timestamp":1792378563000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal association between body weight change and brachial\u2013ankle pulse wave velocity in patients with treated hypertension or diabetes mellitus: A post hoc analysis of the FMD-J study B"],"prefix":"10.1038","author":[{"given":"Tatsuya","family":"Maruhashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kajikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Yamaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Mizobuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farina Mohamad","family":"Yusoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihito","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"2849_CR1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.5551\/jat.32979","volume":"23","author":"H Tomiyama","year":"2016","unstructured":"Tomiyama H, Matsumoto C, Shiina K, Yamashina A. Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and\/or Cardiovascular Risk Factors. J Atheroscler Thromb. 2016;23:128\u201346.","journal-title":"J Atheroscler Thromb"},{"key":"2849_CR2","doi-asserted-by":"publisher","unstructured":"Stone K, Veerasingam D, Meyer ML, Heffernan KS, Higgins S, Maria Bruno R, et al. Reimagining the Value of Brachial-Ankle Pulse Wave Velocity as a Biomarker of Cardiovascular Disease Risk-A Call to Action on Behalf of VascAgeNet. Hypertension 2023.;https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.123.21314).","DOI":"10.1161\/HYPERTENSIONAHA.123.21314)"},{"key":"2849_CR3","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1161\/HYPERTENSIONAHA.117.09097","volume":"69","author":"T Ohkuma","year":"2017","unstructured":"Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, et al. Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease: An Individual Participant Data Meta-Analysis. Hypertension. 2017;69:1045\u201352.","journal-title":"Hypertension"},{"key":"2849_CR4","doi-asserted-by":"crossref","unstructured":"Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, et al. Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD-J (Flow-Mediated Dilation Japan) Study A. J Am Heart Assoc. 2018;7:e008588.","DOI":"10.1161\/JAHA.118.008588"},{"key":"2849_CR5","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1097\/HJH.0000000000001591","volume":"36","author":"YC Lu","year":"2018","unstructured":"Lu YC, Lyu P, Zhu HY, Xu DX, Tahir S, Zhang HF, et al. Brachial-ankle pulse wave velocity compared with mean arterial pressure and pulse pressure in risk stratification in a Chinese population. J Hypertens. 2018;36:528\u201336.","journal-title":"J Hypertens"},{"key":"2849_CR6","doi-asserted-by":"publisher","first-page":"e0267614","DOI":"10.1371\/journal.pone.0267614","volume":"17","author":"HM Kim","year":"2022","unstructured":"Kim HM, Rhee TM, Kim HL. Integrated approach of brachial-ankle pulse wave velocity and cardiovascular risk scores for predicting the risk of cardiovascular events. PLoS ONE. 2022;17:e0267614.","journal-title":"PLoS ONE"},{"key":"2849_CR7","doi-asserted-by":"publisher","first-page":"621","DOI":"10.5551\/jat.RV17041","volume":"27","author":"H Tomiyama","year":"2020","unstructured":"Tomiyama H, Shiina K. State of the Art Review: Brachial-Ankle PWV. J Atheroscler Thromb. 2020;27:621\u201336.","journal-title":"J Atheroscler Thromb"},{"key":"2849_CR8","doi-asserted-by":"publisher","first-page":"e18793","DOI":"10.1097\/MD.0000000000018793","volume":"99","author":"B Tang","year":"2020","unstructured":"Tang B, Luo F, Zhao J, Ma J, Tan I, Butlin M, et al. Relationship between body mass index and arterial stiffness in a health assessment Chinese population. Medicine. 2020;99:e18793.","journal-title":"Medicine"},{"key":"2849_CR9","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1038\/s41440-023-01350-7","volume":"46","author":"A Ishida","year":"2023","unstructured":"Ishida A, Taira H, Shinzato T, Ohya Y. Association between visceral fat mass and arterial stiffness among community-based screening participants. Hypertens Res. 2023;46:2488\u201396.","journal-title":"Hypertens Res"},{"key":"2849_CR10","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1186\/s12872-021-02390-y","volume":"21","author":"F Hu","year":"2021","unstructured":"Hu F, Yu R, Han F, Li J, Zhou W, Wang T, et al. Does body mass index or waist-hip ratio correlate with arterial stiffness based on brachial-ankle pulse wave velocity in Chinese rural adults with hypertension? 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