{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:40:07Z","timestamp":1775482807802,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Impot Res"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1038\/s41443-022-00568-2","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T07:04:21Z","timestamp":1651734261000},"page":"465-471","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Are finasteride-related penile curvature\/Peyronie\u2019s disease Adverse Event Reports worthy of further clinical investigation? Disproportionality analysis based on both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases"],"prefix":"10.1038","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4828-4316","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Schifano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-9504","authenticated-orcid":false,"given":"Paolo","family":"Capogrosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-784X","authenticated-orcid":false,"given":"Luca","family":"Boeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Fallara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Chiappini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Rewhorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7499-7227","authenticated-orcid":false,"given":"Omer Onur","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Castiglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussain M.","family":"Alnajjar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Muneer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Deho\u2019","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Schifano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Montorsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-7165","authenticated-orcid":false,"given":"Andrea","family":"Salonia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"568_CR1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ajur.2015.04.019","volume":"2","author":"AA Hussein","year":"2015","unstructured":"Hussein AA, Alwaal A, Lue TF. All about Peyronie\u2019s disease. Asian J Urol. 2015;2:70\u20138. https:\/\/doi.org\/10.1016\/j.ajur.2015.04.019.","journal-title":"Asian J Urol"},{"key":"568_CR2","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/j.1743-6109.2012.02999.x","volume":"10","author":"CJ Nelson","year":"2013","unstructured":"Nelson CJ, Mulhall JP. Psychological impact of Peyronie\u2019s disease: a review. J Sex Med. 2013;10:653\u201360. https:\/\/doi.org\/10.1111\/j.1743-6109.2012.02999.x.","journal-title":"J Sex Med"},{"key":"568_CR3","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.sxmr.2019.06.004","volume":"8","author":"KL Sharma","year":"2020","unstructured":"Sharma KL, Alom M, Trost L. The etiology of Peyronie\u2019s disease: pathogenesis and genetic contributions. Sex Med Rev. 2020;8:314\u201323. https:\/\/doi.org\/10.1016\/j.sxmr.2019.06.004.","journal-title":"Sex Med Rev"},{"key":"568_CR4","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s00345-019-02723-9","volume":"37","author":"I Aditya","year":"2019","unstructured":"Aditya I, Grober ED, Krakowsky Y. Peyronie\u2019s disease and testosterone deficiency: Is there a link? World J Urol. 2019;37:1035\u201341. https:\/\/doi.org\/10.1007\/s00345-019-02723-9.","journal-title":"World J Urol"},{"key":"568_CR5","doi-asserted-by":"publisher","unstructured":"Ventimiglia E, Capogrosso P, Colicchia M, Boeri L, Serino A, La Croce G, et al. Peyronie\u2019s disease and autoimmunity\u2014a real-life clinical study and comprehensive review. J Sex Med. 2015. https:\/\/doi.org\/10.1111\/jsm.12825.","DOI":"10.1111\/jsm.12825"},{"key":"568_CR6","doi-asserted-by":"publisher","unstructured":"Mulhall JP, Matsushita K, Nelson CJ. Testosterone levels are not associated with magnitude of deformity in men with Peyronie\u2019s disease. J Sex Med. 2019. https:\/\/doi.org\/10.1016\/j.jsxm.2019.05.021.","DOI":"10.1016\/j.jsxm.2019.05.021"},{"key":"568_CR7","doi-asserted-by":"publisher","unstructured":"Candela L, Boeri L, Capogrosso P, Oreggia D, Cazzaniga W, Pozzi E, et al. Serum testosterone levels are not associated with the severity of penile curvature in men with Peyronie\u2019s disease\u2014findings from a cross-sectional study. Int J Impot Res. 2020. https:\/\/doi.org\/10.1038\/s41443-020-0340-7.","DOI":"10.1038\/s41443-020-0340-7"},{"key":"568_CR8","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.ogc.2004.08.005","volume":"31","author":"V Sobel","year":"2004","unstructured":"Sobel V, Zhu YS, Imperato-McGinley J. Fetal hormones and sexual differentiation. Obstet Gynecol Clin North Am. 2004;31:837\u201356. https:\/\/doi.org\/10.1016\/j.ogc.2004.08.005.","journal-title":"Obstet Gynecol Clin North Am"},{"key":"568_CR9","unstructured":"Shen ZJ, Zhou XL, Lu YL, Chen ZD. Effect of androgen deprivation on penile ultrastructure. Asian J Androl. 2003;5:33\u20136."},{"key":"568_CR10","doi-asserted-by":"publisher","unstructured":"Traish AM, Park K, Dhir V, Kim NN, Moreland RB, Goldstein I. Effects of castration and androgen replacement on erectile function in a rabbit model. Endocrinology. 1999. https:\/\/doi.org\/10.1210\/endo.140.4.6655.","DOI":"10.1210\/endo.140.4.6655"},{"key":"568_CR11","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1177\/1557988314538445","volume":"9","author":"CA Ganzer","year":"2015","unstructured":"Ganzer CA, Jacobs AR, Iqbal F. Persistent sexual, emotional, and cognitive impairment post-finasteride: a survey of men reporting symptoms. Am J Mens Health. 2015;9:222\u20138. https:\/\/doi.org\/10.1177\/1557988314538445.","journal-title":"Am J Mens Health"},{"key":"568_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.fertnstert.2019.11.030","volume":"113","author":"AM Traish","year":"2020","unstructured":"Traish AM. Post-finasteride syndrome: a surmountable challenge for clinicians. Fertil Steril. 2020;113:21\u201350. https:\/\/doi.org\/10.1016\/j.fertnstert.2019.11.030.","journal-title":"Fertil Steril"},{"key":"568_CR13","doi-asserted-by":"publisher","unstructured":"Garreton AS, Valzacchi GR, Layus O. Post-finasteride syndrome: about 2 cases and review of the literature. Andrology. 2016;5. https:\/\/doi.org\/10.4172\/2472-1212.1000170.","DOI":"10.4172\/2472-1212.1000170"},{"key":"568_CR14","doi-asserted-by":"publisher","unstructured":"Montastruc JL, Sommet A, Bagheri H, Lapeyre-Mestre M. Benefits and strengths of the disproportionality analysis for identification of adverse drug reactions in a pharmacovigilance database. Br J Clin Pharmacol. 2011. https:\/\/doi.org\/10.1111\/j.1365-2125.2011.04037.x.","DOI":"10.1111\/j.1365-2125.2011.04037.x"},{"key":"568_CR15","doi-asserted-by":"publisher","unstructured":"Schifano F, Chiappini S, Corkery JM, Guirguis A. An insight into Z-drug abuse and dependence: an examination of reports to the European Medicines Agency Database of suspected adverse drug reactions. Int J Neuropsychopharmacol. 2019. https:\/\/doi.org\/10.1093\/ijnp\/pyz007.","DOI":"10.1093\/ijnp\/pyz007"},{"key":"568_CR16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1177\/0018578718795271","volume":"54","author":"A Kumar","year":"2019","unstructured":"Kumar A. The newly available FAERS public dashboard: implications for health care professionals. Hosp Pharm. 2019;54:75\u20137. https:\/\/doi.org\/10.1177\/0018578718795271.","journal-title":"Hosp Pharm"},{"key":"568_CR17","unstructured":"EMA. Guideline on good pharmacovigilance practices (GVP) Annex I\u2014Definitions (Rev 4). Heads Med Agencies; 2017."},{"key":"568_CR18","doi-asserted-by":"publisher","unstructured":"Schifano N, Chiappini S, Castiglione F, Salonia A, Schifano F. Is medicinal ketamine associated with urinary dysfunction issues? Assessment of both the European Medicines Agency (EMA) and the UK Yellow Card Scheme pharmacovigilance database-related reports. Low Urin Tract Symptoms. 2021;13:230\u20137. https:\/\/doi.org\/10.1111\/luts.12355.","DOI":"10.1111\/luts.12355"},{"key":"568_CR19","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s40263-016-0359-y","volume":"30","author":"S Chiappini","year":"2016","unstructured":"Chiappini S, Schifano F. A decade of gabapentinoid misuse: an analysis of the European Medicines Agency\u2019s \u2018Suspected Adverse Drug Reactions\u2019 database. CNS Drugs. 2016;30:647\u201354. https:\/\/doi.org\/10.1007\/s40263-016-0359-y.","journal-title":"CNS Drugs"},{"key":"568_CR20","unstructured":"European Medicines Agency. Guideline on the use of statistical signal detection methods in the EudraVigilance data analysis system. 2008."},{"key":"568_CR21","doi-asserted-by":"publisher","unstructured":"Grundmark B, Holmberg L, Garmo H, Zethelius B. Reducing the noise in signal detection of adverse drug reactions by standardizing the background: a pilot study on analyses of proportional reporting ratios-by-therapeutic area. Eur J Clin Pharmacol. 2014. https:\/\/doi.org\/10.1007\/s00228-014-1658-1.","DOI":"10.1007\/s00228-014-1658-1"},{"key":"568_CR22","unstructured":"Agency for Healthcare Research and Quality. Medical Expenditure Panel Survey, MEPS Data Files, Documentation, and Codebooks. n.d. https:\/\/meps.ahrq.gov\/mepsweb\/data_stats\/download_data_files.jsp."},{"key":"568_CR23","unstructured":"WHO. The WHO Programme for International Drug Monitoring. 2015."},{"key":"568_CR24","doi-asserted-by":"publisher","unstructured":"Felicetti P, Trotta F, Bonetto C, Santuccio C, Brauchli Pernus Y, Burgner D, et al. Spontaneous reports of vasculitis as an adverse event following immunization: a descriptive analysis across three international databases. Vaccine. 2016. https:\/\/doi.org\/10.1016\/j.vaccine.2015.09.027.","DOI":"10.1016\/j.vaccine.2015.09.027"},{"key":"568_CR25","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s40264-014-0225-0","volume":"37","author":"KB Hoffman","year":"2014","unstructured":"Hoffman KB, Demakas AR, Dimbil M, Tatonetti NP, Erdman CB. Stimulated reporting: the impact of US Food and Drug Administration-Issued Alerts on the Adverse Event Reporting System (FAERS). Drug Saf. 2014;37:971\u201380. https:\/\/doi.org\/10.1007\/s40264-014-0225-0.","journal-title":"Drug Saf"},{"key":"568_CR26","doi-asserted-by":"publisher","unstructured":"Rezende HD, Dias MFRG, Tr\u00fceb RM. A comment on the post-finasteride syndrome. Int J Trichology. 2018. https:\/\/doi.org\/10.4103\/ijt.ijt_61_18.","DOI":"10.4103\/ijt.ijt_61_18"},{"key":"568_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s12020-017-1280-y","volume":"57","author":"F Lolli","year":"2017","unstructured":"Lolli F, Pallotti F, Rossi A, Fortuna MC, Caro G, Lenzi A, et al. Androgenetic alopecia: a review. Endocrine. 2017;57:9\u201317. https:\/\/doi.org\/10.1007\/s12020-017-1280-y.","journal-title":"Endocrine"},{"key":"568_CR28","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/jocd.12047","volume":"12","author":"HA Bhatti","year":"2013","unstructured":"Bhatti HA, Basra MKA, Patel GK. Hair restoration approaches for early onset male androgenetic alopecia. J Cosmet Dermatol. 2013;12:223\u201331. https:\/\/doi.org\/10.1111\/jocd.12047.","journal-title":"J Cosmet Dermatol"},{"key":"568_CR29","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.urology.2018.06.022","volume":"120","author":"WR Baas","year":"2018","unstructured":"Baas WR, Butcher MJ, Lwin A, Holland B, Herberts M, Clemons J, et al. A review of the FAERS data on 5-Alpha Reductase inhibitors: implications for postfinasteride syndrome. Urology. 2018;120:143\u20139. https:\/\/doi.org\/10.1016\/j.urology.2018.06.022.","journal-title":"Urology"},{"key":"568_CR30","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1046\/j.1365-4362.1999.00804.x","volume":"38","author":"S Brenner","year":"1999","unstructured":"Brenner S, Matz H. Improvement in androgenetic alopecia in 53-76-year-old men using oral finasteride. Int J Dermatol. 1999;38:928\u201330. https:\/\/doi.org\/10.1046\/j.1365-4362.1999.00804.x.","journal-title":"Int J Dermatol"},{"key":"568_CR31","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/ijir.2012.48","volume":"25","author":"TJ Walsh","year":"2013","unstructured":"Walsh TJ, Hotaling JM, Lue TF, Smith JF. How curved is too curved? the severity of penile deformity may predict sexual disability among men with Peyronie\u2019s disease. Int J Impot Res. 2013;25:109\u201312. https:\/\/doi.org\/10.1038\/ijir.2012.48.","journal-title":"Int J Impot Res"},{"key":"568_CR32","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1111\/j.1743-6109.2012.02846.x","volume":"9","author":"MS Irwig","year":"2012","unstructured":"Irwig MS. Persistent sexual side effects of finasteride: could they be permanent? J Sex Med. 2012;9:2927\u201332. https:\/\/doi.org\/10.1111\/j.1743-6109.2012.02846.x.","journal-title":"J Sex Med"},{"key":"568_CR33","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1136\/bmj.l5047","volume":"366","author":"SL Gray","year":"2019","unstructured":"Gray SL, Semla TP. Post-finasteride syndrome. BMJ. 2019;366:9\u201310. https:\/\/doi.org\/10.1136\/bmj.l5047.","journal-title":"BMJ"},{"key":"568_CR34","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/S0090-4295(02)02401-9","volume":"61","author":"H Wessells","year":"2003","unstructured":"Wessells H, Roy J, Bannow J, Grayhack J, Matsumoto AM, Tenover L, et al. Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia. Urology. 2003;61:579\u201384. https:\/\/doi.org\/10.1016\/S0090-4295(02)02401-9.","journal-title":"Urology"},{"key":"568_CR35","doi-asserted-by":"publisher","unstructured":"Ellis JA, Stebbing M, Harrap SB. Polymorphism of the androgen receptor gene is associated with male pattern baldness. J Invest Dermatol. 2001. https:\/\/doi.org\/10.1046\/j.1523-1747.2001.01261.x.","DOI":"10.1046\/j.1523-1747.2001.01261.x"},{"key":"568_CR36","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1016\/j.esxm.2016.11.001","volume":"5","author":"S Cauci","year":"2017","unstructured":"Cauci S, Chiriac\u00f2 G, Cecchin E, Toffoli G, Xodo S, Stinco G, et al. Androgen receptor (AR) gene (CAG)n and (GGN)n length polymorphisms and symptoms in young males with long-lasting adverse effects after finasteride use against androgenic alopecia. Sex Med. 2017;5:e61\u201371. https:\/\/doi.org\/10.1016\/j.esxm.2016.11.001.","journal-title":"Sex Med"},{"key":"568_CR37","doi-asserted-by":"publisher","unstructured":"Chew KK, Stuckey BGA, Earle CM, Dhaliwal SS, Keogh EJ, Porst H. Penile fibrosis in intracavernosal prostaglandin E1 injection therapy for erectile dysfunction. Int J Impot Res. 1997. https:\/\/doi.org\/10.1038\/sj.ijir.3900296.","DOI":"10.1038\/sj.ijir.3900296"},{"key":"568_CR38","unstructured":"European Medicines Agency. Xiapex product information form. 2020. https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/xiapex-epar-product-information."}],"container-title":["International Journal of Impotence Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41443-022-00568-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41443-022-00568-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41443-022-00568-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T07:02:57Z","timestamp":1689058977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41443-022-00568-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["568"],"URL":"https:\/\/doi.org\/10.1038\/s41443-022-00568-2","relation":{},"ISSN":["0955-9930","1476-5489"],"issn-type":[{"value":"0955-9930","type":"print"},{"value":"1476-5489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,5]]},"assertion":[{"value":"5 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"FS is a member of the EMA Advisory board (Psychiatry). No further conflicts of interest are here declared.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}