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The most popular treatment options are on-demand topical anesthetics and off-label daily or on-demand selective serotonin reuptake inhibitors (SSRIs), followed by behavioral therapy. While SSRI treatments are reportedly safe, they are associated with limited efficacy and provide only a temporary delay in ejaculation latency time. The majority of PE patients are dissatisfied with SSRIs; thus, adherence to on-demand or daily SSRI treatments is low. In this article, we review studies on currently available technologies that are not pharmacological, surgical, cognitive or behavioral therapies. Recent data from studies of newly developed medical devices used in PE treatment are encouraging as they provide drug-free spontaneity during coitus, without severe adverse effects.<\/jats:p>","DOI":"10.1038\/s41443-024-00875-w","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T17:03:24Z","timestamp":1711559004000},"page":"700-705","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["New technologies developed for treatment of premature ejaculation"],"prefix":"10.1038","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8270-8069","authenticated-orcid":false,"given":"Arik","family":"Shechter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0330-2859","authenticated-orcid":false,"given":"Ilan","family":"Gruenwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"875_CR1","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/S0022-5347(05)00341-1","volume":"175","author":"S Althof","year":"2006","unstructured":"Althof S. 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