{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:47:36Z","timestamp":1794012456652,"version":"4.8.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The C-type lectin member 5A (CLEC5A) is a pattern recognition receptor for members of the<jats:italic>Flavivirus<\/jats:italic>family and has critical functions in response to dengue virus and Japanese encephalitis virus. Here we show that CLEC5A is involved in neutrophil extracellular trap formation and the production of reactive oxygen species and proinflammatory cytokines in response to<jats:italic>Listeria monocytogenes<\/jats:italic>. Inoculation of<jats:italic>Clec5a<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>mice with<jats:italic>L. monocytogenes<\/jats:italic>causes rapid bacterial spreading, increased bacterial loads in the blood and liver, and severe liver necrosis. In these mice, IL-1\u03b2, IL-17A, and TNF expression is inhibited, CCL2 is induced, and large numbers of CD11b<jats:sup>+<\/jats:sup>Ly6C<jats:sup>hi<\/jats:sup>CCR2<jats:sup>hi<\/jats:sup>CX3CR1<jats:sup>low<\/jats:sup>inflammatory monocytes infiltrate the liver. By day 5 of infection, these mice also have fewer IL-17A<jats:sup>+<\/jats:sup>\u03b3\u03b4 T cells, severe liver necrosis and a higher chance of fatality. Thus, CLEC5A has a pivotal function in the activation of multiple aspects of innate immunity against bacterial invasion.<\/jats:p>","DOI":"10.1038\/s41467-017-00356-3","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T09:59:38Z","timestamp":1502445578000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["CLEC5A is a critical receptor in innate immunity against Listeria infection"],"prefix":"10.1038","volume":"8","author":[{"given":"Szu-Ting","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Ju","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzy-yun","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Mei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chen","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yu","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teh-Ying","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nien-Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shie-Liang","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,21]]},"reference":[{"key":"356_CR1","doi-asserted-by":"publisher","first-page":"9792","DOI":"10.1073\/pnas.96.17.9792","volume":"96","author":"AB Bakker","year":"1999","unstructured":"Bakker, A. B., Baker, E., Sutherland, G. R., Phillips, J. H. & Lanier, L. L. Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc. Natl Acad. Sci. USA 96, 9792\u20139796 (1999).","journal-title":"Proc Natl Acad Sci USA"},{"key":"356_CR2","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1084\/jem.20020470","volume":"196","author":"GD Brown","year":"2002","unstructured":"Brown, G. D. et al. Dectin-1 is a major beta-glucan receptor on macrophages. J. Exp. Med. 196, 407\u2013412 (2002).","journal-title":"J. Exp. Med."},{"key":"356_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/ni1408","volume":"8","author":"PR Taylor","year":"2007","unstructured":"Taylor, P. R. et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat. Immunol. 8, 31\u201338 (2007).","journal-title":"Nat. Immunol."},{"key":"356_CR4","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/nature07013","volume":"453","author":"ST Chen","year":"2008","unstructured":"Chen, S. T. et al. CLEC5A is critical for dengue-virus-induced lethal disease. Nature 453, 672\u2013676 (2008).","journal-title":"Nature"},{"key":"356_CR5","doi-asserted-by":"publisher","first-page":"e1002655","DOI":"10.1371\/journal.ppat.1002655","volume":"8","author":"ST Chen","year":"2012","unstructured":"Chen, S. T. et al. CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality. PLoS. Pathog. 8, e1002655 (2012).","journal-title":"PLoS. Pathog."},{"key":"356_CR6","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1423-0127-20-36","volume":"20","author":"MF Wu","year":"2013","unstructured":"Wu, M. F., Chen, S. T. & Hsieh, S. L. Distinct regulation of dengue virus-induced inflammasome activation in human macrophage subsets. J. Biomed. Sci. 20, 36 (2013).","journal-title":"J. Biomed. Sci."},{"key":"356_CR7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1182\/blood-2012-05-430090","volume":"121","author":"MF Wu","year":"2013","unstructured":"Wu, M. F. et al. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood 121, 95\u2013106 (2013).","journal-title":"Blood"},{"key":"356_CR8","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s00109-016-1409-0","volume":"94","author":"YL Huang","year":"2016","unstructured":"Huang, Y. L. et al. CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis. J. Mol. Med. 94, 1025\u20131037 (2016).","journal-title":"J. Mol. Med."},{"key":"356_CR9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nri1785","volume":"6","author":"C Nathan","year":"2006","unstructured":"Nathan, C. Neutrophils and immunity: challenges and opportunities. Nat. Rev. Immunol. 6, 173\u2013182 (2006).","journal-title":"Nat. Rev. Immunol."},{"key":"356_CR10","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","volume":"26","author":"NV Serbina","year":"2008","unstructured":"Serbina, N. V., Jia, T., Hohl, T. M. & Pamer, E. G. Monocyte-mediated defense against microbial pathogens. Annu. Rev. Immunol. 26, 421\u2013452 (2008).","journal-title":"Annu. Rev. Immunol."},{"key":"356_CR11","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1034\/j.1600-0528.2002.017407.x","volume":"174","author":"LP Cousens","year":"2000","unstructured":"Cousens, L. P. & Wing, E. J. Innate defenses in the liver during listeria infection. Immunol. Rev. 174, 150\u2013159 (2000).","journal-title":"Immunol. Rev."},{"key":"356_CR12","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/nri1461","volume":"4","author":"EG Pamer","year":"2004","unstructured":"Pamer, E. G. Immune responses to Listeria monocytogenes. Nat. Rev. Immunol. 4, 812\u2013823 (2004).","journal-title":"Nat. Rev. Immunol."},{"key":"356_CR13","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann, V. et al. Neutrophil extracellular traps kill bacteria. Science 303, 1532\u20131535 (2004).","journal-title":"Science"},{"key":"356_CR14","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.4049\/jimmunol.181.5.3456","volume":"181","author":"S Hamada","year":"2008","unstructured":"Hamada, S. et al. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver. J. Immunol. 181, 3456\u20133463 (2008).","journal-title":"J. Immunol."},{"key":"356_CR15","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.4049\/jimmunol.169.7.3869","volume":"169","author":"BT Edelson","year":"2002","unstructured":"Edelson, B. T. & Unanue, E. R. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J. Immunol. 169, 3869\u20133875 (2002).","journal-title":"J. Immunol."},{"key":"356_CR16","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/B978-0-12-394590-7.00002-6","volume":"113","author":"CE Witte","year":"2012","unstructured":"Witte, C. E. et al. Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity. Adv. Immunol. 113, 135\u2013156 (2012).","journal-title":"Adv. Immunol."},{"key":"356_CR17","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1100\/2011\/212680","volume":"11","author":"M Sahoo","year":"2011","unstructured":"Sahoo, M., Ceballos-Olvera, I., del Barrio, L. & Re, F. Role of the inflammasome, IL-1beta, and IL-18 in bacterial infections. Sci. World J. 11, 2037\u20132050 (2011).","journal-title":"Sci. World J."},{"key":"356_CR18","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1038\/nm1209-1363","volume":"15","author":"KH Mills","year":"2009","unstructured":"Mills, K. H. & Dunne, A. Immune modulation: IL-1, master mediator or initiator of inflammation. Nat. Med. 15, 1363\u20131364 (2009).","journal-title":"Nat. Med."},{"key":"356_CR19","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1146\/annurev-immunol-031210-101405","volume":"29","author":"BK Davis","year":"2011","unstructured":"Davis, B. K., Wen, H. & Ting, J. P. The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu. Rev. Immunol. 29, 707\u2013735 (2011).","journal-title":"Annu. Rev. Immunol."},{"key":"356_CR20","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature07965","volume":"459","author":"O Gross","year":"2009","unstructured":"Gross, O. et al. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 459, 433\u2013436 (2009).","journal-title":"Nature"},{"key":"356_CR21","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/ni.1864","volume":"11","author":"VA Rathinam","year":"2010","unstructured":"Rathinam, V. A. et al. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 11, 395\u2013402 (2010).","journal-title":"Nat. Immunol."},{"key":"356_CR22","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s10875-010-9425-2","volume":"30","author":"J Wu","year":"2010","unstructured":"Wu, J., Fernandes-Alnemri, T. & Alnemri, E. S. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes. J. Clin. Immunol. 30, 693\u2013702 (2010).","journal-title":"J. Clin. Immunol."},{"key":"356_CR23","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1002\/eji.201040425","volume":"40","author":"S Kim","year":"2010","unstructured":"Kim, S. et al. Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome. Eur. J. Immunol. 40, 1545\u20131551 (2010).","journal-title":"Eur. J. Immunol."},{"key":"356_CR24","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1189\/jlb.1211601","volume":"92","author":"H Parker","year":"2012","unstructured":"Parker, H., Dragunow, M., Hampton, M. B., Kettle, A. J. & Winterbourn, C. C. Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus. J. Leukoc. Biol. 92, 841\u2013849 (2012).","journal-title":"J. Leukoc. Biol."},{"key":"356_CR25","first-page":"702","volume-title":"Biomolecules","author":"W Stoiber","year":"2015","unstructured":"Stoiber, W., Obermayer, A., Steinbacher, P. & Krautgartner, W. D. The role of reactive oxygen species (ROS) in the formation of extracellular traps (ETs) in humans. Biomolecules 5, (702\u2013723 (2015)."},{"key":"356_CR26","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.4049\/jimmunol.164.4.2064","volume":"164","author":"TH Flo","year":"2000","unstructured":"Flo, T. H. et al. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. J. Immunol. 164, 2064\u20132069 (2000).","journal-title":"J. Immunol."},{"key":"356_CR27","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1126\/science.1101400","volume":"306","author":"Y Wang","year":"2004","unstructured":"Wang, Y. et al. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science 306, 279\u2013283 (2004).","journal-title":"Science"},{"key":"356_CR28","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1084\/jem.20100239","volume":"207","author":"P Li","year":"2010","unstructured":"Li, P. et al. PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J. Exp. Med. 207, 1853\u20131862 (2010).","journal-title":"J. Exp. Med."},{"key":"356_CR29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1189\/jlb.72.2.239","volume":"72","author":"SH Gregory","year":"2002","unstructured":"Gregory, S. H. & Wing, E. J. Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections. J. Leukoc. Biol. 72, 239\u2013248 (2002).","journal-title":"J. Leukoc. Biol."},{"key":"356_CR30","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S0171-2985(99)80057-6","volume":"201","author":"JW Conlan","year":"1999","unstructured":"Conlan, J. W. Early host-pathogen interactions in the liver and spleen during systemic murine listeriosis: an overview. Immunobiology. 201, 178\u2013187 (1999).","journal-title":"Immunobiology."},{"key":"356_CR31","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.4049\/jimmunol.157.6.2514","volume":"157","author":"SH Gregory","year":"1996","unstructured":"Gregory, S. H., Sagnimeni, A. J. & Wing, E. J. Bacteria in the bloodstream are trapped in the liver and killed by immigrating neutrophils. J. Immunol. 157, 2514\u20132520 (1996).","journal-title":"J. Immunol."},{"key":"356_CR32","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1084\/jem.174.3.741","volume":"174","author":"JW Conlan","year":"1991","unstructured":"Conlan, J. W. & North, R. J. Neutrophil-mediated dissolution of infected host cells as a defense strategy against a facultative intracellular bacterium. J. Exp. Med. 174, 741\u2013744 (1991).","journal-title":"J. Exp. Med."},{"key":"356_CR33","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.immuni.2009.08.001","volume":"31","author":"CE Sutton","year":"2009","unstructured":"Sutton, C. E. et al. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31, 331\u2013341 (2009).","journal-title":"Immunity"},{"key":"356_CR34","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/ni1309","volume":"7","author":"NV Serbina","year":"2006","unstructured":"Serbina, N. V. & Pamer, E. G. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 7, 311\u2013317 (2006).","journal-title":"Nat. Immunol."},{"key":"356_CR35","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1083\/jcb.201006052","volume":"191","author":"V Papayannopoulos","year":"2010","unstructured":"Papayannopoulos, V., Metzler, K. D., Hakkim, A. & Zychlinsky, A. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J. Cell Biol. 191, 677\u2013691 (2010).","journal-title":"J. Cell. Biol."},{"key":"356_CR36","doi-asserted-by":"publisher","first-page":"e84704","DOI":"10.1371\/journal.pone.0084704","volume":"9","author":"T Kawakami","year":"2014","unstructured":"Kawakami, T. et al. Rab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cells. PLoS ONE 9, e84704 (2014).","journal-title":"PLoS ONE"},{"key":"356_CR37","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.4049\/jimmunol.180.3.1895","volume":"180","author":"I Neeli","year":"2008","unstructured":"Neeli, I., Khan, S. N. & Radic, M. Histone deimination as a response to inflammatory stimuli in neutrophils. J. Immunol. 180, 1895\u20131902 (2008).","journal-title":"J. Immunol."},{"key":"356_CR38","doi-asserted-by":"publisher","first-page":"e97088","DOI":"10.1371\/journal.pone.0097088","volume":"9","author":"AK Gupta","year":"2014","unstructured":"Gupta, A. K., Giaglis, S., Hasler, P. & Hahn, S. Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A. PLoS ONE 9, e97088 (2014).","journal-title":"PLoS ONE"},{"key":"356_CR39","doi-asserted-by":"publisher","first-page":"e0131645","DOI":"10.1371\/journal.pone.0131645","volume":"10","author":"A Ali","year":"2015","unstructured":"Ali, A. et al. IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in Mice. PLoS ONE 10, e0131645 (2015).","journal-title":"PLoS ONE"},{"key":"356_CR40","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1093\/rheumatology\/ker146","volume":"50","author":"JB Galloway","year":"2011","unstructured":"Galloway, J. B. et al. The risk of serious infections in patients receiving anakinra for rheumatoid arthritis: results from the British society for rheumatology biologics register. Rheumatology 50, 1341\u20131342 (2011).","journal-title":"Rheumatology"},{"key":"356_CR41","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.immuni.2005.11.011","volume":"24","author":"LS Miller","year":"2006","unstructured":"Miller, L. S. et al. MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity 24, 79\u201391 (2006).","journal-title":"Immunity"},{"key":"356_CR42","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/nchembio.1525","volume":"10","author":"SR Stowell","year":"2014","unstructured":"Stowell, S. R. et al. Microbial glycan microarrays define key features of host-microbial interactions. Nat. Chem. Biol. 10, 470\u2013476 (2014).","journal-title":"Nat. Chem. Biol."},{"key":"356_CR43","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1128\/IAI.72.5.2477-2483.2004","volume":"72","author":"N Aoki","year":"2004","unstructured":"Aoki, N., Zganiacz, A., Margetts, P. & Xing, Z. Differential regulation of DAP12 and molecules associated with DAP12 during host responses to mycobacterial infection. Infect. Immun. 72, 2477\u20132483 (2004).","journal-title":"Infect. Immun."},{"key":"356_CR44","doi-asserted-by":"publisher","first-page":"4662","DOI":"10.4049\/jimmunol.177.7.4662","volume":"177","author":"E Lockhart","year":"2006","unstructured":"Lockhart, E., Green, A. M. & Flynn, J. L. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during mycobacterium tuberculosis infection. J. Immunol. 177, 4662\u20134669 (2006).","journal-title":"J. Immunol."},{"key":"356_CR45","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/978-1-4939-0703-8_11","volume":"1157","author":"MR Eugster","year":"2014","unstructured":"Eugster, M. R. & Loessner, M. J. The Listeria cell wall and associated carbohydrate polymers. Methods. Mol. Biol. 1157, 129\u2013140 (2014).","journal-title":"Methods. Mol. Biol."},{"key":"356_CR46","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1128\/JB.183.4.1133-1139.2001","volume":"183","author":"XH Lei","year":"2001","unstructured":"Lei, X. H., Fiedler, F., Lan, Z. & Kathariou, S. A novel serotype-specific gene cassette (gltA-gltB) is required for expression of teichoic acid-associated surface antigens in Listeria monocytogenes of serotype 4b. J. Bacteriol. 183, 1133\u20131139 (2001).","journal-title":"J. Bacteriol."},{"key":"356_CR47","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1128\/JB.181.2.418-425.1999","volume":"181","author":"N Promadej","year":"1999","unstructured":"Promadej, N., Fiedler, F., Cossart, P., Dramsi, S. & Kathariou, S. Cell wall teichoic acid glycosylation in Listeria monocytogenes serotype 4b requires gtcA, a novel, serogroup-specific gene. J. Bacteriol. 181, 418\u2013425 (1999).","journal-title":"J. Bacteriol."},{"key":"356_CR48","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1159\/000205281","volume":"1","author":"D Ermert","year":"2009","unstructured":"Ermert, D. et al. Mouse neutrophil extracellular traps in microbial infections. J. Innate Immun. 1, 181\u2013193 (2009).","journal-title":"J. Innate Immun."},{"key":"356_CR49","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1128\/IAI.00860-08","volume":"77","author":"M Wellington","year":"2009","unstructured":"Wellington, M., Dolan, K. & Krysan, D. J. Live Candida albicans suppresses production of reactive oxygen species in phagocytes. Infect. Immun. 77, 405\u2013413 (2009).","journal-title":"Infect. Immun."},{"key":"356_CR50","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1093\/infdis\/jit157","volume":"208","author":"YT Lin","year":"2013","unstructured":"Lin, Y. T., Liu, C. J., Yeh, Y. C., Chen, T. J. & Fung, C. P. Ampicillin and amoxicillin use and the risk of Klebsiella pneumoniae liver abscess in Taiwan. J. Infect. Dis. 208, 211\u2013217 (2013).","journal-title":"J. Infect. Dis."},{"key":"356_CR51","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1093\/oxfordjournals.jbchem.a134275","volume":"93","author":"K Kamisango","year":"1983","unstructured":"Kamisango, K. et al. Structural and immunochemical studies of teichoic acid of Listeria monocytogenes. J. Biochem. 93, 1401\u20131409 (1983).","journal-title":"J. Biochem."},{"issue":"Suppl 2","key":"356_CR52","doi-asserted-by":"publisher","first-page":"S92","DOI":"10.1007\/BF01639729","volume":"16","author":"F Fiedler","year":"1988","unstructured":"Fiedler, F. Biochemistry of the cell surface of Listeria strains: a locating general view. Infection 16(Suppl 2), S92\u2013S97 (1988).","journal-title":"Infection"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-017-00356-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-017-00356-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-017-00356-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T23:42:28Z","timestamp":1692920548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-017-00356-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,21]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["356"],"URL":"https:\/\/doi.org\/10.1038\/s41467-017-00356-3","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,21]]},"assertion":[{"value":"7 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"299"}}