{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:59:40Z","timestamp":1793933980541,"version":"4.8.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Environmental conditions profoundly affect plant disease development; however, the underlying molecular bases are not well understood. Here we show that elevated temperature significantly increases the susceptibility of <jats:italic>Arabidopsis<\/jats:italic> to <jats:italic>Pseudomonas syringae<\/jats:italic> pv. <jats:italic>tomato<\/jats:italic> (<jats:italic>Pst<\/jats:italic>) DC3000 independently of the phyB\/PIF thermosensing pathway. Instead, elevated temperature promotes translocation of bacterial effector proteins into plant cells and causes a loss of ICS1-mediated salicylic acid (SA) biosynthesis. Global transcriptome analysis reveals a major temperature-sensitive node of SA signalling, impacting ~60% of benzothiadiazole (BTH)-regulated genes, including <jats:italic>ICS1<\/jats:italic> and the canonical SA marker gene, <jats:italic>PR1<\/jats:italic>. Remarkably, BTH can effectively protect <jats:italic>Arabidopsis<\/jats:italic> against <jats:italic>Pst<\/jats:italic> DC3000 infection at elevated temperature despite the lack of <jats:italic>ICS1<\/jats:italic> and <jats:italic>PR1<\/jats:italic> expression. Our results highlight the broad impact of a major climate condition on the enigmatic molecular interplay between temperature, SA defence and function of a central bacterial virulence system in the context of a widely studied susceptible plant\u2013pathogen interaction.<\/jats:p>","DOI":"10.1038\/s41467-017-01674-2","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T17:38:40Z","timestamp":1511285920000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":248,"title":["Dual impact of elevated temperature on plant defence and bacterial virulence in Arabidopsis"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-753X","authenticated-orcid":false,"given":"Bethany","family":"Huot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9982-8451","authenticated-orcid":false,"given":"Christian Danve M.","family":"Castroverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 C.","family":"Vel\u00e1squez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Pulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-062X","authenticated-orcid":false,"given":"Kevin L.","family":"Childs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7074-0731","authenticated-orcid":false,"given":"Kenichi","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beronda L.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng Yang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"1674_CR1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1146\/annurev.phyto.43.113004.133839","volume":"43","author":"RN Strange","year":"2005","unstructured":"Strange, R. N. & Scott, P. R. Plant disease: a threat to global food security. Annu. Rev. Phytopathol. \n                           43, 83\u2013116 (2005).","journal-title":"Annu. Rev. Phytopathol."},{"key":"1674_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1017\/S0021859605005708","volume":"144","author":"EC Oerke","year":"2006","unstructured":"Oerke, E. C. Crop losses to pests. J. Agric. Sci. \n                           144, 31\u201343 (2006).","journal-title":"J. Agric. Sci."},{"key":"1674_CR3","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1146\/annurev.py.11.090173.002015","volume":"11","author":"J Colhoun","year":"1973","unstructured":"Colhoun, J. Effects of environmental factors on plant disease. Annu. Rev. Phytopathol. \n                           11, 343\u2013364 (1973).","journal-title":"Annu. Rev. Phytopathol."},{"key":"1674_CR4","doi-asserted-by":"publisher","first-page":"3523","DOI":"10.1093\/jxb\/ers100","volume":"63","author":"NJ Atkinson","year":"2012","unstructured":"Atkinson, N. J. & Urwin, P. E. The interaction of plant biotic and abiotic stresses: from genes to the field. J. Ex. Bot. \n                           63, 3523\u20133543 (2012).","journal-title":"J. Ex. Bot."},{"key":"1674_CR5","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1146\/annurev-arplant-042809-112116","volume":"61","author":"R Mittler","year":"2010","unstructured":"Mittler, R. & Blumwald, E. Genetic engineering for modern agriculture: challenges and perspectives. Ann. Rev. Plant Biol. \n                           61, 443\u2013462 (2010).","journal-title":"Ann. Rev. Plant Biol."},{"key":"1674_CR6","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1126\/science.277.5329.1063","volume":"277","author":"SD Tanksley","year":"1997","unstructured":"Tanksley, S. D. & McCouch, S. R. Seed banks and molecular maps: unlocking genetic potential from the wild. Science \n                           277, 1063\u20131066 (1997).","journal-title":"Science"},{"key":"1674_CR7","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1146\/annurev-phyto-082712-102321","volume":"51","author":"XF Xin","year":"2013","unstructured":"Xin, X. F. & He, S. Y. Pseudomonas syringae pv. tomato DC3000: a model pathogen for probing disease susceptibility and hormone signaling in plants. Annu. Rev. Phytopathol. \n                           51, 473\u2013498 (2013).","journal-title":"Annu. Rev. Phytopathol."},{"key":"1674_CR8","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s002030100344","volume":"176","author":"A Smirnova","year":"2001","unstructured":"Smirnova, A. et al. Thermoregulated expression of virulence factors in plant-associated bacteria. Arch. Microbiol. \n                           176, 393\u2013399 (2001).","journal-title":"Arch. Microbiol."},{"key":"1674_CR9","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1094\/MPMI.2004.17.10.1095","volume":"17","author":"H Weingart","year":"2004","unstructured":"Weingart, H., Stubner, S., Schenk, A. & Ullrich, M. S. Impact of temperature on in planta expression of genes involved in synthesis of the Pseudomonas syringae phytotoxin coronatine. Mol. Plant Microbe Interact. \n                           17, 1095\u20131102 (2004).","journal-title":"Mol. Plant Microbe Interact."},{"key":"1674_CR10","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1146\/annurev-arplant-042811-105606","volume":"64","author":"ZQ Fu","year":"2013","unstructured":"Fu, Z. Q. & Dong, X. N. Systemic acquired resistance: turning local infection into global defense. Ann. Rev. Plant Biol. \n                           64, 839\u2013863 (2013).","journal-title":"Ann. Rev. Plant Biol."},{"key":"1674_CR11","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/35107108","volume":"414","author":"MC Wildermuth","year":"2001","unstructured":"Wildermuth, M. C., Dewdney, J., Wu, G. & Ausubel, F. M. Isochorismate synthase is required to synthesize salicylic acid for plant defence. Nature \n                           414, 562\u2013565 (2001).","journal-title":"Nature"},{"key":"1674_CR12","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.tplants.2013.04.004","volume":"18","author":"KM Pajerowska-Mukhtar","year":"2013","unstructured":"Pajerowska-Mukhtar, K. M., Emerine, D. K. & Mukhtar, M. S. Tell me more: roles of NPRs in plant immunity. Trends Plant Sci. \n                           18, 402\u2013411 (2013).","journal-title":"Trends Plant Sci."},{"key":"1674_CR13","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1146\/annurev.phyto.44.070505.143425","volume":"44","author":"LC van Loon","year":"2006","unstructured":"van Loon, L. C., Rep, M. & Pieterse, C. M. J. Significance of inducible defense-related proteins in infected plants. Annu. Rev. Phytopathol. \n                           44, 135\u2013162 (2006).","journal-title":"Annu. Rev. Phytopathol."},{"key":"1674_CR14","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1105\/tpc.8.4.629","volume":"8","author":"J Gorlach","year":"1996","unstructured":"Gorlach, J. et al. Benzothiadiazole, a novel class of inducers of systemic acquired resistance, activates gene expression and disease resistance in wheat. Plant Cell \n                           8, 629\u2013643 (1996).","journal-title":"Plant Cell"},{"key":"1674_CR15","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1094\/MPMI.1998.11.7.643","volume":"11","author":"SW Morris","year":"1998","unstructured":"Morris, S. W. et al. Induced resistance responses in maize. Mol. Plant Microbe Interact. \n                           11, 643\u2013658 (1998).","journal-title":"Mol. Plant Microbe Interact."},{"key":"1674_CR16","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1046\/j.1365-313x.2001.01070.x","volume":"27","author":"MS Chern","year":"2001","unstructured":"Chern, M. S. et al. Evidence for a disease-resistance pathway in rice similar to the NPR1-mediated signaling pathway in Arabidopsis. Plant J. \n                           27, 101\u2013113 (2001).","journal-title":"Plant J."},{"key":"1674_CR17","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1105\/tpc.4.3.359","volume":"4","author":"J Malamy","year":"1992","unstructured":"Malamy, J., Hennig, J. & Klessig, D. F. Temperature-dependent induction of salicylic acid and its conjugates during the resistance response to tobacco mosaic virus infection. Plant Cell \n                           4, 359\u2013366 (1992).","journal-title":"Plant Cell"},{"key":"1674_CR18","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1094\/MPMI-22-5-0498","volume":"22","author":"Y Wang","year":"2009","unstructured":"Wang, Y., Bao, Z., Zhu, Y. & Hua, J. Analysis of temperature modulation of plant defense against biotrophic microbes. Mol. Plant Microbe Interact. \n                           22, 498\u2013506 (2009).","journal-title":"Mol. Plant Microbe Interact."},{"key":"1674_CR19","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1111\/j.1365-313X.2007.03369.x","volume":"53","author":"K Tsuda","year":"2008","unstructured":"Tsuda, K., Sato, M., Glazebrook, J., Cohen, J. D. & Katagiri, F. Interplay between MAMP-triggered and SA-mediated defense responses. Plant J. \n                           53, 763\u2013775 (2008).","journal-title":"Plant J."},{"key":"1674_CR20","volume":"4","author":"C Cheng","year":"2013","unstructured":"Cheng, C. et al. Plant immune response to pathogens differs with changing temperatures. Nat. Commun. \n                           4, 2530 (2013).","journal-title":"Nat. Commun."},{"key":"1674_CR21","doi-asserted-by":"publisher","first-page":"15190","DOI":"10.1038\/nplants.2015.190","volume":"2","author":"M Quint","year":"2016","unstructured":"Quint, M. et al. Molecular and genetic control of plant thermomorphogenesis. Nat. Plants \n                           2, 15190 (2016).","journal-title":"Nat. Plants"},{"key":"1674_CR22","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1126\/science.aaf6005","volume":"354","author":"JH Jung","year":"2016","unstructured":"Jung, J. H. et al. Phytochromes function as thermosensors in Arabidopsis. Science \n                           354, 886\u2013889 (2016).","journal-title":"Science"},{"key":"1674_CR23","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1126\/science.aaf5656","volume":"354","author":"M Legris","year":"2016","unstructured":"Legris, M. et al. Phytochrome B integrates light and temperature signals in Arabidopsis. Science \n                           354, 897\u2013900 (2016).","journal-title":"Science"},{"key":"1674_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cub.2016.10.044","volume":"27","author":"SN Gangappa","year":"2017","unstructured":"Gangappa, S. N., Berriri, S. & Kumar, S. V. PIF4 coordinates thermosensory growth and immunity in. Arabidopsis Curr. Biol. \n                           27, 1\u20137 (2017).","journal-title":"Arabidopsis Curr. Biol."},{"key":"1674_CR25","first-page":"267","volume":"6","author":"JZ Liu","year":"2015","unstructured":"Liu, J. Z., Feng, L. L., Li, J. M. & He, Z. H. Genetic and epigenetic control of plant heat responses. Front. Plant Sci. \n                           6, 267 (2015).","journal-title":"Front. Plant Sci."},{"key":"1674_CR26","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3389\/fpls.2015.00995","volume":"6","author":"A Menna","year":"2015","unstructured":"Menna, A., Nguyen, D., Guttman, D. S. & Desveaux, D. Elevated temperature differentially influences effector-triggered immunity outputs in Arabidopsis. Front. Plant Sci. \n                           6, 995 (2015).","journal-title":"Front. Plant Sci."},{"key":"1674_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1105\/tpc.006940","volume":"15","author":"SY Xiao","year":"2003","unstructured":"Xiao, S. Y., Brown, S., Patrick, E., Brearley, C. & Turner, J. G. Enhanced transcription of the Arabidopsis disease resistance genes RPW8.1 and RPW8.2 via a salicylic acid-dependent amplification circuit is required for hypersensitive cell death. Plant Cell \n                           15, 33\u201345 (2003).","journal-title":"Plant Cell"},{"key":"1674_CR28","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.tplants.2012.09.002","volume":"18","author":"MCG Proveniers","year":"2013","unstructured":"Proveniers, M. C. G. & van Zanten, M. High temperature acclimation through PIF4 signaling. Trends Plant Sci. \n                           18, 59\u201364 (2013).","journal-title":"Trends Plant Sci."},{"key":"1674_CR29","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1016\/j.cub.2008.10.058","volume":"18","author":"P Leivar","year":"2008","unstructured":"Leivar, P. et al. Multiple phytochrome-interacting bHLH transcription factors repress premature seedling photomorphogenesis in darkness. Curr. Biol. \n                           18, 1815\u20131823 (2008).","journal-title":"Curr. Biol."},{"key":"1674_CR30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1046\/j.1365-313X.2002.01338.x","volume":"31","author":"T Genoud","year":"2002","unstructured":"Genoud, T., Buchala, A. J., Chua, N.-H. & M\u00e9traux, J.-P. Phytochrome signalling modulates the SA-perceptive pathway in Arabidopsis. Plant J. \n                           31, 87\u201395 (2002).","journal-title":"Plant J."},{"key":"1674_CR31","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1105\/tpc.107.051516","volume":"19","author":"Y-s Su","year":"2007","unstructured":"Su, Y.-s. & Lagarias, J. C. Light-independent phytochrome signaling mediated by dominant GAF domain tyrosine mutants of Arabidopsis phytochromes in transgenic plants. Plant Cell \n                           19, 2124\u20132139 (2007).","journal-title":"Plant Cell"},{"key":"1674_CR32","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/mp\/ssn086","volume":"2","author":"W Hu","year":"2009","unstructured":"Hu, W., Su, Y.-S. & Lagarias, J. C. A light-independent allele of phytochrome B faithfully recapitulates photomorphogenic transcriptional networks. Mol. Plant \n                           2, 166\u2013182 (2009).","journal-title":"Mol. Plant"},{"key":"1674_CR33","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1073\/pnas.94.7.3459","volume":"94","author":"E Roine","year":"1997","unstructured":"Roine, E. et al. Hrp pilus: an hrp-dependent bacterial surface appendage produced by Pseudomonas syringae pv tomato DC3000. Proc. Natl Acad. Sci. USA \n                           94, 3459\u20133464 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1674_CR34","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1094\/MPMI-4-069","volume":"4","author":"S-W Ma","year":"1991","unstructured":"Ma, S.-W., Morris, V. L. & Cuppels, D. A. Characterization of a DNA region required for production of the phytotoxin coronatine by Pseudomonas syringae pv. tomato. Mol. Plant Microbe Interact. \n                           4, 69\u201374 (1991).","journal-title":"Mol. Plant Microbe Interact."},{"key":"1674_CR35","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1128\/JB.186.2.543-555.2004","volume":"186","author":"LM Schechter","year":"2004","unstructured":"Schechter, L. M., Roberts, K. A., Jamir, Y., Alfano, J. R. & Collmer, A. Pseudomonas syringae type III secretion system targeting signals and novel effectors studied with a cya translocation reporter. J. Bacteriol. \n                           186, 543\u2013555 (2004).","journal-title":"J. Bacteriol."},{"key":"1674_CR36","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1046\/j.1365-313X.1996.10010071.x","volume":"10","author":"KA Lawton","year":"1996","unstructured":"Lawton, K. A. et al. Benzothiadiazole induces disease resistance in Arabidopsis by activation of the systemic acquired resistance signal transduction pathway. Plant. J. \n                           10, 71\u201382 (1996).","journal-title":"Plant. J."},{"key":"1674_CR37","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3389\/fpls.2012.00085","volume":"3","author":"W Underwood","year":"2012","unstructured":"Underwood, W. The plant cell wall: A dynamic barrier against pathogen invasion. Front. Plant Sci. \n                           3, 85 (2012).","journal-title":"Front. Plant Sci."},{"key":"1674_CR38","doi-asserted-by":"publisher","first-page":"e1000844","DOI":"10.1371\/journal.ppat.1000844","volume":"6","author":"Y Zhu","year":"2010","unstructured":"Zhu, Y., Qian, W. Q. & Hua, J. Temperature modulates plant defense responses through NB-LRR proteins. PLoS Path. \n                           6, e1000844 (2010).","journal-title":"PLoS Path."},{"key":"1674_CR39","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1105\/tpc.12.12.2339","volume":"12","author":"M Kinkema","year":"2000","unstructured":"Kinkema, M., Fan, W. H. & Dong, X. N. Nuclear localization of NPR1 is required for activation of PR gene expression. Plant Cell \n                           12, 2339\u20132350 (2000).","journal-title":"Plant Cell"},{"key":"1674_CR40","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.chom.2015.07.005","volume":"18","author":"A Saleh","year":"2015","unstructured":"Saleh, A. et al. Posttranslational modifications of the master transcriptional regulator NPR1 enable dynamic but tight control of plant immune responses. Cell Host Microbe \n                           18, 169\u2013182 (2015).","journal-title":"Cell Host Microbe"},{"key":"1674_CR41","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1104\/pp.114.242404","volume":"165","author":"H Shi","year":"2014","unstructured":"Shi, H. et al. The cysteine2\/histidine2-type transcription factor ZINC FINGER OF ARABIDOPSIS THALIANA6 modulates biotic and abiotic stress responses by activating salicylic acid-related genes and C-REPEAT-BINDING FACTOR Genes in Arabidopsis. Plant Physiol. \n                           165, 1367\u20131379 (2014).","journal-title":"Plant Physiol."},{"key":"1674_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-165","volume":"11","author":"RC McLeay","year":"2010","unstructured":"McLeay, R. C. & Bailey, T. L. Motif enrichment analysis: a unified framework and an evaluation on ChIP data. BMC Bioinformatics \n                           11, 165 (2010).","journal-title":"BMC Bioinformatics"},{"key":"1674_CR43","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.tplants.2010.02.006","volume":"15","author":"PJ Rushton","year":"2010","unstructured":"Rushton, P. J., Somssich, I. E., Ringler, P. & Shen, Q. J. WRKY transcription factors. Trends Plant Sci. \n                           15, 247\u2013258 (2010).","journal-title":"Trends Plant Sci."},{"key":"1674_CR44","doi-asserted-by":"publisher","first-page":"3778","DOI":"10.1093\/nar\/23.18.3778","volume":"23","author":"E Lam","year":"1995","unstructured":"Lam, E. & Lam, Y. K. Binding site requirements and differential representation of TGF factors in nuclear ASF-1 activity. Nucleic Acids Res. \n                           23, 3778\u20133785 (1995).","journal-title":"Nucleic Acids Res."},{"key":"1674_CR45","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1126\/science.1061320","volume":"293","author":"D Alabadi","year":"2001","unstructured":"Alabadi, D. et al. Reciprocal regulation between TOC1 and LHY\/CCA1 within the Arabidopsis circadian clock. Science \n                           293, 880\u2013883 (2001).","journal-title":"Science"},{"key":"1674_CR46","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s10265-011-0409-y","volume":"124","author":"FY Cao","year":"2011","unstructured":"Cao, F. Y., Yoshioka, K. & Desveaux, D. The roles of ABA in plant-pathogen interactions. J. Plant Res. \n                           124, 489\u2013499 (2011).","journal-title":"J. Plant Res."},{"key":"1674_CR47","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/nature07612","volume":"457","author":"L Du","year":"2009","unstructured":"Du, L. et al. Ca2+\/calmodulin regulates salicylic-acid-mediated plant immunity. Nature \n                           457, 1154\u20131158 (2009).","journal-title":"Nature"},{"key":"1674_CR48","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1105\/tpc.108.065193","volume":"21","author":"H Chen","year":"2009","unstructured":"Chen, H. et al. ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE3-LIKE1 repress SALICYLIC ACID INDUCTION DEFICIENT2 expression to negatively regulate plant innate immunity in Arabidopsis. Plant Cell \n                           21, 2527\u20132540 (2009).","journal-title":"Plant Cell"},{"key":"1674_CR49","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1105\/tpc.107.054296","volume":"20","author":"M Yasuda","year":"2008","unstructured":"Yasuda, M. et al. Antagonistic interaction between systemic acquired resistance and the abscisic acid\u2013mediated abiotic stress response in Arabidopsis. Plant Cell \n                           20, 1678\u20131692 (2008).","journal-title":"Plant Cell"},{"key":"1674_CR50","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.chom.2012.04.014","volume":"11","author":"XY Zheng","year":"2012","unstructured":"Zheng, X. Y. et al. Coronatine promotes Pseudomonas syringae virulence in plants by activating a signaling cascade that inhibits salicylic acid accumulation. Cell Host Microbe \n                           11, 587\u2013596 (2012).","journal-title":"Cell Host Microbe"},{"key":"1674_CR51","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1046\/j.1365-313X.1996.10040655.x","volume":"10","author":"KM Leon-Kloosterziel","year":"1996","unstructured":"Leon-Kloosterziel, K. M. et al. Isolation and characterization of abscisic acid-deficient Arabidopsis mutants at two new loci. Plant J. \n                           10, 655\u2013661 (1996).","journal-title":"Plant J."},{"key":"1674_CR52","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1104\/pp.114.1.161","volume":"114","author":"SH Schwartz","year":"1997","unstructured":"Schwartz, S. H., Leon-Kloosterziel, K. M., Koornneef, M. & Zeevaart, J. A. Biochemical characterization of the aba2 and aba3 mutants in Arabidopsis thaliana. Plant Physiol. \n                           114, 161\u2013166 (1997).","journal-title":"Plant Physiol."},{"key":"1674_CR53","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00425-002-0906-2","volume":"216","author":"B von Malek","year":"2002","unstructured":"von Malek, B., van der Graaff, E., Schneitz, K. & Keller, B. The Arabidopsis male-sterile mutant dde2-2 is defective in the ALLENE OXIDE SYNTHASE gene encoding one of the key enzymes of the jasmonic acid biosynthesis pathway. Planta \n                           216, 187\u2013192 (2002).","journal-title":"Planta"},{"key":"1674_CR54","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1111\/nph.14638","volume":"215","author":"IT Major","year":"2017","unstructured":"Major, I. T. et al. Regulation of growth\u2013defense balance by the JASMONATE ZIM-DOMAIN (JAZ)-MYC transcriptional module. New Phytol. \n                           215, 1533\u20131547 (2017).","journal-title":"New Phytol."},{"key":"1674_CR55","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1105\/tpc.2.6.513","volume":"2","author":"P Guzm\u00e1n","year":"1990","unstructured":"Guzm\u00e1n, P. & Ecker, J. R. Exploiting the triple response of Arabidopsis to identify ethylene-related mutants. Plant Cell \n                           2, 513\u2013523 (1990).","journal-title":"Plant Cell"},{"key":"1674_CR56","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/tpj.12205","volume":"75","author":"Y Kim","year":"2013","unstructured":"Kim, Y., Park, S., Gilmour, S. J. & Thomashow, M. F. Roles of CAMTA transcription factors and salicylic acid in configuring the low-temperature transcriptome and freezing tolerance of Arabidopsis. Plant J. \n                           75, 364\u2013376 (2013).","journal-title":"Plant J."},{"key":"1674_CR57","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/tpj.12473","volume":"78","author":"L Zhang","year":"2014","unstructured":"Zhang, L., Du, L., Shen, C., Yang, Y. & Poovaiah, B. W. Regulation of plant immunity through ubiquitin-mediated modulation of Ca(2+) -calmodulin-AtSR1\/CAMTA3 signaling. Plant J. \n                           78, 269\u2013281 (2014).","journal-title":"Plant J."},{"key":"1674_CR58","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.pbi.2007.06.002","volume":"10","author":"GJM Beckers","year":"2007","unstructured":"Beckers, G. J. M. & Conrath, U. Priming for stress resistance: from the lab to the field. Curr. Opin. Plant Biol. \n                           10, 425\u2013431 (2007).","journal-title":"Curr. Opin. Plant Biol."},{"key":"1674_CR59","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1105\/tpc.014894","volume":"15","author":"Y Zhang","year":"2003","unstructured":"Zhang, Y., Tessaro, M. J., Lassner, M. & Li, X. Knockout analysis of Arabidopsis transcription factors TGA2, TGA5, and TGA6 reveals their redundant and essential roles in systemic acquired resistance. Plant Cell \n                           15, 2647\u20132653 (2003).","journal-title":"Plant Cell"},{"key":"1674_CR60","unstructured":"Stevens, R. in Plant Pathology, An Advanced Treatise Vol. 3. (ed. Horsfall, J. G.) 357\u2013429 (Academic Press, New York, NY USA; 1960)."},{"key":"1674_CR61","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.tplants.2011.09.001","volume":"16","author":"R Alc\u00e1zar","year":"2011","unstructured":"Alc\u00e1zar, R. & Parker, J. E. The impact of temperature on balancing immune responsiveness and growth in Arabidopsis. Trends Plant Sci. \n                           16, 666\u2013675 (2011).","journal-title":"Trends Plant Sci."},{"key":"1674_CR62","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1086\/280211","volume":"62","author":"JG Dickson","year":"1928","unstructured":"Dickson, J. G. & Holbert, J. R. The relation of temperature to the development of disease in plants. Am. Nat. \n                           62, 311\u2013333 (1928).","journal-title":"Am. Nat."},{"key":"1674_CR63","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1744-7348.1931.tb02320.x","volume":"18","author":"G Samuel","year":"1931","unstructured":"Samuel, G. Some experiments on inoculating methods with plant viruses, and on local lesions. Ann. Appl. Biol. \n                           18, 494\u2013507 (1931).","journal-title":"Ann. Appl. Biol."},{"key":"1674_CR64","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.pbi.2013.06.017","volume":"16","author":"J Hua","year":"2013","unstructured":"Hua, J. Modulation of plant immunity by light, circadian rhythm, and temperature. Curr. Opin. Plant Biol. \n                           16, 406\u2013413 (2013).","journal-title":"Curr. Opin. Plant Biol."},{"key":"1674_CR65","doi-asserted-by":"publisher","first-page":"5919","DOI":"10.1074\/jbc.M605193200","volume":"282","author":"MA Strawn","year":"2007","unstructured":"Strawn, M. A. et al. Arabidopsis isochorismate synthase functional in pathogen-induced salicylate biosynthesis exhibits properties consistent with a role in diverse stress responses. J. Biol. Chem. \n                           282, 5919\u20135933 (2007).","journal-title":"J. Biol. Chem."},{"key":"1674_CR66","doi-asserted-by":"publisher","first-page":"e1002291","DOI":"10.1371\/journal.ppat.1002291","volume":"7","author":"WQ Zeng","year":"2011","unstructured":"Zeng, W. Q. et al. A genetic screen reveals Arabidopsis stomatal and\/or apoplastic defenses against Pseudomonas syringae pv. tomato DC3000. PLoS Path. \n                           7, e1002291 (2011).","journal-title":"PLoS Path."},{"key":"1674_CR67","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1104\/pp.110.159723","volume":"154","author":"E Crabill","year":"2010","unstructured":"Crabill, E., Joe, A., Block, A., van Rooyen, J. M. & Alfano, J. R. Plant immunity directly or indirectly restricts the injection of type III effectors by the Pseudomonas syringae type III secretion system. Plant Physiol. \n                           154, 233\u2013244 (2010).","journal-title":"Plant Physiol."},{"key":"1674_CR68","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/j.1462-5822.2009.01396.x","volume":"12","author":"A Block","year":"2010","unstructured":"Block, A. et al. The Pseudomonas syringae type III effector HopG1 targets mitochondria, alters plant development and suppresses plant innate immunity. Cell Microbiol. \n                           12, 318\u2013330 (2010).","journal-title":"Cell Microbiol."},{"key":"1674_CR69","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cub.2011.12.015","volume":"22","author":"KM Pajerowska-Mukhtar","year":"2012","unstructured":"Pajerowska-Mukhtar, K. M. et al. The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition. Curr. Biol. \n                           22, 103\u2013112 (2012).","journal-title":"Curr. Biol."},{"key":"1674_CR70","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1371\/journal.ppat.0020123","volume":"2","author":"D Wang","year":"2006","unstructured":"Wang, D., Amornsiripanitch, N. & Dong, X. N. A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants. PLoS Path. \n                           2, 1042\u20131050 (2006).","journal-title":"PLoS Path."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-017-01674-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-017-01674-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-017-01674-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T23:20:44Z","timestamp":1671751244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-017-01674-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,27]]},"references-count":70,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["1674"],"URL":"https:\/\/doi.org\/10.1038\/s41467-017-01674-2","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,27]]},"assertion":[{"value":"14 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1808"}}