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We conduct a multiethnic genome-wide association study (GWAS) of POAG in the GERA cohort, with replication in the UK Biobank (UKB), and vice versa, GWAS in UKB with replication in GERA. We identify 24 loci (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20095.0\u2009\u00d7\u200910\n                    <jats:sup>\u22128<\/jats:sup>\n                    ), including 14 novel, of which 9 replicate (near\n                    <jats:italic>FMNL2<\/jats:italic>\n                    ,\n                    <jats:italic>PDE7B<\/jats:italic>\n                    ,\n                    <jats:italic>TMTC2<\/jats:italic>\n                    ,\n                    <jats:italic>IKZF2<\/jats:italic>\n                    ,\n                    <jats:italic>CADM2<\/jats:italic>\n                    ,\n                    <jats:italic>DGKG<\/jats:italic>\n                    ,\n                    <jats:italic>ANKH<\/jats:italic>\n                    ,\n                    <jats:italic>EXOC2<\/jats:italic>\n                    , and\n                    <jats:italic>LMX1B<\/jats:italic>\n                    ). Functional studies support intraocular pressure-related influences of\n                    <jats:italic>FMNL2<\/jats:italic>\n                    and\n                    <jats:italic>LMX1B<\/jats:italic>\n                    , with certain\n                    <jats:italic>Lmx1b<\/jats:italic>\n                    mutations causing high IOP and glaucoma resembling POAG in mice. The newly identified loci increase the proportion of variance explained in each GERA race\/ethnicity group, with the largest gain in African-Americans (0.5\u20133.1%). A meta-analysis combining GERA and UKB identifies 24 additional loci. Our study provides important insights into glaucoma pathogenesis.\n                  <\/jats:p>","DOI":"10.1038\/s41467-018-04555-4","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T09:42:03Z","timestamp":1528191723000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":186,"title":["A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-8667","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Choquet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyedhassan","family":"Paylakhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Kneeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh K.","family":"Thai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark N.","family":"Kvale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yambazi","family":"Banda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Tolman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6194-8397","authenticated-orcid":false,"given":"Pete A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Melles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Risch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon W. 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